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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:RAB3B_PKN2

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: RAB3B_PKN2
	KinaseFusionDB ID: KFG5223
	FusionGDB2.0 ID: KFG5223
		Hgene	Tgene
	Gene symbol	RAB3B	PKN2
	Gene ID	5865	5586
	Gene name	RAB3B, member RAS oncogene family	protein kinase N2
	Synonyms	-	PAK2\|PRK2\|PRKCL2\|PRO2042\|Pak-2\|STK7
	Cytomap	1p32.3	1p22.2
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rab-3Bbrain antigen RAB3B	serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2
	Modification date	20240411	20240323
	UniProtAcc	P20337	Q16513
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371655,	ENST00000370505, ENST00000370513, ENST00000495119, ENST00000544045, ENST00000316005, ENST00000370521,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: RAB3B [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RAB3B(52442562)-PKN2(89206671), # samples:2

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAB3B	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	20007772
Hgene	RAB3B	GO:0097494	regulation of vesicle size	20007772
Hgene	RAB3B	GO:0098693	regulation of synaptic vesicle cycle	20007772
Tgene	PKN2	GO:0006468	protein phosphorylation	17332740
Tgene	PKN2	GO:0010631	epithelial cell migration	21754995

Kinase Fusion gene breakpoints across RAB3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across PKN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-DX-A23U-01A	RAB3B	chr1	52442562	PKN2	chr1	89206671

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000371655	ENST00000316005	RAB3B	chr1	52442562	PKN2	chr1	89206671	2666	683

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000371655_ENST00000316005_RAB3B_chr1_52442562_PKN2_chr1_89206671_length(amino acids)=683
MPSRRPSGSEPVVPHSESAMASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRV
KLQIWGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQ
ELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIR
MQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNE
VPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSR
TSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHG
MCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRI

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:52442562/chr1:89206671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAB3B P20337	PKN2 Q16513
FUNCTION: Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.	FUNCTION: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269\|PubMed:10226025, ECO:0000269\|PubMed:10926925, ECO:0000269\|PubMed:11777936, ECO:0000269\|PubMed:11781095, ECO:0000269\|PubMed:15123640, ECO:0000269\|PubMed:15364941, ECO:0000269\|PubMed:17332740, ECO:0000269\|PubMed:20188095, ECO:0000269\|PubMed:20974804, ECO:0000269\|PubMed:21754995, ECO:0000269\|PubMed:27104747, ECO:0000269\|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269\|PubMed:15364941}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	17	917_984	0	659	Domain	Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00618
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	917_984	0	828	Domain	Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00618
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	917_984	16	937	Domain	Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00618
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	22	917_984	16	985	Domain	Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00618
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	17	353_473	0	659	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00041
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	353_473	0	828	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00041
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	353_473	16	937	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00041
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	22	353_473	16	985	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00041
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	17	657_916	0	659	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	657_916	0	828	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	657_916	16	937	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	22	657_916	16	985	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	17	33_109	0	659	Domain	Note=REM-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	33_109	0	828	Domain	Note=REM-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	33_109	16	937	Domain	Note=REM-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	22	33_109	16	985	Domain	Note=REM-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	17	121_203	0	659	Domain	Note=REM-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	121_203	0	828	Domain	Note=REM-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	121_203	16	937	Domain	Note=REM-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	22	121_203	16	985	Domain	Note=REM-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	17	204_284	0	659	Domain	Note=REM-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	204_284	0	828	Domain	Note=REM-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	21	204_284	16	937	Domain	Note=REM-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207
Tgene	RAB3B	52442562	PKN2	89206671	ENST00000371655	0	22	204_284	16	985	Domain	Note=REM-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU01207

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>402_RAB3B_PKN2	ENST00000371655	ENST00000316005	RAB3B	chr1	52442562	PKN2	chr1	89206671	MPSRRPSGSEPVVPHSESAMASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRV KLQIWGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQ ELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIR MQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNE VPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSR TSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHG MCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRI	683
3D view using mol* of 402_RAB3B_PKN2

PDB file >>>TKFP_682_RAB3B_PKN2	ENST00000371655	ENST00000316005	RAB3B	chr1	52442562	PKN2	chr1	89206671	MPSRRPSGSEPVVPHSESAMASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRV KLQIWGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQ ELNAHIVVSDPEDITDCPRTPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIR MQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNE VPKNHPKSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSR TSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHG MCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRI	683_RAB3B_PKN2

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

RAB3B_PKN2 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/402_RAB3B_PKN2.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

402_RAB3B_PKN2.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

402_RAB3B_PKN2_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of RAB3B_PKN2

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
PKN2	Q16513	human	NOS3	P29474	S1179	RIRtQsFsLQERQLR
PKN2	Q16513	human	MEFV	O15553	S208	VRLRRNAssAGRLQG
PKN2	Q16513	human	MEFV	O15553	S242	SGKMRPRsLEVTIST

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
PKN2	ID	Description	0.00e+00
PKN2	GO:0032102	negative regulation of response to external stimulus	2.18e-02
PKN2	GO:0014745	negative regulation of muscle adaptation	2.18e-02
PKN2	GO:0006527	arginine catabolic process	2.18e-02
PKN2	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	2.18e-02
PKN2	GO:0030728	ovulation	2.18e-02
PKN2	GO:0141086	negative regulation of inflammasome-mediated signaling pathway	2.18e-02
PKN2	GO:0030810	positive regulation of nucleotide biosynthetic process	2.18e-02
PKN2	GO:1900373	positive regulation of purine nucleotide biosynthetic process	2.18e-02
PKN2	GO:0010544	negative regulation of platelet activation	2.18e-02
PKN2	GO:0003184	pulmonary valve morphogenesis	2.18e-02
PKN2	GO:0032695	negative regulation of interleukin-12 production	2.18e-02
PKN2	GO:0006525	arginine metabolic process	2.18e-02
PKN2	GO:0045981	positive regulation of nucleotide metabolic process	2.18e-02
PKN2	GO:1900544	positive regulation of purine nucleotide metabolic process	2.18e-02
PKN2	GO:0003177	pulmonary valve development	2.18e-02
PKN2	GO:0019430	removal of superoxide radicals	2.18e-02
PKN2	GO:0071450	cellular response to oxygen radical	2.18e-02
PKN2	GO:0071451	cellular response to superoxide	2.18e-02
PKN2	GO:0002026	regulation of the force of heart contraction	2.18e-02
PKN2	GO:0009065	glutamine family amino acid catabolic process	2.18e-02
PKN2	GO:0000303	response to superoxide	2.18e-02
PKN2	GO:0000305	response to oxygen radical	2.18e-02
PKN2	GO:0007263	nitric oxide mediated signal transduction	2.18e-02
PKN2	GO:0070168	negative regulation of biomineral tissue development	2.18e-02
PKN2	GO:0032682	negative regulation of chemokine production	2.18e-02
PKN2	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	2.18e-02
PKN2	GO:0030808	regulation of nucleotide biosynthetic process	2.18e-02
PKN2	GO:1900371	regulation of purine nucleotide biosynthetic process	2.18e-02
PKN2	GO:0034405	response to fluid shear stress	2.18e-02
PKN2	GO:1900225	regulation of NLRP3 inflammasome complex assembly	2.18e-02
PKN2	GO:0048873	homeostasis of number of cells within a tissue	2.18e-02
PKN2	GO:0039532	negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway	2.18e-02
PKN2	GO:0043267	negative regulation of potassium ion transport	2.18e-02
PKN2	GO:0044546	NLRP3 inflammasome complex assembly	2.18e-02
PKN2	GO:0070269	pyroptosis	2.18e-02
PKN2	GO:0141085	regulation of inflammasome-mediated signaling pathway	2.18e-02
PKN2	GO:0001990	regulation of systemic arterial blood pressure by hormone	2.18e-02
PKN2	GO:0003180	aortic valve morphogenesis	2.18e-02
PKN2	GO:0031281	positive regulation of cyclase activity	2.18e-02
PKN2	GO:0140632	canonical inflammasome complex assembly	2.18e-02
PKN2	GO:0051349	positive regulation of lyase activity	2.18e-02
PKN2	GO:0003203	endocardial cushion morphogenesis	2.18e-02
PKN2	GO:0045454	cell redox homeostasis	2.18e-02
PKN2	GO:1900016	negative regulation of cytokine production involved in inflammatory response	2.18e-02
PKN2	GO:0141084	inflammasome-mediated signaling pathway	2.18e-02
PKN2	GO:0003176	aortic valve development	2.18e-02
PKN2	GO:0060412	ventricular septum morphogenesis	2.18e-02
PKN2	GO:0032691	negative regulation of interleukin-1 beta production	2.18e-02
PKN2	GO:0003044	regulation of systemic arterial blood pressure mediated by a chemical signal	2.18e-02

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Related Drugs to RAB3B_PKN2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning RAB3B-PKN2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to RAB3B_PKN2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date