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Kinase Fusion Gene:ABL1_NTRK2 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: ABL1_NTRK2 | KinaseFusionDB ID: KFG53 | FusionGDB2.0 ID: KFG53 | Hgene | Tgene | Gene symbol | ABL1 | NTRK2 | Gene ID | 25 | 4915 | |
Gene name | ABL proto-oncogene 1, non-receptor tyrosine kinase | neurotrophic receptor tyrosine kinase 2 | ||||||||||
Synonyms | ABL|BCR-ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl | DEE58|EIEE58|GP145-TrkB|OBHD|TRKB|trk-B | ||||||||||
Cytomap | 9q34.12 | 9q21.33 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1BCR-ABL1 p190BCR/ABL e8a2 fusionBCR/ABL1 e1a2 fusion proteinbcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncog | BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B | ||||||||||
Modification date | 20240416 | 20240411 | ||||||||||
UniProtAcc | P00519 | Q16620 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000318560, | ENST00000277120, ENST00000304053, ENST00000323115, ENST00000359847, ENST00000376208, ENST00000376213, ENST00000376214, ENST00000395866, ENST00000395882, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ABL1 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ABL1(133710912)-NTRK2(87338487), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABL1 | GO:0006974 | DNA damage response | 15657060 |
Hgene | ABL1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 7590236|9144171|10713049|11121037 |
Hgene | ABL1 | GO:0042770 | signal transduction in response to DNA damage | 9037071|15657060|18280240 |
Hgene | ABL1 | GO:0043065 | positive regulation of apoptotic process | 9037071 |
Hgene | ABL1 | GO:0046777 | protein autophosphorylation | 10713049 |
Hgene | ABL1 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15657060 |
Hgene | ABL1 | GO:0051353 | positive regulation of oxidoreductase activity | 12893824 |
Hgene | ABL1 | GO:0051444 | negative regulation of ubiquitin-protein transferase activity | 20823226 |
Hgene | ABL1 | GO:0070301 | cellular response to hydrogen peroxide | 10713049 |
Hgene | ABL1 | GO:0071103 | DNA conformation change | 9558345 |
Hgene | ABL1 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 11121037 |
Hgene | ABL1 | GO:1990051 | activation of protein kinase C activity | 10713049 |
Hgene | ABL1 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination | 9461559 |
Kinase Fusion gene breakpoints across ABL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across NTRK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-VR-A8EW | ABL1 | chr9 | 133710912 | NTRK2 | chr9 | 87338487 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
ENST00000318560 | ENST00000376214 | ABL1 | chr9 | 133710912 | NTRK2 | chr9 | 87338487 | 4547 | 707 |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000318560_ENST00000376214_ABL1_chr9_133710912_NTRK2_chr9_87338487_length(amino acids)=707 MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133710912/chr9:87338487) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ABL1 | NTRK2 |
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. | FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 197_282 | 194 | 478 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 197_282 | 38 | 322 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 17 | 197_282 | 194 | 823 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 13 | 197_282 | 194 | 478 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 14 | 197_282 | 194 | 538 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 15 | 197_282 | 194 | 554 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 19 | 197_282 | 194 | 839 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 7 | 20 | 197_282 | 194 | 823 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 7 | 21 | 197_282 | 194 | 839 | Domain | Note=Ig-like C2-type 1 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 295_365 | 194 | 478 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 295_365 | 38 | 322 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 17 | 295_365 | 194 | 823 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 13 | 295_365 | 194 | 478 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 14 | 295_365 | 194 | 538 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 15 | 295_365 | 194 | 554 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 19 | 295_365 | 194 | 839 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 7 | 20 | 295_365 | 194 | 823 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 7 | 21 | 295_365 | 194 | 839 | Domain | Note=Ig-like C2-type 2 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 148_196 | 38 | 322 | Domain | Note=LRRCT |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 538_807 | 194 | 478 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 12 | 538_807 | 38 | 322 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 4 | 17 | 538_807 | 194 | 823 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 13 | 538_807 | 194 | 478 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 14 | 538_807 | 194 | 538 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 15 | 538_807 | 194 | 554 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 5 | 19 | 538_807 | 194 | 839 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 7 | 20 | 538_807 | 194 | 823 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
Tgene | ABL1 | 133710912 | NTRK2 | 87338487 | ENST00000318560 | 7 | 21 | 538_807 | 194 | 839 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
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Kinase Fusion Protein Structures |
CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
PDB file >>>3_ABL1_NTRK2 | ENST00000318560 | ENST00000376214 | ABL1 | chr9 | 133710912 | NTRK2 | chr9 | 87338487 | MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE | 707 |
3D view using mol* of 3_ABL1_NTRK2 | ||||||||||
PDB file >>>TKFP_6_ABL1_NTRK2 | ENST00000318560 | ENST00000376214 | ABL1 | chr9 | 133710912 | NTRK2 | chr9 | 87338487 | MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE | 707_ABL1_NTRK2 |
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Comparison of Fusion Protein Isoforms |
Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
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Potential Active Site Information |
The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
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Virtual Screening Results |
Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
5'-kinase fusion protein case |
3'-kinase fusion protein case |
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Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
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Kinase-Substrate Information of ABL1_NTRK2 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
ABL1 | P00519 | human | YAP1 | P46937 | Y407 | sGLsMsSySVPRtPD | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y750 | PAPDELVyQVPQStQ | |
ABL1 | P00519 | human | SMAD4 | Q13485 | Y301 | MPPHPGHyWPVHNEL | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S657 | GDyQRPHsAQPADRG | |
ABL1 | P00519 | human | TBX21 | Q9UL17 | Y305 | QFIAVTAyQNAEITQ | T-box |
ABL1 | P00519 | human | CAT | P04040 | Y231 | NANGEAVyCkFHYkT | Catalase |
ABL1 | P00519 | human | MYLK | Q15746 | Y1449 | EKEPEVDyRTVTINT | |
ABL1 | P00519 | human | ABL1 | P00519 | Y393 | RLMtGDtytAHAGAk | PK_Tyr_Ser-Thr |
ABL1 | P00519 | human | TP73 | O15350 | Y99 | SVPTHSPyAQPSSTF | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y715 | PPPLVGtyNtLLsRt | |
ABL1 | P00519 | human | SORBS2 | O94875-2 | Y59 | RPFSPSAySLPASLN | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y565 | KKkTEGtyDLPyWDR | |
ABL1 | P00519 | human | CDC73 | Q6P1J9 | Y315 | KIDTMGTyHGMTLkS | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S695 | THPGTsDsysAPRDC | |
ABL1 | P00519 | human | MET | P08581 | Y1349 | stFIGEHyVHVNAty | |
ABL1 | P00519 | human | HRAS | P01112 | Y137 | AQDLARSyGIPYIEt | Ras |
ABL1 | P00519 | human | MYC | P01106 | Y89 | sGLCsPSyVAVtPFs | Myc_N |
ABL1 | P00519 | human | MDM4 | O15151 | Y55 | TVKEVMHyLGQYIMV | SWIB |
ABL1 | P00519 | human | PIK3AP1 | Q6ZUJ8 | Y513 | LGQEEDVyHTVDDDE | |
ABL1 | P00519 | human | PDGFRB | P09619 | Y970 | GEGYKKKyQQVDEEF | |
ABL1 | P00519 | human | KAT5 | Q92993 | Y294 | HPPGNEIyRkGTISF | MOZ_SAS |
ABL1 | P00519 | human | MYC | P01106 | Y47 | CDEEENFyQQQQQSE | Myc_N |
ABL1 | P00519 | human | CRK | P46108 | Y221 | GGPEPGPyAQPsVNt | |
ABL1 | P00519 | human | CASP9 | P55211 | Y153 | RGNADLAyILSMEPC | |
ABL1 | P00519 | human | PLSCR1 | O15162 | Y69 | PVPNQPVyNQPVyNQ | |
ABL1 | P00519 | human | ANXA1 | P04083 | Y21 | IENEEQEyVQtVkss | |
ABL1 | P00519 | human | PXN | P49023 | Y118 | VGEEEHVysFPNkQk | Paxillin |
ABL1 | P00519 | human | SMAD4 | Q13485 | Y195 | NRASTETyStPALLA | |
ABL1 | P00519 | human | ROBO1 | Q9Y6N7 | Y1038 | MLPESTVyGDVDLSN | |
ABL1 | P00519 | human | CRKL | P46109 | Y207 | IPEPAHAyAQPQttt | |
ABL1 | P00519 | human | VAV1 | P15498 | Y174 | EAEGDEIyEDLMRsE | |
ABL1 | P00519 | human | TP63 | Q9H3D4 | Y290 | RQSVLVPyEPPQVGT | P53 |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | T756 | VyQVPQStQEVsGAG | |
ABL1 | P00519 | human | RB1 | P06400 | Y805 | rIPGGNIyIsPLksP | Rb_C |
ABL1 | P00519 | human | NOX5 | Q96PH1 | Y476 | FHYRPGDyLyLNIPT | FAD_binding_8 |
ABL1 | P00519 | human | FHL2 | Q14192 | Y176 | ITTGGVtyREQPWHK | LIM |
ABL1 | P00519 | human | MDM2 | Q00987 | Y394 | QsQESEDysQPSTSS | |
ABL1 | P00519 | human | ESR1 | P03372 | Y219 | sIQGHNDyMCPATNQ | zf-C4 |
ABL1 | P00519 | human | RAPGEF1 | Q13905 | Y504 | APIPSVPyAPFAAIL | |
ABL1 | P00519 | human | PLK1 | P53350 | Y445 | DSTRLILyNDGDsLQ | POLO_box |
ABL1 | P00519 | human | CRK | P46108 | Y239 | NLQNGPIyARVIQKR | SH3_2 |
ABL1 | P00519 | human | ZAP70 | P43403 | Y319 | tsVyEsPysDPEELk | |
ABL1 | P00519 | human | JUNB | P17275 | Y182 | GPEPPPVyTNLSSyS | Jun |
ABL1 | P00519 | human | EGFR | P00533 | Y1092 | tFLPVPEyINQsVPk | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | S600 | tPVRysssEVNHLsP | |
ABL1 | P00519 | human | ABI1 | Q8IZP0 | Y213 | PPtVPNDyMtsPARL | |
ABL1 | P00519 | human | MAVS | Q7Z434 | Y30 | DVVEILPyLPCLTAR | CARD_2 |
ABL1 | P00519 | human | PHF5A | Q7RTV0 | Y36 | kCVICDSyVRPCTLV | PHF5 |
ABL1 | P00519 | human | TP63 | Q9H3D4 | Y149 | SVTAPSPyAQPSSTF | |
ABL1 | P00519 | human | ABL1 | P00519-2 | Y412 | RLMTGDtyTAHAGAK | PK_Tyr_Ser-Thr |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S697 | PGTsDsysAPRDCLT | |
ABL1 | P00519 | human | PXN | P49023 | Y31 | FLSEEtPysyPtGNH | |
ABL1 | P00519 | human | WASF3 | Q9UPY6 | Y151 | KKDGLKFyTDPSyFF | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y665 | AQPADRGyDRPKAVs | |
ABL1 | P00519 | human | PDGFRB | P09619 | Y686 | IITEyCRyGDLVDyL | PK_Tyr_Ser-Thr |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | S598 | EEtPVRysssEVNHL | |
ABL1 | P00519 | human | CDC73 | Q6P1J9 | Y293 | IPAAyNRyDQERFkG | CDC73_N |
ABL1 | P00519 | human | CASP9 | P55211 | Y397 | AVSVkGIyKQMPGCF | Peptidase_C14 |
ABL1 | P00519 | human | PYCARD | Q9ULZ3 | Y146 | kVLTDEQyQAVRAEP | CARD |
ABL1 | P00519 | human | CD19 | P15391 | Y508 | EDMRGILyAAPQLRs | |
ABL1 | P00519 | human | CDKN1B | P46527 | Y88 | kGsLPEFyyRPPRPP | |
ABL1 | P00519 | human | CTNNB1 | P35222 | Y86 | VADIDGQyAMTRAQR | |
ABL1 | P00519 | human | FOXA1 | P55317 | Y429 | QALQYsPyGSTLPAS | HNF_C |
ABL1 | P00519 | human | MYLK | Q15746 | Y792 | QPWHAGQyEILLKNR | I-set |
ABL1 | P00519 | human | MYLK | Q15746 | Y464 | QEGsIEVyEDAGsHy | I-set |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y655 | GyADLDPyNsPGQEV | |
ABL1 | P00519 | human | JUNB | P17275 | Y173 | PAGPGGVyAGPEPPP | Jun |
ABL1 | P00519 | human | SNCA | P37840 | Y125 | VDPDNEAyEMPsEEG | Synuclein |
ABL1 | P00519 | human | NOX5 | Q96PH1 | Y478 | YRPGDyLyLNIPTIA | FAD_binding_8 |
ABL1 | P00519 | human | MYLK | Q15746 | Y231 | NQDDVGVyTCLVVNG | I-set |
ABL1 | P00519 | human | MYLK | Q15746 | Y846 | DGGGSDRyGsLRPGW | |
ABL1 | P00519 | human | PIK3AP1 | Q6ZUJ8 | Y594 | DRPQssIyDPFAGMk | |
ABL1 | P00519 | human | GPX1 | P07203 | Y98 | EILNSLkyVRPGGGF | GSHPx |
ABL1 | P00519 | human | SRCIN1 | Q9C0H9 | Y396 | LVKGEGLyADPyGLL | |
ABL1 | P00519 | human | NOS3 | P29474 | Y81 | WEVGSITyDTLSAQA | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | S760 | PQStQEVsGAGRDGE | |
ABL1 | P00519 | human | MDM4 | O15151 | Y99 | VkDPsPLyDMLRKNL | |
ABL1 | P00519 | human | HIPK2 | Q9H2X6 | Y367 | tyLQsRYyRAPEIIL | Pkinase |
ABL1 | P00519 | human | TRIM33 | Q9UPN9 | Y1048 | MMKVVQVyADtQEIN | Bromodomain |
ABL1 | P00519 | human | TBX21 | Q9UL17 | Y220 | SMPGNRLyVHPDSPN | T-box |
ABL1 | P00519 | human | PSMA7 | O14818 | Y106 | EDPVTVEyItRyIAS | Proteasome |
ABL1 | P00519 | human | PPARG | P37231 | Y78 | SSISTPHyEDIPFTR | PPARgamma_N |
ABL1 | P00519 | human | ATR | Q13535 | Y291 | DTDQLKLyEEPLSkL | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y649 | EEGKEAGyADLDPyN | |
ABL1 | P00519 | human | AHSA1 | O95433 | Y223 | LtsPEELyRVFTTQE | AHSA1 |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y589 | QRAGRHEyALPLAPP | |
ABL1 | P00519 | human | DNM1L | O00429 | Y266 | TDSIRDEyAFLQkkY | Dynamin_M |
ABL1 | P00519 | human | LGALS3 | P17931 | Y107 | AYPATGPyGAPAGPL | |
ABL1 | P00519 | human | LGALS3 | P17931 | Y79 | GAPAPGVyPGPPSGP | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y600 | LAPPEPEyAtPIVER | |
ABL1 | P00519 | human | WASF3 | Q9UPY6 | Y486 | SRRIAVEySDSDDDS | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S556 | GTVTRKGsTFRPMDT | |
ABL1 | P00519 | human | ESR2 | Q92731 | Y36 | SIYIPSSyVDSHHEY | ERbeta_N |
ABL1 | P00519 | human | RAD51 | Q06609 | Y54 | HTVEAVAyAPkkELI | HHH_5 |
ABL1 | P00519 | human | EGFR | P00533 | Y1197 | stAENAEyLRVAPQS | |
ABL1 | P00519 | human | GLO1 | Q04760 | Y136 | GIAVPDVysACkRFE | Glyoxalase |
ABL1 | P00519 | human | STX17 | P56962 | Y157 | SQSLTQIyALPEIPQ | |
ABL1 | P00519 | human | PPARG | P37231 | Y102 | yDLKLQEyQSAIkVE | PPARgamma_N |
ABL1 | P00519 | human | GMNN | O75496 | Y150 | EVAEHVQyMAELIER | Geminin |
ABL1 | P00519 | human | SNCA | P37840 | Y39 | kTkEGVLyVGsKTkE | Synuclein |
ABL1 | P00519 | human | NFKBIA | P25963 | Y305 | FtEDELPyDDCVFGG | |
ABL1 | P00519 | human | MUC1 | P15941 | Y1243 | NGGSsLsytNPAVAA | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S693 | PPTHPGTsDsysAPR | |
ABL1 | P00519 | human | SORBS2 | O94875-2 | Y573 | NTKGAEDyPDPPIPH | |
ABL1 | P00519 | human | ERRFI1 | Q9UJM3 | Y394 | KKVsstHyyLLPERP | |
ABL1 | P00519 | human | CAV1 | Q03135 | Y14 | VDsEGHLytVPIREQ | |
ABL1 | P00519 | human | RAD51 | Q06609 | Y315 | EtRICKIyDSPCLPE | Rad51 |
ABL1 | P00519 | human | FOXA1 | P55317 | Y464 | PAYYQGVySRPVLNT | |
ABL1 | P00519 | human | RTCB | Q9Y3I0 | Y316 | GMAAAGNyAWVNRSS | RtcB |
ABL1 | P00519 | human | ESR1 | P03372 | Y52 | DssKPAVyNYPEGAA | Oest_recep |
ABL1 | P00519 | human | ATR | Q13535 | Y310 | FPFEAEAyRNIEPVY | |
ABL1 | P00519 | human | BCR | P11274 | Y177 | ADAEKPFyVNVEFHH | |
ABL1 | P00519 | human | PLCG1 | P19174 | Y1003 | KGKKFLQyNRLQLSR | PI-PLC-Y |
ABL1 | P00519 | human | MET | P08581 | Y1356 | yVHVNAtyVNVKCVA | |
ABL1 | P00519 | human | BTK | Q06187 | Y223 | LKKVVALyDyMPMNA | SH3_1 |
ABL1 | P00519 | human | EGFR | P00533 | Y1016 | DVVDADEyLIPQQGF | |
ABL1 | P00519 | human | RACK1 | P63244 | Y52 | LtrDEtNyGIPQRAL | |
ABL1 | P00519 | human | SORBS2 | O94875-2 | Y175 | YTYNAGLyNPPYSAQ | |
ABL1 | P00519 | human | ABL2 | P42684 | Y261 | GLVTTLHyPAPKCNK | |
ABL1 | P00519 | human | STK3 | Q13188 | Y81 | MQQCDSPyVVKYYGS | Pkinase |
ABL1 | P00519 | human | PLCG1 | P19174 | Y771 | IGtAEPdyGALyEGR | |
ABL1 | P00519 | human | PLK1 | P53350 | Y217 | tLCGtPNyIAPEVLs | Pkinase |
ABL1 | P00519 | human | SNW1 | Q13573 | Y292 | AKLAEALyIADRKAR | SKIP_SNW |
ABL1 | P00519 | human | PIK3AP1 | Q6ZUJ8 | Y570 | QERPGNFyVSSEsIR | |
ABL1 | P00519 | human | CEBPB | P17676 | Y78 | RAIDFsPyLEPLGAP | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y540 | ITsDMADyQQPLMIG | |
ABL1 | P00519 | human | OTULIN | Q96BN8 | Y56 | AEHEEDMyRAADEIE | |
ABL1 | P00519 | human | JUN | P05412 | Y170 | LHSEPPVyANLSNFN | Jun |
ABL1 | P00519 | human | IRF3 | Q14653 | Y292 | rLGHCHTyWAVSEEL | IRF-3 |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y597 | HEEtPVRysssEVNH | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y621 | LQADsAEyAQPLVGG | |
ABL1 | P00519 | human | CTTN | Q14247 | Y486 | yPAEDStyDEYENDL | |
ABL1 | P00519 | human | TP63 | Q9H3D4 | Y171 | AIPSNTDyPGPHSFD | P53 |
ABL1 | P00519 | human | NCOA3 | Q9Y6Q9 | Y1357 | HPQAASIyQSSEMKG | |
ABL1 | P00519 | human | RBM39 | Q14498 | Y95 | DRRFRGRyrsPysGP | |
ABL1 | P00519 | human | SNW1 | Q13573 | Y433 | EDEIyNVyDQAWrGG | |
ABL1 | P00519 | human | EMD | P50402 | Y167 | AyQsItHyRPVsAsR | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | T679 | ITGPEyAtPIIMDMS | |
ABL1 | P00519 | human | NCK1 | P16333 | Y105 | VDPGERLyDLNMPAy | |
ABL1 | P00519 | human | PIK3AP1 | Q6ZUJ8 | Y694 | AKVEFGVyEsGPRKs | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y677 | LPITGPEyAtPIIMD | |
ABL1 | P00519 | human | CAT | P04040 | Y386 | yRARVANyQRDGPMC | Catalase |
ABL1 | P00519 | human | RAD52 | P43351 | Y104 | DLNNGKFyVGVCAFV | Rad52_Rad22 |
ABL1 | P00519 | human | ROBO1 | Q9Y6N7 | Y1114 | QEVAPVQyNIVEQNk | |
ABL1 | P00519 | human | YAP1 | P46937-3 | Y357 | SGLSMSSySVPRtPD | |
ABL1 | P00519 | human | WASF3 | Q9UPY6 | Y337 | LPAQIIEyYNPSGPP | |
ABL1 | P00519 | human | DDX5 | P17844 | Y593 | NGMNQQAyAyPATAA | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S513 | yPFARHQsAEFtISY | |
ABL1 | P00519 | human | PLK1 | P53350 | Y425 | SDkYGLGyQLCDNSV | POLO_box |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | S618 | TTVLQADsAEyAQPL | |
ABL1 | P00519 | human | CDC73 | Q6P1J9 | Y290 | kQPIPAAyNRyDQER | CDC73_N |
ABL1 | P00519 | human | ARHGDIB | P52566 | Y24 | ELdskLNykPPPQks | Rho_GDI |
ABL1 | P00519 | human | TBX21 | Q9UL17 | Y266 | VLQsLHKyQPRLHIV | T-box |
ABL1 | P00519 | human | MYLK | Q15746 | Y1635 | VAPEVINyEPIGYAT | Pkinase |
ABL1 | P00519 | human | JUNB | P17275 | Y188 | VyTNLSSySPASASS | Jun |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y666 | GQEVyHAyAEPLPIT | |
ABL1 | P00519 | human | PIK3AP1 | Q6ZUJ8 | Y553 | QLPDNEPyIFKVFAE | |
ABL1 | P00519 | human | GMFG | O60234 | Y104 | kPEQQMMyAGSkNRL | Cofilin_ADF |
ABL1 | P00519 | human | SRCIN1 | Q9C0H9 | Y264 | IYRKEPLyAAFPGSH | AIP3 |
ABL1 | P00519 | human | PSMA7 | O14818 | Y153 | QTDPsGtyHAWkANA | Proteasome |
ABL1 | P00519 | human | TRIM33 | Q9UPN9 | Y524 | QHMQQQVyAQKHQQL | |
ABL1 | P00519 | human | CDKN1B | P46527 | Y89 | GsLPEFyyRPPRPPK | |
ABL1 | P00519 | human | NUMA1 | Q14980 | Y1774 | VEsLEsLyFtPIPAR | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y578 | STDAGGHyDCPQRAG | |
ABL1 | P00519 | human | CRK | P46108 | Y251 | QKRVPNAyDktALAL | SH3_2 |
ABL1 | P00519 | human | DNM1L | O00429 | Y368 | CGGARICyIFHETFG | Dynamin_M |
ABL1 | P00519 | human | ZNF746 | Q6NUN9 | Y137 | ETLVSLDyAISKPEV | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | T593 | kAVDHEEtPVRysss | |
ABL1 | P00519 | human | TUBG1 | P23258 | Y443 | HAATRPDyISWGTQE | |
ABL1 | P00519 | human | PLEKHG2 | Q9H7P9 | Y489 | sEPVKDPyVMFPQNA | |
ABL1 | P00519 | human | DDB1 | Q16531 | Y182 | APTICFVyQDPQGRH | MMS1_N |
ABL1 | P00519 | human | SORBS2 | O94875-2 | Y50 | AVSPMSYyQRPFSPS | |
ABL1 | P00519 | human | LGALS3 | P17931 | Y118 | AGPLIVPyNLPLPGG | Gal-bind_lectin |
ABL1 | P00519 | human | PRAG1 | Q86YV5 | Y413 | ATQPEPIyAEsTKRK | |
ABL1 | P00519 | human | MYLK | Q15746 | Y611 | KSSRkSEyLLPVAPS | |
ABL1 | P00519 | human | CTNNB1 | P35222 | Y489 | QNAVRLHyGLPVVVk | |
ABL1 | P00519 | human | CTNNB1 | P35222 | Y654 | RNEGVAtyAAAVLFR | |
ABL1 | P00519 | human | SORBS2 | O94875-2 | Y164 | PDDDTDMyNTPYTYN | |
ABL1 | P00519 | human | DNM1L | O00429 | Y449 | IIQHCSNySTQELLR | Dynamin_M |
ABL1 | P00519 | human | PLSCR1 | O15162 | Y74 | PVyNQPVyNQPVGAA | |
ABL1 | P00519 | human | ERCC6 | Q03468 | Y932 | GANRVVIyDPDWNPS | Helicase_C |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | T714 | QPPPLVGtyNtLLsR | |
ABL1 | P00519 | human | PRKN | O60260 | Y143 | sPAGRSIyNSFYVYC | |
ABL1 | P00519 | human | MYLK | Q15746 | Y556 | LNGQPIQyARSTCEA | I-set |
ABL1 | P00519 | human | SNW1 | Q13573 | Y430 | AGGEDEIyNVyDQAW | |
ABL1 | P00519 | human | FHL2 | Q14192 | Y97 | TDCySNEySSkCQEC | LIM |
ABL1 | P00519 | human | RAD9A | Q99638 | Y28 | SRIGDELyLEPLEDG | Rad9 |
ABL1 | P00519 | human | SPTLC1 | O15269 | Y164 | KTEEAIIySYGFATI | Aminotran_1_2 |
ABL1 | P00519 | human | MAVS | Q7Z434 | Y71 | RRPGWVEyFIAALRG | CARD_2 |
ABL1 | P00519 | human | CHCHD2 | Q9Y6H1 | Y99 | PARPDITyQEPQGTQ | |
ABL1 | P00519 | human | STK4 | Q13043 | Y433 | kIPQDGDyEFLksWt | Mst1_SARAH |
ABL1 | P00519 | human | PDGFRB | P09619 | Y934 | AHAsDEIyEIMQKCW | PK_Tyr_Ser-Thr |
ABL1 | P00519 | human | RBM39 | Q14498 | Y99 | RGRyrsPysGPkFNs | |
ABL1 | P00519 | human | NFAT5 | O94916 | Y143 | PkRHtVLyIsPPPED | |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | Y663 | NsPGQEVyHAyAEPL | |
ABL1 | P00519 | human | ERRFI1 | Q9UJM3 | Y395 | KVsstHyyLLPERPP | |
ABL1 | P00519 | human | TRIM33 | Q9UPN9 | Y610 | PrHSGPQySMMQPHL | |
ABL1 | P00519 | human | WASF3 | Q9UPY6 | Y248 | HASDVtDySYPATPN | |
ABL1 | P00519 | human | HDAC2 | Q92769 | Y222 | IGAGkGkyYAVNFPM | Hist_deacetyl |
ABL1 | P00519 | human | FHL2 | Q14192 | Y236 | SGLGGTkyIsFEERQ | LIM |
ABL1 | P00519 | human | ROBO1 | Q9Y6N7 | Y1073 | PSGQPTPyAtTQLIQ | |
ABL1 | P00519 | human | MYLK | Q15746 | Y1575 | QISEGVEyIHKQGIV | Pkinase |
ABL1 | P00519 | human | PDHA1 | P08559 | Y301 | MsDPGVsyRtREEIQ | E1_dh |
ABL1 | P00519 | human | MDM2 | Q00987 | Y276 | sDEDDEVyQVtVyQA | |
ABL1 | P00519 | human | RTCB | Q9Y3I0 | Y306 | AsPEGQDyLkGMAAA | RtcB |
ABL1 | P00519 | human | PDK1 | Q15118 | Y243 | ARRLCDLyyINSPEL | |
ABL1 | P00519 | human | FUS | P35637 | Y526 | QDrrErPy_______ | |
ABL1 | P00519 | human | FHL2 | Q14192 | Y217 | LNCFCDLyAKkCAGC | LIM |
ABL1 | P00519 | human | DCBLD2 | Q96PD2 | S599 | EtPVRysssEVNHLs | |
ABL1 | P00519 | human | MDM2 | Q00987 | Y405 | STSSSIIyssQEDVK | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y621 | tFsAQsGyRVPGPQP | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y696 | HPGTsDsysAPRDCL | |
ABL1 | P00519 | human | LASP1 | Q14847 | Y171 | IPtsAPVyQQPQQQP | |
ABL1 | P00519 | human | PRKD1 | Q15139 | Y463 | NDTGsRYyKEIPLSE | PH |
ABL1 | P00519 | human | YY1 | P25490 | Y254 | sPPDySEyMTGkKLP | |
ABL1 | P00519 | human | ARHGDIB | P52566 | Y130 | LkYVQHtyRTGVkVD | Rho_GDI |
ABL1 | P00519 | human | DDB1 | Q16531 | Y718 | HIRtVPLyEsPRkIC | |
ABL1 | P00519 | human | WAS | P42768 | Y291 | AEtsKLIyDFIEDQG | PBD |
ABL1 | P00519 | human | CKMT1B | P12532 | Y153 | AsKIRsGyFDErYVL | |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | S535 | QkLDLITsDMADyQQ | |
ABL1 | P00519 | human | KAT5 | Q92993 | Y44 | ISGRKLFyVHYIDFN | Tudor-knot |
ABL1 | P00519 | human | MAVS | Q7Z434 | Y9 | PFAEDkTykyICRNF | CARD_2 |
ABL1 | P00519 | human | RTCB | Q9Y3I0 | Y475 | MEEAPESykNVTDVV | RtcB |
ABL1 | P00519 | human | DCBLD1 | Q8N8Z6 | Y652 | VGAQDGDyQRPHsAQ | |
ABL1 | P00519 | human | TOP1 | P11387 | Y268 | AkMLDHEyTTkEIFR | Topoisom_I_N |
ABL1 | P00519 | human | SMAD4 | Q13485 | Y322 | SNHPAPEyWCSIAYF | |
ABL1 | P00519 | human | VAV1 | P15498 | Y267 | TPGAANLyQVFIKYK | RhoGEF |
NTRK2 | Q16620 | human | NTRK2 | Q16620 | Y516 | PVIENPQyFGITNSQ | |
NTRK2 | Q16620 | human | SHC3 | Q92529-2 | Y218 | GDGSDHPyyNSIPSK | |
NTRK2 | Q16620 | human | SHC3 | Q92529-2 | Y256 | FAGKEQTyyQGRHLG | |
NTRK2 | Q16620 | human | KCNA3 | P22001 | Y499 | EGEEQSQyMHVGsCQ | |
NTRK2 | Q16620 | human | KCNA3 | P22001 | Y161 | PSFDAILyyyQSGGR | BTB_2 |
NTRK2 | Q16620 | human | KCNA3 | P22001 | Y162 | SFDAILyyyQSGGRI | BTB_2 |
NTRK2 | Q16620 | human | SHC3 | Q92529-2 | Y301 | PTGEAPTyVNTQQIP | |
NTRK2 | Q16620 | human | SHC3 | Q92529-2 | Y257 | AGKEQTyyQGRHLGD | |
NTRK2 | Q16620 | human | SHC3 | Q92529-2 | Y283 | RQGSSDIySTPEGKL | |
NTRK2 | Q16620 | human | SHC3 | Q92529-2 | Y219 | DGSDHPyyNSIPSKM | |
NTRK2 | Q16620 | human | KCNA3 | P22001 | Y163 | FDAILyyyQSGGRIR | BTB_2 |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
ABL1 | ID | Description | 0.00e+00 |
ABL1 | GO:0097193 | intrinsic apoptotic signaling pathway | 2.05e-15 |
ABL1 | GO:0062197 | cellular response to chemical stress | 1.46e-14 |
ABL1 | GO:0034599 | cellular response to oxidative stress | 9.05e-12 |
ABL1 | GO:2001233 | regulation of apoptotic signaling pathway | 1.04e-10 |
ABL1 | GO:0006979 | response to oxidative stress | 1.04e-10 |
ABL1 | GO:0030522 | intracellular receptor signaling pathway | 1.04e-10 |
ABL1 | GO:0050673 | epithelial cell proliferation | 2.35e-10 |
ABL1 | GO:0000302 | response to reactive oxygen species | 4.09e-10 |
ABL1 | GO:0072331 | signal transduction by p53 class mediator | 6.46e-10 |
ABL1 | GO:0032355 | response to estradiol | 8.39e-10 |
ABL1 | GO:0042770 | signal transduction in response to DNA damage | 1.51e-09 |
ABL1 | GO:0032970 | regulation of actin filament-based process | 1.94e-09 |
ABL1 | GO:1902903 | regulation of supramolecular fiber organization | 2.61e-09 |
ABL1 | GO:0032956 | regulation of actin cytoskeleton organization | 2.61e-09 |
ABL1 | GO:0050678 | regulation of epithelial cell proliferation | 5.06e-09 |
ABL1 | GO:0002757 | immune response-activating signaling pathway | 6.54e-09 |
ABL1 | GO:0051098 | regulation of binding | 6.54e-09 |
ABL1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 1.06e-08 |
ABL1 | GO:0002764 | immune response-regulating signaling pathway | 1.42e-08 |
ABL1 | GO:0034614 | cellular response to reactive oxygen species | 1.67e-08 |
ABL1 | GO:0031334 | positive regulation of protein-containing complex assembly | 2.17e-08 |
ABL1 | GO:0061614 | miRNA transcription | 4.65e-08 |
ABL1 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 5.89e-08 |
ABL1 | GO:1902905 | positive regulation of supramolecular fiber organization | 6.15e-08 |
ABL1 | GO:0010212 | response to ionizing radiation | 6.56e-08 |
ABL1 | GO:0010586 | miRNA metabolic process | 6.96e-08 |
ABL1 | GO:0031400 | negative regulation of protein modification process | 7.69e-08 |
ABL1 | GO:0048144 | fibroblast proliferation | 7.79e-08 |
ABL1 | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 1.31e-07 |
ABL1 | GO:0051090 | regulation of DNA-binding transcription factor activity | 1.86e-07 |
ABL1 | GO:2000628 | regulation of miRNA metabolic process | 1.86e-07 |
ABL1 | GO:0010517 | regulation of phospholipase activity | 1.86e-07 |
ABL1 | GO:0048145 | regulation of fibroblast proliferation | 2.43e-07 |
ABL1 | GO:0001933 | negative regulation of protein phosphorylation | 2.59e-07 |
ABL1 | GO:0043254 | regulation of protein-containing complex assembly | 2.59e-07 |
ABL1 | GO:0051099 | positive regulation of binding | 3.27e-07 |
ABL1 | GO:0009314 | response to radiation | 3.32e-07 |
ABL1 | GO:0045936 | negative regulation of phosphate metabolic process | 4.34e-07 |
ABL1 | GO:0010563 | negative regulation of phosphorus metabolic process | 4.38e-07 |
ABL1 | GO:0048732 | gland development | 5.01e-07 |
ABL1 | GO:0042326 | negative regulation of phosphorylation | 5.46e-07 |
ABL1 | GO:0098781 | ncRNA transcription | 5.46e-07 |
ABL1 | GO:1902893 | regulation of miRNA transcription | 5.58e-07 |
ABL1 | GO:0030330 | DNA damage respons | 1.01e-08 |
ABL1 | GO:2001235 | positive regulation of apoptotic signaling pathway | 9.26e-07 |
ABL1 | GO:0033673 | negative regulation of kinase activity | 1.19e-06 |
ABL1 | GO:0060191 | regulation of lipase activity | 1.19e-06 |
ABL1 | GO:0010332 | response to gamma radiation | 1.20e-06 |
ABL1 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 1.28e-06 |
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Related Drugs to ABL1_NTRK2 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning ABL1-NTRK2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ABL1_NTRK2 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABL1 | C0023473 | Myeloid Leukemia, Chronic | 3 | CGI;CTD_human;ORPHANET |
Hgene | ABL1 | C0023452 | Childhood Acute Lymphoblastic Leukemia | 2 | CTD_human |
Hgene | ABL1 | C0023453 | L2 Acute Lymphoblastic Leukemia | 2 | CTD_human |
Hgene | ABL1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | CGI;CTD_human |
Tgene | NTRK2 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | NTRK2 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | NTRK2 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Tgene | NTRK2 | C0525045 | Mood Disorders | 5 | PSYGENET |
Tgene | NTRK2 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Tgene | NTRK2 | C3151303 | Obesity, Hyperphagia, and Developmental Delay | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | NTRK2 | C0005586 | Bipolar Disorder | 3 | CTD_human;PSYGENET |
Tgene | NTRK2 | C4693367 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 58 | 3 | GENOMICS_ENGLAND;UNIPROT |
Tgene | NTRK2 | C0009171 | Cocaine Abuse | 2 | CTD_human |
Tgene | NTRK2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | NTRK2 | C0038220 | Status Epilepticus | 2 | CTD_human |
Tgene | NTRK2 | C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
Tgene | NTRK2 | C0270823 | Petit mal status | 2 | CTD_human |
Tgene | NTRK2 | C0311335 | Grand Mal Status Epilepticus | 2 | CTD_human |
Tgene | NTRK2 | C0393734 | Complex Partial Status Epilepticus | 2 | CTD_human |
Tgene | NTRK2 | C0600427 | Cocaine Dependence | 2 | CTD_human |
Tgene | NTRK2 | C0751217 | Hyperkinesia, Generalized | 2 | CTD_human |
Tgene | NTRK2 | C0751522 | Status Epilepticus, Subclinical | 2 | CTD_human |
Tgene | NTRK2 | C0751523 | Non-Convulsive Status Epilepticus | 2 | CTD_human |
Tgene | NTRK2 | C0751524 | Simple Partial Status Epilepticus | 2 | CTD_human |
Tgene | NTRK2 | C3887506 | Hyperkinesia | 2 | CTD_human |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |