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Kinase Fusion Gene:RBP4_RPS6KB2 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: RBP4_RPS6KB2 | KinaseFusionDB ID: KFG5326 | FusionGDB2.0 ID: KFG5326 | Hgene | Tgene | Gene symbol | RBP4 | RPS6KB2 | Gene ID | 5950 | 6199 | |
Gene name | retinol binding protein 4 | ribosomal protein S6 kinase B2 | ||||||||||
Synonyms | MCOPCB10|RDCCAS | KLS|P70-beta|P70-beta-1|P70-beta-2|S6K-beta2|S6K2|S6KB|S6KI(2)|S6Kbeta|SRK|STK14B|p70(S6K)-beta|p70S6Kb | ||||||||||
Cytomap | 10q23.33 | 11q13.2 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | retinol-binding protein 4PRBPRBPplasma retinol-binding proteinretinol binding protein 4, plasmaretinol-binding protein 4, interstitial | ribosomal protein S6 kinase beta-270 kDa ribosomal protein S6 kinase 2P70S6K2S6 kinase-related kinaseS6K-betaS6K-beta-2p70 S6 kinase betap70 S6K-betap70 S6KBp70 ribosomal S6 kinase betap70-S6K 2ribosomal protein S6 kinase, 70kDa, polypeptide 2 | ||||||||||
Modification date | 20240305 | 20240411 | ||||||||||
UniProtAcc | P02753 | Q9UBS0 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000371464, ENST00000371467, ENST00000371469, | ENST00000312629, ENST00000524814, ENST00000539188, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: RBP4 [Title/Abstract] AND RPS6KB2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | RBP4(95360147)-RPS6KB2(67200673), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RBP4 | GO:0030277 | maintenance of gastrointestinal epithelium | 10944490 |
Hgene | RBP4 | GO:0032526 | response to retinoic acid | 571335 |
Hgene | RBP4 | GO:0042593 | glucose homeostasis | 17003346 |
Tgene | RPS6KB2 | GO:0045948 | positive regulation of translational initiation | 29750193 |
Kinase Fusion gene breakpoints across RBP4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across RPS6KB2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-DD-AADG | RBP4 | chr10 | 95360147 | RPS6KB2 | chr11 | 67200673 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:95360147/:67200673) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
RBP4 | RPS6KB2 |
FUNCTION: Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). {ECO:0000269|PubMed:22665496, ECO:0000305, ECO:0000305|PubMed:5541771}. | FUNCTION: Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of RBP4_RPS6KB2 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
RPS6KB2 | Q9UBS0 | human | EEF2K | O00418 | S366 | sPQVRtLsGSRPPLL | |
RPS6KB2 | Q9UBS0 | human | HSPB1 | P04792 | S82 | RALsRQLssGVsEIr | |
RPS6KB2 | Q9UBS0 | human | TARBP2 | Q15633 | S283 | ILSLRsCsLGsLGAL | |
RPS6KB2 | Q9UBS0 | human | HSPB1 | P04792 | S78 | PAysRALsRQLssGV | |
RPS6KB2 | Q9UBS0 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
RPS6KB2 | Q9UBS0 | human | KRT18 | P05783 | S53 | IsVsrstsFrGGMGs | |
RPS6KB2 | Q9UBS0 | human | HNRNPA1 | P09651 | S4 | ____MsksEsPkEPE | |
RPS6KB2 | Q9UBS0 | human | HNRNPA1 | P09651 | S6 | __MsksEsPkEPEQL | |
RPS6KB2 | Q9UBS0 | human | RICTOR | Q6R327 | T1135 | NRRIRtLtEPsVDFN | RICTOR_phospho |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
RPS6KB2 | ID | Description | 0.00e+00 |
RPS6KB2 | GO:0051348 | negative regulation of transferase activity | 3.07e-02 |
RPS6KB2 | GO:0048814 | regulation of dendrite morphogenesis | 3.31e-02 |
RPS6KB2 | GO:0045936 | negative regulation of phosphate metabolic process | 3.31e-02 |
RPS6KB2 | GO:0010563 | negative regulation of phosphorus metabolic process | 3.31e-02 |
RPS6KB2 | GO:0031400 | negative regulation of protein modification process | 3.31e-02 |
RPS6KB2 | GO:0106027 | neuron projection organization | 3.31e-02 |
RPS6KB2 | GO:0043086 | negative regulation of catalytic activity | 3.31e-02 |
RPS6KB2 | GO:0050773 | regulation of dendrite development | 3.31e-02 |
RPS6KB2 | GO:0019080 | viral gene expression | 3.31e-02 |
RPS6KB2 | GO:0009408 | response to heat | 3.31e-02 |
RPS6KB2 | GO:0048813 | dendrite morphogenesis | 5.45e-02 |
RPS6KB2 | GO:0030010 | establishment of cell polarity | 5.86e-02 |
RPS6KB2 | GO:0051168 | nuclear export | 5.86e-02 |
RPS6KB2 | GO:0009266 | response to temperature stimulus | 5.86e-02 |
RPS6KB2 | GO:0006469 | negative regulation of protein kinase activity | 5.86e-02 |
RPS6KB2 | GO:0033673 | negative regulation of kinase activity | 5.86e-02 |
RPS6KB2 | GO:0031334 | positive regulation of protein-containing complex assembly | 5.86e-02 |
RPS6KB2 | GO:0046777 | protein autophosphorylation | 5.86e-02 |
RPS6KB2 | GO:1902075 | cellular response to salt | 5.86e-02 |
RPS6KB2 | GO:0032869 | cellular response to insulin stimulus | 5.86e-02 |
RPS6KB2 | GO:0007163 | establishment or maintenance of cell polarity | 5.86e-02 |
RPS6KB2 | GO:0097191 | extrinsic apoptotic signaling pathway | 5.86e-02 |
RPS6KB2 | GO:0016358 | dendrite development | 5.86e-02 |
RPS6KB2 | GO:2001234 | negative regulation of apoptotic signaling pathway | 5.86e-02 |
RPS6KB2 | GO:0032984 | protein-containing complex disassembly | 5.86e-02 |
RPS6KB2 | GO:0031669 | cellular response to nutrient levels | 5.86e-02 |
RPS6KB2 | GO:0070874 | negative regulation of glycogen metabolic process | 5.86e-02 |
RPS6KB2 | GO:0070922 | RISC complex assembly | 5.86e-02 |
RPS6KB2 | GO:0032868 | response to insulin | 5.86e-02 |
RPS6KB2 | GO:0006983 | ER overload response | 5.86e-02 |
RPS6KB2 | GO:1901984 | negative regulation of protein acetylation | 5.86e-02 |
RPS6KB2 | GO:1903564 | regulation of protein localization to cilium | 5.86e-02 |
RPS6KB2 | GO:1905383 | protein localization to presynapse | 5.86e-02 |
RPS6KB2 | GO:0031668 | cellular response to extracellular stimulus | 5.86e-02 |
RPS6KB2 | GO:0034454 | microtubule anchoring at centrosome | 5.86e-02 |
RPS6KB2 | GO:0072497 | mesenchymal stem cell differentiation | 5.86e-02 |
RPS6KB2 | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 5.86e-02 |
RPS6KB2 | GO:1904338 | regulation of dopaminergic neuron differentiation | 5.86e-02 |
RPS6KB2 | GO:1904779 | regulation of protein localization to centrosome | 5.86e-02 |
RPS6KB2 | GO:0018105 | peptidyl-serine phosphorylation | 5.86e-02 |
RPS6KB2 | GO:0001933 | negative regulation of protein phosphorylation | 5.86e-02 |
RPS6KB2 | GO:0038203 | TORC2 signaling | 5.86e-02 |
RPS6KB2 | GO:0072393 | microtubule anchoring at microtubule organizing center | 5.86e-02 |
RPS6KB2 | GO:0098840 | protein transport along microtubule | 5.86e-02 |
RPS6KB2 | GO:0099118 | microtubule-based protein transport | 5.86e-02 |
RPS6KB2 | GO:0018209 | peptidyl-serine modification | 5.86e-02 |
RPS6KB2 | GO:0071375 | cellular response to peptide hormone stimulus | 5.86e-02 |
RPS6KB2 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 5.86e-02 |
RPS6KB2 | GO:0106057 | negative regulation of calcineurin-mediated signaling | 5.86e-02 |
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Related Drugs to RBP4_RPS6KB2 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning RBP4-RPS6KB2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to RBP4_RPS6KB2 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |