UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
Kinase Fusion Gene:BACH2_MAP3K7 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: BACH2_MAP3K7 | KinaseFusionDB ID: KFG542 | FusionGDB2.0 ID: KFG542 | Hgene | Tgene | Gene symbol | BACH2 | MAP3K7 | Gene ID | 60468 | 6885 | |
Gene name | BTB domain and CNC homolog 2 | mitogen-activated protein kinase kinase kinase 7 | ||||||||||
Synonyms | BTBD25|IMD60 | CSCF|FMD2|MEKK7|TAK1|TGF1a | ||||||||||
Cytomap | 6q15 | 6q15 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | transcription regulator protein BACH2BTB and CNC homolog 2BTB and CNC homology 1, basic leucine zipper transcription factor 2 | mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1 | ||||||||||
Modification date | 20240317 | 20240408 | ||||||||||
UniProtAcc | Q9BYV9 | O43318 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000257749, ENST00000343122, ENST00000470301, ENST00000537989, | ENST00000369325, ENST00000369327, ENST00000369329, ENST00000369332, ENST00000369320, ENST00000479630, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: BACH2 [Title/Abstract] AND MAP3K7 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BACH2(90916288)-MAP3K7(91281526), # samples:3 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAP3K7 | GO:0000165 | MAPK cascade | 8663074|11865055 |
Tgene | MAP3K7 | GO:0006954 | inflammatory response | 34017102 |
Tgene | MAP3K7 | GO:0007249 | canonical NF-kappaB signal transduction | 10882101|19675569|34871740|35952808 |
Tgene | MAP3K7 | GO:0007252 | I-kappaB phosphorylation | 11460167 |
Tgene | MAP3K7 | GO:0007254 | JNK cascade | 9079627 |
Tgene | MAP3K7 | GO:0034142 | toll-like receptor 4 signaling pathway | 25371197 |
Tgene | MAP3K7 | GO:0038066 | p38MAPK cascade | 11460167 |
Tgene | MAP3K7 | GO:0038172 | interleukin-33-mediated signaling pathway | 20532808 |
Tgene | MAP3K7 | GO:0038173 | interleukin-17A-mediated signaling pathway | 31376257 |
Tgene | MAP3K7 | GO:0042742 | defense response to bacterium | 11460167 |
Tgene | MAP3K7 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 11460167 |
Tgene | MAP3K7 | GO:0043507 | positive regulation of JUN kinase activity | 11460167 |
Tgene | MAP3K7 | GO:0051403 | stress-activated MAPK cascade | 9079627 |
Kinase Fusion gene breakpoints across BACH2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across MAP3K7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-DU-6403-01A | BACH2 | chr6 | 90916288 | MAP3K7 | chr6 | 91281526 |
Top |
Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:90916288/:91281526) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
BACH2 | MAP3K7 |
FUNCTION: Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. | FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:9079627, PubMed:16893890). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:8663074, PubMed:11460167). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:8663074, PubMed:11460167, PubMed:12589052). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:8663074, PubMed:12589052). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of BACH2_MAP3K7 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
MAP3K7 | O43318 | human | TUBA1B | P68363 | T334 | DVNAAIAtIktkrsI | Tubulin_C |
MAP3K7 | O43318 | human | PTPN3 | P26045 | S359 | PAMRRsLsVEHLETK | |
MAP3K7 | O43318 | human | EIF4B | P23588 | S230 | kyRDRyDsDRyRDGy | |
MAP3K7 | O43318 | human | HNRNPA2B1 | P22626 | T176 | IVLQkyHtINGHNAE | RRM_1 |
MAP3K7 | O43318 | human | FLNA | P21333 | T1286 | sVDARALtQtGGPHV | Filamin |
MAP3K7 | O43318 | human | RBMX | P38159 | T216 | PRDDGystkDsyssR | RBM1CTR |
MAP3K7 | O43318 | human | MAP3K7 | O43318 | T184 | GtACDIQtHMtNNKG | PK_Tyr_Ser-Thr |
MAP3K7 | O43318 | human | TAB1 | Q15750 | S452 | STNTHTQssSSssDG | |
MAP3K7 | O43318 | human | MAP3K7 | O43318 | S192 | HMtNNKGsAAWMAPE | PK_Tyr_Ser-Thr |
MAP3K7 | O43318 | human | PKP2 | Q99959 | S82 | GNLHRtssVPEyVyN | |
MAP3K7 | O43318 | human | TAB1 | Q15750 | S456 | HTQssSSssDGGLFR | |
MAP3K7 | O43318 | human | HIPK2 | Q9H2X6 | Y361 | SkAVCstyLQsRYyR | Pkinase |
MAP3K7 | O43318 | human | HSP90B1 | P14625 | S674 | yQtGkDIstNyyAsQ | HSP90 |
MAP3K7 | O43318 | human | HSP90B1 | P14625 | T669 | MkAQAyQtGkDIstN | HSP90 |
MAP3K7 | O43318 | human | HSP90B1 | P14625 | T675 | QtGkDIstNyyAsQk | HSP90 |
MAP3K7 | O43318 | human | RAB1A | P62820 | T75 | AGQERFRtItSSyyR | Ras |
MAP3K7 | O43318 | human | RAB8A | P61006 | T72 | AGQERFRtITTAyyR | Ras |
MAP3K7 | O43318 | human | CDC25C | P30307 | S216 | sGLyRsPsMPENLNR | M-inducer_phosp |
MAP3K7 | O43318 | human | POLD2 | P49005 | T33 | RVPVATytNSSQPFR | |
MAP3K7 | O43318 | human | HDAC7 | Q8WUI4 | S155 | FPLRKtVsEPNLkLR | |
MAP3K7 | O43318 | human | HDAC4 | P56524 | S246 | FPLRkTAsEPNLKLR | |
MAP3K7 | O43318 | human | TUBB | P07437 | T166 | yPDrIMNtFsVVPsP | Tubulin |
MAP3K7 | O43318 | human | KSR1 | Q8IVT5 | S406 | TRLRRtEsVPsDINN | |
MAP3K7 | O43318 | human | TAB1 | Q15750 | S457 | TQssSSssDGGLFRS | |
MAP3K7 | O43318 | human | TNFAIP8L2 | Q6P589 | S3 | _____MEsFSSKSLA | |
MAP3K7 | O43318 | human | MAP3K7 | O43318 | T187 | CDIQtHMtNNKGsAA | PK_Tyr_Ser-Thr |
MAP3K7 | O43318 | human | TAB1 | Q15750 | S453 | TNTHTQssSSssDGG | |
MAP3K7 | O43318 | human | GAPVD1 | Q14C86 | T1013 | LGPDRFstLtDDPsP | |
MAP3K7 | O43318 | human | PRKAA2 | P54646 | T172 | sDGEFLRtsCGsPNy | Pkinase |
MAP3K7 | O43318 | human | GAPVD1 | Q14C86 | S1012 | DLGPDRFstLtDDPs | |
MAP3K7 | O43318 | human | E2F1 | Q01094 | S337 | IVsPPPSsPPSSLTT | |
MAP3K7 | O43318 | human | IKBKB | O14920 | S177 | AkELDQGsLCtsFVG | Pkinase |
MAP3K7 | O43318 | human | ATAT1 | Q5SQI0 | S237 | GDIkPYSsSDREFLK | |
MAP3K7 | O43318 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
MAP3K7 | O43318 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
MAP3K7 | O43318 | human | MAP3K7 | O43318 | T178 | LKICDFGtACDIQtH | PK_Tyr_Ser-Thr |
MAP3K7 | O43318 | human | EEF1A1 | P68104 | T261 | ykIGGIGtVPVGrVE | GTP_EFTU_D2 |
MAP3K7 | O43318 | human | LDHA | P00338 | T3 | _____MAtLkDQLIy |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
MAP3K7 | ID | Description | 0.00e+00 |
MAP3K7 | GO:0006476 | protein deacetylation | 1.13e-03 |
MAP3K7 | GO:0035601 | protein deacylation | 1.13e-03 |
MAP3K7 | GO:0098732 | macromolecule deacylation | 1.13e-03 |
MAP3K7 | GO:0018205 | peptidyl-lysine modification | 4.06e-03 |
MAP3K7 | GO:0070555 | response to interleukin-1 | 1.06e-02 |
MAP3K7 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 1.86e-02 |
MAP3K7 | GO:0018394 | peptidyl-lysine acetylation | 1.86e-02 |
MAP3K7 | GO:0009895 | negative regulation of catabolic process | 1.86e-02 |
MAP3K7 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 2.20e-02 |
MAP3K7 | GO:0010832 | negative regulation of myotube differentiation | 2.20e-02 |
MAP3K7 | GO:0045216 | cell-cell junction organization | 2.20e-02 |
MAP3K7 | GO:0051090 | regulation of DNA-binding transcription factor activity | 2.20e-02 |
MAP3K7 | GO:0006096 | glycolytic process | 2.20e-02 |
MAP3K7 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 2.20e-02 |
MAP3K7 | GO:1903312 | negative regulation of mRNA metabolic process | 2.20e-02 |
MAP3K7 | GO:0034446 | substrate adhesion-dependent cell spreading | 2.20e-02 |
MAP3K7 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 2.20e-02 |
MAP3K7 | GO:0048025 | negative regulation of mRNA splicin | 4.82e-04 |
MAP3K7 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 2.20e-02 |
MAP3K7 | GO:0090042 | tubulin deacetylation | 2.20e-02 |
MAP3K7 | GO:1990840 | response to lectin | 2.20e-02 |
MAP3K7 | GO:1990858 | cellular response to lectin | 2.20e-02 |
MAP3K7 | GO:0051098 | regulation of binding | 2.20e-02 |
MAP3K7 | GO:0034138 | toll-like receptor 3 signaling pathway | 2.20e-02 |
MAP3K7 | GO:0050686 | negative regulation of mRNA processing | 2.20e-02 |
MAP3K7 | GO:0071347 | cellular response to interleukin-1 | 2.20e-02 |
MAP3K7 | GO:0038095 | Fc-epsilon receptor signaling pathway | 2.27e-02 |
MAP3K7 | GO:0006090 | pyruvate metabolic process | 2.45e-02 |
MAP3K7 | GO:0033119 | negative regulation of RNA splicing | 2.48e-02 |
MAP3K7 | GO:0071900 | regulation of protein serine/threonine kinase activity | 2.58e-02 |
MAP3K7 | GO:0072659 | protein localization to plasma membrane | 2.67e-02 |
MAP3K7 | GO:0070498 | interleukin-1-mediated signaling pathway | 3.17e-02 |
MAP3K7 | GO:0043276 | anoikis | 3.37e-02 |
MAP3K7 | GO:0086019 | cell-cell signaling involved in cardiac conduction | 3.37e-02 |
MAP3K7 | GO:0043393 | regulation of protein binding | 3.38e-02 |
MAP3K7 | GO:0001508 | action potential | 3.44e-02 |
MAP3K7 | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 3.44e-02 |
MAP3K7 | GO:0043543 | protein acylation | 3.44e-02 |
MAP3K7 | GO:0007043 | cell-cell junction assembly | 4.06e-02 |
MAP3K7 | GO:0051154 | negative regulation of striated muscle cell differentiation | 4.10e-02 |
MAP3K7 | GO:1990778 | protein localization to cell periphery | 4.10e-02 |
MAP3K7 | GO:0010506 | regulation of autophagy | 4.10e-02 |
MAP3K7 | GO:0016052 | carbohydrate catabolic process | 4.10e-02 |
MAP3K7 | GO:0006509 | membrane protein ectodomain proteolysis | 4.38e-02 |
MAP3K7 | GO:0140894 | endolysosomal toll-like receptor signaling pathway | 4.49e-02 |
MAP3K7 | GO:0010830 | regulation of myotube differentiation | 4.68e-02 |
MAP3K7 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 4.68e-02 |
MAP3K7 | GO:0006110 | regulation of glycolytic process | 5.60e-02 |
MAP3K7 | GO:0086002 | cardiac muscle cell action potential involved in contraction | 5.70e-02 |
Top |
Related Drugs to BACH2_MAP3K7 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning BACH2-MAP3K7 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to BACH2_MAP3K7 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |