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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ROR1_ALG6

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: ROR1_ALG6
	KinaseFusionDB ID: KFG5463
	FusionGDB2.0 ID: KFG5463
		Hgene	Tgene
	Gene symbol	ROR1	ALG6
	Gene ID	6095	29929
	Gene name	RAR related orphan receptor A	ALG6 alpha-1,3-glucosyltransferase
	Synonyms	IDDECA\|NR1F1\|ROR1\|ROR2\|ROR3\|RORa1\|RORalpha\|RZR-ALPHA\|RZRA	CDG1C
	Cytomap	15q22.2	1p31.3
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor ROR-alphaRAR-related orphan nuclear receptor alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphatranscripti	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferaseMan(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferaseasparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)asparagine-linked glycosylation 6 homolog (yeast
	Modification date	20240403	20240305
	UniProtAcc	Q01973	Q9Y672
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000482426, ENST00000371079, ENST00000371080, ENST00000545203,	ENST00000263440, ENST00000371108, ENST00000494765,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: ROR1 [Title/Abstract] AND ALG6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ROR1(64516388)-ALG6(63867924), # samples:1 ROR1(64516388)-ALG6(63902494), # samples:1

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROR1	GO:0006355	regulation of DNA-templated transcription	9328355
Hgene	ROR1	GO:0030522	intracellular receptor signaling pathway	19965867
Hgene	ROR1	GO:0036315	cellular response to sterol	19965867
Hgene	ROR1	GO:0045893	positive regulation of DNA-templated transcription	7926749
Hgene	ROR1	GO:0045944	positive regulation of transcription by RNA polymerase II	17545671\|19955433
Tgene	ALG6	GO:0006487	protein N-linked glycosylation	10924277

Kinase Fusion gene breakpoints across ROR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across ALG6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-13-0765	ROR1	chr1	64516388	ALG6	chr1	63867924
ChimerDB4	TCGA-HU-A4GN-01A	ROR1	chr1	64516388	ALG6	chr1	63902494

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000371080	ENST00000371108	ROR1	chr1	64516388	ALG6	chr1	63867924	3777	625
ENST00000371080	ENST00000263440	ROR1	chr1	64516388	ALG6	chr1	63902494	1233	184

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000371080_ENST00000371108_ROR1_chr1_64516388_ALG6_chr1_63867924_length(amino acids)=625
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSYFNSSD
NNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILL
YPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASF
VLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSC
ALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFS

--------------------------------------------------------------

>ENST00000371080_ENST00000263440_ROR1_chr1_64516388_ALG6_chr1_63902494_length(amino acids)=184
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL
HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSFLSQSS

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:64516388/chr1:63867924)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ROR1 Q01973	ALG6 Q9Y672
FUNCTION: Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). {ECO:0000269\|PubMed:25029443, ECO:0000269\|PubMed:27162350}.	FUNCTION: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

160160160160

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Hgene

ROR1

64516388

ALG6

63867924

ENST00000371080

42_147

394

Domain

Note=Ig-like C2-type

Hgene

ROR1

64516388

ALG6

63867924

ENST00000371080

42_147

938

Domain

Note=Ig-like C2-type

Hgene

ROR1

64516388

ALG6

63902494

ENST00000371080

42_147

394

Domain

Note=Ig-like C2-type

Hgene

ROR1

64516388

ALG6

63902494

ENST00000371080

42_147

938

Domain

Note=Ig-like C2-type

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>241_ROR1_ALG6	ENST00000371080	ENST00000263440	ROR1	chr1	64516388	ALG6	chr1	63902494	MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSFLSQSS	184
3D view using mol* of 241_ROR1_ALG6

PDB file >>>HKFP_350_ROR1_ALG6	ENST00000371080	ENST00000371108	ROR1	chr1	64516388	ALG6	chr1	63867924	MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSYFNSSD NNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIADLLIYIPAVVLYCCCLKEISTKKKIANALCILL YPGLILIDYGHFQYNSVSLGFALWGVLGISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVASF VLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIMSFCSTFLSLLPACIKLILQPSSKGFKFTLVSC ALSFFLFSFQVHEKSILLVSLPVCLVLSEIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKSFS	625_ROR1_ALG6
PDB file >>>HKFP_351_ROR1_ALG6	ENST00000371080	ENST00000263440	ROR1	chr1	64516388	ALG6	chr1	63902494	MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAEL HCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSFLSQSS	184_ROR1_ALG6
3D view using mol* of HKFP_351_ROR1_ALG6

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_350_ROR1_ALG6_vs_HKFP_351_ROR1_ALG6_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/HKFP_351_ROR1_ALG6_vs_HKFP_350_ROR1_ALG6.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ROR1_ALG6 does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

241_ROR1_ALG6.png

HKFP_351_ROR1_ALG6.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
HKFP_351_ROR1_ALG6	0.796	45	0.814	111.475	0.612	0.623	0.932	1.365	0.584	2.338	0.814	Chain A: 91,92,93,119,120,121,123,125,126,127,128, 130

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

241_ROR1_ALG6_ramachandran.png

HKFP_351_ROR1_ALG6_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Nilotinib	-5.4683199999999985	-5.60792	-42.597
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Nilotinib	-5.4683199999999985	-5.60792	-42.597
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Upadacitinib	-5.14039	-5.14139	-33.8334
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Belumosudil	-4.94612	-4.95382	-42.2467
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Belumosudil	-4.92908	-4.9367800000000015	-42.1555
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Larotrectinib	-4.90746	-4.90746	-38.2341
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Ruxolitinib	-4.55651	-4.55651	-27.3102
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Abrocitinib	-4.53756	-4.54866	-33.5718
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Abrocitinib	-4.53756	-4.54866	-33.5718
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Zanubrutinib	-4.5313300000000005	-4.5313300000000005	-41.1777
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Mobocertinib	-4.52977	-4.53747	-43.0481
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Tofacitinib	-4.24104	-4.25254	-26.7679
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Tofacitinib	-4.24104	-4.25254	-26.7679
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Ibrutinib	-4.22276	-4.22276	-39.5703
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Cobimetinib	-4.16748	-4.17028	-36.8168
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Abrocitinib	-4.13854	-4.14964	-31.9473
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Abrocitinib	-4.13854	-4.14964	-31.9473
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Crizotinib	-4.0881	-4.4243	-36.7517
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Crizotinib	-4.0881	-4.4243	-36.7517
HKFP_351_ROR1_ALG6_vsw_1-DOCK_HTVS_1-001	Axitinib	-4.0754800000000015	-4.07868	-34.88
241_ROR1_ALG6-DOCK_HTVS_1-001	Fostamatinib	-5.4107	-5.4743	-38.1625
241_ROR1_ALG6-DOCK_HTVS_1-001	Fostamatinib	-5.4107	-5.4743	-38.1625
241_ROR1_ALG6-DOCK_HTVS_1-001	Larotrectinib	-5.13319	-5.13319	-35.8869
241_ROR1_ALG6-DOCK_HTVS_1-001	Belumosudil	-4.36014	-4.36784	-38.5336
241_ROR1_ALG6-DOCK_HTVS_1-001	Capmatinib	-4.2893	-4.2949	-32.6823
241_ROR1_ALG6-DOCK_HTVS_1-001	Larotrectinib	-4.27771	-4.27771	-34.8354
241_ROR1_ALG6-DOCK_HTVS_1-001	Upadacitinib	-4.25154	-4.25254	-31.4448
241_ROR1_ALG6-DOCK_HTVS_1-001	Belumosudil	-4.24979	-4.25749	-37.6793
241_ROR1_ALG6-DOCK_HTVS_1-001	Sunitinib	-4.21954	-4.22374	-37.056
241_ROR1_ALG6-DOCK_HTVS_1-001	Tofacitinib	-4.16475	-4.17625	-27.1617
241_ROR1_ALG6-DOCK_HTVS_1-001	Tofacitinib	-4.16475	-4.17625	-27.1617
241_ROR1_ALG6-DOCK_HTVS_1-001	Ruxolitinib	-4.15103	-4.15103	-25.2303
241_ROR1_ALG6-DOCK_HTVS_1-001	Larotrectinib	-4.086869999999999	-4.086869999999999	-32.8002
241_ROR1_ALG6-DOCK_HTVS_1-001	Netarsudil	-4.06944	-4.08054	-37.0402
241_ROR1_ALG6-DOCK_HTVS_1-001	Netarsudil	-4.06944	-4.08054	-37.0402
241_ROR1_ALG6-DOCK_HTVS_1-001	Pralsetinib	-4.01288	-4.10438	-40.3531
241_ROR1_ALG6-DOCK_HTVS_1-001	Asciminib	-3.96876	-4.33186	-37.1865
241_ROR1_ALG6-DOCK_HTVS_1-001	Regorafenib	-3.83371	-3.83371	-37.7984
241_ROR1_ALG6-DOCK_HTVS_1-001	Cobimetinib	-3.8222099999999997	-3.82501	-33.0821
241_ROR1_ALG6-DOCK_HTVS_1-001	Pralsetinib	-3.78864	-3.8801400000000004	-34.4768

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Kinase-Substrate Information of ROR1_ALG6

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
ROR1	Q01973	human	ERBB3	P21860	Y1307	HQAPHVHyARLKtLR

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
ROR1	ID	Description	0.00e+00
ROR1	GO:2000672	negative regulation of motor neuron apoptotic process	7.49e-03
ROR1	GO:2000671	regulation of motor neuron apoptotic process	7.49e-03
ROR1	GO:0016202	regulation of striated muscle tissue development	7.49e-03
ROR1	GO:0038128	ERBB2 signaling pathway	7.49e-03
ROR1	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	7.49e-03
ROR1	GO:0097049	motor neuron apoptotic process	7.49e-03
ROR1	GO:0106058	positive regulation of calcineurin-mediated signaling	7.49e-03
ROR1	GO:0048634	regulation of muscle organ development	7.49e-03
ROR1	GO:1901863	positive regulation of muscle tissue development	7.49e-03
ROR1	GO:0061098	positive regulation of protein tyrosine kinase activity	7.93e-03
ROR1	GO:0014037	Schwann cell differentiation	7.93e-03
ROR1	GO:0070884	regulation of calcineurin-NFAT signaling cascade	7.93e-03
ROR1	GO:0106056	regulation of calcineurin-mediated signaling	7.93e-03
ROR1	GO:0050850	positive regulation of calcium-mediated signaling	7.93e-03
ROR1	GO:0033173	calcineurin-NFAT signaling cascade	7.93e-03
ROR1	GO:1901861	regulation of muscle tissue development	7.93e-03
ROR1	GO:0097720	calcineurin-mediated signaling	7.93e-03
ROR1	GO:0003197	endocardial cushion development	8.11e-03
ROR1	GO:0061097	regulation of protein tyrosine kinase activity	8.28e-03
ROR1	GO:0021545	cranial nerve development	8.55e-03
ROR1	GO:0038034	signal transduction in absence of ligand	8.55e-03
ROR1	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	8.55e-03
ROR1	GO:0007422	peripheral nervous system development	9.71e-03
ROR1	GO:0050848	regulation of calcium-mediated signaling	9.71e-03
ROR1	GO:0021675	nerve development	1.09e-02
ROR1	GO:0038127	ERBB signaling pathway	1.34e-02
ROR1	GO:0043524	negative regulation of neuron apoptotic process	1.61e-02
ROR1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	1.61e-02
ROR1	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1.61e-02
ROR1	GO:0051048	negative regulation of secretion	1.61e-02
ROR1	GO:0019722	calcium-mediated signaling	1.89e-02
ROR1	GO:0097191	extrinsic apoptotic signaling pathway	1.89e-02
ROR1	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	1.89e-02
ROR1	GO:0043523	regulation of neuron apoptotic process	1.89e-02
ROR1	GO:0048738	cardiac muscle tissue development	1.89e-02
ROR1	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1.89e-02
ROR1	GO:0010001	glial cell differentiation	1.89e-02
ROR1	GO:0014706	striated muscle tissue development	1.89e-02
ROR1	GO:0018108	peptidyl-tyrosine phosphorylation	1.89e-02
ROR1	GO:0018212	peptidyl-tyrosine modification	1.89e-02
ROR1	GO:0051402	neuron apoptotic process	1.89e-02
ROR1	GO:0045860	positive regulation of protein kinase activity	1.89e-02
ROR1	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	1.89e-02
ROR1	GO:0019932	second-messenger-mediated signaling	1.95e-02
ROR1	GO:0007162	negative regulation of cell adhesion	1.95e-02
ROR1	GO:0060485	mesenchyme development	1.98e-02
ROR1	GO:0033674	positive regulation of kinase activity	1.98e-02
ROR1	GO:0042063	gliogenesis	1.98e-02
ROR1	GO:0007517	muscle organ development	2.03e-02

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Related Drugs to ROR1_ALG6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning ROR1-ALG6 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to ROR1_ALG6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date