UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:RPP14_STK11

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: RPP14_STK11
KinaseFusionDB ID: KFG5528
FusionGDB2.0 ID: KFG5528
HgeneTgene
Gene symbol

RPP14

STK11

Gene ID

11102

6794

Gene nameribonuclease P/MRP subunit p14serine/threonine kinase 11
SynonymsP14LKB1|PJS|hLKB1
Cytomap

3p14.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionribonuclease P protein subunit p14ribonuclease P/MRP 14kDa subunitserine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1
Modification date2024030520240416
UniProtAcc

O95059

Q15831

Ensembl transtripts involved in fusion geneENST idsENST00000295959, ENST00000445193, 
ENST00000466547, ENST00000477305, 
ENST00000528153, 		ENST00000326873, 
ENST00000585748, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: RPP14 [Title/Abstract] AND STK11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RPP14(58305165)-STK11(1224740), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPP14

GO:0001682

tRNA 5'-leader removal

16723659|30454648

TgeneSTK11

GO:0006468

protein phosphorylation

12805220|25329316

TgeneSTK11

GO:0018107

peptidyl-threonine phosphorylation

12805220

TgeneSTK11

GO:0046777

protein autophosphorylation

11430832

TgeneSTK11

GO:0070314

G1 to G0 transition

17216128

TgeneSTK11

GO:0071493

cellular response to UV-B

25329316

TgeneSTK11

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

11430832


check buttonKinase Fusion gene breakpoints across RPP14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across STK11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0AI365374RPP14chr3

58305165

STK11chr19

1224740



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:58305165/:1224740)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPP14

O95059

STK11

Q15831

FUNCTION: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. {ECO:0000269|PubMed:10024167, ECO:0000269|PubMed:30454648}.FUNCTION: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379, ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


Top

Kinase-Substrate Information of RPP14_STK11


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
STK11Q15831humanPTENP60484S380EPDHyRYsDttDsDP
STK11Q15831humanSMAD4Q13485T77kCVTIQRtLDGRLQVMH1
STK11Q15831humanNUAK2Q9H093T208HQGKFLQtFCGSPLYPkinase
STK11Q15831humanSIRT1Q96EB6S615GEkNERtsVAGtVRk
STK11Q15831humanCRTC1Q6UUV9S151TSWRRtNsDsALHQsTORC_M
STK11Q15831humanNUAK1O60285T211QKDKFLQtFCGSPLYPkinase
STK11Q15831humanMELKQ14680T167NkDyHLQtCCGsLAYPkinase
STK11Q15831humanPRKAA1Q13131T183sDGEFLRtsCGsPNyPkinase
STK11Q15831humanMARK4Q96L34T214TLGSKLDtFCGsPPYPkinase
STK11Q15831humanBRSK2Q8IWQ3T174VGDSLLEtSCGSPHYPkinase
STK11Q15831humanSIRT1Q96EB6S732EAINEAIsVkQEVTD
STK11Q15831humanTP53P04637S392FktEGPDsD______
STK11Q15831humanYAP1P46937-2S127PQHVRAHssPASLQL
STK11Q15831humanSIK2Q9H0K1T175kSGELLAtWCGSPPYPkinase
STK11Q15831humanMARK2Q7KZI7T208tFGNKLDtFCGsPPYPkinase
STK11Q15831humanSTK11Q15831T363IEDDIIYtQDFTVPG
STK11Q15831humanSTK11Q15831T185kPGNLLLtTGGtLKIPkinase
STK11Q15831humanPRMT5O14744T132PLNQEDNtNLARVLtPRMT5_TIM
STK11Q15831humanSTK11Q15831T189LLLtTGGtLKISDLGPkinase
STK11Q15831humanMARK3P27448T211TVGGKLDtFCGsPPYPkinase
STK11Q15831humanSTRADAQ7RTN6T329GLSDSLTtSTPRPSNPkinase
STK11Q15831humanMARK3P27448S215KLDtFCGsPPYAAPEPkinase
STK11Q15831humanBRSK1Q8TDC3-2T205VGDSLLEtSCGsPHYPkinase
STK11Q15831humanSTK11Q15831S428SSkIRRLsACkQQ__
STK11Q15831humanSIK1P57059T182kSGEPLStWCGSPPYPkinase
STK11Q15831humanPRMT5O14744T144VLtNHIHtGHHSSMFPRMT5_TIM
STK11Q15831humanPAK1Q13153T109QWARLLQtsNITKsEPBD
STK11Q15831humanSTK11Q15831T402TEAAQLstKsRAEGR
STK11Q15831humanPTBP1P26599-1T138sNHkELktDssPNQARRM_5
STK11Q15831humanBRSK1Q8TDC3T189VGDSLLEtSCGSPHYPkinase
STK11Q15831humanCDKN1AP38936T80LPkLYLPtGPRRGRD
STK11Q15831humanSIK3Q9Y2K2T221TPGQLLKtWCGSPPYPkinase
STK11Q15831humanSTK11Q15831T336KDRWRsMtVVPYLED
STK11Q15831humanSIRT1Q96EB6S669EDDVLSSsSCGSNSD
STK11Q15831humanPRMT5O14744T139tNLARVLtNHIHtGHPRMT5_TIM
STK11Q15831humanMARK1Q9P0L2T215TVGNKLDtFCGsPPYPkinase
STK11Q15831humanPRKAA2P54646T172sDGEFLRtsCGsPNyPkinase
STK11Q15831humanSTRADAQ7RTN6T419SGIFGLVtNLEELEV
STK11Q15831humanTP53P04637S15PsVEPPLsQEtFsDLP53_TAD
STK11Q15831humanPTENP60484T383HyRYsDttDsDPENE
STK11Q15831humanSNRKQ9NRH2T173QPGKKLttsCGSLAYPkinase
STK11Q15831humanPTENP60484T382DHyRYsDttDsDPEN


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
STK11IDDescription0.00e+00
STK11GO:0042149cellular response to glucose starvation1.14e-07
STK11GO:0007623circadian rhythm2.40e-07
STK11GO:0032007negative regulation of TOR signaling4.34e-07
STK11GO:0032006regulation of TOR signaling4.66e-07
STK11GO:0031929TOR signaling9.10e-07
STK11GO:0009267cellular response to starvation1.08e-06
STK11GO:0009314response to radiation1.08e-06
STK11GO:0048511rhythmic process1.13e-06
STK11GO:0046777protein autophosphorylation1.59e-06
STK11GO:0009416response to light stimulus1.59e-06
STK11GO:0042594response to starvation2.63e-06
STK11GO:0010212response to ionizing radiation4.73e-06
STK11GO:0031669cellular response to nutrient levels5.85e-06
STK11GO:0032886regulation of microtubule-based process6.56e-06
STK11GO:0009411response to UV6.74e-06
STK11GO:0050770regulation of axonogenesis7.66e-06
STK11GO:0031668cellular response to extracellular stimulus9.68e-06
STK11GO:0018105peptidyl-serine phosphorylation1.23e-05
STK11GO:0072331signal transduction by p53 class mediator1.23e-05
STK11GO:0018209peptidyl-serine modification1.54e-05
STK11GO:0006109regulation of carbohydrate metabolic process1.70e-05
STK11GO:1901796regulation of signal transduction by p53 class mediator2.81e-05
STK11GO:0071496cellular response to external stimulus2.93e-05
STK11GO:0090398cellular senescence2.96e-05
STK11GO:0042752regulation of circadian rhythm3.40e-05
STK11GO:0010332response to gamma radiation4.84e-05
STK11GO:2000772regulation of cellular senescence5.88e-05
STK11GO:0042593glucose homeostasis6.84e-05
STK11GO:0033500carbohydrate homeostasis6.84e-05
STK11GO:0051347positive regulation of transferase activity7.40e-05
STK11GO:0097091synaptic vesicle clustering7.40e-05
STK11GO:0055089fatty acid homeostasis8.69e-05
STK11GO:0007409axonogenesis1.09e-04
STK11GO:0045860positive regulation of protein kinase activity1.09e-04
STK11GO:0044839cell cycle G2/M phase transition1.09e-04
STK11GO:0070314G1 to G0 transition1.09e-04
STK11GO:0010975regulation of neuron projection development1.09e-04
STK11GO:0001678intracellular glucose homeostasis1.09e-04
STK11GO:0016055Wnt signaling pathway1.12e-04
STK11GO:0071479cellular response to ionizing radiation1.12e-04
STK11GO:0198738cell-cell signaling by wnt1.12e-04
STK11GO:0034504protein localization to nucleus1.57e-04
STK11GO:0097009energy homeostasis1.63e-04
STK11GO:0031667response to nutrient levels1.66e-04
STK11GO:0097193intrinsic apoptotic signaling pathway1.72e-04
STK11GO:0045913positive regulation of carbohydrate metabolic process1.76e-04
STK11GO:0071478cellular response to radiation1.76e-04
STK11GO:0043153entrainment of circadian clock by photoperiod1.92e-04
STK11GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator1.92e-04

Top

Related Drugs to RPP14_STK11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning RPP14-STK11 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to RPP14_STK11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate