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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:RPS25_STK4

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: RPS25_STK4
KinaseFusionDB ID: KFG5538
FusionGDB2.0 ID: KFG5538
HgeneTgene
Gene symbol

RPS25

STK4

Gene ID

6230

6789

Gene nameribosomal protein S25serine/threonine kinase 4
SynonymsS25|eS25KRS2|MST1|YSK3
Cytomap

11q23.3

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionsmall ribosomal subunit protein eS2540S ribosomal protein S25serine/threonine-protein kinase 4STE20-like kinase MST1hippo homologkinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2
Modification date2024040720240416
UniProtAcc

P62851

Q8N2I9

Ensembl transtripts involved in fusion geneENST idsENST00000527673, ENST00000528547, 
ENST00000372806, ENST00000372801, 
ENST00000396731, ENST00000487587, 
ENST00000499879, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: RPS25 [Title/Abstract] AND STK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RPS25(118888201)-STK4(43707835), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTK4

GO:0000902

cell morphogenesis

11805089

TgeneSTK4

GO:0001934

positive regulation of protein phosphorylation

19962960

TgeneSTK4

GO:0006468

protein phosphorylation

11805089

TgeneSTK4

GO:0006468

protein phosphorylation

8566796

TgeneSTK4

GO:0006606

protein import into nucleus

16751106

TgeneSTK4

GO:0006915

apoptotic process

21212262

TgeneSTK4

GO:0018105

peptidyl-serine phosphorylation

16751106

TgeneSTK4

GO:0032092

positive regulation of protein binding

22292086

TgeneSTK4

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19962960

TgeneSTK4

GO:0035329

hippo signaling

20412773

TgeneSTK4

GO:0035556

intracellular signal transduction

8566796

TgeneSTK4

GO:0043065

positive regulation of apoptotic process

15109305

TgeneSTK4

GO:0046777

protein autophosphorylation

11805089

TgeneSTK4

GO:0050821

protein stabilization

19962960


check buttonKinase Fusion gene breakpoints across RPS25 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across STK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0BP271042RPS25chr11

118888201

STK4chr20

43707835



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:118888201/:43707835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS25

P62851

STK4

Q8N2I9

FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). {ECO:0000269|PubMed:23636399}.FUNCTION: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. {ECO:0000269|PubMed:13679039}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of RPS25_STK4


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
STK4Q13043humanTNNI3P19429T129ITEIADLtQkIFDLRTroponin
STK4Q13043humanPRDX1Q06830T183GWkPGsDtIkPDVQk1-cysPrx_C
STK4Q13043humanNR3C1P04150S682VPkDGLksQELFDEIHormone_recep
STK4Q13043humanGJA1P17302S255HAtsGALsPAkDCGs
STK4Q13043humanSTK4Q13043T183DtMAkRNtVIGTPFWPkinase
STK4Q13043humanFOXO1Q12778S212SSAGWkNsIRHNLsLForkhead
STK4Q13043humanABL1P00519T735DTEWRSVtLPRDLQS
STK4Q13043humanFOXO1Q12778S218NsIRHNLsLHSkFIRForkhead
STK4Q13043humanNR3C1P04150T562StWRIMTtLNMLGGRHormone_recep
STK4Q13043humanMOB1AQ9H8S9T35LLkHAEAtLGsGNLRMob1_phocein
STK4Q13043humanPRKAA1Q13131T183sDGEFLRtsCGsPNyPkinase
STK4Q13043humanH2BC3P33778S14APAPkkGskkAItkAHistone
STK4Q13043humanSTK38Q15208T444DWVFINytyKRFEGLPkinase_C
STK4Q13043humanTNNI3P19429T143RGKFKRPtLRrVrIsTroponin
STK4Q13043humanSTK4Q13043T353TMTDGANtMIEHDDt
STK4Q13043humanFOXO3O43524S243INPDGGksGkAPRRRForkhead
STK4Q13043humanFOXO3O43524S209SSAGWkNsIRHNLsLForkhead
STK4Q13043humanNR3C1P04150T668EEYLCMKtLLLLSSVHormone_recep
STK4Q13043humanLATS1O95835T1079EHAFyEFtFRRFFDD
STK4Q13043humanUNC5BQ8IZJ1T428FHPVNFKtARPSNPQ
STK4Q13043humanBECN1Q14457T108GEASDGGtMENLSRRBH3
STK4Q13043humanPRDX1Q06830T90CHLAWVNtPkkQGGLAhpC-TSA
STK4Q13043humanFOXO3O43524S231QNEGTGKssWWIINPForkhead
STK4Q13043humanIRF3Q14653T75RDkPDLPtWkRNFRsIRF
STK4Q13043humanFOXO1Q12778S235NEGTGKssWWMLNPEForkhead
STK4Q13043humanNR3C1P04150S746TFLDKTMsIEFPEML
STK4Q13043humanAURKBQ96GD4T232APsLRRktMCGtLDyPkinase
STK4Q13043humanFOXO1Q12778S234QNEGTGKssWWMLNPForkhead
STK4Q13043humanFOXO3O43524S232NEGTGKssWWIINPDForkhead
STK4Q13043humanTNNI3P19429T31sNyRAyAtEPHAKKKTroponin-I_N
STK4Q13043humanMAP1LC3BQ9GZQ8T50QLPVLDktkFLVPDHATG8
STK4Q13043humanNR4A1P22736T366AsPANLLtSLVRAHL
STK4Q13043humanFOXO3O43524S215NsIRHNLsLHSRFMRForkhead
STK4Q13043humanMOB1BQ7L9L4T35LLkHAEAtLGsGNLRMob1_phocein
STK4Q13043humanITGA2P17301S1180IDETtELss______
STK4Q13043humanSTK4Q13043T367tLPSQLGtMVINAED
STK4Q13043humanSIK3Q9Y2K2T221TPGQLLKtWCGSPPYPkinase
STK4Q13043humanPRDX1Q06830T18PAPNFkAtAVMPDGQAhpC-TSA
STK4Q13043humanH2AXP16104S139GkkAtQAsQEy____
STK4Q13043humanTNNI3P19429T51sRKLQLKtLLLQIAKTroponin
STK4Q13043humanMOB1BQ7L9L4T12FGsRssktFKPkkNI
STK4Q13043humanIRF3Q14653T253PDPGMSLtDRGVMsYIRF-3


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
STK4IDDescription0.00e+00
STK4GO:0035329hippo signaling2.20e-04
STK4GO:0090257regulation of muscle system process2.20e-04
STK4GO:0034599cellular response to oxidative stress2.20e-04
STK4GO:0003012muscle system process2.62e-04
STK4GO:0062197cellular response to chemical stress4.69e-04
STK4GO:0009267cellular response to starvation4.89e-04
STK4GO:0071496cellular response to external stimulus5.56e-04
STK4GO:0042594response to starvation9.62e-04
STK4GO:0006979response to oxidative stress9.95e-04
STK4GO:0031669cellular response to nutrient levels1.53e-03
STK4GO:0031668cellular response to extracellular stimulus2.39e-03
STK4GO:0031667response to nutrient levels2.51e-03
STK4GO:0042149cellular response to glucose starvation2.97e-03
STK4GO:0010508positive regulation of autophagy2.97e-03
STK4GO:0034614cellular response to reactive oxygen species3.08e-03
STK4GO:0043525positive regulation of neuron apoptotic process3.62e-03
STK4GO:0099024plasma membrane invagination3.79e-03
STK4GO:0010506regulation of autophagy4.46e-03
STK4GO:1903943regulation of hepatocyte apoptotic process4.53e-03
STK4GO:0010324membrane invagination4.53e-03
STK4GO:0070301cellular response to hydrogen peroxide4.73e-03
STK4GO:0051987positive regulation of attachment of spindle microtubules to kinetochore4.86e-03
STK4GO:0046777protein autophosphorylation5.13e-03
STK4GO:0006995cellular response to nitrogen starvation5.13e-03
STK4GO:0043562cellular response to nitrogen levels5.13e-03
STK4GO:0000302response to reactive oxygen species5.40e-03
STK4GO:0090235regulation of metaphase plate congression5.47e-03
STK4GO:0045786negative regulation of cell cycle5.47e-03
STK4GO:0060537muscle tissue development7.06e-03
STK4GO:0043523regulation of neuron apoptotic process7.54e-03
STK4GO:0043502regulation of muscle adaptation8.31e-03
STK4GO:0016055Wnt signaling pathway8.31e-03
STK4GO:0198738cell-cell signaling by wnt8.31e-03
STK4GO:0071901negative regulation of protein serine/threonine kinase activity9.33e-03
STK4GO:0006390mitochondrial transcription9.33e-03
STK4GO:0042542response to hydrogen peroxide9.33e-03
STK4GO:0051315attachment of mitotic spindle microtubules to kinetochore1.04e-02
STK4GO:0051988regulation of attachment of spindle microtubules to kinetochore1.04e-02
STK4GO:0097284hepatocyte apoptotic process1.04e-02
STK4GO:0051402neuron apoptotic process1.13e-02
STK4GO:1904035regulation of epithelial cell apoptotic process1.14e-02
STK4GO:0061744motor behavior1.16e-02
STK4GO:0043500muscle adaptation1.23e-02
STK4GO:0018105peptidyl-serine phosphorylation1.28e-02
STK4GO:0006929substrate-dependent cell migration1.39e-02
STK4GO:0018209peptidyl-serine modification1.44e-02
STK4GO:0051984positive regulation of chromosome segregation1.44e-02
STK4GO:0030879mammary gland development1.57e-02
STK4GO:0033135regulation of peptidyl-serine phosphorylation1.71e-02

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Related Drugs to RPS25_STK4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning RPS25-STK4 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to RPS25_STK4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate