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Kinase Fusion Gene:RPS6KA2_TSGA10 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: RPS6KA2_TSGA10 | KinaseFusionDB ID: KFG5552 | FusionGDB2.0 ID: KFG5552 | Hgene | Tgene | Gene symbol | RPS6KA2 | TSGA10 | Gene ID | 6196 | 80705 | |
| Gene name | ribosomal protein S6 kinase A2 | testis specific 10 | ||||||||||
| Synonyms | HU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3 | CEP4L|CT79|SPGF26 | ||||||||||
| Cytomap | 6q27 | 2q11.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | ribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptide 2 | testis-specific gene 10 proteincancer/testis antigen 79testis development protein NYD-SP7testis-specific 10 protein | ||||||||||
| Modification date | 20240411 | 20240403 | ||||||||||
| UniProtAcc | Q15349 | Q3SY00 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000265678, ENST00000366863, ENST00000405189, ENST00000481261, ENST00000503859, ENST00000509742, ENST00000510118, | ENST00000355053, ENST00000393483, ENST00000410001, ENST00000478090, ENST00000539964, ENST00000542655, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: RPS6KA2 [Title/Abstract] AND TSGA10 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | RPS6KA2(167298669)-TSGA10(99617304), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPS6KA2 | GO:0008285 | negative regulation of cell population proliferation | 16878154 |
| Hgene | RPS6KA2 | GO:0043065 | positive regulation of apoptotic process | 16878154 |
| Hgene | RPS6KA2 | GO:0045786 | negative regulation of cell cycle | 16878154 |
| Kinase Fusion gene breakpoints across RPS6KA2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across TSGA10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | EI790969 | RPS6KA2 | chr6 | 167298669 | TSGA10 | chr2 | 99617304 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:167298669/:99617304) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS6KA2 | TSGA10 |
| FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of RPS6KA2_TSGA10 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| RPS6KA2 | Q15349 | human | RPS6KA2 | Q15349 | S218 | DHDKRAysFCGtIEY | Pkinase |
| RPS6KA2 | Q15349 | human | RPS6KA2 | Q15349 | T570 | AGNGLLMtPCytANF | Pkinase |
| RPS6KA2 | Q15349 | human | CREB1 | P16220 | S119 | EILsRRPsyRkILND | pKID |
| RPS6KA2 | Q15349 | human | ATXN1 | P54253 | S775 | AtRKRRWsAPESRKL |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| RPS6KA2 | ID | Description | 0.00e+00 |
| RPS6KA2 | GO:0007613 | memory | 2.03e-02 |
| RPS6KA2 | GO:0007611 | learning or memory | 3.11e-02 |
| RPS6KA2 | GO:0050890 | cognition | 3.11e-02 |
| RPS6KA2 | GO:0060430 | lung saccule development | 3.11e-02 |
| RPS6KA2 | GO:0061370 | testosterone biosynthetic process | 3.11e-02 |
| RPS6KA2 | GO:0010944 | negative regulation of transcription by competitive promoter binding | 3.11e-02 |
| RPS6KA2 | GO:0001976 | nervous system process involved in regulation of systemic arterial blood pressure | 3.11e-02 |
| RPS6KA2 | GO:1904321 | response to forskolin | 3.11e-02 |
| RPS6KA2 | GO:1904322 | cellular response to forskolin | 3.11e-02 |
| RPS6KA2 | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 3.11e-02 |
| RPS6KA2 | GO:0051447 | negative regulation of meiotic cell cycle | 3.11e-02 |
| RPS6KA2 | GO:0016202 | regulation of striated muscle tissue development | 3.11e-02 |
| RPS6KA2 | GO:0035728 | response to hepatocyte growth factor | 3.11e-02 |
| RPS6KA2 | GO:0010566 | regulation of ketone biosynthetic process | 3.11e-02 |
| RPS6KA2 | GO:0033762 | response to glucagon | 3.11e-02 |
| RPS6KA2 | GO:0048634 | regulation of muscle organ development | 3.11e-02 |
| RPS6KA2 | GO:0003081 | regulation of systemic arterial blood pressure by renin-angiotensin | 3.11e-02 |
| RPS6KA2 | GO:0071294 | cellular response to zinc ion | 3.11e-02 |
| RPS6KA2 | GO:1901863 | positive regulation of muscle tissue development | 3.11e-02 |
| RPS6KA2 | GO:0045672 | positive regulation of osteoclast differentiation | 3.11e-02 |
| RPS6KA2 | GO:0060479 | lung cell differentiation | 3.11e-02 |
| RPS6KA2 | GO:0060487 | lung epithelial cell differentiation | 3.11e-02 |
| RPS6KA2 | GO:0120255 | olefinic compound biosynthetic process | 3.11e-02 |
| RPS6KA2 | GO:0040018 | positive regulation of multicellular organism growth | 3.24e-02 |
| RPS6KA2 | GO:0001556 | oocyte maturation | 3.24e-02 |
| RPS6KA2 | GO:0040020 | regulation of meiotic nuclear division | 3.24e-02 |
| RPS6KA2 | GO:0001990 | regulation of systemic arterial blood pressure by hormone | 3.35e-02 |
| RPS6KA2 | GO:0007595 | lactation | 3.35e-02 |
| RPS6KA2 | GO:0021983 | pituitary gland development | 3.35e-02 |
| RPS6KA2 | GO:0060428 | lung epithelium development | 3.35e-02 |
| RPS6KA2 | GO:0042789 | mRNA transcription by RNA polymerase II | 3.35e-02 |
| RPS6KA2 | GO:1901861 | regulation of muscle tissue development | 3.35e-02 |
| RPS6KA2 | GO:0003044 | regulation of systemic arterial blood pressure mediated by a chemical signal | 3.35e-02 |
| RPS6KA2 | GO:0042181 | ketone biosynthetic process | 3.35e-02 |
| RPS6KA2 | GO:0048286 | lung alveolus development | 3.35e-02 |
| RPS6KA2 | GO:0009299 | mRNA transcription | 3.35e-02 |
| RPS6KA2 | GO:0010043 | response to zinc ion | 3.35e-02 |
| RPS6KA2 | GO:0035176 | social behavior | 3.35e-02 |
| RPS6KA2 | GO:0019933 | cAMP-mediated signaling | 3.35e-02 |
| RPS6KA2 | GO:0010659 | cardiac muscle cell apoptotic process | 3.35e-02 |
| RPS6KA2 | GO:0051703 | biological process involved in intraspecies interaction between organisms | 3.35e-02 |
| RPS6KA2 | GO:0010658 | striated muscle cell apoptotic process | 3.35e-02 |
| RPS6KA2 | GO:0002763 | positive regulation of myeloid leukocyte differentiation | 3.35e-02 |
| RPS6KA2 | GO:0048599 | oocyte development | 3.35e-02 |
| RPS6KA2 | GO:0040014 | regulation of multicellular organism growth | 3.35e-02 |
| RPS6KA2 | GO:0051784 | negative regulation of nuclear division | 3.35e-02 |
| RPS6KA2 | GO:0033363 | secretory granule organization | 3.35e-02 |
| RPS6KA2 | GO:0009994 | oocyte differentiation | 3.35e-02 |
| RPS6KA2 | GO:0051445 | regulation of meiotic cell cycle | 3.35e-02 |
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Related Drugs to RPS6KA2_TSGA10 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning RPS6KA2-TSGA10 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to RPS6KA2_TSGA10 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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