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Kinase Fusion Gene:RPS6KA4_TEX40 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: RPS6KA4_TEX40 | KinaseFusionDB ID: KFG5572 | FusionGDB2.0 ID: KFG5572 | Hgene | Tgene | Gene symbol | RPS6KA4 | TEX40 | Gene ID | 8986 | 25858 | |
| Gene name | ribosomal protein S6 kinase A4 | catsper channel auxiliary subunit zeta | ||||||||||
| Synonyms | MSK2|RSK-B|S6K-alpha-4 | C11orf20|TEX40 | ||||||||||
| Cytomap | 11q13.1 | 11q13.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | ribosomal protein S6 kinase alpha-490 kDa ribosomal protein S6 kinase 4mitogen- and stress-activated protein kinase 2nuclear mitogen- and stress-activated protein kinase 2ribosomal protein S6 kinase, 90kDa, polypeptide 4ribosomal protein kinase B | cation channel sperm-associated auxiliary subunit zetacatSper-zetacatSperzetacation channel sperm-associated protein subunit zetatestis expressed 40testis-expressed protein 40testis-expressed sequence 40 protein | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | O75676 | Q9NTU4 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000294261, ENST00000334205, ENST00000528057, | ENST00000328404, ENST00000539943, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: RPS6KA4 [Title/Abstract] AND TEX40 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | RPS6KA4(64126921)-TEX40(64070954), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPS6KA4 | GO:0006355 | regulation of DNA-templated transcription | 9792677 |
| Hgene | RPS6KA4 | GO:0006468 | protein phosphorylation | 9792677 |
| Hgene | RPS6KA4 | GO:0035556 | intracellular signal transduction | 9792677 |
| Kinase Fusion gene breakpoints across RPS6KA4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across TEX40 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-EB-A82B-01A | RPS6KA4 | chr11 | 64126921 | TEX40 | chr11 | 64071245 |
| ChimerDB4 | TCGA-EB-A82B-01A | RPS6KA4 | chr11 | 64126921 | TEX40 | chr11 | 64070954 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64126921/chr11:64070954) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS6KA4 | TEX40 |
| FUNCTION: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. | FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. {ECO:0000250|UniProtKB:Q9CQP8}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of RPS6KA4_TEX40 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| RPS6KA4 | O75676 | human | H3C1 | P68431 | S28 | ATkAArksAPATGGV | Histone |
| RPS6KA4 | O75676 | human | CREB1 | P16220 | S119 | EILsRRPsyRkILND | pKID |
| RPS6KA4 | O75676 | human | ATXN1 | P54253 | S775 | AtRKRRWsAPESRKL | |
| RPS6KA4 | O75676 | human | RELA | Q04206 | S276 | sMQLRRPsDRELsEP | RHD_dimer |
| RPS6KA4 | O75676 | human | RPS6KA4 | O75676 | S196 | EEkERtFsFCGTIEY | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| RPS6KA4 | ID | Description | 0.00e+00 |
| RPS6KA4 | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 1.34e-03 |
| RPS6KA4 | GO:0035728 | response to hepatocyte growth factor | 1.34e-03 |
| RPS6KA4 | GO:0070498 | interleukin-1-mediated signaling pathway | 2.90e-03 |
| RPS6KA4 | GO:0071347 | cellular response to interleukin-1 | 2.42e-02 |
| RPS6KA4 | GO:0007613 | memory | 2.42e-02 |
| RPS6KA4 | GO:0070555 | response to interleukin-1 | 2.42e-02 |
| RPS6KA4 | GO:0014074 | response to purine-containing compound | 2.42e-02 |
| RPS6KA4 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 2.42e-02 |
| RPS6KA4 | GO:1901654 | response to ketone | 4.11e-02 |
| RPS6KA4 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 4.45e-02 |
| RPS6KA4 | GO:0007611 | learning or memory | 4.45e-02 |
| RPS6KA4 | GO:0060430 | lung saccule development | 4.45e-02 |
| RPS6KA4 | GO:0070391 | response to lipoteichoic acid | 4.45e-02 |
| RPS6KA4 | GO:0071223 | cellular response to lipoteichoic acid | 4.45e-02 |
| RPS6KA4 | GO:0050890 | cognition | 4.45e-02 |
| RPS6KA4 | GO:0033234 | negative regulation of protein sumoylation | 4.45e-02 |
| RPS6KA4 | GO:0061370 | testosterone biosynthetic process | 4.45e-02 |
| RPS6KA4 | GO:0010944 | negative regulation of transcription by competitive promoter binding | 4.45e-02 |
| RPS6KA4 | GO:0002357 | defense response to tumor cell | 4.45e-02 |
| RPS6KA4 | GO:0032494 | response to peptidoglycan | 4.45e-02 |
| RPS6KA4 | GO:1904321 | response to forskolin | 4.45e-02 |
| RPS6KA4 | GO:1904322 | cellular response to forskolin | 4.45e-02 |
| RPS6KA4 | GO:0032793 | positive regulation of CREB transcription factor activity | 4.45e-02 |
| RPS6KA4 | GO:0051090 | regulation of DNA-binding transcription factor activity | 4.45e-02 |
| RPS6KA4 | GO:0050862 | positive regulation of T cell receptor signaling pathway | 4.45e-02 |
| RPS6KA4 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 4.45e-02 |
| RPS6KA4 | GO:0016202 | regulation of striated muscle tissue development | 4.45e-02 |
| RPS6KA4 | GO:0043434 | response to peptide hormone | 4.45e-02 |
| RPS6KA4 | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway | 4.45e-02 |
| RPS6KA4 | GO:0009410 | response to xenobiotic stimulus | 4.45e-02 |
| RPS6KA4 | GO:0048732 | gland development | 4.45e-02 |
| RPS6KA4 | GO:0010720 | positive regulation of cell development | 4.45e-02 |
| RPS6KA4 | GO:1902004 | positive regulation of amyloid-beta formation | 4.45e-02 |
| RPS6KA4 | GO:0010224 | response to UV-B | 4.45e-02 |
| RPS6KA4 | GO:0010566 | regulation of ketone biosynthetic process | 4.45e-02 |
| RPS6KA4 | GO:0032495 | response to muramyl dipeptide | 4.45e-02 |
| RPS6KA4 | GO:0033762 | response to glucagon | 4.45e-02 |
| RPS6KA4 | GO:0048634 | regulation of muscle organ development | 4.45e-02 |
| RPS6KA4 | GO:0033233 | regulation of protein sumoylation | 4.45e-02 |
| RPS6KA4 | GO:0071294 | cellular response to zinc ion | 4.45e-02 |
| RPS6KA4 | GO:1901863 | positive regulation of muscle tissue development | 4.45e-02 |
| RPS6KA4 | GO:0035994 | response to muscle stretch | 4.45e-02 |
| RPS6KA4 | GO:1902894 | negative regulation of miRNA transcription | 4.45e-02 |
| RPS6KA4 | GO:1902993 | positive regulation of amyloid precursor protein catabolic process | 4.45e-02 |
| RPS6KA4 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell | 4.45e-02 |
| RPS6KA4 | GO:2000629 | negative regulation of miRNA metabolic process | 4.45e-02 |
| RPS6KA4 | GO:0045672 | positive regulation of osteoclast differentiation | 4.45e-02 |
| RPS6KA4 | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 4.45e-02 |
| RPS6KA4 | GO:0060479 | lung cell differentiation | 4.45e-02 |
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Related Drugs to RPS6KA4_TEX40 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning RPS6KA4-TEX40 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to RPS6KA4_TEX40 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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