UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:RPS6KB1_VMP1

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: RPS6KB1_VMP1
	KinaseFusionDB ID: KFG5604
	FusionGDB2.0 ID: KFG5604
		Hgene	Tgene
	Gene symbol	RPS6KB1	VMP1
	Gene ID	6198	81671
	Gene name	ribosomal protein S6 kinase B1	vacuole membrane protein 1
	Synonyms	PS6K\|S6K\|S6K-beta-1\|S6K1\|STK14A\|p70 S6KA\|p70(S6K)-alpha\|p70-S6K\|p70-alpha	EPG3\|TANGO5\|TMEM49
	Cytomap	17q23.1	17q23.1
	Type of gene	protein-coding	protein-coding
	Description	ribosomal protein S6 kinase beta-1ribosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14A	vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
	Modification date	20240411	20240416
	UniProtAcc	P23443	Q96GC9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000225577, ENST00000393021, ENST00000406116, ENST00000443572, ENST00000587061,	ENST00000588617, ENST00000262291, ENST00000536180, ENST00000537567, ENST00000539763, ENST00000545362,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: RPS6KB1 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RPS6KB1(57970686)-VMP1(57886157), # samples:14 VMP1(57915758)-RPS6KB1(57987922), # samples:4

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6KB1	GO:0031667	response to nutrient levels	29750193
Hgene	RPS6KB1	GO:0031670	cellular response to nutrient	22017876
Hgene	RPS6KB1	GO:0031929	TOR signaling	12150926
Hgene	RPS6KB1	GO:0045948	positive regulation of translational initiation	1922062
Hgene	RPS6KB1	GO:0071363	cellular response to growth factor stimulus	17936702
Hgene	RPS6KB1	GO:1904263	positive regulation of TORC1 signaling	22017876
Tgene	VMP1	GO:0000045	autophagosome assembly	28890335
Tgene	VMP1	GO:0006914	autophagy	28890335
Tgene	VMP1	GO:0016240	autophagosome membrane docking	28890335
Tgene	VMP1	GO:0140056	organelle localization by membrane tethering	28890335
Tgene	VMP1	GO:1901896	positive regulation of ATPase-coupled calcium transmembrane transporter activity	28890335
Tgene	VMP1	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	28890335

Kinase Fusion gene breakpoints across RPS6KB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across VMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-4Z-AA7Q	RPS6KB1	chr17	57992064	VMP1	chr17	57917128
ChimerDB4	TCGA-4Z-AA7Q	RPS6KB1	chr17	57992064	VMP1	chr17	57917129
ChimerDB4	TCGA-86-7711-01A	RPS6KB1	chr17	58003943	VMP1	chr17	57917129
ChimerDB4	TCGA-86-7711	RPS6KB1	chr17	58003943	VMP1	chr17	57917128
ChimerDB4	TCGA-D7-6519	RPS6KB1	chr17	57970686	VMP1	chr17	57917128
ChimerDB4	TCGA-LN-A4A8	RPS6KB1	chr17	57992064	VMP1	chr17	57808781
ChimerDB4	TCGA-LN-A4A8	RPS6KB1	chr17	57992064	VMP1	chr17	57808782
ChimerDB4	TCGA-93-A4JQ-01A	RPS6KB1	chr17	57992063	VMP1	chr17	57842331
ChimerDB4	TCGA-93-A4JQ-01A	RPS6KB1	chr17	57992064	VMP1	chr17	57842332
ChimerDB4	TCGA-93-A4JQ	RPS6KB1	chr17	57992064	VMP1	chr17	57842331
ChimerDB4	TCGA-D8-A27H-01A	RPS6KB1	chr17	57970686	VMP1	chr17	57842332
ChimerDB4	TCGA-D8-A27H	RPS6KB1	chr17	57970686	VMP1	chr17	57842331
ChimerDB4	TCGA-69-7978-01A	RPS6KB1	chr17	57970686	VMP1	chr17	57814814
ChimerDB4	TCGA-24-2280-01A	RPS6KB1	chr17	57970686	VMP1	chr17	57889031
ChimerDB4	TCGA-24-2280	RPS6KB1	chr17	57970686	VMP1	chr17	57889030
ChimerDB4	TCGA-49-AAQV	RPS6KB1	chr17	58013902	VMP1	chr17	57915656
ChimerDB4	TCGA-50-6592-01A	RPS6KB1	chr17	58007535	VMP1	chr17	57915656
ChimerDB4	TCGA-50-6592	RPS6KB1	chr17	58007535	VMP1	chr17	57915655
ChimerDB4	TCGA-55-A490	RPS6KB1	chr17	58012661	VMP1	chr17	57886157
ChimerDB4	TCGA-69-7978-01A	RPS6KB1	chr17	57992064	VMP1	chr17	57886157
ChimerDB4	TCGA-69-7978	RPS6KB1	chr17	57992064	VMP1	chr17	57886156
ChimerDB4	TCGA-94-8035	RPS6KB1	chr17	57992064	VMP1	chr17	57889031
ChimerDB4	TCGA-A8-A09I	RPS6KB1	chr17	57970686	VMP1	chr17	57886156
ChimerDB4	TCGA-AC-A2BK-01A	RPS6KB1	chr17	57987972	VMP1	chr17	57886157
ChimerDB4	TCGA-AC-A2BK	RPS6KB1	chr17	57987972	VMP1	chr17	57886156
ChimerDB4	TCGA-BA-6868	RPS6KB1	chr17	57990165	VMP1	chr17	57915655
ChimerDB4	TCGA-BA-6868	RPS6KB1	chr17	57990165	VMP1	chr17	57915656
ChimerDB4	TCGA-BH-A0B9	RPS6KB1	chr17	57992064	VMP1	chr17	57915655
ChimerDB4	TCGA-C5-A7X5-01A	RPS6KB1	chr17	58009083	VMP1	chr17	57895073
ChimerDB4	TCGA-DK-A2I4-01A	RPS6KB1	chr17	57970686	VMP1	chr17	57915656
ChimerDB4	TCGA-EY-A1GS-01A	RPS6KB1	chr17	57992064	VMP1	chr17	57851115
ChimerDB4	TCGA-HQ-A2OE-01A	RPS6KB1	chr17	57970686	VMP1	chr17	57886157
ChimerDB4	TCGA-JL-A3YW-01A	RPS6KB1	chr17	57970685	VMP1	chr17	57915655
ChimerDB4	TCGA-JL-A3YW	RPS6KB1	chr17	57970686	VMP1	chr17	57915655
ChimerDB4	TCGA-P3-A6T4	RPS6KB1	chr17	57990165	VMP1	chr17	57886157
ChimerDB4	TCGA-PQ-A6FI-01A	RPS6KB1	chr17	57992064	VMP1	chr17	57915656
ChimerDB4	TCGA-CR-7369	RPS6KB1	chr17	57971285	VMP1	chr17	57915656
ChimerKB4	.	RPS6KB1	chr17	57987922	VMP1	chr17	57987922
CCLE	COLO-680N	RPS6KB1	chr17	58018304	VMP1	chr17	57889031
CCLE	TE-11	RPS6KB1	chr17	58007535	VMP1	chr17	57886157
CCLE	TE-11	RPS6KB1	chr17	58009083	VMP1	chr17	57886157
CCLE	MCF7	RPS6KB1	chr17	57987972	VMP1	chr17	57915656
CCLE	KPL-1	RPS6KB1	chr17	57987972	VMP1	chr17	57915656
CCLE	CME-1	RPS6KB1	chr17	57987972	VMP1	chr17	57915656
CCLE	C-33 A	RPS6KB1	chr17	57987972	VMP1	chr17	57915656
CCLE	SNU-1105	RPS6KB1	chr17	58013902	VMP1	chr17	57886157
CCLE	VM-CUB1	RPS6KB1	chr17	58022879	VMP1	chr17	57915656
CCLE	1273/99	RPS6KB1	chr17	58003943	VMP1	chr17	57895073
CCLE	TFK-1	RPS6KB1	chr17	58003943	VMP1	chr17	57915656
CCLE	NCI-H2196	RPS6KB1	chr17	57970686	VMP1	chr17	57842413
CCLE	NCI-H1385	RPS6KB1	chr17	57992064	VMP1	chr17	57812699
CCLE	HMC-1-8	RPS6KB1	chr17	58022879	VMP1	chr17	57917129
CCLE	U-251 MG	RPS6KB1	chr17	57992064	VMP1	chr17	57895073
CCLE	COV504	RPS6KB1	chr17	57992064	VMP1	chr17	57895073
CCLE	C-33 A	RPS6KB1	chr17	58011885	VMP1	chr17	57886157
CCLE	ICC4	RPS6KB1	chr17	57970686	VMP1	chr17	57917129

Top

Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000443572	ENST00000262291	RPS6KB1	chr17	58018304	VMP1	chr17	57889031	2820	527
ENST00000443572	ENST00000262291	RPS6KB1	chr17	58013902	VMP1	chr17	57886157	2793	518
ENST00000443572	ENST00000262291	RPS6KB1	chr17	58022879	VMP1	chr17	57915656	2754	505
ENST00000443572	ENST00000539763	RPS6KB1	chr17	58022879	VMP1	chr17	57917129	1690	463

Top

Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000443572_ENST00000262291_RPS6KB1_chr17_58018304_VMP1_chr17_57889031_length(amino acids)=527
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC
FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS
MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF
TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD
SKFTRQTPVDSPDDSTLSESANQVFLIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPG

--------------------------------------------------------------

>ENST00000443572_ENST00000262291_RPS6KB1_chr17_58013902_VMP1_chr17_57886157_length(amino acids)=518
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC
FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS
MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF
TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLDFASRAKLAV
QKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPF

--------------------------------------------------------------

>ENST00000443572_ENST00000262291_RPS6KB1_chr17_58022879_VMP1_chr17_57915656_length(amino acids)=505
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC
FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS
MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF
TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD
SKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSAVPGIGPSLQKPFQEYLEAQRQKLHH

--------------------------------------------------------------

>ENST00000443572_ENST00000539763_RPS6KB1_chr17_58022879_VMP1_chr17_57917129_length(amino acids)=463
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC
FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS
MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF
TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD
SKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVREKTGCPGCLKSWSLSWCVTSSYLSLT

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

Top

Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57970686/chr17:57886157)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RPS6KB1 P23443	VMP1 Q96GC9
FUNCTION: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:23429703, PubMed:28178239, PubMed:22017876). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:23429703, PubMed:28178239, PubMed:22017876). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239). {ECO:0000250\|UniProtKB:P67999, ECO:0000250\|UniProtKB:Q8BSK8, ECO:0000269\|PubMed:11500364, ECO:0000269\|PubMed:12801526, ECO:0000269\|PubMed:14673156, ECO:0000269\|PubMed:15071500, ECO:0000269\|PubMed:15341740, ECO:0000269\|PubMed:16286006, ECO:0000269\|PubMed:17052453, ECO:0000269\|PubMed:17053147, ECO:0000269\|PubMed:17936702, ECO:0000269\|PubMed:18952604, ECO:0000269\|PubMed:19085255, ECO:0000269\|PubMed:19720745, ECO:0000269\|PubMed:19935711, ECO:0000269\|PubMed:19995915, ECO:0000269\|PubMed:22017876, ECO:0000269\|PubMed:23429703, ECO:0000269\|PubMed:28178239}.	FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33929485, PubMed:33850023). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33929485, PubMed:33850023). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:28890335, PubMed:30093494, PubMed:30933966, PubMed:33929485, PubMed:33850023). Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:31526472, PubMed:33850023). Modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). Plays an essential role in formation of cell junctions (PubMed:17724469). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). {ECO:0000250\|UniProtKB:Q91ZQ0, ECO:0000269\|PubMed:17724469, ECO:0000269\|PubMed:28890335, ECO:0000269\|PubMed:30093494, ECO:0000269\|PubMed:30933966, ECO:0000269\|PubMed:31526472, ECO:0000269\|PubMed:33850023, ECO:0000269\|PubMed:33929485}.; FUNCTION: (Microbial infection) Host factor required for infection by all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33338421). Probably required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33338421). {ECO:0000269\|PubMed:33338421}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

446446373409446446

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Hgene

RPS6KB1

58022879

VMP1

57915656

ENST00000443572

353_423

526

Domain

Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618

Hgene

RPS6KB1

58022879

VMP1

57917129

ENST00000443572

353_423

526

Domain

Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618

Hgene

RPS6KB1

58013902

VMP1

57886157

ENST00000443572

91_352

526

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Hgene

RPS6KB1

58018304

VMP1

57889031

ENST00000443572

91_352

526

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Hgene

RPS6KB1

58022879

VMP1

57915656

ENST00000443572

91_352

526

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Hgene

RPS6KB1

58022879

VMP1

57917129

ENST00000443572

91_352

526

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Top

Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>246_RPS6KB1_VMP1	ENST00000443572	ENST00000539763	RPS6KB1	chr17	58022879	VMP1	chr17	57917129	MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD SKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVREKTGCPGCLKSWSLSWCVTSSYLSLT	463
3D view using mol* of 246_RPS6KB1_VMP1

PDB file >>>HKFP_358_RPS6KB1_VMP1	ENST00000443572	ENST00000262291	RPS6KB1	chr17	58018304	VMP1	chr17	57889031	MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD SKFTRQTPVDSPDDSTLSESANQVFLIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPG	527_RPS6KB1_VMP1
PDB file >>>HKFP_359_RPS6KB1_VMP1	ENST00000443572	ENST00000262291	RPS6KB1	chr17	58013902	VMP1	chr17	57886157	MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLDFASRAKLAV QKLVQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHIQKIFVIITFSKHIVEQMVAFIGAVPGIGPSLQKPF	518_RPS6KB1_VMP1
3D view using mol* of HKFP_359_RPS6KB1_VMP1

PDB file >>>HKFP_360_RPS6KB1_VMP1	ENST00000443572	ENST00000262291	RPS6KB1	chr17	58022879	VMP1	chr17	57915656	MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD SKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSAVPGIGPSLQKPFQEYLEAQRQKLHH	505_RPS6KB1_VMP1
3D view using mol* of HKFP_360_RPS6KB1_VMP1

PDB file >>>HKFP_361_RPS6KB1_VMP1	ENST00000443572	ENST00000539763	RPS6KB1	chr17	58022879	VMP1	chr17	57917129	MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPEC FELLRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPF TGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD SKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVREKTGCPGCLKSWSLSWCVTSSYLSLT	463_RPS6KB1_VMP1
3D view using mol* of HKFP_361_RPS6KB1_VMP1

Top

Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_358_RPS6KB1_VMP1_vs_HKFP_359_RPS6KB1_VMP1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_358_RPS6KB1_VMP1_vs_HKFP_360_RPS6KB1_VMP1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_358_RPS6KB1_VMP1_vs_HKFP_361_RPS6KB1_VMP1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_359_RPS6KB1_VMP1_vs_HKFP_360_RPS6KB1_VMP1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_359_RPS6KB1_VMP1_vs_HKFP_361_RPS6KB1_VMP1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_360_RPS6KB1_VMP1_vs_HKFP_361_RPS6KB1_VMP1_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/HKFP_359_RPS6KB1_VMP1_vs_HKFP_358_RPS6KB1_VMP1.png

./secondary_str/HKFP_359_RPS6KB1_VMP1_vs_HKFP_360_RPS6KB1_VMP1.png

./secondary_str/HKFP_360_RPS6KB1_VMP1_vs_HKFP_358_RPS6KB1_VMP1.png

./secondary_str/HKFP_361_RPS6KB1_VMP1_vs_HKFP_358_RPS6KB1_VMP1.png

./secondary_str/HKFP_361_RPS6KB1_VMP1_vs_HKFP_359_RPS6KB1_VMP1.png

./secondary_str/HKFP_361_RPS6KB1_VMP1_vs_HKFP_360_RPS6KB1_VMP1.png

Top

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

RPS6KB1_VMP1 does not have any known PDB structures.

Top

pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

246_RPS6KB1_VMP1.png

HKFP_359_RPS6KB1_VMP1.png

HKFP_360_RPS6KB1_VMP1.png

HKFP_361_RPS6KB1_VMP1.png

Top

Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
HKFP_359_RPS6KB1_VMP1	1.053	169	1.089	326.879	0.524	0.735	0.978	0.89	0.894	0.995	0.779	Chain A: 112,116,187,190,191,192,194,195,196,197,2 15,216,217,218,220,221,222,223,224,225,226,227,228 ,229,230,231,232,233,236,237,238,240,241,244,246,2 47,248,249,251,255,319
HKFP_360_RPS6KB1_VMP1	1.035	655	1.052	1509.886	0.497	0.748	0.954	0.534	1.034	0.517	0.799	Chain A: 1,2,3,91,93,94,95,96,97,98,99,100,101,102 ,103,104,105,106,107,108,112,113,116,117,120,124,1 33,136,137,145,146,147,148,149,150,151,152,153,156 ,159,187,190,191,192,194,195,196,197,199,202,204,2 05,212,213,214,215,216,217,218,219,220,221,222,223 ,224,225,226,227,228,229,230,231,232,233,234,236,2 37,238,241,242,244,246,247,248,249,251,255,279,350 ,352,353,354,356,359,360,363,368,369,370
HKFP_361_RPS6KB1_VMP1	1.097	110	1.088	286.748	0.5	0.843	1.168	0.756	1.099	0.688	0.72	Chain A: 102,115,116,119,194,195,196,197,216,217,2 18,219,227,228,229,230,231,232,233,236,237,238,241 ,242,244,247,251,252,255

Top

Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

246_RPS6KB1_VMP1_ramachandran.png

HKFP_359_RPS6KB1_VMP1_ramachandran.png

HKFP_360_RPS6KB1_VMP1_ramachandran.png

HKFP_361_RPS6KB1_VMP1_ramachandran.png

Top

Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

Top

Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Ripretinib	-6.2699099999999985	-6.27691	-51.3774
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Ripretinib	-6.2699099999999985	-6.27691	-51.3774
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Sunitinib	-6.2695	-6.2737	-54.1429
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Sorafenib	-6.22241	-6.23451	-45.5832
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Sorafenib	-6.22241	-6.23451	-45.5832
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Asciminib	-6.2155	-6.6805	-37.5782
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Asciminib	-6.20927	-6.67427	-38.1841
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Abrocitinib	-5.99199	-6.00309	-42.0783
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Abrocitinib	-5.99199	-6.00309	-42.0783
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Baricitinib	-5.9853	-5.9853	-43.9125
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Upadacitinib	-5.96638	-5.96738	-43.1799
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Lenvatinib	-5.83875	-5.83875	-44.5716
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Cabozantinib	-5.77464	-5.81964	-49.8536
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Cabozantinib	-5.77464	-5.81964	-49.8536
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Tivozanib	-5.64131	-5.64131	-46.226000000000006
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Larotrectinib	-5.62903	-5.62903	-31.1636
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Fedratinib	-5.53558	-5.5869800000000005	-63.0163
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Fedratinib	-5.53558	-5.5869800000000005	-63.0163
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Tofacitinib	-5.4676300000000015	-5.4791300000000005	-31.5994
HKFP_360_RPS6KB1_VMP1_vsw_3-DOCK_HTVS_1-001	Tofacitinib	-5.4676300000000015	-5.4791300000000005	-31.5994
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Baricitinib	-4.69586	-4.69586	-36.9878
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Ibrutinib	-4.62661	-4.62661	-41.878
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Tucatinib	-4.55999	-4.93519	-44.4708
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Vemurafenib	-4.55195	-4.99595	-41.9236
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Vemurafenib	-4.55195	-4.99595	-41.9236
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Vandetanib	-4.45964	-4.45964	-42.2799
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Lenvatinib	-4.31174	-4.31174	-31.5182
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Tepotinib	-4.2987	-4.2998	-48.5758
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Ponatinib	-4.2811	-4.4877	-44.3021
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Ponatinib	-4.2811	-4.4877	-44.3021
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Ponatinib	-4.2811	-4.4877	-44.3021
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Imatinib	-4.1469	-4.3535	-43.2204
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Imatinib	-4.1469	-4.3535	-43.2204
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Imatinib	-4.1469	-4.3535	-43.2204
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Sorafenib	-4.12129	-4.13339	-39.7904
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Sorafenib	-4.12129	-4.13339	-39.7904
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Pexidartinib	-3.99972	-4.21652	-31.6439
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Pexidartinib	-3.99972	-4.21652	-31.6439
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Zanubrutinib	-3.89963	-3.89963	-34.9466
HKFP_361_RPS6KB1_VMP1_vsw_4-DOCK_HTVS_1-001	Fostamatinib	-3.85766	-3.92126	-43.8182
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Imatinib	-6.67938	-7.434080000000001	-43.4699
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Imatinib	-6.67938	-7.434080000000001	-43.4699
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Imatinib	-6.67938	-7.434080000000001	-43.4699
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Pexidartinib	-6.45726	-6.674060000000001	-43.951
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Pexidartinib	-6.45726	-6.674060000000001	-43.951
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Cabozantinib	-6.27254	-6.31754	-46.7445
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Cabozantinib	-6.27254	-6.31754	-46.7445
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Pralsetinib	-6.174580000000001	-7.32678	-35.4534
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Selpercatinib	-6.1304099999999995	-6.160909999999999	-43.2315
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Ibrutinib	-6.014530000000001	-6.014530000000001	-43.0274
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Neratinib	-6.00401	-6.18631	-52.5765
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Neratinib	-6.00401	-6.18631	-52.5765
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Sorafenib	-5.93014	-5.94224	-46.9252
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Sorafenib	-5.93014	-5.94224	-46.9252
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Ruxolitinib	-5.92469	-5.92469	-32.2087
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Pazopanib	-5.85025	-5.85715	-42.1085
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Pazopanib	-5.85025	-5.85715	-42.1085
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Baricitinib	-5.8394	-5.8394	-39.3011
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Pralsetinib	-5.81118	-5.90268	-31.49
246_RPS6KB1_VMP1-DOCK_HTVS_1-001	Osimertinib	-5.7612	-5.7689	-37.7112

Top

Kinase-Substrate Information of RPS6KB1_VMP1

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
RPS6KB1	P23443	human	BACH2	Q9BYV9	S521	ETRTRTssSCSsYsY
RPS6KB1	P23443	human	IRS1	P35568	S636	sGDyMPMsPKsVSAP
RPS6KB1	P23443	human	NDRG2	Q9UN36	S350	RsRsRtLsQssEsGt
RPS6KB1	P23443	human	KHSRP	Q92945	S395	DLLQSLrsGPPGPPG
RPS6KB1	P23443	human	PDCD4	Q53EL6	S67	kRRLRKNssRDsGrG
RPS6KB1	P23443	human	TP63	Q9H3D4	S560	LARLGCSsCLDYFTT	SAM_2
RPS6KB1	P23443	human	MTOR	P42345	S2448	RsRtRtDsysAGQsV
RPS6KB1	P23443	human	TRIB2	Q92519	S83	FRAVHLHsGEELVCK	Pkinase
RPS6KB1	P23443	human	RPS6	P62753	S240	RLssLRAstsKsEss
RPS6KB1	P23443	human	RPS6KB1	P23443	T412	NQVFLGFtyVAPsVL	Pkinase_C
RPS6KB1	P23443	human	SMN1	Q16637	S49	AyDkAVAsFkHALkN	SMN
RPS6KB1	P23443	human	EEF2K	O00418	S366	sPQVRtLsGSRPPLL
RPS6KB1	P23443	human	BACH2	Q9BYV9	S520	LETRTRTssSCSsYs
RPS6KB1	P23443	human	MXD1	Q05195	S145	IERIRMDsIGSTVSS
RPS6KB1	P23443	human	IRS1	P35568	S307	TRRsRtEsItAtsPA
RPS6KB1	P23443	human	URI1	O94763	S372	AKRKRKNstGsGHsA
RPS6KB1	P23443	human	MAPT	P10636-8	S262	NVKskIGstENLkHQ	Tubulin-binding
RPS6KB1	P23443	human	PDCD4	Q53EL6	S457	RGRKRFVsEGDGGRL
RPS6KB1	P23443	human	IRS1	P35568	S527	RFRKRtHsAGtsPtI
RPS6KB1	P23443	human	NCBP1	Q09161	S7	_MSRRRHsDENDGGQ
RPS6KB1	P23443	human	IRS1	P35568	S270	EFRPRsKsQSssNCs
RPS6KB1	P23443	human	H2BC3	P33778	S36	RKRsRkEsysIyVyk	Histone
RPS6KB1	P23443	human	PIP5K1C	O60331	T553	QPRYRRRtQssGQDG
RPS6KB1	P23443	human	POLDIP3	Q9BY77	S385	PRRVNsAsSsNPPAE
RPS6KB1	P23443	human	TARBP2	Q15633	S283	ILSLRsCsLGsLGAL
RPS6KB1	P23443	human	MTOR	P42345	T2446	NKRsRtRtDsysAGQ
RPS6KB1	P23443	human	FMR1	Q06787	S500	NSEASNAsETESDHR	FXMRP1_C_core
RPS6KB1	P23443	human	IRS1	P35568	S1101	GCRRRHssEtFsStP
RPS6KB1	P23443	human	RPS6	P62753	S244	LRAstsKsEssQK__
RPS6KB1	P23443	human	GSK3B	P49841	S9	SGRPRttsFAEsCkP
RPS6KB1	P23443	human	ZBTB33	Q86T24	T606	yLSDRSStIPAMkDD
RPS6KB1	P23443	human	NDRG2	Q9UN36	S332	LsRsRtAsLtsAAsV
RPS6KB1	P23443	human	MAPT	P10636-8	S214	GsRsRtPsLPtPPtR
RPS6KB1	P23443	human	DEPTOR	Q8TB45	S287	sMssCGssGyFsssP
RPS6KB1	P23443	human	ESR1	P03372	S167	GGRERLAsTNDkGSM	Oest_recep
RPS6KB1	P23443	human	LTC4S	Q16873	S36	ARRAFRVsPPLtTGP	MAPEG
RPS6KB1	P23443	human	RPS6	P62753	S236	AKRRRLssLRAstsK
RPS6KB1	P23443	human	MRE11	P49959	T597	sQrGrADtGLETSTr
RPS6KB1	P23443	human	CAD	P27708	S1859	PPRIhRAsDPGLPAE
RPS6KB1	P23443	human	NCBP1	Q09161	S22	PHKRRKtsDANEtED
RPS6KB1	P23443	human	DEPTOR	Q8TB45	S286	ssMssCGssGyFsss
RPS6KB1	P23443	human	EGLN1	Q9GZT9	S125	ADPAAAAsPCRAAAG
RPS6KB1	P23443	human	CCT2	P78371	S260	GsRVRVDstAkVAEI	Cpn60_TCP1
RPS6KB1	P23443	human	MAPT	P10636-8	T212	tPGsRsRtPsLPtPP
RPS6KB1	P23443	human	PIP5K1C	O60331	S555	RYRRRtQssGQDGRP
RPS6KB1	P23443	human	GLI1	P08151	S84	LTKKRALsISPLSDA
RPS6KB1	P23443	human	MSH6	P52701	S309	RMVtGNGsLKRKSSR
RPS6KB1	P23443	human	RICTOR	Q6R327	T1135	NRRIRtLtEPsVDFN	RICTOR_phospho
RPS6KB1	P23443	human	SRPK2	P78362	S494	HDRSRtVsAsstGDL
RPS6KB1	P23443	human	NCBP1	Q09161	T21	QPHKRRKtsDANEtE
RPS6KB1	P23443	human	EIF4B	P23588	S422	RERsRtGsEssQtGt
RPS6KB1	P23443	human	RPS6	P62753	S235	IAKRRRLssLRAsts
RPS6KB1	P23443	human	POLDIP3	Q9BY77	S383	ELPRRVNsAsSsNPP
RPS6KB1	P23443	human	DEPTOR	Q8TB45	S291	CGssGyFsssPtLss
RPS6KB1	P23443	human	EPRS1	P07814	S999	NQGGGLsssGAGEGQ
RPS6KB1	P23443	human	CDK1	P06493	S39	MkkIRLEsEEEGVPs	Pkinase
RPS6KB1	P23443-2	human	GSK3B	P49841	S9	SGRPRttsFAEsCkP
RPS6KB1	P23443-2	human	EPRS1	P07814	S999	NQGGGLsssGAGEGQ

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
RPS6KB1	ID	Description	0.00e+00
RPS6KB1	GO:0045927	positive regulation of growth	4.45e-04
RPS6KB1	GO:0006446	regulation of translational initiation	4.45e-04
RPS6KB1	GO:0032868	response to insulin	4.45e-04
RPS6KB1	GO:0032869	cellular response to insulin stimulus	9.65e-04
RPS6KB1	GO:0043086	negative regulation of catalytic activity	9.65e-04
RPS6KB1	GO:1900034	regulation of cellular response to heat	9.65e-04
RPS6KB1	GO:0006413	translational initiation	9.65e-04
RPS6KB1	GO:0051348	negative regulation of transferase activity	9.69e-04
RPS6KB1	GO:0045936	negative regulation of phosphate metabolic process	1.25e-03
RPS6KB1	GO:0010563	negative regulation of phosphorus metabolic process	1.25e-03
RPS6KB1	GO:0043434	response to peptide hormone	2.49e-03
RPS6KB1	GO:0031929	TOR signaling	2.49e-03
RPS6KB1	GO:0018105	peptidyl-serine phosphorylation	2.79e-03
RPS6KB1	GO:0018209	peptidyl-serine modification	3.19e-03
RPS6KB1	GO:0071375	cellular response to peptide hormone stimulus	3.19e-03
RPS6KB1	GO:0033673	negative regulation of kinase activity	3.47e-03
RPS6KB1	GO:0006403	RNA localization	3.47e-03
RPS6KB1	GO:0006913	nucleocytoplasmic transport	3.47e-03
RPS6KB1	GO:0051169	nuclear transport	3.47e-03
RPS6KB1	GO:0046777	protein autophosphorylation	3.47e-03
RPS6KB1	GO:1901653	cellular response to peptide	6.48e-03
RPS6KB1	GO:0051028	mRNA transport	8.35e-03
RPS6KB1	GO:0033002	muscle cell proliferation	8.39e-03
RPS6KB1	GO:0030850	prostate gland development	8.98e-03
RPS6KB1	GO:0001558	regulation of cell growth	9.68e-03
RPS6KB1	GO:0043467	regulation of generation of precursor metabolites and energy	9.68e-03
RPS6KB1	GO:0045727	positive regulation of translation	9.68e-03
RPS6KB1	GO:0060525	prostate glandular acinus development	9.68e-03
RPS6KB1	GO:1905214	regulation of RNA binding	9.68e-03
RPS6KB1	GO:1900180	regulation of protein localization to nucleus	9.68e-03
RPS6KB1	GO:0031400	negative regulation of protein modification process	1.03e-02
RPS6KB1	GO:0010921	regulation of phosphatase activity	1.20e-02
RPS6KB1	GO:0002181	cytoplasmic translation	1.20e-02
RPS6KB1	GO:0050657	nucleic acid transport	1.20e-02
RPS6KB1	GO:0050658	RNA transport	1.20e-02
RPS6KB1	GO:0031100	animal organ regeneration	1.20e-02
RPS6KB1	GO:0048524	positive regulation of viral process	1.20e-02
RPS6KB1	GO:0051236	establishment of RNA localization	1.20e-02
RPS6KB1	GO:0030307	positive regulation of cell growth	1.23e-02
RPS6KB1	GO:0034605	cellular response to heat	1.23e-02
RPS6KB1	GO:0001655	urogenital system development	1.23e-02
RPS6KB1	GO:0048639	positive regulation of developmental growth	1.23e-02
RPS6KB1	GO:0051168	nuclear export	1.23e-02
RPS6KB1	GO:0034250	positive regulation of amide metabolic process	1.23e-02
RPS6KB1	GO:0038203	TORC2 signaling	1.23e-02
RPS6KB1	GO:1900452	regulation of long-term synaptic depression	1.23e-02
RPS6KB1	GO:0006406	mRNA export from nucleus	1.25e-02
RPS6KB1	GO:0016049	cell growth	1.28e-02
RPS6KB1	GO:0043201	response to leucine	1.28e-02

Top

Related Drugs to RPS6KB1_VMP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning RPS6KB1-VMP1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

Top

Related Diseases to RPS6KB1_VMP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Top

Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date