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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:RPS6KB2_ST3GAL2

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: RPS6KB2_ST3GAL2
KinaseFusionDB ID: KFG5609
FusionGDB2.0 ID: KFG5609
HgeneTgene
Gene symbol

RPS6KB2

ST3GAL2

Gene ID

6199

6483

Gene nameribosomal protein S6 kinase B2ST3 beta-galactoside alpha-2,3-sialyltransferase 2
SynonymsKLS|P70-beta|P70-beta-1|P70-beta-2|S6K-beta2|S6K2|S6KB|S6KI(2)|S6Kbeta|SRK|STK14B|p70(S6K)-beta|p70S6KbGal-NAc6S|SIAT4B|ST3GALII|ST3GalA.2
Cytomap

11q13.2

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionribosomal protein S6 kinase beta-270 kDa ribosomal protein S6 kinase 2P70S6K2S6 kinase-related kinaseS6K-betaS6K-beta-2p70 S6 kinase betap70 S6K-betap70 S6KBp70 ribosomal S6 kinase betap70-S6K 2ribosomal protein S6 kinase, 70kDa, polypeptide 2CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferaseSIAT4-BST3Gal IIalpha 2,3-ST 2beta-galactoside alpha-2,3-sialyltransferase 2monosialoganglioside sialyltransferasesialyltransfera
Modification date2024041120240411
UniProtAcc

Q9UBS0

Q16842

Ensembl transtripts involved in fusion geneENST idsENST00000524814, ENST00000312629, 
ENST00000539188, 		ENST00000342907, 
ENST00000393640, ENST00000566097, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: RPS6KB2 [Title/Abstract] AND ST3GAL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RPS6KB2(67197066)-ST3GAL2(70422449), # samples:3
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS6KB2

GO:0045948

positive regulation of translational initiation

29750193

TgeneST3GAL2

GO:0006486

protein glycosylation

9266697

TgeneST3GAL2

GO:0009101

glycoprotein biosynthetic process

9266697

TgeneST3GAL2

GO:0009247

glycolipid biosynthetic process

9266697

TgeneST3GAL2

GO:0009312

oligosaccharide biosynthetic process

9266697

TgeneST3GAL2

GO:0010706

ganglioside biosynthetic process via lactosylceramide

8920913

TgeneST3GAL2

GO:0010707

globoside biosynthetic process via lactosylceramide

12716912

TgeneST3GAL2

GO:0030259

lipid glycosylation

9266697

TgeneST3GAL2

GO:0097503

sialylation

9266697

TgeneST3GAL2

GO:1990743

protein sialylation

9266697


check buttonKinase Fusion gene breakpoints across RPS6KB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across ST3GAL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-DK-A6AV-01ARPS6KB2chr11

67197066

ST3GAL2chr16

70422449



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67197066/:70422449)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RPS6KB2

Q9UBS0

ST3GAL2

Q16842

FUNCTION: Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193). {ECO:0000269|PubMed:29750193}.FUNCTION: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169). Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697). Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (PubMed:12716912). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:9266697, PubMed:25916169). {ECO:0000250|UniProtKB:Q11204, ECO:0000269|PubMed:12716912, ECO:0000269|PubMed:25916169, ECO:0000269|PubMed:8920913, ECO:0000269|PubMed:9266697}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of RPS6KB2_ST3GAL2


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
RPS6KB2Q9UBS0humanEEF2KO00418S366sPQVRtLsGSRPPLL
RPS6KB2Q9UBS0humanHSPB1P04792S82RALsRQLssGVsEIr
RPS6KB2Q9UBS0humanTARBP2Q15633S283ILSLRsCsLGsLGAL
RPS6KB2Q9UBS0humanHSPB1P04792S78PAysRALsRQLssGV
RPS6KB2Q9UBS0humanGSK3BP49841S9SGRPRttsFAEsCkP
RPS6KB2Q9UBS0humanKRT18P05783S53IsVsrstsFrGGMGs
RPS6KB2Q9UBS0humanHNRNPA1P09651S4____MsksEsPkEPE
RPS6KB2Q9UBS0humanHNRNPA1P09651S6__MsksEsPkEPEQL
RPS6KB2Q9UBS0humanRICTORQ6R327T1135NRRIRtLtEPsVDFNRICTOR_phospho


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
RPS6KB2IDDescription0.00e+00
RPS6KB2GO:0051348negative regulation of transferase activity3.07e-02
RPS6KB2GO:0048814regulation of dendrite morphogenesis3.31e-02
RPS6KB2GO:0045936negative regulation of phosphate metabolic process3.31e-02
RPS6KB2GO:0010563negative regulation of phosphorus metabolic process3.31e-02
RPS6KB2GO:0031400negative regulation of protein modification process3.31e-02
RPS6KB2GO:0106027neuron projection organization3.31e-02
RPS6KB2GO:0043086negative regulation of catalytic activity3.31e-02
RPS6KB2GO:0050773regulation of dendrite development3.31e-02
RPS6KB2GO:0019080viral gene expression3.31e-02
RPS6KB2GO:0009408response to heat3.31e-02
RPS6KB2GO:0048813dendrite morphogenesis5.45e-02
RPS6KB2GO:0030010establishment of cell polarity5.86e-02
RPS6KB2GO:0051168nuclear export5.86e-02
RPS6KB2GO:0009266response to temperature stimulus5.86e-02
RPS6KB2GO:0006469negative regulation of protein kinase activity5.86e-02
RPS6KB2GO:0033673negative regulation of kinase activity5.86e-02
RPS6KB2GO:0031334positive regulation of protein-containing complex assembly5.86e-02
RPS6KB2GO:0046777protein autophosphorylation5.86e-02
RPS6KB2GO:1902075cellular response to salt5.86e-02
RPS6KB2GO:0032869cellular response to insulin stimulus5.86e-02
RPS6KB2GO:0007163establishment or maintenance of cell polarity5.86e-02
RPS6KB2GO:0097191extrinsic apoptotic signaling pathway5.86e-02
RPS6KB2GO:0016358dendrite development5.86e-02
RPS6KB2GO:2001234negative regulation of apoptotic signaling pathway5.86e-02
RPS6KB2GO:0032984protein-containing complex disassembly5.86e-02
RPS6KB2GO:0031669cellular response to nutrient levels5.86e-02
RPS6KB2GO:0070874negative regulation of glycogen metabolic process5.86e-02
RPS6KB2GO:0070922RISC complex assembly5.86e-02
RPS6KB2GO:0032868response to insulin5.86e-02
RPS6KB2GO:0006983ER overload response5.86e-02
RPS6KB2GO:1901984negative regulation of protein acetylation5.86e-02
RPS6KB2GO:1903564regulation of protein localization to cilium5.86e-02
RPS6KB2GO:1905383protein localization to presynapse5.86e-02
RPS6KB2GO:0031668cellular response to extracellular stimulus5.86e-02
RPS6KB2GO:0034454microtubule anchoring at centrosome5.86e-02
RPS6KB2GO:0072497mesenchymal stem cell differentiation5.86e-02
RPS6KB2GO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway5.86e-02
RPS6KB2GO:1904338regulation of dopaminergic neuron differentiation5.86e-02
RPS6KB2GO:1904779regulation of protein localization to centrosome5.86e-02
RPS6KB2GO:0018105peptidyl-serine phosphorylation5.86e-02
RPS6KB2GO:0001933negative regulation of protein phosphorylation5.86e-02
RPS6KB2GO:0038203TORC2 signaling5.86e-02
RPS6KB2GO:0072393microtubule anchoring at microtubule organizing center5.86e-02
RPS6KB2GO:0098840protein transport along microtubule5.86e-02
RPS6KB2GO:0099118microtubule-based protein transport5.86e-02
RPS6KB2GO:0018209peptidyl-serine modification5.86e-02
RPS6KB2GO:0071375cellular response to peptide hormone stimulus5.86e-02
RPS6KB2GO:0070885negative regulation of calcineurin-NFAT signaling cascade5.86e-02
RPS6KB2GO:0106057negative regulation of calcineurin-mediated signaling5.86e-02

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Related Drugs to RPS6KB2_ST3GAL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning RPS6KB2-ST3GAL2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to RPS6KB2_ST3GAL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate