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Kinase Fusion Gene:SCAF1_MAP4K1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: SCAF1_MAP4K1 | KinaseFusionDB ID: KFG5680 | FusionGDB2.0 ID: KFG5680 | Hgene | Tgene | Gene symbol | SCAF1 | MAP4K1 | Gene ID | 58506 | 11184 | |
| Gene name | SR-related CTD associated factor 1 | mitogen-activated protein kinase kinase kinase kinase 1 | ||||||||||
| Synonyms | SRA1 | HPK1 | ||||||||||
| Cytomap | 19q13.33 | 19q13.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | splicing factor, arginine/serine-rich 19SCAFSR-related C-terminal domain-associated factor 1SR-related and CTD-associated factor 1SR-related-CTD-associated factorserine arginine-rich pre-mRNA splicing factor SR-A1 | mitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1 | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | Q99590 | Q92918 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000360565, | ENST00000423454, ENST00000589002, ENST00000396857, ENST00000589130, ENST00000591517, ENST00000586296, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SCAF1 [Title/Abstract] AND MAP4K1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SCAF1(50161146)-MAP4K1(39078457), # samples:3 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAP4K1 | GO:0006468 | protein phosphorylation | 8824585 |
| Tgene | MAP4K1 | GO:0007254 | JNK cascade | 8824585 |
| Tgene | MAP4K1 | GO:0018105 | peptidyl-serine phosphorylation | 11053428|24362026 |
| Tgene | MAP4K1 | GO:0043410 | positive regulation of MAPK cascade | 11053428 |
| Tgene | MAP4K1 | GO:0046777 | protein autophosphorylation | 8824585|24362026 |
| Tgene | MAP4K1 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 8824585 |
| Kinase Fusion gene breakpoints across SCAF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across MAP4K1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-A2-A0EV-01A | SCAF1 | chr19 | 50161146 | MAP4K1 | chr19 | 39078457 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:50161146/chr19:39078457) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCAF1 | MAP4K1 |
| FUNCTION: Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. | FUNCTION: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SCAF1_MAP4K1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP4K1 | Q92918 | human | CARD11 | Q9BXL7 | S558 | MQPPRsRssIMsITA | |
| MAP4K1 | Q92918 | human | MAP3K11 | Q16584 | S281 | WHKtTQMsAAGTYAW | PK_Tyr_Ser-Thr |
| MAP4K1 | Q92918 | human | CARD11 | Q9BXL7 | S556 | tKMQPPRsRssIMsI | |
| MAP4K1 | Q92918 | human | PSMD2 | Q13200 | S361 | ENNrFGGsGsQVDsA | |
| MAP4K1 | Q92918 | human | MAP4K1 | Q92918 | T165 | ISAQIGAtLARRLsF | Pkinase |
| MAP4K1 | Q92918 | human | LCP2 | Q13094 | S376 | SSFPQsAsLPPYFSQ |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP4K1 | ID | Description | 0.00e+00 |
| MAP4K1 | GO:0050852 | T cell receptor signaling pathway | 3.02e-02 |
| MAP4K1 | GO:0007254 | JNK cascade | 3.02e-02 |
| MAP4K1 | GO:0046777 | protein autophosphorylation | 3.02e-02 |
| MAP4K1 | GO:0050851 | antigen receptor-mediated signaling pathway | 3.02e-02 |
| MAP4K1 | GO:0051403 | stress-activated MAPK cascade | 3.02e-02 |
| MAP4K1 | GO:0031098 | stress-activated protein kinase signaling cascade | 3.02e-02 |
| MAP4K1 | GO:0045860 | positive regulation of protein kinase activity | 3.02e-02 |
| MAP4K1 | GO:1904627 | response to phorbol 13-acetate 12-myristate | 3.02e-02 |
| MAP4K1 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 3.02e-02 |
| MAP4K1 | GO:2000563 | positive regulation of CD4-positiv | 2.65e-03 |
| MAP4K1 | GO:0046710 | GDP metabolic process | 3.02e-02 |
| MAP4K1 | GO:0033674 | positive regulation of kinase activity | 3.02e-02 |
| MAP4K1 | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 3.02e-02 |
| MAP4K1 | GO:0050862 | positive regulation of T cell receptor signaling pathway | 3.46e-02 |
| MAP4K1 | GO:0051347 | positive regulation of transferase activity | 3.46e-02 |
| MAP4K1 | GO:0009135 | purine nucleoside diphosphate metabolic process | 3.46e-02 |
| MAP4K1 | GO:0009179 | purine ribonucleoside diphosphate metabolic process | 3.46e-02 |
| MAP4K1 | GO:0035739 | CD4-positiv | 5.82e-03 |
| MAP4K1 | GO:0043410 | positive regulation of MAPK cascade | 3.46e-02 |
| MAP4K1 | GO:0045061 | thymic T cell selection | 3.46e-02 |
| MAP4K1 | GO:0046641 | positive regulation of alpha-beta T cell proliferation | 3.46e-02 |
| MAP4K1 | GO:0002764 | immune response-regulating signaling pathway | 3.46e-02 |
| MAP4K1 | GO:0046037 | GMP metabolic process | 3.46e-02 |
| MAP4K1 | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 3.46e-02 |
| MAP4K1 | GO:0009185 | ribonucleoside diphosphate metabolic process | 3.70e-02 |
| MAP4K1 | GO:0043507 | positive regulation of JUN kinase activity | 3.70e-02 |
| MAP4K1 | GO:0045577 | regulation of B cell differentiation | 3.79e-02 |
| MAP4K1 | GO:0032743 | positive regulation of interleukin-2 production | 3.79e-02 |
| MAP4K1 | GO:0009132 | nucleoside diphosphate metabolic process | 3.99e-02 |
| MAP4K1 | GO:0009167 | purine ribonucleoside monophosphate metabolic process | 3.99e-02 |
| MAP4K1 | GO:0009126 | purine nucleoside monophosphate metabolic process | 3.99e-02 |
| MAP4K1 | GO:0043506 | regulation of JUN kinase activity | 3.99e-02 |
| MAP4K1 | GO:0046640 | regulation of alpha-beta T cell proliferation | 3.99e-02 |
| MAP4K1 | GO:2000516 | positive regulation of CD4-positiv | 1.16e-02 |
| MAP4K1 | GO:0050856 | regulation of T cell receptor signaling pathway | 3.99e-02 |
| MAP4K1 | GO:0046633 | alpha-beta T cell proliferation | 4.04e-02 |
| MAP4K1 | GO:0031295 | T cell costimulation | 4.04e-02 |
| MAP4K1 | GO:0031294 | lymphocyte costimulation | 4.11e-02 |
| MAP4K1 | GO:0045058 | T cell selection | 4.25e-02 |
| MAP4K1 | GO:0043525 | positive regulation of neuron apoptotic process | 4.39e-02 |
| MAP4K1 | GO:0009161 | ribonucleoside monophosphate metabolic process | 4.52e-02 |
| MAP4K1 | GO:0032623 | interleukin-2 production | 4.62e-02 |
| MAP4K1 | GO:0032663 | regulation of interleukin-2 production | 4.62e-02 |
| MAP4K1 | GO:0030888 | regulation of B cell proliferation | 4.64e-02 |
| MAP4K1 | GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 4.64e-02 |
| MAP4K1 | GO:0045576 | mast cell activation | 4.76e-02 |
| MAP4K1 | GO:0046635 | positive regulation of alpha-beta T cell activation | 4.86e-02 |
| MAP4K1 | GO:0009123 | nucleoside monophosphate metabolic process | 5.07e-02 |
| MAP4K1 | GO:2000514 | regulation of CD4-positiv | 2.05e-02 |
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Related Drugs to SCAF1_MAP4K1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning SCAF1-MAP4K1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SCAF1_MAP4K1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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