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Kinase Fusion Gene:BCAS3_TEC |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: BCAS3_TEC | KinaseFusionDB ID: KFG574 | FusionGDB2.0 ID: KFG574 | Hgene | Tgene | Gene symbol | BCAS3 | TEC | Gene ID | 54828 | 7006 | |
| Gene name | BCAS3 microtubule associated cell migration factor | tec protein tyrosine kinase | ||||||||||
| Synonyms | GAOB1|HEMARS|MAAB|PHAF2 | PSCTK4 | ||||||||||
| Cytomap | 17q23.2 | 4p12-p11 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | BCAS3 microtubule associated cell migration factorBCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinbreast carcinoma-amplified sequence 3metastasis associated antigen of breast cancerphagophore assembly factor 2protein | tyrosine-protein kinase Tec | ||||||||||
| Modification date | 20240305 | 20240411 | ||||||||||
| UniProtAcc | Q9H6U6 | Q9NZ01 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000589222, ENST00000407086, ENST00000390652, ENST00000408905, ENST00000588462, ENST00000585744, ENST00000588874, ENST00000585812, | ENST00000381501, ENST00000511471, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: BCAS3 [Title/Abstract] AND TEC [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BCAS3 | GO:0043085 | positive regulation of catalytic activity | 17505058 |
| Hgene | BCAS3 | GO:0043627 | response to estrogen | 16617102 |
| Hgene | BCAS3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17505058 |
| Hgene | BCAS3 | GO:0071391 | cellular response to estrogen stimulus | 17505058 |
| Tgene | TEC | GO:0007229 | integrin-mediated signaling pathway | 9652744 |
| Tgene | TEC | GO:0010543 | regulation of platelet activation | 9299487|9652744 |
| Tgene | TEC | GO:0050853 | B cell receptor signaling pathway | 10518561 |
| Kinase Fusion gene breakpoints across BCAS3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across TEC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | TE-4 | BCAS3 | chr17 | 58964572 | TEC | chr4 | 48143436 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCAS3 | TEC |
| FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. | FUNCTION: Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234). {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:25049234}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of BCAS3_TEC |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| TEC | P42680 | human | PTPN18 | Q99952 | Y389 | sAEEAPLysKVtPRA | |
| TEC | P42680 | human | BMX | P51813 | Y216 | SSTSLAQyDSNSKKI | |
| TEC | P42680 | human | TEC | P42680 | Y206 | RLERGQEyLILEKND | SH3_1 |
| TEC | P42680 | human | PTPN18 | Q99952 | Y303 | LQNASPHyQNIKENC | |
| TEC | P42680 | human | BTK | Q06187 | Y223 | LKKVVALyDyMPMNA | SH3_1 |
| TEC | P42680 | human | ITK | Q08881 | Y180 | ETVVIALyDyQtNDP | SH3_1 |
| TEC | P42680 | human | PTPN18 | Q99952 | Y281 | AVQTEEQyRFLYHTV | Y_phosphatase |
| TEC | P42680 | human | FGF2 | P09038-2 | Y82 | KGVCANRyLAMKEDG | FGF |
| TEC | P42680 | human | PTPN18 | Q99952 | Y354 | GHAMADTyAVVQKRG |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| TEC | ID | Description | 0.00e+00 |
| TEC | GO:0050853 | B cell receptor signaling pathway | 2.01e-06 |
| TEC | GO:0050851 | antigen receptor-mediated signaling pathway | 5.24e-05 |
| TEC | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 2.02e-04 |
| TEC | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 2.12e-04 |
| TEC | GO:0002757 | immune response-activating signaling pathway | 5.90e-04 |
| TEC | GO:0002764 | immune response-regulating signaling pathway | 6.13e-04 |
| TEC | GO:0050852 | T cell receptor signaling pathway | 6.42e-04 |
| TEC | GO:0010863 | positive regulation of phospholipase C activity | 3.62e-03 |
| TEC | GO:1900274 | regulation of phospholipase C activity | 3.62e-03 |
| TEC | GO:0010518 | positive regulation of phospholipase activity | 5.17e-03 |
| TEC | GO:0010517 | regulation of phospholipase activity | 6.47e-03 |
| TEC | GO:0060193 | positive regulation of lipase activity | 6.47e-03 |
| TEC | GO:0060191 | regulation of lipase activity | 1.01e-02 |
| TEC | GO:0006661 | phosphatidylinositol biosynthetic process | 2.64e-02 |
| TEC | GO:0007498 | mesoderm development | 2.66e-02 |
| TEC | GO:0046488 | phosphatidylinositol metabolic process | 3.23e-02 |
| TEC | GO:1901136 | carbohydrate derivative catabolic process | 4.00e-02 |
| TEC | GO:0046474 | glycerophospholipid biosynthetic process | 5.23e-02 |
| TEC | GO:0050679 | positive regulation of epithelial cell proliferation | 5.23e-02 |
| TEC | GO:0045017 | glycerolipid biosynthetic process | 5.23e-02 |
| TEC | GO:0008654 | phospholipid biosynthetic process | 5.23e-02 |
| TEC | GO:0002883 | regulation of hypersensitivity | 5.23e-02 |
| TEC | GO:0035768 | endothelial cell chemotaxis to fibroblast growth factor | 5.23e-02 |
| TEC | GO:2000544 | regulation of endothelial cell chemotaxis to fibroblast growth factor | 5.23e-02 |
| TEC | GO:0001821 | histamine secretion | 5.23e-02 |
| TEC | GO:0001865 | NK T cell differentiation | 5.23e-02 |
| TEC | GO:0010764 | negative regulation of fibroblast migration | 5.23e-02 |
| TEC | GO:0021936 | regulation of cerebellar granule cell precursor proliferation | 5.23e-02 |
| TEC | GO:0030167 | proteoglycan catabolic process | 5.23e-02 |
| TEC | GO:0035766 | cell chemotaxis to fibroblast growth factor | 5.23e-02 |
| TEC | GO:1904847 | regulation of cell chemotaxis to fibroblast growth factor | 5.23e-02 |
| TEC | GO:0006650 | glycerophospholipid metabolic process | 5.23e-02 |
| TEC | GO:0014842 | regulation of skeletal muscle satellite cell proliferation | 5.23e-02 |
| TEC | GO:0002863 | positive regulation of inflammatory response to antigenic stimulus | 5.23e-02 |
| TEC | GO:0010455 | positive regulation of cell fate commitment | 5.23e-02 |
| TEC | GO:0098761 | cellular response to interleukin-7 | 5.23e-02 |
| TEC | GO:0002524 | hypersensitivity | 5.23e-02 |
| TEC | GO:0051608 | histamine transport | 5.23e-02 |
| TEC | GO:0098760 | response to interleukin-7 | 5.23e-02 |
| TEC | GO:2001028 | positive regulation of endothelial cell chemotaxis | 5.23e-02 |
| TEC | GO:0002864 | regulation of acute inflammatory response to antigenic stimulus | 5.23e-02 |
| TEC | GO:0014857 | regulation of skeletal muscle cell proliferation | 5.23e-02 |
| TEC | GO:0021534 | cell proliferation in hindbrain | 5.23e-02 |
| TEC | GO:0021924 | cell proliferation in external granule layer | 5.23e-02 |
| TEC | GO:0021930 | cerebellar granule cell precursor proliferation | 5.23e-02 |
| TEC | GO:0021984 | adenohypophysis development | 5.23e-02 |
| TEC | GO:0030214 | hyaluronan catabolic process | 5.23e-02 |
| TEC | GO:0045579 | positive regulation of B cell differentiation | 5.23e-02 |
| TEC | GO:0061101 | neuroendocrine cell differentiation | 5.23e-02 |
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Related Drugs to BCAS3_TEC |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning BCAS3-TEC and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to BCAS3_TEC |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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