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Kinase Fusion Gene:BCAS4_AURKA |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: BCAS4_AURKA | KinaseFusionDB ID: KFG576 | FusionGDB2.0 ID: KFG576 | Hgene | Tgene | Gene symbol | BCAS4 | AURKA | Gene ID | 55653 | 6790 | |
Gene name | breast carcinoma amplified sequence 4 | aurora kinase A | ||||||||||
Synonyms | CNOL | AIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7 | ||||||||||
Cytomap | 20q13.13 | 20q13.2 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | breast carcinoma-amplified sequence 4BCAS4/BCAS3 fusionbreast carcinoma amplified sequence 4/3 fusion protein | aurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase a | ||||||||||
Modification date | 20240305 | 20240407 | ||||||||||
UniProtAcc | Q8TDM0 | O14965 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262591, ENST00000358791, ENST00000371608, ENST00000485049, ENST00000609336, | ENST00000312783, ENST00000347343, ENST00000371356, ENST00000395907, ENST00000395909, ENST00000395911, ENST00000395913, ENST00000395914, ENST00000395915, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: BCAS4 [Title/Abstract] AND AURKA [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | AURKA | GO:0006468 | protein phosphorylation | 21600873 |
Tgene | AURKA | GO:0006468 | protein phosphorylation | 21820309 |
Tgene | AURKA | GO:0009611 | response to wounding | 19435814 |
Tgene | AURKA | GO:0032091 | negative regulation of protein binding | 21820309 |
Tgene | AURKA | GO:0097421 | liver regeneration | 19435814 |
Kinase Fusion gene breakpoints across BCAS4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across AURKA (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerKB4 | . | BCAS4 | chr20 | 49446815 | AURKA | chr20 | 49446815 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
BCAS4 | AURKA |
FUNCTION: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of BCAS4_AURKA |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
AURKA | O14965 | human | SDCBP | O00560 | T200 | RPFERTItMHKDSTG | PDZ; Peptidase_M50 |
AURKA | O14965 | human | CRMP1 | Q14194 | T101 | RAALVGGttMIIDHV | Amidohydro_1 |
AURKA | O14965 | human | WDR62 | O43379 | S49 | LRRRtRLstAsEEtV | |
AURKA | O14965 | human | FAF1 | Q9UNN5 | S291 | DVHMVsDsDGDDFED | |
AURKA | O14965 | human | WDR62 | O43379 | T50 | RRRtRLstAsEEtVQ | |
AURKA | O14965 | human | AURKA | O14965 | S67 | QAQkLVssHkPVQNQ | |
AURKA | O14965 | human | SECISBP2L | Q93073 | T573 | IAKLKRPtALKKVIL | |
AURKA | O14965 | human | AURKA | O14965 | T287 | HAPSsRRttLCGtLD | Pkinase |
AURKA | O14965 | human | ARPC1B | O15143 | T21 | HAWNkDRtQIAICPN | |
AURKA | O14965 | human | NUMA1 | Q14980 | S1887 | tRssARRsQAGVsSG | |
AURKA | O14965 | human | MCRS1 | Q96EZ8 | S36 | AGQkRAssQALGTIP | |
AURKA | O14965 | human | SPAG5 | Q96R06 | S115 | IsStPkTsEEAVDPL | |
AURKA | O14965 | human | DCTN1 | Q14203 | S19 | TPSGSrMsAEAsArP | |
AURKA | O14965 | human | RUNX3 | Q13761 | T14 | PSTSRRFtPPsPAFP | |
AURKA | O14965 | human | ALDH1A1 | P00352 | T493 | yTEVkTVtVkISQKN | |
AURKA | O14965 | human | YAP1 | P46937 | S397 | tyHSRDEstDsGLsM | |
AURKA | O14965 | human | AURKA | O14965 | Y148 | kGkFGNVyLAREKQS | Pkinase |
AURKA | O14965 | human | AURKA | O14965 | S266 | PENLLLGsAGELKIA | Pkinase |
AURKA | O14965 | human | ARHGEF2 | Q92974 | S886 | PVDPRRRsLPAGDAL | |
AURKA | O14965 | human | FAF1 | Q9UNN5 | S289 | ITDVHMVsDsDGDDF | |
AURKA | O14965 | human | AURKA | O14965 | S278 | KIADFGWsVHAPSsR | Pkinase |
AURKA | O14965 | human | SPIN1 | Q9Y657 | S124 | RVAtSRIsDAHLADt | |
AURKA | O14965 | human | WDR62 | O43379 | S33 | PARRGQssPPPAPPI | |
AURKA | O14965 | human | BRCA1 | P38398 | S308 | KAEFCNKskQPGLAR | |
AURKA | O14965 | human | SKI | P12755 | S383 | LsAFRPWsPAVSASE | |
AURKA | O14965 | human | CRMP1 | Q14194 | T102 | AALVGGttMIIDHVV | Amidohydro_1 |
AURKA | O14965 | human | LDHB | P07195 | S162 | PkHrVIGsGCNLDsA | |
AURKA | O14965 | human | PAX8 | Q06710 | S209 | DQDSCRLsIDSQSSS | |
AURKA | O14965 | human | MYBBP1A | Q9BQG0 | S1303 | ARKKARLsLVIRsPs | |
AURKA | O14965 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
AURKA | O14965 | human | PHLDA1 | Q8WV24 | S95 | PLCLLRVsLLCALRA | |
AURKA | O14965 | human | CENPJ | Q9HC77 | S467 | LKCSNRksLsPsGLK | |
AURKA | O14965 | human | CETN2 | P41208 | S170 | LRIMkKTsLY_____ | |
AURKA | O14965 | human | KIF4A | O95239 | T799 | PPKLRRRtFsLTEVR | |
AURKA | O14965 | human | HAUS8 | Q9BT25 | S20 | ATGPTNsssAKKKDK | |
AURKA | O14965 | human | PAX8 | Q06710 | T277 | TLDDGkAtLTPSNTP | |
AURKA | O14965 | human | NUMA1 | Q14980 | T1811 | tRsARRRttQIINIt | |
AURKA | O14965 | human | VHL | P40337 | S72 | SVNsREPsQVIFCNr | VHL |
AURKA | O14965 | human | LIMK2 | P53671 | T494 | kATTKKRtLRKNDRK | PK_Tyr_Ser-Thr |
AURKA | O14965 | human | PARD3 | Q8TEW0 | S962 | SSRsGREsVSTAsDQ | |
AURKA | O14965 | human | NEDD1 | Q8NHV4 | S405 | FDDtGKssLGDMFsP | |
AURKA | O14965 | human | AURKA | O14965 | S226 | YRELQKLskFDEQRT | Pkinase |
AURKA | O14965 | human | PLK1 | P53350 | T210 | YDGERKktLCGtPNy | Pkinase |
AURKA | O14965 | human | ESR1 | P03372 | S167 | GGRERLAsTNDkGSM | Oest_recep |
AURKA | O14965 | human | NPM1 | P06748 | S125 | AVEEDAEsEDEEEED | |
AURKA | O14965 | human | DLGAP5 | Q15398 | S627 | VKLFsGLsVssEGPs | |
AURKA | O14965 | human | AURKA | O14965 | T16 | IsGPVkAtAPVGGPk | |
AURKA | O14965 | human | FADD | Q13158 | S203 | MsWNsDAsTSEAS__ | |
AURKA | O14965 | human | LATS2 | Q9NRM7 | S83 | ALREIRysLLPFANE | |
AURKA | O14965 | human | SKI | P12755 | S326 | RRVPRVssEPPASIR | |
AURKA | O14965 | human | TP73 | O15350 | S235 | DPVTGRQsVVVPYEP | P53 |
AURKA | O14965 | human | AURKA | O14965 | S10 | RsKENCIsGPVkAtA | |
AURKA | O14965 | human | NDC80 | O14777 | S44 | kPtFGkLsINkPtsE | |
AURKA | O14965 | human | MCRS1 | Q96EZ8 | S35 | LAGQkRAssQALGTI | |
AURKA | O14965 | human | NUMA1 | Q14980 | S2047 | kQADRRQsMAFsILN | |
AURKA | O14965 | human | MBD3 | O95983 | S85 | RQRVRyDssNQVKGk | MBDa |
AURKA | O14965 | human | RBBP8 | Q99708 | S593 | IPLRPREsLETENVL | |
AURKA | O14965 | human | H3C1 | P68431 | S10 | tkQtArkstGGkAPr | Histone |
AURKA | O14965 | human | RBBP8 | Q99708 | S327 | ELPtRVssPVFGATS | |
AURKA | O14965 | human | MAP9 | Q49MG5 | S625 | RKQKKRHsFLESEAL | |
AURKA | O14965 | human | SIRT1 | Q96EB6 | T344 | GkLLRNYtQNIDTLE | SIR2 |
AURKA | O14965 | human | SPIN1 | Q9Y657 | S109 | LNkDERVsALEVLPD | |
AURKA | O14965 | human | PSEN2 | P49810 | S19 | EVCDERTsLMsAEsP | |
AURKA | O14965 | human | KCTD12 | Q96CX2 | S243 | ITVCGKTsLAkEVFG | |
AURKA | O14965 | human | NUMA1 | Q14980 | S1883 | YrPttRssARRsQAG | |
AURKA | O14965 | human | ALDH1A1 | P00352 | T442 | kDIDKAItISSALQA | Aldedh |
AURKA | O14965 | human | AURKA | O14965 | S41 | QNPLPVNsGQAQRVL | |
AURKA | O14965 | human | BCL2L11 | O43521 | S98 | RSssGyFsFDTDRsP | |
AURKA | O14965 | human | SDCBP | O00560 | S131 | kIGLRLKsIDNGIFV | PDZ; Peptidase_M50 |
AURKA | O14965 | human | NFKBIA | P25963 | S63 | PQEVPRGsEPWkQQL | |
AURKA | O14965 | human | PKD2 | Q13563 | S829 | HSSRRRGsISSGVSY | |
AURKA | O14965 | human | NEDD9 | Q14511 | S296 | PVARRHQsLsPNHPP | |
AURKA | O14965 | human | MAP9 | Q49MG5 | S305 | AVEKSKEsQVTADDL | |
AURKA | O14965 | human | NSD2 | O96028 | S56 | SkAQLSSsLQEGVMQ | |
AURKA | O14965 | human | LATS2 | Q9NRM7 | S380 | ATLARRDsLQKPGLE | |
AURKA | O14965 | human | DLGAP5 | Q15398 | S725 | CLssERMsLPLLAGG | |
AURKA | O14965 | human | NFKBIA | P25963 | S262 | QLTWGRPsTRIQQQL | |
AURKA | O14965 | human | LIMK2 | P53671 | T505 | NDRKKRYtVVGNPYW | PK_Tyr_Ser-Thr |
AURKA | O14965 | human | RUNX3 | Q13761 | T173 | YHRAIkVtVDGPREP | Runt |
AURKA | O14965 | human | DLGAP5 | Q15398 | S830 | QEHARHIsFGGNLIt | |
AURKA | O14965 | human | NDC80 | O14777 | S55 | PtsERkVsLFGkRts | Ndc80_HEC |
AURKA | O14965 | human | TPX2 | Q9ULW0 | S121 | PAQPQRRsLRLsAQk | |
AURKA | O14965 | human | AURKA | O14965 | S98 | PLNNTQKskQPLPsA | |
AURKA | O14965 | human | HAUS8 | Q9BT25 | S19 | PATGPTNsssAKKKD | |
AURKA | O14965 | human | MAPRE3 | Q9UPY8 | S176 | MQTSGRLsNVAPPCI | |
AURKA | O14965 | human | NUMA1 | Q14980 | T2084 | sPNtRSGtRRsPRIA | |
AURKA | O14965 | human | TP53 | P04637 | S106 | sQkTYQGsYGFrLGF | P53 |
AURKA | O14965 | human | POU6F1 | Q14863 | S197 | kLDITPKsAQKLKPV | Pou |
AURKA | O14965 | human | NUMA1 | Q14980 | T1812 | RsARRRttQIINItM | |
AURKA | O14965 | human | BCL2L11 | O43521 | S93 | SsLLSRSssGyFsFD | |
AURKA | O14965 | human | PHB2 | Q99623 | S39 | VAyGVREsVFTVEGG | |
AURKA | O14965 | human | PIN1 | Q13526 | S16 | PGWEkRMsRSSGRVy | WW |
AURKA | O14965 | human | AURKAIP1 | Q9NWT8 | S70 | MLVPRKMsVSPLESW | |
AURKA | O14965 | human | AURKA | O14965 | S342 | QETYKRIsRVEFTFP | Pkinase |
AURKA | O14965 | human | BCL2L11 | O43521 | S94 | sLLSRSssGyFsFDT | |
AURKA | O14965 | human | AURKA | O14965 | S104 | KskQPLPsAPENNPE | |
AURKA | O14965 | human | NUMA1 | Q14980 | S1969 | QEtLRRAsMQPIQIA | |
AURKA | O14965 | human | NUMA1 | Q14980 | T1804 | FLDsGrKtRsARRRt | |
AURKA | O14965 | human | SOX8 | P57073 | S327 | SAPSASAsPTETGPP | |
AURKA | O14965 | human | WDR62 | O43379 | S32 | VPARRGQssPPPAPP | |
AURKA | O14965 | human | WWC1 | Q8IX03 | S539 | tsLsPRSsLSsPSPP | |
AURKA | O14965 | human | AR | P10275 | T282 | VPPAVRPtPCAPLAE | Androgen_recep |
AURKA | O14965 | human | DLGAP5 | Q15398 | S757 | EGMELNSsItSQDVL | |
AURKA | O14965 | human | MBD3 | O95983 | S24 | REEVPRRsGLSAGHR | MBD |
AURKA | O14965 | human | TIFA | Q96CG3 | T9 | tSFEDADtEEtVTCL | |
AURKA | O14965 | human | FANCA | O15360 | S165 | HSMFSRLsFCQELWK | |
AURKA | O14965 | human | TP53 | P04637 | S215 | DrNtFrHsVVVPyEP | P53 |
AURKA | O14965 | human | NDC80 | O14777 | S69 | sGHGsRNsQLGIFss | Ndc80_HEC |
AURKA | O14965 | human | TPX2 | Q9ULW0 | S125 | QRRsLRLsAQkDLEQ | |
AURKA | O14965 | human | LIMK1 | P53667 | T508 | PDRKKRYtVVGNPYW | PK_Tyr_Ser-Thr |
AURKA | O14965 | human | NUMA1 | Q14980 | S2087 | tRSGtRRsPRIATTT | |
AURKA | O14965 | human | AURKA | O14965 | S83 | QKQLQATsVPHPVsR | |
AURKA | O14965 | human | NUSAP1 | Q9BXS6 | S240 | VPPRGRLsVAstPIs | NUSAP |
AURKA | O14965 | human | AURKA | O14965 | S391 | TANSSKPsNCQNKES | |
AURKA | O14965 | human | HNRNPK | P61978 | S379 | syAGGrGsyGDLGGP | |
AURKA | O14965 | human | AURKA | O14965 | T288 | APSsRRttLCGtLDy | Pkinase |
AURKA | O14965 | human | LIMK1 | P53667 | S307 | DRsPGAGsLGsPAsQ | |
AURKA | O14965 | human | CENPA | P49450 | S7 | _MGPRRRsRKPEAPR | Histone |
AURKA | O14965 | human | RASSF1 | Q9NS23-2 | S203 | TsVRRRtsFYLPKDA | RA |
AURKA | O14965 | human | ESR1 | P03372 | S305 | IkRSkkNsLALSLtA | |
AURKA | O14965 | human | LIMK2 | P53671 | S283 | EGtLRRRsLRRsNsI | |
AURKA | O14965 | human | MCM2 | P49736 | S220 | NVFkERIsDMCkENR | MCM_N |
AURKA | O14965 | human | NFKBIA | P25963 | S32 | LLDDRHDsGLDsMkD | |
AURKA | O14965 | human | AR | P10275 | S293 | PLAECKGsLLDDsAG | Androgen_recep |
AURKA | O14965 | human | PKM | P14618 | T45 | PPItARNtGIICtIG | PK |
AURKA | O14965 | human | ALDH1A1 | P00352 | T267 | KSNLKRVtLELGGKS | Aldedh |
AURKA | O14965 | human | TP53 | P04637 | S315 | LPNNtsssPQPkkkP | |
AURKA | O14965 | human | GMNN | O75496 | T25 | NSSVPRRtLkMIQPS | Geminin |
AURKA | O14965 | human | KCTD12 | Q96CX2 | S200 | PLLtPsQsLDGsRRs | |
AURKA | O14965 | human | RALA | P11233 | S194 | NGKKKRKsLAKRIRE | |
AURKA | O14965 | human | RASSF1 | Q9NS23-2 | T202 | GTsVRRRtsFYLPKD | RA |
AURKA | O14965 | human | TACC3 | Q9Y6A5 | S558 | ESALRKQsLyLkFDP | |
AURKA | O14965 | human | NUMA1 | Q14980 | S1991 | RQQRkRVsLEPHQGP | |
AURKA | O14965 | human | YY1 | P25490 | S365 | EGCGkRFsLDFNLRT | zf-C2H2 |
AURKA | O14965 | human | CDC25B | P30305 | S353 | VQNkRRRsVtPPEEQ | M-inducer_phosp |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
AURKA | ID | Description | 0.00e+00 |
AURKA | GO:0007051 | spindle organization | 1.89e-13 |
AURKA | GO:0032886 | regulation of microtubule-based process | 2.07e-13 |
AURKA | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 2.04e-12 |
AURKA | GO:0007098 | centrosome cycle | 4.87e-12 |
AURKA | GO:0031023 | microtubule organizing center organization | 1.64e-11 |
AURKA | GO:0007052 | mitotic spindle organization | 4.84e-11 |
AURKA | GO:0140694 | non-membrane-bounded organelle assembly | 1.12e-10 |
AURKA | GO:0070507 | regulation of microtubule cytoskeleton organization | 4.76e-10 |
AURKA | GO:0051225 | spindle assembly | 1.22e-09 |
AURKA | GO:0048285 | organelle fission | 1.38e-09 |
AURKA | GO:0090224 | regulation of spindle organization | 2.10e-09 |
AURKA | GO:0000280 | nuclear division | 2.87e-09 |
AURKA | GO:0140014 | mitotic nuclear division | 9.87e-09 |
AURKA | GO:0007059 | chromosome segregation | 1.65e-08 |
AURKA | GO:0060236 | regulation of mitotic spindle organization | 4.46e-08 |
AURKA | GO:0051298 | centrosome duplication | 8.51e-08 |
AURKA | GO:0045787 | positive regulation of cell cycle | 8.67e-08 |
AURKA | GO:0051293 | establishment of spindle localization | 3.47e-07 |
AURKA | GO:0051653 | spindle localization | 6.02e-07 |
AURKA | GO:0040001 | establishment of mitotic spindle localization | 1.26e-06 |
AURKA | GO:0030010 | establishment of cell polarity | 1.26e-06 |
AURKA | GO:1902115 | regulation of organelle assembly | 1.54e-06 |
AURKA | GO:0051294 | establishment of spindle orientation | 1.54e-06 |
AURKA | GO:0000819 | sister chromatid segregation | 1.97e-06 |
AURKA | GO:0035265 | organ growth | 3.19e-06 |
AURKA | GO:0044772 | mitotic cell cycle phase transition | 3.30e-06 |
AURKA | GO:0034504 | protein localization to nucleus | 3.30e-06 |
AURKA | GO:0098813 | nuclear chromosome segregation | 3.40e-06 |
AURKA | GO:0000070 | mitotic sister chromatid segregation | 3.84e-06 |
AURKA | GO:2001233 | regulation of apoptotic signaling pathway | 4.07e-06 |
AURKA | GO:0000910 | cytokinesis | 4.32e-06 |
AURKA | GO:0031109 | microtubule polymerization or depolymerization | 4.36e-06 |
AURKA | GO:0045786 | negative regulation of cell cycle | 4.72e-06 |
AURKA | GO:0046605 | regulation of centrosome cycle | 4.94e-06 |
AURKA | GO:0090068 | positive regulation of cell cycle process | 5.66e-06 |
AURKA | GO:0046785 | microtubule polymerization | 5.98e-06 |
AURKA | GO:1900180 | regulation of protein localization to nucleus | 6.25e-06 |
AURKA | GO:1901990 | regulation of mitotic cell cycle phase transition | 9.27e-06 |
AURKA | GO:0044839 | cell cycle G2/M phase transition | 1.10e-05 |
AURKA | GO:1901875 | positive regulation of post-translational protein modification | 1.30e-05 |
AURKA | GO:1901987 | regulation of cell cycle phase transition | 1.30e-05 |
AURKA | GO:0000132 | establishment of mitotic spindle orientation | 1.44e-05 |
AURKA | GO:0007163 | establishment or maintenance of cell polarity | 1.61e-05 |
AURKA | GO:1902749 | regulation of cell cycle G2/M phase transition | 2.08e-05 |
AURKA | GO:0007088 | regulation of mitotic nuclear division | 2.28e-05 |
AURKA | GO:0007099 | centriole replication | 3.79e-05 |
AURKA | GO:0007020 | microtubule nucleation | 4.68e-05 |
AURKA | GO:0098534 | centriole assembly | 6.37e-05 |
AURKA | GO:0072234 | metanephric nephron tubule development | 7.66e-05 |
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Related Drugs to BCAS4_AURKA |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning BCAS4-AURKA and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to BCAS4_AURKA |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |