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Kinase Fusion Gene:SGK2_PTPRH |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: SGK2_PTPRH | KinaseFusionDB ID: KFG5771 | FusionGDB2.0 ID: KFG5771 | Hgene | Tgene | Gene symbol | SGK2 | PTPRH | Gene ID | 23678 | 5794 | |
| Gene name | serum/glucocorticoid regulated kinase family member 3 | protein tyrosine phosphatase receptor type H | ||||||||||
| Synonyms | CISK|SGK2|SGKL | R-PTP-H|SAP1 | ||||||||||
| Cytomap | 8q13.1 | 19q13.42 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase Sgk3cytokine-independent survival kinase | receptor-type tyrosine-protein phosphatase Hstomach cancer-associated protein tyrosine phosphatase 1transmembrane-type protein-tyrosine phosphatase type H | ||||||||||
| Modification date | 20240305 | 20240305 | ||||||||||
| UniProtAcc | Q9HBY8 | Q9HD43 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000373077, ENST00000373092, ENST00000373100, ENST00000341458, ENST00000423407, ENST00000426287, ENST00000485914, | ENST00000263434, ENST00000376350, ENST00000588559, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SGK2 [Title/Abstract] AND PTPRH [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SGK2(42187799)-PTPRH(55693519), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across SGK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PTPRH (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-BR-A4PD-01A | SGK2 | chr20 | 42187799 | PTPRH | chr19 | 55693519 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:42187799/:55693519) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SGK2 | PTPRH |
| FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. {ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}. | FUNCTION: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). {ECO:0000250|UniProtKB:E9Q0N2, ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SGK2_PTPRH |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| SGK2 | Q9HBY8 | human | PTOV1 | Q86YD1 | S53 | PPRIRARsAPPMEGA | |
| SGK2 | Q9HBY8 | human | PTOV1 | Q86YD1 | S36 | VRAVRsRsWPAsPRG | |
| SGK2 | Q9HBY8 | human | LCP1 | P13796 | S5 | ___MARGsVsDEEMM | |
| SGK2 | Q9HBY8 | human | MDM2 | Q00987 | S166 | SsRRRAIsEtEENsD |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| SGK2 | ID | Description | 0.00e+00 |
| SGK2 | GO:0033157 | regulation of intracellular protein transport | 3.44e-02 |
| SGK2 | GO:0032386 | regulation of intracellular transport | 3.44e-02 |
| SGK2 | GO:0071803 | positive regulation of podosome assembly | 3.44e-02 |
| SGK2 | GO:0045472 | response to ether | 3.44e-02 |
| SGK2 | GO:0071236 | cellular response to antibiotic | 3.44e-02 |
| SGK2 | GO:0051764 | actin crosslink formation | 3.44e-02 |
| SGK2 | GO:0071801 | regulation of podosome assembly | 3.44e-02 |
| SGK2 | GO:0010225 | response to UV-C | 3.44e-02 |
| SGK2 | GO:0043518 | negative regulation of DNA damage respons | 2.38e-03 |
| SGK2 | GO:0006977 | DNA damage respons | 2.86e-03 |
| SGK2 | GO:0046827 | positive regulation of protein export from nucleus | 3.44e-02 |
| SGK2 | GO:0071391 | cellular response to estrogen stimulus | 3.44e-02 |
| SGK2 | GO:0071800 | podosome assembly | 3.44e-02 |
| SGK2 | GO:0003283 | atrial septum development | 3.44e-02 |
| SGK2 | GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 3.44e-02 |
| SGK2 | GO:0035902 | response to immobilization stress | 3.44e-02 |
| SGK2 | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration | 3.44e-02 |
| SGK2 | GO:0003181 | atrioventricular valve morphogenesis | 3.44e-02 |
| SGK2 | GO:0071480 | cellular response to gamma radiation | 3.44e-02 |
| SGK2 | GO:0003171 | atrioventricular valve development | 3.44e-02 |
| SGK2 | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | 3.44e-02 |
| SGK2 | GO:0044819 | mitotic G1/S transition checkpoint signaling | 3.44e-02 |
| SGK2 | GO:0010039 | response to iron ion | 3.44e-02 |
| SGK2 | GO:0010955 | negative regulation of protein processing | 3.44e-02 |
| SGK2 | GO:0071295 | cellular response to vitamin | 3.44e-02 |
| SGK2 | GO:1903318 | negative regulation of protein maturation | 3.44e-02 |
| SGK2 | GO:0046825 | regulation of protein export from nucleus | 3.44e-02 |
| SGK2 | GO:1901797 | negative regulation of signal transduction by p53 class mediator | 3.44e-02 |
| SGK2 | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 3.44e-02 |
| SGK2 | GO:0003230 | cardiac atrium development | 3.44e-02 |
| SGK2 | GO:0046677 | response to antibiotic | 3.44e-02 |
| SGK2 | GO:0071312 | cellular response to alkaloid | 3.44e-02 |
| SGK2 | GO:0010737 | protein kinase A signaling | 3.44e-02 |
| SGK2 | GO:0043516 | regulation of DNA damage respons | 6.03e-03 |
| SGK2 | GO:0030866 | cortical actin cytoskeleton organization | 3.44e-02 |
| SGK2 | GO:1990000 | amyloid fibril formation | 3.44e-02 |
| SGK2 | GO:0031670 | cellular response to nutrient | 3.44e-02 |
| SGK2 | GO:0014911 | positive regulation of smooth muscle cell migration | 3.44e-02 |
| SGK2 | GO:0031648 | protein destabilization | 3.44e-02 |
| SGK2 | GO:0042220 | response to cocaine | 3.44e-02 |
| SGK2 | GO:0030865 | cortical cytoskeleton organization | 3.44e-02 |
| SGK2 | GO:1904752 | regulation of vascular associated smooth muscle cell migration | 3.44e-02 |
| SGK2 | GO:0001974 | blood vessel remodeling | 3.44e-02 |
| SGK2 | GO:0010332 | response to gamma radiation | 3.44e-02 |
| SGK2 | GO:0003197 | endocardial cushion development | 3.44e-02 |
| SGK2 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | 3.44e-02 |
| SGK2 | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | 3.44e-02 |
| SGK2 | GO:1904738 | vascular associated smooth muscle cell migration | 3.44e-02 |
| SGK2 | GO:0072132 | mesenchyme morphogenesis | 3.62e-02 |
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Related Drugs to SGK2_PTPRH |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning SGK2-PTPRH and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SGK2_PTPRH |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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