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Kinase Fusion Gene:SGK3_TRIM55 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: SGK3_TRIM55 | KinaseFusionDB ID: KFG5779 | FusionGDB2.0 ID: KFG5779 | Hgene | Tgene | Gene symbol | SGK3 | TRIM55 | Gene ID | 23678 | 84675 | |
| Gene name | serum/glucocorticoid regulated kinase family member 3 | tripartite motif containing 55 | ||||||||||
| Synonyms | CISK|SGK2|SGKL | MURF-2|RNF29|muRF2 | ||||||||||
| Cytomap | 8q13.1 | 8q13.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase Sgk3cytokine-independent survival kinase | tripartite motif-containing protein 55muscle specific ring finger 2muscle-specific RING finger protein 2ring finger protein 29 | ||||||||||
| Modification date | 20240305 | 20240305 | ||||||||||
| UniProtAcc | Q96BR1 | Q9BYV6 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000345714, ENST00000396596, ENST00000520976, ENST00000521198, ENST00000521435, ENST00000522398, | ENST00000276573, ENST00000315962, ENST00000350034, ENST00000353317, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SGK3 [Title/Abstract] AND TRIM55 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SGK3(67602995)-TRIM55(67047225), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIM55 | GO:0070936 | protein K48-linked ubiquitination | 37816088 |
| Tgene | TRIM55 | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction | 37816088 |
| Kinase Fusion gene breakpoints across SGK3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across TRIM55 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-E9-A228-01A | SGK3 | chr8 | 67602995 | TRIM55 | chr8 | 67047225 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67602995/:67047225) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SGK3 | TRIM55 |
| FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. {ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16888620, ECO:0000269|PubMed:17167223, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:19293151, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}. | FUNCTION: May regulate gene expression and protein turnover in muscle cells. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SGK3_TRIM55 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| SGK3 | Q96BR1 | human | ITCH | Q96J02 | S450 | GWEkRTDsNGRVYFV | WW |
| SGK3 | Q96BR1 | human | LCP1 | P13796 | S5 | ___MARGsVsDEEMM | |
| SGK3 | Q96BR1 | human | ITCH | Q96J02 | T385 | DHFTRTTtWQRPTLE | WW |
| SGK3 | Q96BR1 | human | WDR44 | Q5JSH3 | S344 | PQRPRsNsGRELtDE | |
| SGK3 | Q96BR1 | human | FLII | Q13045 | S436 | RLRRRKDsAQDDQAK | |
| SGK3 | Q96BR1 | human | FLII | Q13045 | T818 | LHRPRHAtVSRsLEG | Gelsolin |
| SGK3 | Q96BR1 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
| SGK3 | Q96BR1 | human | MDM2 | Q00987 | S166 | SsRRRAIsEtEENsD | |
| SGK3 | Q96BR1 | human | HSD17B4 | P51659 | S318 | NHtSRAtstATsGFA |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| SGK3 | ID | Description | 0.00e+00 |
| SGK3 | GO:0046827 | positive regulation of protein export from nucleus | 8.11e-03 |
| SGK3 | GO:0045732 | positive regulation of protein catabolic process | 8.11e-03 |
| SGK3 | GO:1902115 | regulation of organelle assembly | 8.11e-03 |
| SGK3 | GO:0033157 | regulation of intracellular protein transport | 8.11e-03 |
| SGK3 | GO:0046825 | regulation of protein export from nucleus | 8.11e-03 |
| SGK3 | GO:0032386 | regulation of intracellular transport | 1.61e-02 |
| SGK3 | GO:0006611 | protein export from nucleus | 1.61e-02 |
| SGK3 | GO:0046824 | positive regulation of nucleocytoplasmic transport | 1.61e-02 |
| SGK3 | GO:0042176 | regulation of protein catabolic process | 1.61e-02 |
| SGK3 | GO:0051865 | protein autoubiquitination | 1.62e-02 |
| SGK3 | GO:1902017 | regulation of cilium assembly | 1.62e-02 |
| SGK3 | GO:2000736 | regulation of stem cell differentiation | 1.69e-02 |
| SGK3 | GO:0043254 | regulation of protein-containing complex assembly | 1.69e-02 |
| SGK3 | GO:1902117 | positive regulation of organelle assembly | 1.74e-02 |
| SGK3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 1.90e-02 |
| SGK3 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 1.91e-02 |
| SGK3 | GO:0022411 | cellular component disassembly | 2.13e-02 |
| SGK3 | GO:0046822 | regulation of nucleocytoplasmic transport | 2.33e-02 |
| SGK3 | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 2.37e-02 |
| SGK3 | GO:1901800 | positive regulation of proteasomal protein catabolic process | 2.42e-02 |
| SGK3 | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 3.24e-02 |
| SGK3 | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 3.27e-02 |
| SGK3 | GO:0031333 | negative regulation of protein-containing complex assembly | 3.30e-02 |
| SGK3 | GO:0090316 | positive regulation of intracellular protein transport | 3.65e-02 |
| SGK3 | GO:0051168 | nuclear export | 3.96e-02 |
| SGK3 | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 4.27e-02 |
| SGK3 | GO:0031345 | negative regulation of cell projection organization | 4.58e-02 |
| SGK3 | GO:0061136 | regulation of proteasomal protein catabolic process | 4.58e-02 |
| SGK3 | GO:0031334 | positive regulation of protein-containing complex assembly | 4.58e-02 |
| SGK3 | GO:0032388 | positive regulation of intracellular transport | 4.58e-02 |
| SGK3 | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 4.58e-02 |
| SGK3 | GO:0060491 | regulation of cell projection assembly | 4.58e-02 |
| SGK3 | GO:0002064 | epithelial cell development | 4.77e-02 |
| SGK3 | GO:0000209 | protein polyubiquitination | 4.77e-02 |
| SGK3 | GO:1903050 | regulation of proteolysis involved in protein catabolic process | 4.77e-02 |
| SGK3 | GO:1903320 | regulation of protein modification by small protein conjugation or removal | 4.77e-02 |
| SGK3 | GO:2001234 | negative regulation of apoptotic signaling pathway | 4.77e-02 |
| SGK3 | GO:0032984 | protein-containing complex disassembly | 4.77e-02 |
| SGK3 | GO:0048863 | stem cell differentiation | 4.77e-02 |
| SGK3 | GO:0070874 | negative regulation of glycogen metabolic process | 4.77e-02 |
| SGK3 | GO:0071803 | positive regulation of podosome assembly | 4.77e-02 |
| SGK3 | GO:0090085 | regulation of protein deubiquitination | 4.77e-02 |
| SGK3 | GO:0001649 | osteoblast differentiation | 4.77e-02 |
| SGK3 | GO:0006983 | ER overload response | 4.77e-02 |
| SGK3 | GO:1901984 | negative regulation of protein acetylation | 4.77e-02 |
| SGK3 | GO:1903564 | regulation of protein localization to cilium | 4.77e-02 |
| SGK3 | GO:2000644 | regulation of receptor catabolic process | 4.77e-02 |
| SGK3 | GO:0002645 | positive regulation of tolerance induction | 4.77e-02 |
| SGK3 | GO:0034454 | microtubule anchoring at centrosome | 4.77e-02 |
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Related Drugs to SGK3_TRIM55 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning SGK3-TRIM55 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SGK3_TRIM55 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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