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Kinase Fusion Gene:SIPA1L1_CLK4 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: SIPA1L1_CLK4 | KinaseFusionDB ID: KFG5844 | FusionGDB2.0 ID: KFG5844 | Hgene | Tgene | Gene symbol | SIPA1L1 | CLK4 | Gene ID | 26037 | 57396 | |
| Gene name | signal induced proliferation associated 1 like 1 | CDC like kinase 4 | ||||||||||
| Synonyms | E6TP1|SPAR1 | - | ||||||||||
| Cytomap | 14q24.2 | 5q35.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | signal-induced proliferation-associated 1-like protein 1SIPA1-like protein 1high-risk human papilloma viruses E6 oncoproteins targeted protein 1spine-associated RapGAP 1 | dual specificity protein kinase CLK4protein serine threonine kinase Clk4 | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | O43166 | Q9HAZ1 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000381232, ENST00000555818, ENST00000358550, ENST00000537413, ENST00000554874, | ENST00000316308, ENST00000520957, ENST00000522749, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SIPA1L1 [Title/Abstract] AND CLK4 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SIPA1L1(71996087)-CLK4(178050417), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across SIPA1L1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CLK4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-CD-A486-01A | SIPA1L1 | chr14 | 71996087 | CLK4 | chr5 | 178050417 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:71996087/:178050417) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIPA1L1 | CLK4 |
| FUNCTION: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. | FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SIPA1L1_CLK4 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CLK4 | Q9HAZ1 | human | ABL1 | P00519 | T735 | DTEWRSVtLPRDLQS | |
| CLK4 | Q9HAZ1 | human | MITF | O75030 | Y360 | ILKAsVDyIRKLQRE | HLH |
| CLK4 | Q9HAZ1 | human | NR5A1 | Q13285 | S203 | EYPEPYAsPPQPGLP |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CLK4 | ID | Description | 0.00e+00 |
| CLK4 | GO:0051651 | maintenance of location in cell | 4.18e-02 |
| CLK4 | GO:1902105 | regulation of leukocyte differentiation | 4.18e-02 |
| CLK4 | GO:0051235 | maintenance of location | 4.18e-02 |
| CLK4 | GO:1903706 | regulation of hemopoiesis | 4.18e-02 |
| CLK4 | GO:0048732 | gland development | 4.18e-02 |
| CLK4 | GO:0016055 | Wnt signaling pathway | 4.18e-02 |
| CLK4 | GO:0033327 | Leydig cell differentiation | 4.18e-02 |
| CLK4 | GO:0060020 | Bergmann glial cell differentiation | 4.18e-02 |
| CLK4 | GO:0198738 | cell-cell signaling by wnt | 4.18e-02 |
| CLK4 | GO:0001553 | luteinization | 4.18e-02 |
| CLK4 | GO:0002327 | immature B cell differentiation | 4.18e-02 |
| CLK4 | GO:0033690 | positive regulation of osteoblast proliferation | 4.18e-02 |
| CLK4 | GO:1900272 | negative regulation of long-term synaptic potentiation | 4.18e-02 |
| CLK4 | GO:1905244 | regulation of modification of synaptic structure | 4.18e-02 |
| CLK4 | GO:1905939 | regulation of gonad development | 4.18e-02 |
| CLK4 | GO:0030238 | male sex determination | 4.18e-02 |
| CLK4 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway | 4.18e-02 |
| CLK4 | GO:0071871 | response to epinephrine | 4.18e-02 |
| CLK4 | GO:0001768 | establishment of T cell polarity | 4.18e-02 |
| CLK4 | GO:0051444 | negative regulation of ubiquitin-protein transferase activity | 4.18e-02 |
| CLK4 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway | 4.18e-02 |
| CLK4 | GO:0001767 | establishment of lymphocyte polarity | 4.18e-02 |
| CLK4 | GO:1900006 | positive regulation of dendrite development | 4.18e-02 |
| CLK4 | GO:2000095 | regulation of Wnt signaling pathwa | 2.54e-03 |
| CLK4 | GO:0060192 | negative regulation of lipase activity | 4.18e-02 |
| CLK4 | GO:1902036 | regulation of hematopoietic stem cell differentiation | 4.18e-02 |
| CLK4 | GO:0038083 | peptidyl-tyrosine autophosphorylation | 4.18e-02 |
| CLK4 | GO:0035372 | protein localization to microtubule | 4.18e-02 |
| CLK4 | GO:0007530 | sex determination | 4.18e-02 |
| CLK4 | GO:0060008 | Sertoli cell differentiation | 4.18e-02 |
| CLK4 | GO:0051457 | maintenance of protein location in nucleus | 4.18e-02 |
| CLK4 | GO:0051882 | mitochondrial depolarization | 4.18e-02 |
| CLK4 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination | 4.18e-02 |
| CLK4 | GO:2000114 | regulation of establishment of cell polarity | 4.18e-02 |
| CLK4 | GO:0030318 | melanocyte differentiation | 4.18e-02 |
| CLK4 | GO:2000773 | negative regulation of cellular senescence | 4.18e-02 |
| CLK4 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 4.18e-02 |
| CLK4 | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 4.18e-02 |
| CLK4 | GO:0051894 | positive regulation of focal adhesion assembly | 4.18e-02 |
| CLK4 | GO:2000050 | regulation of non-canonical Wnt signaling pathway | 4.18e-02 |
| CLK4 | GO:0032878 | regulation of establishment or maintenance of cell polarity | 4.18e-02 |
| CLK4 | GO:0030325 | adrenal gland development | 4.18e-02 |
| CLK4 | GO:0099563 | modification of synaptic structure | 4.18e-02 |
| CLK4 | GO:1903055 | positive regulation of extracellular matrix organization | 4.18e-02 |
| CLK4 | GO:0033688 | regulation of osteoblast proliferation | 4.18e-02 |
| CLK4 | GO:0150117 | positive regulation of cell-substrate junction organization | 4.18e-02 |
| CLK4 | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 4.18e-02 |
| CLK4 | GO:0045907 | positive regulation of vasoconstriction | 4.18e-02 |
| CLK4 | GO:0038094 | Fc-gamma receptor signaling pathway | 4.18e-02 |
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Related Drugs to SIPA1L1_CLK4 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning SIPA1L1-CLK4 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SIPA1L1_CLK4 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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