UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:BCR_ARVCF

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: BCR_ARVCF
	KinaseFusionDB ID: KFG588
	FusionGDB2.0 ID: KFG588
		Hgene	Tgene
	Gene symbol	BCR	ARVCF
	Gene ID	613	421
	Gene name	BCR activator of RhoGEF and GTPase	ARVCF delta catenin family member
	Synonyms	ALL\|BCR1\|CML\|D22S11\|D22S662\|PHL	-
	Cytomap	22q11.23	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	breakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26	splicing regulator ARVCFarmadillo repeat gene deleted in velocardiofacial syndromearmadillo repeat protein deleted in velo-cardio-facial syndrome
	Modification date	20240416	20240411
	UniProtAcc	P11274	O00192
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990,	ENST00000487793, ENST00000263207, ENST00000344269, ENST00000401994, ENST00000406259, ENST00000406522,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: BCR [Title/Abstract] AND ARVCF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BCR(23615961)-ARVCF(19969614), # samples:2

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BCR	GO:0090630	activation of GTPase activity	7479768

Kinase Fusion gene breakpoints across BCR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across ARVCF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-A6-5657-01A	BCR	chr22	23615961	ARVCF	chr22	19969614

Top

Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000305877	ENST00000263207	BCR	chr22	23615961	ARVCF	chr22	19969614	6405	1597

Top

Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000305877_ENST00000263207_BCR_chr22_23615961_ARVCF_chr22_19969614_length(amino acids)=1597
MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP
RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP
WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ
DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA
KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEEQSPGSQASLATMPE
APDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPV
ATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDT
RSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRW
RDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGV
PALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAE
ARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEE
WFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLV
ELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPA
LVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDA

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

Top

Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:23615961/chr22:19969614)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCR P11274	ARVCF O00192
FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250\|UniProtKB:Q6PAJ1, ECO:0000269\|PubMed:1657398, ECO:0000269\|PubMed:17116687, ECO:0000269\|PubMed:1903516, ECO:0000269\|PubMed:23940119, ECO:0000269\|PubMed:7479768}.	FUNCTION: Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269\|PubMed:24644279}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

705705

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Hgene

BCR

23615961

ARVCF

19969614

ENST00000305877

498_691

1228

Domain

Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062

Hgene

BCR

23615961

ARVCF

19969614

ENST00000305877

498_691

1272

Domain

Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00062

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Top

Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>38_BCR_ARVCF	ENST00000305877	ENST00000263207	BCR	chr22	23615961	ARVCF	chr22	19969614	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEEQSPGSQASLATMPE APDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPV ATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDT RSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRW RDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGV PALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAE ARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEE WFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLV ELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPA LVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDA	1597
3D view using mol* of 38_BCR_ARVCF

PDB file >>>HKFP_54_BCR_ARVCF	ENST00000305877	ENST00000263207	BCR	chr22	23615961	ARVCF	chr22	19969614	MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRRAAQAPDGASEP RASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDNLIDANGGSRPP WPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEGAFHGDADGSFGTPPGYGCAADRAEEQRRHQ DGLPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDA KDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEEQSPGSQASLATMPE APDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPV ATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDT RSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRW RDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGV PALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAE ARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEE WFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLV ELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPA LVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDA	1597_BCR_ARVCF

Top

Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

Top

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

BCR_ARVCF does not have any known PDB structures.

Top

pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

38_BCR_ARVCF.png

Top

Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

Top

Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

38_BCR_ARVCF_ramachandran.png

Top

Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

Top

Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
38_BCR_ARVCF-DOCK_HTVS_1-001	Nilotinib	-6.81785	-6.95745	-50.2056
38_BCR_ARVCF-DOCK_HTVS_1-001	Nilotinib	-6.81785	-6.95745	-50.2056
38_BCR_ARVCF-DOCK_HTVS_1-001	Entrectinib	-6.48396	-6.54866	-50.4075
38_BCR_ARVCF-DOCK_HTVS_1-001	Entrectinib	-6.48396	-6.54866	-50.4075
38_BCR_ARVCF-DOCK_HTVS_1-001	Ibrutinib	-6.48156	-6.48156	-40.4762
38_BCR_ARVCF-DOCK_HTVS_1-001	Temsirolimus	-6.4411	-6.4425	-51.3244
38_BCR_ARVCF-DOCK_HTVS_1-001	Ribociclib	-6.4362699999999995	-6.505269999999999	-39.8666
38_BCR_ARVCF-DOCK_HTVS_1-001	Ribociclib	-6.4362699999999995	-6.505269999999999	-39.8666
38_BCR_ARVCF-DOCK_HTVS_1-001	Everolimus	-6.4025300000000005	-6.40393	-48.8098
38_BCR_ARVCF-DOCK_HTVS_1-001	Nilotinib	-6.38039	-7.30519	-51.5952
38_BCR_ARVCF-DOCK_HTVS_1-001	Nilotinib	-6.38039	-7.30519	-51.5952
38_BCR_ARVCF-DOCK_HTVS_1-001	Palbociclib	-6.29701	-6.7039100000000005	-46.3146
38_BCR_ARVCF-DOCK_HTVS_1-001	Palbociclib	-6.29701	-6.7039100000000005	-46.3146
38_BCR_ARVCF-DOCK_HTVS_1-001	Neratinib	-6.28806	-6.47396	-46.6732
38_BCR_ARVCF-DOCK_HTVS_1-001	Larotrectinib	-6.2039	-6.2039	-42.9236
38_BCR_ARVCF-DOCK_HTVS_1-001	Cobimetinib	-6.0445199999999994	-6.04732	-42.7307
38_BCR_ARVCF-DOCK_HTVS_1-001	Entrectinib	-6.00821	-6.07291	-52.0847
38_BCR_ARVCF-DOCK_HTVS_1-001	Avapritinib	-5.96287	-6.294169999999999	-45.4387
38_BCR_ARVCF-DOCK_HTVS_1-001	Avapritinib	-5.96287	-6.294169999999999	-45.4387
38_BCR_ARVCF-DOCK_HTVS_1-001	Avapritinib	-5.96287	-6.294169999999999	-45.4387

Top

Kinase-Substrate Information of BCR_ARVCF

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
BCR	P11274	human	YWHAQ	P27348	S232	LTLWtsDsAGEECDA
BCR	P11274	human	YWHAZ	P63104	T232	LTLWtsDtQGDEAEA
BCR	P11274	human	AFDN	P55196	T909	VVTVAENtADELARS

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
BCR	ID	Description	0.00e+00
BCR	GO:0007265	Ras protein signal transduction	4.45e-04
BCR	GO:2000404	regulation of T cell migration	8.95e-04
BCR	GO:0007264	small GTPase mediated signal transduction	8.95e-04
BCR	GO:0002685	regulation of leukocyte migration	1.08e-03
BCR	GO:2000401	regulation of lymphocyte migration	1.11e-03
BCR	GO:0072678	T cell migration	1.11e-03
BCR	GO:0048041	focal adhesion assembly	1.50e-03
BCR	GO:0007044	cell-substrate junction assembly	1.54e-03
BCR	GO:0034446	substrate adhesion-dependent cell spreading	1.54e-03
BCR	GO:0150115	cell-substrate junction organization	1.54e-03
BCR	GO:0032956	regulation of actin cytoskeleton organization	1.54e-03
BCR	GO:0110020	regulation of actomyosin structure organization	1.54e-03
BCR	GO:1905244	regulation of modification of synaptic structure	1.54e-03
BCR	GO:0031589	cell-substrate adhesion	1.74e-03
BCR	GO:0003188	heart valve formation	1.81e-03
BCR	GO:0032970	regulation of actin filament-based process	1.81e-03
BCR	GO:0072676	lymphocyte migration	1.81e-03
BCR	GO:0071675	regulation of mononuclear cell migration	1.81e-03
BCR	GO:1902903	regulation of supramolecular fiber organization	1.81e-03
BCR	GO:0050900	leukocyte migration	1.84e-03
BCR	GO:0007266	Rho protein signal transduction	2.09e-03
BCR	GO:2000377	regulation of reactive oxygen species metabolic process	2.47e-03
BCR	GO:0034329	cell junction assembly	2.55e-03
BCR	GO:0030010	establishment of cell polarity	2.70e-03
BCR	GO:0006312	mitotic recombination	3.06e-03
BCR	GO:0000724	double-strand break repair via homologous recombination	3.36e-03
BCR	GO:1902905	positive regulation of supramolecular fiber organization	3.36e-03
BCR	GO:0099563	modification of synaptic structure	3.36e-03
BCR	GO:0000725	recombinational repair	3.36e-03
BCR	GO:0051495	positive regulation of cytoskeleton organization	3.52e-03
BCR	GO:0061138	morphogenesis of a branching epithelium	3.58e-03
BCR	GO:0042770	signal transduction in response to DNA damage	3.58e-03
BCR	GO:0033688	regulation of osteoblast proliferation	3.59e-03
BCR	GO:0045907	positive regulation of vasoconstriction	3.71e-03
BCR	GO:0001763	morphogenesis of a branching structure	3.90e-03
BCR	GO:0050851	antigen receptor-mediated signaling pathway	3.90e-03
BCR	GO:0071674	mononuclear cell migration	3.90e-03
BCR	GO:2000406	positive regulation of T cell migration	3.90e-03
BCR	GO:0031032	actomyosin structure organization	3.90e-03
BCR	GO:0033687	osteoblast proliferation	4.01e-03
BCR	GO:0006282	regulation of DNA repair	4.09e-03
BCR	GO:0010810	regulation of cell-substrate adhesion	4.27e-03
BCR	GO:0071222	cellular response to lipopolysaccharide	4.52e-03
BCR	GO:0007163	establishment or maintenance of cell polarity	4.53e-03
BCR	GO:0072593	reactive oxygen species metabolic process	4.65e-03
BCR	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	4.65e-03
BCR	GO:2000403	positive regulation of lymphocyte migration	4.65e-03
BCR	GO:0007160	cell-matrix adhesion	4.67e-03
BCR	GO:0071219	cellular response to molecule of bacterial origin	4.67e-03

Top

Related Drugs to BCR_ARVCF

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning BCR-ARVCF and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

Top

Related Diseases to BCR_ARVCF

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BCR	C0005586	Bipolar Disorder	4	PSYGENET
Hgene	BCR	C0023473	Myeloid Leukemia, Chronic	3	CTD_human;ORPHANET

Top

Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date