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Kinase Fusion Gene:SRPK1_TBC1D17 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: SRPK1_TBC1D17 | KinaseFusionDB ID: KFG6069 | FusionGDB2.0 ID: KFG6069 | Hgene | Tgene | Gene symbol | SRPK1 | TBC1D17 | Gene ID | 6732 | 79735 | |
| Gene name | SRSF protein kinase 1 | TBC1 domain family member 17 | ||||||||||
| Synonyms | SFRSK1 | - | ||||||||||
| Cytomap | 6p21.31 | 19q13.33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | SRSF protein kinase 1SFRS protein kinase 1SR-protein-specific kinase 1serine/arginine-rich splicing factor kinase 1serine/threonine-protein kinase SRPK1 | TBC1 domain family member 17 | ||||||||||
| Modification date | 20240331 | 20240403 | ||||||||||
| UniProtAcc | Q96SB4 | Q9HA65 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000373825, ENST00000423325, ENST00000373822, ENST00000373821, | ENST00000221543, ENST00000535102, ENST00000598789, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SRPK1 [Title/Abstract] AND TBC1D17 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SRPK1 | GO:0006468 | protein phosphorylation | 9237760|11509566 |
| Hgene | SRPK1 | GO:0007059 | chromosome segregation | 15034300 |
| Hgene | SRPK1 | GO:0035556 | intracellular signal transduction | 11509566 |
| Hgene | SRPK1 | GO:0045070 | positive regulation of viral genome replication | 20498328 |
| Hgene | SRPK1 | GO:0045071 | negative regulation of viral genome replication | 12417631 |
| Hgene | SRPK1 | GO:0050684 | regulation of mRNA processing | 8208298 |
| Kinase Fusion gene breakpoints across SRPK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across TBC1D17 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | SU-DHL-5 | SRPK1 | chr6 | 35803087 | TBC1D17 | chr19 | 50385514 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SRPK1 | TBC1D17 |
| FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. | FUNCTION: Probable RAB GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR) (PubMed:22854040). Involved in regulation of autophagy. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SRPK1_TBC1D17 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| SRPK1 | Q96SB4 | human | SRPK1 | Q96SB4 | S309 | RPNKQEEsEsPVERP | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S219 | RsRsRsRsNsRsRsy | |
| SRPK1 | Q96SB4 | human | SRPK1 | Q96SB4 | S33 | sEtQHRGsAPHsEsD | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S209 | yGRsRsRsRsRsRsR | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S223 | RsRsNsRsRsysPRR | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S215 | RsRsRsRsRsRsNsR | |
| SRPK1 | Q96SB4 | human | RBM8A | Q9Y5S9 | S168 | GGRRRsRsPDRRRR_ | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S207 | PsyGRsRsRsRsRsR | |
| SRPK1 | Q96SB4 | human | SRPK1 | Q96SB4 | S587 | LIVAGkYskEFFTKK | Pkinase |
| SRPK1 | Q96SB4 | human | RBM8A | Q9Y5S9 | S166 | RRGGRRRsRsPDRRR | |
| SRPK1 | Q96SB4 | human | RBM4 | Q9BWF3 | S309 | SyYGRDRsPLRRATA | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S225 | RsNsRsRsysPRRsR | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S211 | RsRsRsRsRsRsRsR | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S213 | RsRsRsRsRsRsRsN | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S221 | RsRsRsNsRsRsysP | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S217 | RsRsRsRsRsNsRsR | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S227 | NsRsRsysPRRsRGs | |
| SRPK1 | Q96SB4 | human | SRPK1 | Q96SB4 | T326 | ENPPNKMtQEKLEEs | |
| SRPK1 | Q96SB4 | human | SRSF1 | Q07955 | S205 | RsPsyGRsRsRsRsR |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| SRPK1 | ID | Description | 0.00e+00 |
| SRPK1 | GO:0043484 | regulation of RNA splicing | 1.02e-06 |
| SRPK1 | GO:0000377 | RNA splicin | 9.41e-08 |
| SRPK1 | GO:0048024 | regulation of mRNA splicin | 7.06e-07 |
| SRPK1 | GO:1903311 | regulation of mRNA metabolic process | 3.80e-04 |
| SRPK1 | GO:0000381 | regulation of alternative mRNA splicin | 4.81e-05 |
| SRPK1 | GO:0051028 | mRNA transport | 2.76e-03 |
| SRPK1 | GO:0050657 | nucleic acid transport | 3.55e-03 |
| SRPK1 | GO:0050658 | RNA transport | 3.55e-03 |
| SRPK1 | GO:0051236 | establishment of RNA localization | 3.55e-03 |
| SRPK1 | GO:0006403 | RNA localization | 4.97e-03 |
| SRPK1 | GO:0015931 | nucleobase-containing compound transport | 6.10e-03 |
| SRPK1 | GO:0022618 | protein-RNA complex assembly | 6.28e-03 |
| SRPK1 | GO:0071826 | protein-RNA complex organization | 6.36e-03 |
| SRPK1 | GO:0006913 | nucleocytoplasmic transport | 1.06e-02 |
| SRPK1 | GO:0051169 | nuclear transport | 1.06e-02 |
| SRPK1 | GO:2000622 | regulation of nuclear-transcribed mRNA catabolic proces | 2.75e-03 |
| SRPK1 | GO:0043555 | regulation of translation in response to stress | 2.30e-02 |
| SRPK1 | GO:0045947 | negative regulation of translational initiation | 2.31e-02 |
| SRPK1 | GO:0000395 | mRNA 5'-splice site recognition | 2.42e-02 |
| SRPK1 | GO:0043153 | entrainment of circadian clock by photoperiod | 2.43e-02 |
| SRPK1 | GO:0007289 | spermatid nucleus differentiation | 2.53e-02 |
| SRPK1 | GO:0009648 | photoperiodism | 2.53e-02 |
| SRPK1 | GO:0097421 | liver regeneration | 2.54e-02 |
| SRPK1 | GO:0009649 | entrainment of circadian clock | 2.54e-02 |
| SRPK1 | GO:0045070 | positive regulation of viral genome replication | 2.54e-02 |
| SRPK1 | GO:0046685 | response to arsenic-containing substance | 2.54e-02 |
| SRPK1 | GO:0035883 | enteroendocrine cell differentiation | 2.85e-02 |
| SRPK1 | GO:0002183 | cytoplasmic translational initiation | 2.99e-02 |
| SRPK1 | GO:0045292 | mRNA cis splicin | 8.87e-03 |
| SRPK1 | GO:0006376 | mRNA splice site recognition | 3.29e-02 |
| SRPK1 | GO:0045071 | negative regulation of viral genome replication | 3.60e-02 |
| SRPK1 | GO:0031100 | animal organ regeneration | 3.89e-02 |
| SRPK1 | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 3.89e-02 |
| SRPK1 | GO:0048524 | positive regulation of viral process | 3.89e-02 |
| SRPK1 | GO:0046626 | regulation of insulin receptor signaling pathway | 3.98e-02 |
| SRPK1 | GO:0006406 | mRNA export from nucleus | 3.98e-02 |
| SRPK1 | GO:0032922 | circadian regulation of gene expression | 3.98e-02 |
| SRPK1 | GO:0002067 | glandular epithelial cell differentiation | 4.06e-02 |
| SRPK1 | GO:0031016 | pancreas development | 4.30e-02 |
| SRPK1 | GO:0006446 | regulation of translational initiation | 4.33e-02 |
| SRPK1 | GO:0051149 | positive regulation of muscle cell differentiation | 4.33e-02 |
| SRPK1 | GO:0045069 | regulation of viral genome replication | 4.35e-02 |
| SRPK1 | GO:0006405 | RNA export from nucleus | 4.58e-02 |
| SRPK1 | GO:0048525 | negative regulation of viral process | 4.58e-02 |
| SRPK1 | GO:0035278 | miRNA-mediated gene silencing by inhibition of translation | 4.69e-02 |
| SRPK1 | GO:0048709 | oligodendrocyte differentiation | 5.02e-02 |
| SRPK1 | GO:0046822 | regulation of nucleocytoplasmic transport | 5.07e-02 |
| SRPK1 | GO:0042752 | regulation of circadian rhythm | 5.21e-02 |
| SRPK1 | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 5.38e-02 |
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Related Drugs to SRPK1_TBC1D17 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning SRPK1-TBC1D17 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SRPK1_TBC1D17 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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