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Kinase Fusion Gene:SSR1_SRPK2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: SSR1_SRPK2 | KinaseFusionDB ID: KFG6098 | FusionGDB2.0 ID: KFG6098 | Hgene | Tgene | Gene symbol | SSR1 | SRPK2 | Gene ID | 6745 | 6733 | |
| Gene name | signal sequence receptor subunit 1 | SRSF protein kinase 2 | ||||||||||
| Synonyms | TRAPA | SFRSK2 | ||||||||||
| Cytomap | 6p24.3 | 7q22.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | translocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunit | SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2 | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | P43307 | P78362 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000244763, ENST00000397511, ENST00000462112, ENST00000474597, ENST00000479365, ENST00000488834, ENST00000489567, ENST00000534851, | ENST00000357311, ENST00000393651, ENST00000489828, ENST00000493638, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SSR1 [Title/Abstract] AND SRPK2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SSR1(7288657)-SRPK2(104783707), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SRPK2 | GO:0000245 | spliceosomal complex assembly | 9472028 |
| Tgene | SRPK2 | GO:0006468 | protein phosphorylation | 9472028 |
| Tgene | SRPK2 | GO:0008284 | positive regulation of cell population proliferation | 18559500 |
| Tgene | SRPK2 | GO:0008380 | RNA splicing | 9472028 |
| Tgene | SRPK2 | GO:0035556 | intracellular signal transduction | 9472028 |
| Tgene | SRPK2 | GO:0045070 | positive regulation of viral genome replication | 20498328 |
| Tgene | SRPK2 | GO:0045071 | negative regulation of viral genome replication | 12417631 |
| Tgene | SRPK2 | GO:0062176 | R-loop processing | 28076779 |
| Kinase Fusion gene breakpoints across SSR1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across SRPK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | AW392218 | SSR1 | chr6 | 7288657 | SRPK2 | chr7 | 104783707 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:7288657/:104783707) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SSR1 | SRPK2 |
| FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. | FUNCTION: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:9472028, PubMed:18559500, PubMed:21056976). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SSR1_SRPK2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| SRPK2 | P78362 | human | LGMN | Q99538 | S226 | CYYDEkRsTYLGDWY | Peptidase_C13 |
| SRPK2 | P78362 | human | ACIN1 | Q9UKV3 | S1180 | GPRsRsRsRDRRRKE | RSB_motif |
| SRPK2 | P78362 | human | SRPK2 | P78362 | S494 | HDRSRtVsAsstGDL | |
| SRPK2 | P78362 | human | MAPT | P10636 | S214 | GGKERPGsKEEVDED |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| SRPK2 | ID | Description | 0.00e+00 |
| SRPK2 | GO:0007613 | memory | 3.02e-02 |
| SRPK2 | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 3.02e-02 |
| SRPK2 | GO:0010950 | positive regulation of endopeptidase activity | 3.02e-02 |
| SRPK2 | GO:0010952 | positive regulation of peptidase activity | 3.02e-02 |
| SRPK2 | GO:2000116 | regulation of cysteine-type endopeptidase activity | 3.02e-02 |
| SRPK2 | GO:0048167 | regulation of synaptic plasticity | 3.02e-02 |
| SRPK2 | GO:0043523 | regulation of neuron apoptotic process | 3.02e-02 |
| SRPK2 | GO:0007611 | learning or memory | 3.02e-02 |
| SRPK2 | GO:0051402 | neuron apoptotic process | 3.02e-02 |
| SRPK2 | GO:0052548 | regulation of endopeptidase activity | 3.02e-02 |
| SRPK2 | GO:0052547 | regulation of peptidase activity | 3.02e-02 |
| SRPK2 | GO:0050890 | cognition | 3.02e-02 |
| SRPK2 | GO:0048638 | regulation of developmental growth | 3.02e-02 |
| SRPK2 | GO:0045787 | positive regulation of cell cycle | 3.02e-02 |
| SRPK2 | GO:0045862 | positive regulation of proteolysis | 3.02e-02 |
| SRPK2 | GO:0010038 | response to metal ion | 3.02e-02 |
| SRPK2 | GO:0045657 | positive regulation of monocyte differentiation | 3.02e-02 |
| SRPK2 | GO:0010917 | negative regulation of mitochondrial membrane potential | 3.02e-02 |
| SRPK2 | GO:0040015 | negative regulation of multicellular organism growth | 3.02e-02 |
| SRPK2 | GO:0045837 | negative regulation of membrane potential | 3.02e-02 |
| SRPK2 | GO:0097264 | self proteolysis | 3.02e-02 |
| SRPK2 | GO:0097202 | activation of cysteine-type endopeptidase activity | 3.02e-02 |
| SRPK2 | GO:1900452 | regulation of long-term synaptic depression | 3.02e-02 |
| SRPK2 | GO:2001028 | positive regulation of endothelial cell chemotaxis | 3.02e-02 |
| SRPK2 | GO:0010720 | positive regulation of cell development | 3.02e-02 |
| SRPK2 | GO:0030575 | nuclear body organization | 3.02e-02 |
| SRPK2 | GO:0032930 | positive regulation of superoxide anion generation | 3.02e-02 |
| SRPK2 | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 3.02e-02 |
| SRPK2 | GO:1900034 | regulation of cellular response to heat | 3.02e-02 |
| SRPK2 | GO:0048311 | mitochondrion distribution | 3.02e-02 |
| SRPK2 | GO:0008380 | RNA splicing | 3.02e-02 |
| SRPK2 | GO:0050808 | synapse organization | 3.02e-02 |
| SRPK2 | GO:0019896 | axonal transport of mitochondrion | 3.02e-02 |
| SRPK2 | GO:0035728 | response to hepatocyte growth factor | 3.02e-02 |
| SRPK2 | GO:0050804 | modulation of chemical synaptic transmission | 3.02e-02 |
| SRPK2 | GO:0099177 | regulation of trans-synaptic signaling | 3.02e-02 |
| SRPK2 | GO:0032928 | regulation of superoxide anion generation | 3.02e-02 |
| SRPK2 | GO:0042359 | vitamin D metabolic process | 3.02e-02 |
| SRPK2 | GO:0045655 | regulation of monocyte differentiation | 3.02e-02 |
| SRPK2 | GO:0010288 | response to lead ion | 3.02e-02 |
| SRPK2 | GO:0090026 | positive regulation of monocyte chemotaxis | 3.02e-02 |
| SRPK2 | GO:0090043 | regulation of tubulin deacetylation | 3.02e-02 |
| SRPK2 | GO:1900273 | positive regulation of long-term synaptic potentiation | 3.02e-02 |
| SRPK2 | GO:1902473 | regulation of protein localization to synapse | 3.02e-02 |
| SRPK2 | GO:0090042 | tubulin deacetylation | 3.02e-02 |
| SRPK2 | GO:0070841 | inclusion body assembly | 3.02e-02 |
| SRPK2 | GO:2001026 | regulation of endothelial cell chemotaxis | 3.02e-02 |
| SRPK2 | GO:0048143 | astrocyte activation | 3.02e-02 |
| SRPK2 | GO:0034643 | establishment of mitochondrion localizatio | 5.50e-03 |
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Related Drugs to SSR1_SRPK2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning SSR1-SRPK2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SSR1_SRPK2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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