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Kinase Fusion Gene:STK16_PLCD4 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: STK16_PLCD4 | KinaseFusionDB ID: KFG6143 | FusionGDB2.0 ID: KFG6143 | Hgene | Tgene | Gene symbol | STK16 | PLCD4 | Gene ID | 8576 | 84812 | |
| Gene name | serine/threonine kinase 16 | phospholipase C delta 4 | ||||||||||
| Synonyms | KRCT|MPSK|PKL12|PSK|TSF1|hPSK | - | ||||||||||
| Cytomap | 2q35 | 2q35 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase 16TGF-beta-stimulated factor 1myristoylated and palmitoylated serine/threonine-protein kinaseprotein kinase PKL12protein kinase expressed in day 12 fetal livertyrosine-protein kinase STK16 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4PLC delta4phosphoinositide phospholipase C-delta-4 | ||||||||||
| Modification date | 20240305 | 20240411 | ||||||||||
| UniProtAcc | O75716 | Q9BRC7 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000396738, ENST00000409260, ENST00000409516, ENST00000409638, ENST00000409743, ENST00000486813, | ENST00000417849, ENST00000432688, ENST00000450993, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: STK16 [Title/Abstract] AND PLCD4 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK16(220112479)-PLCD4(219496858), # samples:1 STK16(220112479)-PLCD4(219496859), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK16 | GO:0046777 | protein autophosphorylation | 18184589 |
| Kinase Fusion gene breakpoints across STK16 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across PLCD4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-CG-4443-01A | STK16 | chr2 | 220112479 | PLCD4 | chr2 | 219496859 |
| ChimerDB4 | TCGA-CG-4443 | STK16 | chr2 | 220112479 | PLCD4 | chr2 | 219496858 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:220112479/chr2:219496858) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK16 | PLCD4 |
| FUNCTION: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000269|PubMed:10364453}. | FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.; FUNCTION: [Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3. {ECO:0000269|PubMed:30194280}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of STK16_PLCD4 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STK16 | O75716 | human | STK16 | O75716 | S197 | AAQRCTIsyRAPELF | Pkinase |
| STK16 | O75716 | human | STK16 | O75716 | Y198 | AQRCTIsyRAPELFS | Pkinase |
| STK16 | O75716 | human | STK16 | O75716 | T185 | EGSRQALtLQDWAAQ | Pkinase |
| STK16 | O75716 | human | DRG1 | Q9Y295 | T101 | yEFTTLTtVPGVIRY | MMR_HSR1 |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STK16 | ID | Description | 0.00e+00 |
| STK16 | GO:1901673 | regulation of mitotic spindle assembly | 3.08e-02 |
| STK16 | GO:0031116 | positive regulation of microtubule polymerization | 3.08e-02 |
| STK16 | GO:0090169 | regulation of spindle assembly | 3.08e-02 |
| STK16 | GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 3.08e-02 |
| STK16 | GO:0060236 | regulation of mitotic spindle organization | 3.08e-02 |
| STK16 | GO:0090224 | regulation of spindle organization | 3.08e-02 |
| STK16 | GO:0031113 | regulation of microtubule polymerization | 3.41e-02 |
| STK16 | GO:0090307 | mitotic spindle assembly | 3.41e-02 |
| STK16 | GO:0032273 | positive regulation of protein polymerization | 3.41e-02 |
| STK16 | GO:0046785 | microtubule polymerization | 3.41e-02 |
| STK16 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 3.41e-02 |
| STK16 | GO:0007052 | mitotic spindle organization | 3.41e-02 |
| STK16 | GO:0051225 | spindle assembly | 3.41e-02 |
| STK16 | GO:0031109 | microtubule polymerization or depolymerization | 3.41e-02 |
| STK16 | GO:0002181 | cytoplasmic translation | 3.41e-02 |
| STK16 | GO:0070507 | regulation of microtubule cytoskeleton organization | 3.41e-02 |
| STK16 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 3.41e-02 |
| STK16 | GO:1902905 | positive regulation of supramolecular fiber organization | 3.41e-02 |
| STK16 | GO:0000070 | mitotic sister chromatid segregation | 3.41e-02 |
| STK16 | GO:0051495 | positive regulation of cytoskeleton organization | 3.41e-02 |
| STK16 | GO:0031334 | positive regulation of protein-containing complex assembly | 3.41e-02 |
| STK16 | GO:0046777 | protein autophosphorylation | 3.41e-02 |
| STK16 | GO:0007051 | spindle organization | 3.41e-02 |
| STK16 | GO:0032271 | regulation of protein polymerization | 3.41e-02 |
| STK16 | GO:1902115 | regulation of organelle assembly | 3.46e-02 |
| STK16 | GO:0000819 | sister chromatid segregation | 3.46e-02 |
| STK16 | GO:0032886 | regulation of microtubule-based process | 3.78e-02 |
| STK16 | GO:0140014 | mitotic nuclear division | 3.78e-02 |
| STK16 | GO:0051258 | protein polymerization | 3.78e-02 |
| STK16 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 3.78e-02 |
| STK16 | GO:0071559 | response to transforming growth factor beta | 3.78e-02 |
| STK16 | GO:0098813 | nuclear chromosome segregation | 3.89e-02 |
| STK16 | GO:1902903 | regulation of supramolecular fiber organization | 4.69e-02 |
| STK16 | GO:0140694 | non-membrane-bounded organelle assembly | 4.69e-02 |
| STK16 | GO:0043254 | regulation of protein-containing complex assembly | 4.69e-02 |
| STK16 | GO:0007059 | chromosome segregation | 4.69e-02 |
| STK16 | GO:0000280 | nuclear division | 4.74e-02 |
| STK16 | GO:0048285 | organelle fission | 5.11e-02 |
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Related Drugs to STK16_PLCD4 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning STK16-PLCD4 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to STK16_PLCD4 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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