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Kinase Fusion Gene:STK17A_ERC1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: STK17A_ERC1 | KinaseFusionDB ID: KFG6146 | FusionGDB2.0 ID: KFG6146 | Hgene | Tgene | Gene symbol | STK17A | ERC1 | Gene ID | 9263 | 23085 | |
| Gene name | serine/threonine kinase 17a | ELKS/RAB6-interacting/CAST family member 1 | ||||||||||
| Synonyms | DRAK1 | Cast2|ELKS|ERC-1|RAB6IP2 | ||||||||||
| Cytomap | 7p13 | 12p13.33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase 17ADAP kinase-related apoptosis-inducing protein kinase 1death-associated protein kinase-related 1serine/threonine kinase 17a (apoptosis-inducing) | ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2 | ||||||||||
| Modification date | 20240305 | 20240407 | ||||||||||
| UniProtAcc | Q9UEE5 | Q8IUD2 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000319357, ENST00000462448, | ENST00000536573, ENST00000355446, ENST00000360905, ENST00000397203, ENST00000543086, ENST00000546231, ENST00000589028, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: STK17A [Title/Abstract] AND ERC1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK17A(43623048)-ERC1(1345934), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK17A | GO:0006468 | protein phosphorylation | 9786912 |
| Hgene | STK17A | GO:0035556 | intracellular signal transduction | 9786912 |
| Tgene | ERC1 | GO:0006355 | regulation of DNA-templated transcription | 15218148 |
| Tgene | ERC1 | GO:0007252 | I-kappaB phosphorylation | 15218148 |
| Tgene | ERC1 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15218148 |
| Kinase Fusion gene breakpoints across STK17A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across ERC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-D7-8579 | STK17A | chr7 | 43623048 | ERC1 | chr12 | 1345934 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:43623048/chr12:1345934) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK17A | ERC1 |
| FUNCTION: Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. {ECO:0000269|PubMed:21489989, ECO:0000269|PubMed:9786912}. | FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of STK17A_ERC1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STK17A | Q9UEE5 | human | TP53 | P04637 | S20 | PLsQEtFsDLWkLLP | P53_TAD |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STK17A | ID | Description | 0.00e+00 |
| STK17A | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 9.26e-03 |
| STK17A | GO:1900543 | negative regulation of purine nucleotide metabolic process | 9.26e-03 |
| STK17A | GO:1903799 | negative regulation of miRNA processing | 9.26e-03 |
| STK17A | GO:0006983 | ER overload response | 9.26e-03 |
| STK17A | GO:0007406 | negative regulation of neuroblast proliferation | 9.26e-03 |
| STK17A | GO:0045980 | negative regulation of nucleotide metabolic process | 9.26e-03 |
| STK17A | GO:0051095 | regulation of helicase activity | 9.26e-03 |
| STK17A | GO:0062100 | positive regulation of programmed necrotic cell death | 9.26e-03 |
| STK17A | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 9.26e-03 |
| STK17A | GO:0060965 | negative regulation of miRNA-mediated gene silencing | 9.26e-03 |
| STK17A | GO:0071236 | cellular response to antibiotic | 9.26e-03 |
| STK17A | GO:0060149 | negative regulation of post-transcriptional gene silencing | 9.26e-03 |
| STK17A | GO:0060967 | negative regulation of gene silencing by regulatory ncRNA | 9.26e-03 |
| STK17A | GO:0070234 | positive regulation of T cell apoptotic process | 9.26e-03 |
| STK17A | GO:1900369 | negative regulation of post-transcriptional gene silencing by regulatory ncRNA | 9.26e-03 |
| STK17A | GO:0010225 | response to UV-C | 9.26e-03 |
| STK17A | GO:0070243 | regulation of thymocyte apoptotic process | 9.26e-03 |
| STK17A | GO:0034349 | glial cell apoptotic process | 9.26e-03 |
| STK17A | GO:0070230 | positive regulation of lymphocyte apoptotic process | 9.26e-03 |
| STK17A | GO:1901524 | regulation of mitophagy | 9.26e-03 |
| STK17A | GO:1903798 | regulation of miRNA processing | 9.26e-03 |
| STK17A | GO:0032780 | negative regulation of ATP-dependent activity | 9.26e-03 |
| STK17A | GO:0060253 | negative regulation of glial cell proliferation | 9.26e-03 |
| STK17A | GO:0070920 | regulation of regulatory ncRNA processing | 9.26e-03 |
| STK17A | GO:0090399 | replicative senescence | 9.26e-03 |
| STK17A | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 9.26e-03 |
| STK17A | GO:0006089 | lactate metabolic process | 9.26e-03 |
| STK17A | GO:0006977 | DNA damage respons | 9.54e-04 |
| STK17A | GO:0010663 | positive regulation of striated muscle cell apoptotic process | 9.26e-03 |
| STK17A | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 9.26e-03 |
| STK17A | GO:0042772 | DNA damage respons | 1.01e-03 |
| STK17A | GO:2000774 | positive regulation of cellular senescence | 9.26e-03 |
| STK17A | GO:0006098 | pentose-phosphate shunt | 9.26e-03 |
| STK17A | GO:0070242 | thymocyte apoptotic process | 9.26e-03 |
| STK17A | GO:2000269 | regulation of fibroblast apoptotic process | 9.26e-03 |
| STK17A | GO:0032042 | mitochondrial DNA metabolic process | 9.26e-03 |
| STK17A | GO:0006740 | NADPH regeneration | 9.26e-03 |
| STK17A | GO:0009651 | response to salt stress | 9.26e-03 |
| STK17A | GO:0008156 | negative regulation of DNA replication | 9.26e-03 |
| STK17A | GO:0043153 | entrainment of circadian clock by photoperiod | 9.26e-03 |
| STK17A | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 9.26e-03 |
| STK17A | GO:2000178 | negative regulation of neural precursor cell proliferation | 9.26e-03 |
| STK17A | GO:0044346 | fibroblast apoptotic process | 9.26e-03 |
| STK17A | GO:0060333 | type II interferon-mediated signaling pathway | 9.26e-03 |
| STK17A | GO:0006007 | glucose catabolic process | 9.26e-03 |
| STK17A | GO:0071480 | cellular response to gamma radiation | 9.26e-03 |
| STK17A | GO:0009648 | photoperiodism | 9.26e-03 |
| STK17A | GO:0060964 | regulation of miRNA-mediated gene silencing | 9.26e-03 |
| STK17A | GO:2000108 | positive regulation of leukocyte apoptotic process | 9.26e-03 |
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Related Drugs to STK17A_ERC1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning STK17A-ERC1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to STK17A_ERC1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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