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Kinase Fusion Gene:STK25_STK25 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: STK25_STK25 | KinaseFusionDB ID: KFG6178 | FusionGDB2.0 ID: KFG6178 | Hgene | Tgene | Gene symbol | STK25 | STK25 | Gene ID | 10494 | 10494 | |
| Gene name | serine/threonine kinase 25 | serine/threonine kinase 25 | ||||||||||
| Synonyms | SOK1|YSK1 | SOK1|YSK1 | ||||||||||
| Cytomap | 2q37.3 | 2q37.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase 25Ste20, yeast homologste20-like kinaseste20/oxidant stress response kinase 1sterile 20/oxidant stress-response kinase 1 | serine/threonine-protein kinase 25Ste20, yeast homologste20-like kinaseste20/oxidant stress response kinase 1sterile 20/oxidant stress-response kinase 1 | ||||||||||
| Modification date | 20240411 | 20240411 | ||||||||||
| UniProtAcc | O00506 | O00506 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000316586, ENST00000401869, ENST00000403346, ENST00000405585, ENST00000405883, ENST00000478403, ENST00000535007, ENST00000543554, | ENST00000316586, ENST00000401869, ENST00000403346, ENST00000405883, ENST00000405585, ENST00000478403, ENST00000535007, ENST00000543554, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: STK25 [Title/Abstract] AND STK25 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK25(242434510)-STK25(242434558), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK25 | GO:0006468 | protein phosphorylation | 17657516 |
| Hgene | STK25 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 |
| Hgene | STK25 | GO:0034599 | cellular response to oxidative stress | 22291017 |
| Hgene | STK25 | GO:0046777 | protein autophosphorylation | 17657516 |
| Hgene | STK25 | GO:0051645 | Golgi localization | 15037601 |
| Tgene | STK25 | GO:0006468 | protein phosphorylation | 17657516 |
| Tgene | STK25 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 |
| Tgene | STK25 | GO:0034599 | cellular response to oxidative stress | 22291017 |
| Tgene | STK25 | GO:0046777 | protein autophosphorylation | 17657516 |
| Tgene | STK25 | GO:0051645 | Golgi localization | 15037601 |
| Kinase Fusion gene breakpoints across STK25 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across STK25 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | EC542654 | STK25 | chr2 | 242434510 | STK25 | chr2 | 242434558 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:242434510/:242434558) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK25 | STK25 |
| FUNCTION: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. {ECO:0000269|PubMed:15037601}. | FUNCTION: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. {ECO:0000269|PubMed:15037601}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of STK25_STK25 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STK25 | O00506 | human | PRKAR1A | P10644 | S83 | DsREDEIsPPPPNPV | |
| STK25 | O00506 | human | CCM2 | Q9BSQ5 | S384 | GRGIITDsFGRHRRA | CCM2_C |
| STK25 | O00506 | human | PDCD10 | Q9BUL8 | T43 | VNLsAAQtLRAAFIk | DUF1241 |
| STK25 | O00506 | human | PDCD10 | Q9BUL8 | S39 | ELERVNLsAAQtLRA | DUF1241 |
| STK25 | O00506 | human | PRKAR1A | P10644 | S77 | kAGtRtDsREDEIsP |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STK25 | ID | Description | 0.00e+00 |
| STK25 | GO:0003158 | endothelium development | 2.44e-02 |
| STK25 | GO:0051403 | stress-activated MAPK cascade | 2.44e-02 |
| STK25 | GO:0031098 | stress-activated protein kinase signaling cascade | 2.44e-02 |
| STK25 | GO:0071900 | regulation of protein serine/threonine kinase activity | 2.44e-02 |
| STK25 | GO:0051222 | positive regulation of protein transport | 2.44e-02 |
| STK25 | GO:1904951 | positive regulation of establishment of protein localization | 2.44e-02 |
| STK25 | GO:0045765 | regulation of angiogenesis | 2.44e-02 |
| STK25 | GO:1901342 | regulation of vasculature development | 2.44e-02 |
| STK25 | GO:1903829 | positive regulation of protein localization | 2.44e-02 |
| STK25 | GO:0071377 | cellular response to glucagon stimulus | 2.44e-02 |
| STK25 | GO:0051645 | Golgi localization | 2.44e-02 |
| STK25 | GO:0060837 | blood vessel endothelial cell differentiation | 2.44e-02 |
| STK25 | GO:0046007 | negative regulation of activated T cell proliferation | 2.44e-02 |
| STK25 | GO:0048308 | organelle inheritance | 2.44e-02 |
| STK25 | GO:0048313 | Golgi inheritance | 2.44e-02 |
| STK25 | GO:2000479 | regulation of cAMP-dependent protein kinase activity | 2.44e-02 |
| STK25 | GO:0060841 | venous blood vessel development | 2.44e-02 |
| STK25 | GO:1903358 | regulation of Golgi organization | 2.44e-02 |
| STK25 | GO:0003159 | morphogenesis of an endothelium | 2.44e-02 |
| STK25 | GO:0010421 | hydrogen peroxide-mediated programmed cell death | 2.44e-02 |
| STK25 | GO:0061154 | endothelial tube morphogenesis | 2.44e-02 |
| STK25 | GO:0060039 | pericardium development | 2.49e-02 |
| STK25 | GO:0097468 | programmed cell death in response to reactive oxygen species | 2.49e-02 |
| STK25 | GO:0033762 | response to glucagon | 2.77e-02 |
| STK25 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 3.14e-02 |
| STK25 | GO:0044319 | wound healin | 5.87e-03 |
| STK25 | GO:0090504 | epiboly | 4.09e-02 |
| STK25 | GO:0046006 | regulation of activated T cell proliferation | 4.25e-02 |
| STK25 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 4.25e-02 |
| STK25 | GO:0045214 | sarcomere organization | 4.25e-02 |
| STK25 | GO:0050798 | activated T cell proliferation | 4.25e-02 |
| STK25 | GO:0045747 | positive regulation of Notch signaling pathway | 4.25e-02 |
| STK25 | GO:1903587 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 4.25e-02 |
| STK25 | GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 4.73e-02 |
| STK25 | GO:0060038 | cardiac muscle cell proliferation | 4.88e-02 |
| STK25 | GO:0002011 | morphogenesis of an epithelial sheet | 4.88e-02 |
| STK25 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 4.94e-02 |
| STK25 | GO:0001885 | endothelial cell development | 4.94e-02 |
| STK25 | GO:0030239 | myofibril assembly | 4.96e-02 |
| STK25 | GO:0042130 | negative regulation of T cell proliferation | 4.96e-02 |
| STK25 | GO:0055002 | striated muscle cell development | 4.96e-02 |
| STK25 | GO:0001707 | mesoderm formation | 4.96e-02 |
| STK25 | GO:0001937 | negative regulation of endothelial cell proliferation | 4.96e-02 |
| STK25 | GO:0048332 | mesoderm morphogenesis | 4.96e-02 |
| STK25 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 4.96e-02 |
| STK25 | GO:0090049 | regulation of cell migration involved in sprouting angiogenesis | 4.96e-02 |
| STK25 | GO:0001570 | vasculogenesis | 4.96e-02 |
| STK25 | GO:0014855 | striated muscle cell proliferation | 4.96e-02 |
| STK25 | GO:0032024 | positive regulation of insulin secretion | 4.96e-02 |
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Related Drugs to STK25_STK25 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning STK25-STK25 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to STK25_STK25 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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