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Kinase Fusion Gene:STK38_GMDS |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: STK38_GMDS | KinaseFusionDB ID: KFG6214 | FusionGDB2.0 ID: KFG6214 | Hgene | Tgene | Gene symbol | STK38 | GMDS | Gene ID | 11329 | 2762 | |
| Gene name | serine/threonine kinase 38 | GDP-mannose 4,6-dehydratase | ||||||||||
| Synonyms | NDR|NDR1 | GMD|SDR3E1 | ||||||||||
| Cytomap | 6p21.31 | 6p25.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase 38NDR1 protein kinaseNdr Ser/Thr kinase-like proteinnuclear Dbf2-related kinase 1 | GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1 | ||||||||||
| Modification date | 20240407 | 20240403 | ||||||||||
| UniProtAcc | Q9Y2H1 | O60547 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000229812, | ENST00000467288, ENST00000380815, ENST00000530927, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: STK38 [Title/Abstract] AND GMDS [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK38(36467650)-GMDS(1742820), # samples:3 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK38 | GO:0006468 | protein phosphorylation | 12493777 |
| Hgene | STK38 | GO:0035556 | intracellular signal transduction | 12493777 |
| Hgene | STK38 | GO:0036211 | protein modification process | 7761441 |
| Hgene | STK38 | GO:0043407 | negative regulation of MAP kinase activity | 17906693 |
| Tgene | GMDS | GO:0019673 | GDP-mannose metabolic process | 9525924 |
| Tgene | GMDS | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process | 9525924 |
| Kinase Fusion gene breakpoints across STK38 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across GMDS (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-A5-A7WK-01A | STK38 | chr6 | 36467650 | GMDS | chr6 | 1742820 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:36467650/chr6:1742820) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK38 | GMDS |
| FUNCTION: Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}. | FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924, ECO:0000269|PubMed:9603974}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of STK38_GMDS |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STK38 | Q15208 | human | YAP1 | P46937 | S61 | IVHVRGDsEtDLEAL | |
| STK38 | Q15208 | human | YAP1 | P46937 | S164 | AQHLRQssFEIPDDV | |
| STK38 | Q15208 | human | XPO1 | O14980 | S1055 | EKHKRQMsVPGIFNP | |
| STK38 | Q15208 | human | STK38 | Q15208 | T444 | DWVFINytyKRFEGL | Pkinase_C |
| STK38 | Q15208 | human | RAB3IP | Q96QF0 | S288 | KGHTRNKstSSAMSG | |
| STK38 | Q15208 | human | KIF23 | Q02241 | S814 | LRHRRsRsAGDRWVD | MKLP1_Arf_bdg |
| STK38 | Q15208 | human | KIF23 | Q02241 | S716 | QLHRRsNsCsSISVA | |
| STK38 | Q15208 | human | YAP1 | P46937 | S127 | PQHVRAHssPAsLQL | |
| STK38 | Q15208 | human | STK38 | Q15208 | S281 | NRRQLAFstVGtPDy | Pkinase |
| STK38 | Q15208 | human | YAP1 | P46937 | S109 | ksHsRQAstDAGtAG |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STK38 | ID | Description | 0.00e+00 |
| STK38 | GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 1.10e-02 |
| STK38 | GO:0031345 | negative regulation of cell projection organization | 5.02e-02 |
| STK38 | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 5.02e-02 |
| STK38 | GO:0060491 | regulation of cell projection assembly | 5.02e-02 |
| STK38 | GO:0034504 | protein localization to nucleus | 5.02e-02 |
| STK38 | GO:0060245 | detection of cell density | 5.02e-02 |
| STK38 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 5.02e-02 |
| STK38 | GO:0050847 | progesterone receptor signaling pathway | 5.02e-02 |
| STK38 | GO:0051256 | mitotic spindle midzone assembly | 5.02e-02 |
| STK38 | GO:0000022 | mitotic spindle elongation | 5.02e-02 |
| STK38 | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway | 5.02e-02 |
| STK38 | GO:0072182 | regulation of nephron tubule epithelial cell differentiation | 5.02e-02 |
| STK38 | GO:0000054 | ribosomal subunit export from nucleus | 5.02e-02 |
| STK38 | GO:0033750 | ribosome localization | 5.02e-02 |
| STK38 | GO:0051231 | spindle elongation | 5.02e-02 |
| STK38 | GO:0051255 | spindle midzone assembly | 5.02e-02 |
| STK38 | GO:0072160 | nephron tubule epithelial cell differentiation | 5.02e-02 |
| STK38 | GO:0060271 | cilium assembly | 5.02e-02 |
| STK38 | GO:0048368 | lateral mesoderm development | 5.02e-02 |
| STK38 | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development | 5.02e-02 |
| STK38 | GO:0044782 | cilium organization | 5.02e-02 |
| STK38 | GO:0048339 | paraxial mesoderm development | 5.02e-02 |
| STK38 | GO:0060576 | intestinal epithelial cell development | 5.02e-02 |
| STK38 | GO:0001829 | trophectodermal cell differentiation | 5.02e-02 |
| STK38 | GO:0030903 | notochord development | 5.02e-02 |
| STK38 | GO:0060602 | branch elongation of an epithelium | 5.02e-02 |
| STK38 | GO:1902018 | negative regulation of cilium assembly | 5.02e-02 |
| STK38 | GO:0072234 | metanephric nephron tubule development | 5.02e-02 |
| STK38 | GO:0072202 | cell differentiation involved in metanephros development | 5.02e-02 |
| STK38 | GO:0030859 | polarized epithelial cell differentiation | 5.02e-02 |
| STK38 | GO:0072170 | metanephric tubule development | 5.02e-02 |
| STK38 | GO:0072243 | metanephric nephron epithelium development | 5.02e-02 |
| STK38 | GO:0070102 | interleukin-6-mediated signaling pathway | 5.02e-02 |
| STK38 | GO:2000737 | negative regulation of stem cell differentiation | 5.02e-02 |
| STK38 | GO:0071480 | cellular response to gamma radiation | 5.02e-02 |
| STK38 | GO:0060479 | lung cell differentiation | 5.02e-02 |
| STK38 | GO:0060487 | lung epithelial cell differentiation | 5.02e-02 |
| STK38 | GO:0060575 | intestinal epithelial cell differentiation | 5.02e-02 |
| STK38 | GO:0003401 | axis elongation | 5.02e-02 |
| STK38 | GO:0072207 | metanephric epithelium development | 5.02e-02 |
| STK38 | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 5.02e-02 |
| STK38 | GO:0060441 | epithelial tube branching involved in lung morphogenesis | 5.02e-02 |
| STK38 | GO:0046825 | regulation of protein export from nucleus | 5.49e-02 |
| STK38 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 5.49e-02 |
| STK38 | GO:0055023 | positive regulation of cardiac muscle tissue growth | 5.49e-02 |
| STK38 | GO:0009595 | detection of biotic stimulus | 5.49e-02 |
| STK38 | GO:0032570 | response to progesterone | 5.49e-02 |
| STK38 | GO:0060421 | positive regulation of heart growth | 5.49e-02 |
| STK38 | GO:0071354 | cellular response to interleukin-6 | 5.49e-02 |
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Related Drugs to STK38_GMDS |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning STK38-GMDS and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to STK38_GMDS |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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