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Kinase Fusion Gene:STK39_NCKAP5 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: STK39_NCKAP5 | KinaseFusionDB ID: KFG6228 | FusionGDB2.0 ID: KFG6228 | Hgene | Tgene | Gene symbol | STK39 | NCKAP5 | Gene ID | 27347 | 344148 | |
Gene name | serine/threonine kinase 39 | NCK associated protein 5 | ||||||||||
Synonyms | DCHT|PASK|SPAK | ERIH1|ERIH2|NAP5 | ||||||||||
Cytomap | 2q24.3 | 2q21.2 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | STE20/SPS1-related proline-alanine-rich protein kinaseSTE20/SPS1 homologSte20-like protein kinaseproline-alanine-rich STE20-related kinaseserine threonine kinase 39 (STE20/SPS1 homolog, yeast)serine/threonine-protein kinase 39small intestine SPAK-li | nck-associated protein 5NAP-5peripheral clock protein 2 | ||||||||||
Modification date | 20240411 | 20240305 | ||||||||||
UniProtAcc | Q9UEW8 | O14513 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000355999, ENST00000487143, | ENST00000473859, ENST00000317721, ENST00000405974, ENST00000409213, ENST00000409261, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: STK39 [Title/Abstract] AND NCKAP5 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK39(168869144)-NCKAP5(133489624), # samples:3 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STK39 | GO:0006884 | cell volume homeostasis | 36318922 |
Hgene | STK39 | GO:0007165 | signal transduction | 24393035 |
Hgene | STK39 | GO:0018105 | peptidyl-serine phosphorylation | 24393035 |
Hgene | STK39 | GO:0018107 | peptidyl-threonine phosphorylation | 24393035 |
Hgene | STK39 | GO:0035556 | intracellular signal transduction | 24393035 |
Hgene | STK39 | GO:0070294 | renal sodium ion absorption | 18270262 |
Hgene | STK39 | GO:0071474 | cellular hyperosmotic response | 36318922 |
Hgene | STK39 | GO:0071476 | cellular hypotonic response | 24393035 |
Hgene | STK39 | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity | 24393035 |
Hgene | STK39 | GO:1901380 | negative regulation of potassium ion transmembrane transport | 24393035 |
Hgene | STK39 | GO:1905408 | negative regulation of creatine transmembrane transporter activity | 25531585 |
Hgene | STK39 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity | 25531585 |
Kinase Fusion gene breakpoints across STK39 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across NCKAP5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-CN-A49A-01A | STK39 | chr2 | 168869144 | NCKAP5 | chr2 | 133489624 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
ENST00000355999 | ENST00000409261 | STK39 | chr2 | 168869144 | NCKAP5 | chr2 | 133489624 | 4294 | 783 |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000355999_ENST00000409261_STK39_chr2_168869144_NCKAP5_chr2_133489624_length(amino acids)=783 MGARRAQRPPPPPFPASAGAASSLRPARPPLLPPLLAGFGGDGGGGGGRGGRAPAERCRRRGKGSFKWKVVRRPARPPALLRSIMAEPSG SPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINL EKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKY PPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRR VPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVL RLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPDSPEDAEPLLPLQS ALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQP -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:168869144/chr2:133489624) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
STK39 | NCKAP5 |
FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Hgene | STK39 | 168869144 | NCKAP5 | 133489624 | ENST00000355999 | 16 | 18 | 63_337 | 4991 | 546 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase Fusion Protein Structures |
CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
PDB file >>>263_STK39_NCKAP5 | ENST00000355999 | ENST00000409261 | STK39 | chr2 | 168869144 | NCKAP5 | chr2 | 133489624 | MGARRAQRPPPPPFPASAGAASSLRPARPPLLPPLLAGFGGDGGGGGGRGGRAPAERCRRRGKGSFKWKVVRRPARPPALLRSIMAEPSG SPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINL EKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKY PPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRR VPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVL RLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPDSPEDAEPLLPLQS ALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQP | 783 |
3D view using mol* of 263_STK39_NCKAP5 | ||||||||||
PDB file >>>HKFP_390_STK39_NCKAP5 | ENST00000355999 | ENST00000409261 | STK39 | chr2 | 168869144 | NCKAP5 | chr2 | 133489624 | MGARRAQRPPPPPFPASAGAASSLRPARPPLLPPLLAGFGGDGGGGGGRGGRAPAERCRRRGKGSFKWKVVRRPARPPALLRSIMAEPSG SPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINL EKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKY PPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRR VPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVL RLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLCQPDSPEDAEPLLPLQS ALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARGMRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQP | 783_STK39_NCKAP5 |
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Comparison of Fusion Protein Isoforms |
Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
263_STK39_NCKAP5.png |
263_STK39_NCKAP5.png |
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Potential Active Site Information |
The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
263_STK39_NCKAP5_ramachandran.png |
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Virtual Screening Results |
Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
5'-kinase fusion protein case |
3'-kinase fusion protein case |
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Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Netarsudil | -8.69144 | -8.702539999999999 | -53.8097 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Netarsudil | -8.69144 | -8.702539999999999 | -53.8097 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Upadacitinib | -7.06452 | -7.065519999999999 | -24.3723 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Netarsudil | -6.9872 | -6.9983 | -47.9679 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Netarsudil | -6.9872 | -6.9983 | -47.9679 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Temsirolimus | -6.66728 | -6.66868 | -65.0225 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Temsirolimus | -6.52359 | -6.52499 | -66.104 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Dacomitinib | -6.37626 | -6.48456 | -46.5503 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Dacomitinib | -6.37626 | -6.48456 | -46.5503 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Dacomitinib | -6.37556 | -6.48456 | -46.5503 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Sunitinib | -6.36149 | -6.36569 | -46.0373 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Baricitinib | -6.32097 | -6.32097 | -42.1686 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Belumosudil | -6.1108199999999995 | -6.118519999999999 | -47.8518 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Everolimus | -6.06853 | -6.06993 | -58.7501 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Fostamatinib | -5.98604 | -6.04964 | -50.4625 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Fostamatinib | -5.98604 | -6.04964 | -50.4625 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Temsirolimus | -5.923830000000001 | -5.92523 | -58.1345 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Temsirolimus | -5.831580000000001 | -5.83298 | -55.1495 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Lorlatinib | -5.72759 | -6.06379 | -41.4766 |
263_STK39_NCKAP5-DOCK_HTVS_1-001 | Lorlatinib | -5.72759 | -6.06379 | -41.4766 |
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Kinase-Substrate Information of STK39_NCKAP5 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
STK39 | Q9UEW8 | human | SLC12A1 | Q13621 | T105 | LQtFGHNtMDAVPKI | AA_permease_N |
STK39 | Q9UEW8 | human | SLC4A4 | Q9Y6R1 | S65 | ERIsENysDKsDIEN | |
STK39 | Q9UEW8 | human | SLC12A2 | P55011 | T207 | YYDtHTNtyYLRtFG | AA_permease_N |
STK39 | Q9UEW8 | human | SLC12A2 | P55011 | T203 | HQHYYYDtHTNtyYL | AA_permease_N |
STK39 | Q9UEW8 | human | SLC12A6 | Q9UHW9 | T1048 | YQEKVHMtWTKDKYM | SLC12 |
STK39 | Q9UEW8 | human | SLC12A1 | Q13621 | T95 | AYDsHTNtYYLQtFG | AA_permease_N |
STK39 | Q9UEW8 | human | SLC12A6 | Q9UHW9 | S96 | IEDLSQNsITGEHSQ | |
STK39 | Q9UEW8 | human | SLC12A1 | Q13621 | T100 | TNtYYLQtFGHNtMD | AA_permease_N |
STK39 | Q9UEW8 | human | SLC12A3 | P55017 | T60 | MRtFGYNtIDVVPtY | AA_permease_N |
STK39 | Q9UEW8 | human | SLC12A3 | P55017 | T46 | SSHPSHLtHSStFCM | AA_permease_N |
STK39 | Q9UEW8 | human | SLC12A3 | P55017 | T55 | SStFCMRtFGYNtID | AA_permease_N |
STK39 | Q9UEW8 | human | SNAI1 | O95863 | T203 | QGHVRtHtGEkPFSC | |
STK39 | Q9UEW8 | human | SLC12A2 | P55011 | T212 | TNtyYLRtFGHNtMD | AA_permease_N |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
STK39 | ID | Description | 0.00e+00 |
STK39 | GO:0055064 | chloride ion homeostasis | 2.10e-09 |
STK39 | GO:0055081 | monoatomic anion homeostasis | 2.10e-09 |
STK39 | GO:0055075 | potassium ion homeostasis | 7.89e-09 |
STK39 | GO:0006884 | cell volume homeostasis | 7.89e-09 |
STK39 | GO:0098656 | monoatomic anion transmembrane transport | 7.89e-09 |
STK39 | GO:0015698 | inorganic anion transport | 1.25e-08 |
STK39 | GO:0006820 | monoatomic anion transport | 1.25e-08 |
STK39 | GO:1990573 | potassium ion import across plasma membrane | 1.43e-08 |
STK39 | GO:1902476 | chloride transmembrane transport | 4.46e-07 |
STK39 | GO:0006821 | chloride transport | 6.73e-07 |
STK39 | GO:0098661 | inorganic anion transmembrane transport | 7.39e-07 |
STK39 | GO:0098659 | inorganic cation import across plasma membrane | 7.49e-07 |
STK39 | GO:0099587 | inorganic ion import across plasma membrane | 7.49e-07 |
STK39 | GO:0035725 | sodium ion transmembrane transport | 2.09e-06 |
STK39 | GO:0008361 | regulation of cell size | 2.27e-06 |
STK39 | GO:0098739 | import across plasma membrane | 3.52e-06 |
STK39 | GO:0071805 | potassium ion transmembrane transport | 3.64e-06 |
STK39 | GO:0055078 | sodium ion homeostasis | 3.70e-06 |
STK39 | GO:0006813 | potassium ion transport | 4.96e-06 |
STK39 | GO:0006814 | sodium ion transport | 5.28e-06 |
STK39 | GO:0032535 | regulation of cellular component size | 2.49e-05 |
STK39 | GO:0072488 | ammonium transmembrane transport | 6.23e-05 |
STK39 | GO:0006970 | response to osmotic stress | 2.90e-03 |
STK39 | GO:0010232 | vascular transport | 3.08e-03 |
STK39 | GO:0150104 | transport across blood-brain barrier | 3.08e-03 |
STK39 | GO:0071241 | cellular response to inorganic substance | 2.02e-02 |
STK39 | GO:0003018 | vascular process in circulatory system | 2.40e-02 |
STK39 | GO:0030002 | intracellular monoatomic anion homeostasis | 2.40e-02 |
STK39 | GO:0030644 | intracellular chloride ion homeostasis | 2.40e-02 |
STK39 | GO:0042368 | vitamin D biosynthetic process | 2.40e-02 |
STK39 | GO:0060536 | cartilage morphogenesis | 2.40e-02 |
STK39 | GO:0061314 | Notch signaling involved in heart development | 2.40e-02 |
STK39 | GO:0071476 | cellular hypotonic response | 2.40e-02 |
STK39 | GO:1904464 | regulation of matrix metallopeptidase secretion | 2.40e-02 |
STK39 | GO:1990773 | matrix metallopeptidase secretion | 2.40e-02 |
STK39 | GO:0030656 | regulation of vitamin metabolic process | 2.40e-02 |
STK39 | GO:0060707 | trophoblast giant cell differentiation | 2.40e-02 |
STK39 | GO:0006971 | hypotonic response | 2.40e-02 |
STK39 | GO:0035865 | cellular response to potassium ion | 2.40e-02 |
STK39 | GO:0042362 | fat-soluble vitamin biosynthetic process | 2.40e-02 |
STK39 | GO:0070294 | renal sodium ion absorption | 2.40e-02 |
STK39 | GO:0061043 | regulation of vascular wound healing | 2.40e-02 |
STK39 | GO:0071472 | cellular response to salt stress | 2.40e-02 |
STK39 | GO:0098814 | spontaneous synaptic transmission | 2.40e-02 |
STK39 | GO:0062012 | regulation of small molecule metabolic process | 2.40e-02 |
STK39 | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | 2.40e-02 |
STK39 | GO:0030007 | intracellular potassium ion homeostasis | 2.40e-02 |
STK39 | GO:0036376 | sodium ion export across plasma membrane | 2.40e-02 |
STK39 | GO:0043518 | negative regulation of DNA damage respons | 4.76e-03 |
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Related Drugs to STK39_NCKAP5 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning STK39-NCKAP5 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to STK39_NCKAP5 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |