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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:STK39_OXSR1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: STK39_OXSR1
KinaseFusionDB ID: KFG6230
FusionGDB2.0 ID: KFG6230
HgeneTgene
Gene symbol

STK39

OXSR1

Gene ID

27347

9943

Gene nameserine/threonine kinase 39oxidative stress responsive kinase 1
SynonymsDCHT|PASK|SPAKOSR1
Cytomap

2q24.3

3p22.2

Type of geneprotein-codingprotein-coding
DescriptionSTE20/SPS1-related proline-alanine-rich protein kinaseSTE20/SPS1 homologSte20-like protein kinaseproline-alanine-rich STE20-related kinaseserine threonine kinase 39 (STE20/SPS1 homolog, yeast)serine/threonine-protein kinase 39small intestine SPAK-liserine/threonine-protein kinase OSR1oxidative stress responsive 1oxidative stress-responsive 1 protein
Modification date2024041120240403
UniProtAcc

Q9UEW8

O95747

Ensembl transtripts involved in fusion geneENST idsENST00000355999, ENST00000487143, 
ENST00000492714, ENST00000311806, 
ENST00000446845, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: STK39 [Title/Abstract] AND OXSR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)STK39(169018296)-OXSR1(38232221), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK39

GO:0006884

cell volume homeostasis

36318922

HgeneSTK39

GO:0007165

signal transduction

24393035

HgeneSTK39

GO:0018105

peptidyl-serine phosphorylation

24393035

HgeneSTK39

GO:0018107

peptidyl-threonine phosphorylation

24393035

HgeneSTK39

GO:0035556

intracellular signal transduction

24393035

HgeneSTK39

GO:0070294

renal sodium ion absorption

18270262

HgeneSTK39

GO:0071474

cellular hyperosmotic response

36318922

HgeneSTK39

GO:0071476

cellular hypotonic response

24393035

HgeneSTK39

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

24393035

HgeneSTK39

GO:1901380

negative regulation of potassium ion transmembrane transport

24393035

HgeneSTK39

GO:1905408

negative regulation of creatine transmembrane transporter activity

25531585

HgeneSTK39

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

25531585

TgeneOXSR1

GO:0006468

protein phosphorylation

14707132

TgeneOXSR1

GO:0006884

cell volume homeostasis

36318922

TgeneOXSR1

GO:0018107

peptidyl-threonine phosphorylation

24393035

TgeneOXSR1

GO:0035556

intracellular signal transduction

14707132

TgeneOXSR1

GO:0046777

protein autophosphorylation

22052202

TgeneOXSR1

GO:0070294

renal sodium ion absorption

18270262

TgeneOXSR1

GO:0071474

cellular hyperosmotic response

36318922


check buttonKinase Fusion gene breakpoints across STK39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across OXSR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-A6-2677STK39chr2

169018296

OXSR1chr3

38232221



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:169018296/:38232221)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STK39

Q9UEW8

OXSR1

O95747

FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}.FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328, PubMed:17721439). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of STK39_OXSR1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
OXSR1O95747humanSLC12A1Q13621T105LQtFGHNtMDAVPKIAA_permease_N
OXSR1O95747humanSLC12A2P55011T207YYDtHTNtyYLRtFGAA_permease_N
OXSR1O95747humanSLC12A1Q13621T118KIEYYRNtGsISGPKAA_permease_N
OXSR1O95747humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
OXSR1O95747humanSLC12A3P55017T60MRtFGYNtIDVVPtYAA_permease_N
OXSR1O95747humanSLC12A3P55017S73tYEHyANstQPGEPRAA_permease_N
OXSR1O95747humanSMAD3P84022T179PQSNIPEtPPPGYLS
OXSR1O95747humanSLC12A2P55011T212TNtyYLRtFGHNtMDAA_permease_N
OXSR1O95747humanSLC12A2P55011T230RIDHyRHtAAQLGEkAA_permease_N
OXSR1O95747humanSLC12A2P55011T203HQHYYYDtHTNtyYLAA_permease_N
OXSR1O95747humanSLC12A1Q13621S120EYYRNtGsISGPKVNAA_permease_N
OXSR1O95747humanSLC12A1Q13621T95AYDsHTNtYYLQtFGAA_permease_N
OXSR1O95747humanMAPTP10636-8T30RKDQGGytMHQDQEG
OXSR1O95747humanSLC12A1Q13621T100TNtYYLQtFGHNtMDAA_permease_N
OXSR1O95747humanSLC12A3P55017T46SSHPSHLtHSStFCMAA_permease_N
OXSR1O95747humanSLC12A3P55017T55SStFCMRtFGYNtIDAA_permease_N
OXSR1O95747humanSMAD2Q15796T220QSNYIPEtPPPGYIS
OXSR1O95747humanSLC12A2P55011T217LRtFGHNtMDAVPRIAA_permease_N
STK39Q9UEW8humanSLC12A1Q13621T105LQtFGHNtMDAVPKIAA_permease_N
STK39Q9UEW8humanSLC4A4Q9Y6R1S65ERIsENysDKsDIEN
STK39Q9UEW8humanSLC12A2P55011T207YYDtHTNtyYLRtFGAA_permease_N
STK39Q9UEW8humanSLC12A2P55011T203HQHYYYDtHTNtyYLAA_permease_N
STK39Q9UEW8humanSLC12A6Q9UHW9T1048YQEKVHMtWTKDKYMSLC12
STK39Q9UEW8humanSLC12A1Q13621T95AYDsHTNtYYLQtFGAA_permease_N
STK39Q9UEW8humanSLC12A6Q9UHW9S96IEDLSQNsITGEHSQ
STK39Q9UEW8humanSLC12A1Q13621T100TNtYYLQtFGHNtMDAA_permease_N
STK39Q9UEW8humanSLC12A3P55017T60MRtFGYNtIDVVPtYAA_permease_N
STK39Q9UEW8humanSLC12A3P55017T46SSHPSHLtHSStFCMAA_permease_N
STK39Q9UEW8humanSLC12A3P55017T55SStFCMRtFGYNtIDAA_permease_N
STK39Q9UEW8humanSNAI1O95863T203QGHVRtHtGEkPFSC
STK39Q9UEW8humanSLC12A2P55011T212TNtyYLRtFGHNtMDAA_permease_N


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
OXSR1IDDescription0.00e+00
OXSR1GO:0055064chloride ion homeostasis6.72e-06
OXSR1GO:0055081monoatomic anion homeostasis6.72e-06
OXSR1GO:0055075potassium ion homeostasis1.56e-05
OXSR1GO:0006884cell volume homeostasis1.56e-05
OXSR1GO:0008361regulation of cell size1.56e-05
OXSR1GO:0055078sodium ion homeostasis2.19e-05
OXSR1GO:1990573potassium ion import across plasma membrane2.19e-05
OXSR1GO:0032535regulation of cellular component size1.50e-04
OXSR1GO:0007440foregut morphogenesis1.96e-04
OXSR1GO:0048340paraxial mesoderm morphogenesis1.96e-04
OXSR1GO:1902476chloride transmembrane transport1.96e-04
OXSR1GO:0006821chloride transport2.64e-04
OXSR1GO:0098661inorganic anion transmembrane transport2.79e-04
OXSR1GO:0098659inorganic cation import across plasma membrane2.79e-04
OXSR1GO:0099587inorganic ion import across plasma membrane2.79e-04
OXSR1GO:0098656monoatomic anion transmembrane transport3.23e-04
OXSR1GO:0048339paraxial mesoderm development4.12e-04
OXSR1GO:0015698inorganic anion transport4.12e-04
OXSR1GO:0060039pericardium development4.12e-04
OXSR1GO:0006820monoatomic anion transport4.12e-04
OXSR1GO:0031053primary miRNA processing4.12e-04
OXSR1GO:0038092nodal signaling pathway4.12e-04
OXSR1GO:0035725sodium ion transmembrane transport4.12e-04
OXSR1GO:0023019signal transduction involved in regulation of gene expression4.59e-04
OXSR1GO:0098739import across plasma membrane6.19e-04
OXSR1GO:0071805potassium ion transmembrane transport6.38e-04
OXSR1GO:0030325adrenal gland development6.66e-04
OXSR1GO:0006813potassium ion transport8.10e-04
OXSR1GO:0006814sodium ion transport8.52e-04
OXSR1GO:0048701embryonic cranial skeleton morphogenesis1.57e-03
OXSR1GO:0035196miRNA processing1.66e-03
OXSR1GO:0032924activin receptor signaling pathway1.69e-03
OXSR1GO:0048546digestive tract morphogenesis1.69e-03
OXSR1GO:0072132mesenchyme morphogenesis2.23e-03
OXSR1GO:0010718positive regulation of epithelial to mesenchymal transition2.32e-03
OXSR1GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process2.99e-03
OXSR1GO:1904888cranial skeletal system development3.27e-03
OXSR1GO:0009880embryonic pattern specification3.28e-03
OXSR1GO:0001707mesoderm formation3.28e-03
OXSR1GO:0061045negative regulation of wound healing3.28e-03
OXSR1GO:0048332mesoderm morphogenesis3.37e-03
OXSR1GO:0007492endoderm development3.83e-03
OXSR1GO:0060395SMAD protein signal transduction3.83e-03
OXSR1GO:0070918regulatory ncRNA processing3.92e-03
OXSR1GO:0048704embryonic skeletal system morphogenesis4.58e-03
OXSR1GO:1903035negative regulation of response to wounding4.67e-03
OXSR1GO:0001657ureteric bud development4.67e-03
OXSR1GO:0072163mesonephric epithelium development4.67e-03
OXSR1GO:0072164mesonephric tubule development4.67e-03

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Related Drugs to STK39_OXSR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning STK39-OXSR1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to STK39_OXSR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate