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Kinase Fusion Gene:SUN2_ULK1 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: SUN2_ULK1 | KinaseFusionDB ID: KFG6313 | FusionGDB2.0 ID: KFG6313 | Hgene | Tgene | Gene symbol | SUN2 | ULK1 | Gene ID | 25777 | 8408 | |
Gene name | Sad1 and UNC84 domain containing 2 | unc-51 like autophagy activating kinase 1 | ||||||||||
Synonyms | UNC84B|rab5IP | ATG1|ATG1A|UNC51|Unc51.1|hATG1 | ||||||||||
Cytomap | 22q13.1 | 12q24.33 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | SUN domain-containing protein 2Sad1 unc-84 domain protein 2nuclear envelope proteinprotein unc-84 homolog Brab5-interacting proteinsad1/unc-84 protein-like 2unc-84 homolog B | serine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homolog | ||||||||||
Modification date | 20240403 | 20240407 | ||||||||||
UniProtAcc | Q9UH99 | O75385 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000216064, ENST00000405018, ENST00000405510, ENST00000406622, ENST00000411587, | ENST00000321867, ENST00000540647, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: SUN2 [Title/Abstract] AND ULK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SUN2(39135775)-ULK1(132405706), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SUN2 | GO:0090292 | nuclear matrix anchoring at nuclear membrane | 19933576 |
Tgene | ULK1 | GO:0000045 | autophagosome assembly | 19225151|28890335 |
Tgene | ULK1 | GO:0006914 | autophagy | 18936157|25891078 |
Tgene | ULK1 | GO:0008285 | negative regulation of cell population proliferation | 21795849 |
Tgene | ULK1 | GO:0010508 | positive regulation of autophagy | 25126726|29487085|35670107 |
Tgene | ULK1 | GO:0016241 | regulation of macroautophagy | 20921139 |
Tgene | ULK1 | GO:0018105 | peptidyl-serine phosphorylation | 25126726|27103069 |
Tgene | ULK1 | GO:0018107 | peptidyl-threonine phosphorylation | 27103069 |
Tgene | ULK1 | GO:0031333 | negative regulation of protein-containing complex assembly | 25126726 |
Tgene | ULK1 | GO:0046777 | protein autophosphorylation | 18936157 |
Tgene | ULK1 | GO:1903059 | regulation of protein lipidation | 19225151 |
Kinase Fusion gene breakpoints across SUN2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across ULK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | BM808097 | SUN2 | chr22 | 39135775 | ULK1 | chr12 | 132405706 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39135775/:132405706) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SUN2 | ULK1 |
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000250|UniProtKB:Q8BJS4, ECO:0000269|PubMed:18396275, ECO:0000305}. | FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:31123703, PubMed:29487085). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of SUN2_ULK1 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
ULK1 | O75385 | human | CDC37 | Q16543 | S339 | HMQRCIDsGLWVPNs | CDC37_C |
ULK1 | O75385 | human | ATG9A | Q7Z3C6 | S761 | QsIPRsAsYPCAAPR | |
ULK1 | O75385 | human | FBP1 | P09467 | S88 | LVMNMLKsSFATCVL | FBPase |
ULK1 | O75385 | human | RIPK1 | Q13546 | T337 | ssRsNsAtEQPGSLH | |
ULK1 | O75385 | human | NR3C2 | P08235 | S843 | NEEKMHQsAMYELCQ | Hormone_recep |
ULK1 | O75385 | human | RIPK1 | Q13546 | S296 | YLsQLEEsVEEDVks | |
ULK1 | O75385 | human | SMCR8 | Q8TEV9 | S400 | PSQDRPPsSsLEECP | |
ULK1 | O75385 | human | STING1 | Q86WV6 | S366 | QEPELLIsGMEkPLP | |
ULK1 | O75385 | human | BNIP3L | O60238 | S35 | PPAGLNssWVELPMN | BNIP3 |
ULK1 | O75385 | human | ATG13 | O75143 | S355 | DTETVSNssEGRAsP | |
ULK1 | O75385 | human | YAP1 | P46937 | S227 | VQQNMMNsASGPLPD | |
ULK1 | O75385 | human | ATG16L1 | Q676U5 | S278 | PAGGLLDsITNIFGR | |
ULK1 | O75385 | human | SQSTM1 | Q13501 | S349 | sskEVDPstGELQsL | |
ULK1 | O75385 | human | ATG9A | Q7Z3C6 | S14 | EyQRLEAsysDsPPG | |
ULK1 | O75385 | human | RIPK1 | Q13546 | S335 | VPssRsNsAtEQPGS | |
ULK1 | O75385 | human | PFKM | P08237 | S762 | yEIDLDTsDHAHLEH | |
ULK1 | O75385 | human | BECN1 | Q14457 | S30 | QPLkLDTsFkILDRV | |
ULK1 | O75385 | human | RPTOR | Q8N122 | S792 | DKMRRAssYSsLNSL | |
ULK1 | O75385 | human | RPTOR | Q8N122 | S877 | HIHQAGGsPPAssts | |
ULK1 | O75385 | human | BECN1 | Q14457 | S337 | LVPyGNHsYLESLTD | APG6 |
ULK1 | O75385 | human | ENO1 | P06733 | S282 | QLADLyksFIkDyPV | Enolase_C |
ULK1 | O75385 | human | BECN1 | Q14457 | S96 | MstEsANsFTLIGEA | |
ULK1 | O75385 | human | RB1CC1 | Q8TDY2 | S986 | ELQsLEQsHLkELED | |
ULK1 | O75385 | human | RB1CC1 | Q8TDY2 | S943 | EMENIMHsQNCEIKE | |
ULK1 | O75385 | human | SMCR8 | Q8TEV9 | S562 | IRFQASIsPPELGET | |
ULK1 | O75385 | human | SDCBP | O00560 | S60 | LsQyMGLsLNEEEIR | Peptidase_M50 |
ULK1 | O75385 | human | ATG4B | Q9Y4P1 | S316 | SIAELDPsIAVGFFC | Peptidase_C54 |
ULK1 | O75385 | human | SESN2 | P58004 | S254 | NNsGGFEsARDVEAL | PA26 |
ULK1 | O75385 | human | ULK1 | O75385 | S317 | SHLASPPsLGEMQQL | |
ULK1 | O75385 | human | RIPK1 | Q13546 | S291 | kFRPFYLsQLEEsVE | |
ULK1 | O75385 | human | SDCBP | O00560 | S6 | __MsLyPsLEDLkVD | |
ULK1 | O75385 | human | HK1 | P19367 | S124 | NIVHGSGsQLFDHVA | Hexokinase_1 |
ULK1 | O75385 | human | RIPK1 | Q13546 | S345 | EQPGSLHssQGLGMG | |
ULK1 | O75385 | human | BNIP3 | Q12983 | S17 | QEESLQGsWVELHFs | BNIP3 |
ULK1 | O75385 | human | SESN2 | P58004 | S73 | GLEALMSsGRVDNLA | PA26 |
ULK1 | O75385 | human | AMBRA1 | Q9C0C7 | S635 | ssSRLELsSSAsPQE | |
ULK1 | O75385 | human | SMCR8 | Q8TEV9 | S492 | SKsDsQAsLtVPLsP | |
ULK1 | O75385 | human | DENND3 | A2RUS2 | S490 | ELAPRNSsLRLtDTA | |
ULK1 | O75385 | human | FLCN | Q8NFG4 | S406 | CVRIIPYsSQYEEAY | Folliculin_C |
ULK1 | O75385 | human | AMBRA1 | Q9C0C7 | S465 | SQASVYTsATEGRGF | |
ULK1 | O75385 | human | RPTOR | Q8N122 | S855 | QRVLDtssLtQsAPA | |
ULK1 | O75385 | human | RPTOR | Q8N122 | S859 | DtssLtQsAPAsPtN | |
ULK1 | O75385 | human | SQSTM1 | Q13501 | S403 | ESLSQMLsMGFsDEG | UBA_5 |
ULK1 | O75385 | human | SEC23A | Q15436 | S207 | LQEMLGLskVPLTQA | Sec23_trunk |
ULK1 | O75385 | human | ATG13 | O75143 | S389 | INQVTLTsLDIPFAM | |
ULK1 | O75385 | human | FBP1 | P09467 | S63 | HLyGIAGsTNVTGDQ | FBPase |
ULK1 | O75385 | human | SMCR8 | Q8TEV9 | T666 | ASRDISktsLDNYSD | |
ULK1 | O75385 | human | PFKM | P08237 | S74 | EATWESVsMMLQLGG | PFK |
ULK1 | O75385 | human | RIPK1 | Q13546 | S357 | GMGPVEEsWFAPSLE | |
ULK1 | O75385 | human | PRKN | O60260 | S108 | sLTRVDLsssVLPGD | |
ULK1 | O75385 | human | ATG101 | Q9BSB4 | S203 | ITDALGTsVTTTMRR | |
ULK1 | O75385 | human | RIPK1 | Q13546 | S389 | ANyHLyGsRMDRQTK | |
ULK1 | O75385 | human | SEC23B | Q15437 | S186 | SCEGISksYVFRGTk | Sec23_trunk |
ULK1 | O75385 | human | ENO1 | P06733 | S115 | ANAILGVsLAVCkAG | Enolase_N |
ULK1 | O75385 | human | RPTOR | Q8N122 | S863 | LtQsAPAsPtNkGVH | |
ULK1 | O75385 | human | FLCN | Q8NFG4 | S537 | EDTQkLLsILGAsEE | Folliculin_C |
ULK1 | O75385 | human | FUNDC1 | Q8IVP5 | S17 | DyEsDDDsyEVLDLT | |
ULK1 | O75385 | human | FLCN | Q8NFG4 | S542 | LLsILGAsEEDNVKL | Folliculin_C |
ULK1 | O75385 | human | HK1 | P19367 | S364 | TRLGVEPsDDDCVSV | Hexokinase_2 |
ULK1 | O75385 | human | RIPK1 | Q13546 | S320 | AVVkRMQsLQLdCVA | |
ULK1 | O75385 | human | RB1CC1 | Q8TDY2 | S1323 | EMQNVRTsLIAEQQT | |
ULK1 | O75385 | human | RIPK1 | Q13546 | S333 | VAVPssRsNsAtEQP | |
ULK1 | O75385 | human | RIPK1 | Q13546 | S346 | QPGSLHssQGLGMGP | |
ULK1 | O75385 | human | MAD1L1 | Q9Y6D9 | S546 | RTKVLHMsLNPTsVA | MAD |
ULK1 | O75385 | human | BECN1 | Q14457 | S15 | NNSTMQVsFVCQRCS | |
ULK1 | O75385 | human | SEC16A | O15027 | S846 | LAQPINFsVSLSNSH | |
ULK1 | O75385 | human | ATG14 | Q6ZNE5 | S29 | LARDLVDsVDDAEGL | |
ULK1 | O75385 | human | SEC23A | Q15436 | T405 | FKMGFGGtLEIKTSR | Sec23_BS |
ULK1 | O75385 | human | ATG101 | Q9BSB4 | S11 | RSEVLEVsVEGRQVE | ATG101 |
ULK1 | O75385 | human | PIK3C3 | Q8NEB9 | S249 | ESsPILTsFELVKVP | |
ULK1 | O75385 | human | DENND3 | A2RUS2 | S472 | THRRMVVsMPNLQDI | |
ULK1 | O75385 | human | RIPK1 | Q13546 | S262 | YCPREIIsLMKLCWE | PK_Tyr_Ser-Thr |
ULK1 | O75385 | human | BECN1 | Q14457 | S279 | ATFHIWHsGQFGTIN | APG6 |
ULK1 | O75385 | human | FLII | Q13045 | S64 | KLEHLSVsHNNLTTL | LRR_8 |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
ULK1 | ID | Description | 0.00e+00 |
ULK1 | GO:0016236 | macroautophagy | 2.30e-21 |
ULK1 | GO:0061912 | selective autophagy | 4.62e-21 |
ULK1 | GO:0000422 | autophagy of mitochondrion | 4.62e-21 |
ULK1 | GO:0061726 | mitochondrion disassembly | 4.62e-21 |
ULK1 | GO:1903008 | organelle disassembly | 1.34e-20 |
ULK1 | GO:0010508 | positive regulation of autophagy | 1.70e-20 |
ULK1 | GO:0010506 | regulation of autophagy | 7.32e-20 |
ULK1 | GO:0000045 | autophagosome assembly | 2.46e-18 |
ULK1 | GO:1905037 | autophagosome organization | 4.91e-18 |
ULK1 | GO:0022411 | cellular component disassembly | 2.18e-17 |
ULK1 | GO:0007033 | vacuole organization | 4.47e-16 |
ULK1 | GO:0031331 | positive regulation of cellular catabolic process | 5.89e-16 |
ULK1 | GO:0000423 | mitophagy | 4.68e-13 |
ULK1 | GO:0098780 | response to mitochondrial depolarisation | 5.46e-13 |
ULK1 | GO:0016241 | regulation of macroautophagy | 2.58e-11 |
ULK1 | GO:0016239 | positive regulation of macroautophagy | 9.94e-11 |
ULK1 | GO:0016237 | lysosomal microautophagy | 1.92e-09 |
ULK1 | GO:0034497 | protein localization to phagophore assembly site | 6.13e-09 |
ULK1 | GO:1903059 | regulation of protein lipidation | 2.60e-07 |
ULK1 | GO:0042594 | response to starvation | 4.33e-07 |
ULK1 | GO:0006605 | protein targeting | 6.95e-07 |
ULK1 | GO:0071496 | cellular response to external stimulus | 7.92e-07 |
ULK1 | GO:0006096 | glycolytic process | 9.50e-07 |
ULK1 | GO:0006497 | protein lipidation | 1.01e-06 |
ULK1 | GO:0031669 | cellular response to nutrient levels | 1.01e-06 |
ULK1 | GO:0031667 | response to nutrient levels | 1.01e-06 |
ULK1 | GO:0016052 | carbohydrate catabolic process | 1.07e-06 |
ULK1 | GO:0050746 | regulation of lipoprotein metabolic process | 1.26e-06 |
ULK1 | GO:0042158 | lipoprotein biosynthetic process | 1.27e-06 |
ULK1 | GO:0009267 | cellular response to starvation | 1.84e-06 |
ULK1 | GO:0044804 | nucleophagy | 1.85e-06 |
ULK1 | GO:0031668 | cellular response to extracellular stimulus | 1.95e-06 |
ULK1 | GO:0006090 | pyruvate metabolic process | 3.61e-06 |
ULK1 | GO:0062197 | cellular response to chemical stress | 4.65e-06 |
ULK1 | GO:0042157 | lipoprotein metabolic process | 7.58e-06 |
ULK1 | GO:0010639 | negative regulation of organelle organization | 1.24e-05 |
ULK1 | GO:0010821 | regulation of mitochondrion organization | 1.45e-05 |
ULK1 | GO:0007034 | vacuolar transport | 2.57e-05 |
ULK1 | GO:0030242 | autophagy of peroxisome | 2.57e-05 |
ULK1 | GO:0034727 | piecemeal microautophagy of the nucleus | 2.57e-05 |
ULK1 | GO:0001558 | regulation of cell growth | 3.09e-05 |
ULK1 | GO:1903146 | regulation of autophagy of mitochondrion | 3.13e-05 |
ULK1 | GO:0006002 | fructose 6-phosphate metabolic process | 3.28e-05 |
ULK1 | GO:0006006 | glucose metabolic process | 4.92e-05 |
ULK1 | GO:0072594 | establishment of protein localization to organelle | 5.77e-05 |
ULK1 | GO:0006623 | protein targeting to vacuole | 6.02e-05 |
ULK1 | GO:0042149 | cellular response to glucose starvation | 6.96e-05 |
ULK1 | GO:1903599 | positive regulation of autophagy of mitochondrion | 8.06e-05 |
ULK1 | GO:0016049 | cell growth | 9.57e-05 |
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Related Drugs to SUN2_ULK1 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning SUN2-ULK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to SUN2_ULK1 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |