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Kinase Fusion Gene:BMP2K_SLC4A4 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: BMP2K_SLC4A4 | KinaseFusionDB ID: KFG637 | FusionGDB2.0 ID: KFG637 | Hgene | Tgene | Gene symbol | BMP2K | SLC4A4 | Gene ID | 55589 | 8671 | |
| Gene name | BMP2 inducible kinase | solute carrier family 4 member 4 | ||||||||||
| Synonyms | BIKE|HRIHFB2017 | HNBC1|KNBC|NBC1|NBC2|NBCe1|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC | ||||||||||
| Cytomap | 4q21.21 | 4q13.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | BMP-2-inducible protein kinase | electrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransporterkidney type Na+/HCO3- cotransporterpancreatic sodium bicarbonate cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate co | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | Q9NSY1 | Q9Y6R1 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000335016, ENST00000502871, | ENST00000512686, ENST00000514331, ENST00000264485, ENST00000340595, ENST00000351898, ENST00000425175, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: BMP2K [Title/Abstract] AND SLC4A4 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BMP2K(79772210)-SLC4A4(72352665), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC4A4 | GO:0006814 | sodium ion transport | 16769890 |
| Tgene | SLC4A4 | GO:0015701 | bicarbonate transport | 10069984 |
| Tgene | SLC4A4 | GO:0035725 | sodium ion transmembrane transport | 10069984 |
| Tgene | SLC4A4 | GO:0042391 | regulation of membrane potential | 10069984|15273250 |
| Tgene | SLC4A4 | GO:0051453 | regulation of intracellular pH | 10069984 |
| Kinase Fusion gene breakpoints across BMP2K (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across SLC4A4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-E9-A22D-01A | BMP2K | chr4 | 79772210 | SLC4A4 | chr4 | 72352665 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:79772210/chr4:72352665) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BMP2K | SLC4A4 |
| FUNCTION: May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. | FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of BMP2K_SLC4A4 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| BMP2K | Q9NSY1 | human | AP2M1 | Q96CW1 | T156 | SQItsQVtGQIGWRR | |
| BMP2K | Q9NSY1 | human | CLINT1 | Q14677 | T294 | LGAAAHytGDkAsPD |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| BMP2K | ID | Description | 0.00e+00 |
| BMP2K | GO:0048268 | clathrin coat assembly | 1.15e-02 |
| BMP2K | GO:0097494 | regulation of vesicle size | 1.15e-02 |
| BMP2K | GO:1900242 | regulation of synaptic vesicle endocytosis | 1.15e-02 |
| BMP2K | GO:0098884 | postsynaptic neurotransmitter receptor internalization | 1.15e-02 |
| BMP2K | GO:0140239 | postsynaptic endocytosis | 1.15e-02 |
| BMP2K | GO:1903421 | regulation of synaptic vesicle recycling | 1.15e-02 |
| BMP2K | GO:0002092 | positive regulation of receptor internalization | 1.15e-02 |
| BMP2K | GO:1903077 | negative regulation of protein localization to plasma membrane | 1.15e-02 |
| BMP2K | GO:1904376 | negative regulation of protein localization to cell periphery | 1.15e-02 |
| BMP2K | GO:0099590 | neurotransmitter receptor internalization | 1.15e-02 |
| BMP2K | GO:1905476 | negative regulation of protein localization to membrane | 1.25e-02 |
| BMP2K | GO:0072583 | clathrin-dependent endocytosis | 1.45e-02 |
| BMP2K | GO:0048260 | positive regulation of receptor-mediated endocytosis | 1.51e-02 |
| BMP2K | GO:0002090 | regulation of receptor internalization | 1.67e-02 |
| BMP2K | GO:0048488 | synaptic vesicle endocytosis | 1.67e-02 |
| BMP2K | GO:0140238 | presynaptic endocytosis | 1.67e-02 |
| BMP2K | GO:0036465 | synaptic vesicle recycling | 1.71e-02 |
| BMP2K | GO:0006900 | vesicle budding from membrane | 1.71e-02 |
| BMP2K | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | 1.71e-02 |
| BMP2K | GO:1903076 | regulation of protein localization to plasma membrane | 2.00e-02 |
| BMP2K | GO:0048259 | regulation of receptor-mediated endocytosis | 2.03e-02 |
| BMP2K | GO:0031623 | receptor internalization | 2.15e-02 |
| BMP2K | GO:1904375 | regulation of protein localization to cell periphery | 2.20e-02 |
| BMP2K | GO:0045807 | positive regulation of endocytosis | 2.39e-02 |
| BMP2K | GO:1905475 | regulation of protein localization to membrane | 2.67e-02 |
| BMP2K | GO:0031503 | protein-containing complex localization | 2.67e-02 |
| BMP2K | GO:0099504 | synaptic vesicle cycle | 2.71e-02 |
| BMP2K | GO:1903828 | negative regulation of protein localization | 2.80e-02 |
| BMP2K | GO:0099003 | vesicle-mediated transport in synapse | 2.80e-02 |
| BMP2K | GO:0006898 | receptor-mediated endocytosis | 3.17e-02 |
| BMP2K | GO:0072659 | protein localization to plasma membrane | 3.35e-02 |
| BMP2K | GO:0030100 | regulation of endocytosis | 3.35e-02 |
| BMP2K | GO:1990778 | protein localization to cell periphery | 3.88e-02 |
| BMP2K | GO:0016050 | vesicle organization | 3.88e-02 |
| BMP2K | GO:0032535 | regulation of cellular component size | 3.88e-02 |
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Related Drugs to BMP2K_SLC4A4 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning BMP2K-SLC4A4 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to BMP2K_SLC4A4 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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