| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:TAOK1_EFCAB5 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: TAOK1_EFCAB5 | KinaseFusionDB ID: KFG6370 | FusionGDB2.0 ID: KFG6370 | Hgene | Tgene | Gene symbol | TAOK1 | EFCAB5 | Gene ID | 57551 | 374786 | |
| Gene name | TAO kinase 1 | EF-hand calcium binding domain 5 | ||||||||||
| Synonyms | DDIB|KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1 | - | ||||||||||
| Cytomap | 17q11.2 | 17q11.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin | EF-hand calcium-binding domain-containing protein 5 | ||||||||||
| Modification date | 20240407 | 20240403 | ||||||||||
| UniProtAcc | Q7L7X3 | A4FU69 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261716, ENST00000536202, | ENST00000320856, ENST00000378738, ENST00000394832, ENST00000394835, ENST00000534836, ENST00000536908, ENST00000541045, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TAOK1 [Title/Abstract] AND EFCAB5 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TAOK1(27844674)-EFCAB5(28418889), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK1 | GO:0006974 | DNA damage response | 17396146 |
| Hgene | TAOK1 | GO:0016310 | phosphorylation | 12639963 |
| Hgene | TAOK1 | GO:0046330 | positive regulation of JNK cascade | 16407310 |
| Hgene | TAOK1 | GO:0097194 | execution phase of apoptosis | 16407310 |
| Kinase Fusion gene breakpoints across TAOK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across EFCAB5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-AR-A0TY-01A | TAOK1 | chr17 | 27844674 | EFCAB5 | chr17 | 28418889 |
| ChimerDB4 | TCGA-AR-A0TY-01A | TAOK1 | chr17 | 27844674 | EFCAB5 | chr17 | 28434852 |
| ChimerDB4 | TCGA-AR-A0TY | TAOK1 | chr17 | 27844674 | EFCAB5 | chr17 | 28434851 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27844674/:28418889) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK1 | EFCAB5 |
| FUNCTION: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of TAOK1_EFCAB5 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| TAOK1 | Q7L7X3 | human | RND3 | P61587 | S210 | KNVKRNKsQRATKRI | |
| TAOK1 | Q7L7X3 | human | RND3 | P61587 | S218 | QRATKRIsHMPsRPE | |
| TAOK1 | Q7L7X3 | human | TAOK1 | Q7L7X3 | T440 | RNREHFAtIRtAsLV | |
| TAOK1 | Q7L7X3 | human | LATS1 | O95835 | T1079 | EHAFyEFtFRRFFDD | |
| TAOK1 | Q7L7X3 | human | TAOK1 | Q7L7X3 | T443 | EHFAtIRtAsLVTRQ | |
| TAOK1 | Q7L7X3 | human | RND3 | P61587 | S240 | LRKDKAKsCTVM___ | |
| TAOK1 | Q7L7X3 | human | SEPTIN7 | Q16181 | T426 | EQQNssrtLEKNKKK | |
| TAOK1 | Q7L7X3 | human | TAOK1 | Q7L7X3 | S181 | SMAsPANsFVGtPyW | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| TAOK1 | ID | Description | 0.00e+00 |
| TAOK1 | GO:0000086 | G2/M transition of mitotic cell cycle | 3.28e-02 |
| TAOK1 | GO:0044839 | cell cycle G2/M phase transition | 3.28e-02 |
| TAOK1 | GO:0032956 | regulation of actin cytoskeleton organization | 5.94e-02 |
| TAOK1 | GO:1902855 | regulation of non-motile cilium assembly | 5.94e-02 |
| TAOK1 | GO:0032970 | regulation of actin filament-based process | 5.94e-02 |
| TAOK1 | GO:1902903 | regulation of supramolecular fiber organization | 5.94e-02 |
| TAOK1 | GO:0045786 | negative regulation of cell cycle | 5.94e-02 |
| TAOK1 | GO:0007015 | actin filament organization | 5.94e-02 |
| TAOK1 | GO:0044772 | mitotic cell cycle phase transition | 5.94e-02 |
| TAOK1 | GO:0060644 | mammary gland epithelial cell differentiation | 5.94e-02 |
| TAOK1 | GO:0051220 | cytoplasmic sequestering of protein | 6.05e-02 |
| TAOK1 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 6.05e-02 |
| TAOK1 | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | 6.05e-02 |
| TAOK1 | GO:1901985 | positive regulation of protein acetylation | 6.05e-02 |
| TAOK1 | GO:0007026 | negative regulation of microtubule depolymerization | 6.05e-02 |
| TAOK1 | GO:0045724 | positive regulation of cilium assembly | 6.11e-02 |
| TAOK1 | GO:0031114 | regulation of microtubule depolymerization | 6.16e-02 |
| TAOK1 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 6.27e-02 |
| TAOK1 | GO:0007095 | mitotic G2 DNA damage checkpoint signaling | 6.27e-02 |
| TAOK1 | GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 6.27e-02 |
| TAOK1 | GO:1900181 | negative regulation of protein localization to nucleus | 6.27e-02 |
| TAOK1 | GO:1901983 | regulation of protein acetylation | 6.27e-02 |
| TAOK1 | GO:0035329 | hippo signaling | 6.27e-02 |
| TAOK1 | GO:0001825 | blastocyst formation | 6.27e-02 |
| TAOK1 | GO:0007019 | microtubule depolymerization | 6.27e-02 |
| TAOK1 | GO:0044818 | mitotic G2/M transition checkpoint | 6.68e-02 |
| TAOK1 | GO:0030520 | intracellular estrogen receptor signaling pathway | 6.68e-02 |
| TAOK1 | GO:0070050 | neuron cellular homeostasis | 6.68e-02 |
| TAOK1 | GO:1905515 | non-motile cilium assembly | 6.68e-02 |
| TAOK1 | GO:0061180 | mammary gland epithelium development | 6.68e-02 |
| TAOK1 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 6.68e-02 |
| TAOK1 | GO:1901880 | negative regulation of protein depolymerization | 6.68e-02 |
| TAOK1 | GO:1902750 | negative regulation of cell cycle G2/M phase transition | 6.68e-02 |
| TAOK1 | GO:1902017 | regulation of cilium assembly | 6.68e-02 |
| TAOK1 | GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 6.68e-02 |
| TAOK1 | GO:0043242 | negative regulation of protein-containing complex disassembly | 6.68e-02 |
| TAOK1 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 6.68e-02 |
| TAOK1 | GO:0044773 | mitotic DNA damage checkpoint signaling | 6.68e-02 |
| TAOK1 | GO:1902117 | positive regulation of organelle assembly | 6.68e-02 |
| TAOK1 | GO:1904029 | regulation of cyclin-dependent protein kinase activity | 6.68e-02 |
| TAOK1 | GO:1901879 | regulation of protein depolymerization | 6.68e-02 |
| TAOK1 | GO:0044774 | mitotic DNA integrity checkpoint signaling | 6.68e-02 |
| TAOK1 | GO:0046330 | positive regulation of JNK cascade | 6.68e-02 |
| TAOK1 | GO:0021954 | central nervous system neuron development | 6.68e-02 |
| TAOK1 | GO:0097194 | execution phase of apoptosis | 6.68e-02 |
| TAOK1 | GO:0045185 | maintenance of protein location | 6.68e-02 |
| TAOK1 | GO:0045995 | regulation of embryonic development | 6.68e-02 |
| TAOK1 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 6.68e-02 |
| TAOK1 | GO:0046620 | regulation of organ growth | 6.68e-02 |
Top |
Related Drugs to TAOK1_EFCAB5 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning TAOK1-EFCAB5 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to TAOK1_EFCAB5 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |