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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:TGFBR1_COL15A1

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: TGFBR1_COL15A1
	KinaseFusionDB ID: KFG6511
	FusionGDB2.0 ID: KFG6511
		Hgene	Tgene
	Gene symbol	TGFBR1	COL15A1
	Gene ID	7046	1306
	Gene name	transforming growth factor beta receptor 1	collagen type XV alpha 1 chain
	Synonyms	AAT5\|ACVRLK4\|ALK-5\|ALK5\|ESS1\|LDS1\|LDS1A\|LDS2A\|MSSE\|SKR4\|TBR-i\|TBRI\|TGFR-1\|tbetaR-I	-
	Cytomap	9q22.33	9q22.33
	Type of gene	protein-coding	protein-coding
	Description	TGF-beta receptor type-1activin A receptor type II-like kinase, 53kDaactivin A receptor type II-like protein kinase of 53kDactivin receptor-like kinase 5mutant transforming growth factor beta receptor Iserine/threonine-protein kinase receptor R4tran	collagen alpha-1(XV) chaincollagen XV, alpha-1 polypeptidecollagen type XV proteoglycancollagen, type XV, alpha 1endostatin-XVrestin
	Modification date	20240403	20240305
	UniProtAcc	P36897	P39059
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000374990, ENST00000374994, ENST00000550253, ENST00000552516,	ENST00000467052, ENST00000375001,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: TGFBR1 [Title/Abstract] AND COL15A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TGFBR1(101910066)-COL15A1(101777699), # samples:3

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TGFBR1	GO:0001837	epithelial to mesenchymal transition	15761148
Hgene	TGFBR1	GO:0006355	regulation of DNA-templated transcription	14517293
Hgene	TGFBR1	GO:0007165	signal transduction	14633705
Hgene	TGFBR1	GO:0007179	transforming growth factor beta receptor signaling pathway	1333888\|9311995\|9389648\|11157754\|12065756
Hgene	TGFBR1	GO:0018105	peptidyl-serine phosphorylation	15761148
Hgene	TGFBR1	GO:0030307	positive regulation of cell growth	18625725
Hgene	TGFBR1	GO:0030335	positive regulation of cell migration	19736306
Hgene	TGFBR1	GO:0031396	regulation of protein ubiquitination	18758450
Hgene	TGFBR1	GO:0045893	positive regulation of DNA-templated transcription	9311995\|9389648
Hgene	TGFBR1	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	18625725
Hgene	TGFBR1	GO:0060391	positive regulation of SMAD protein signal transduction	9311995\|9389648\|11157754\|12015308\|18625725\|19736306
Hgene	TGFBR1	GO:0070723	response to cholesterol	17878231
Hgene	TGFBR1	GO:0071560	cellular response to transforming growth factor beta stimulus	19494318
Hgene	TGFBR1	GO:2001235	positive regulation of apoptotic signaling pathway	18758450

Kinase Fusion gene breakpoints across TGFBR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across COL15A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-RC-A6M3-01A	TGFBR1	chr9	101910066	COL15A1	chr9	101777699

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000374994	ENST00000375001	TGFBR1	chr9	101910066	COL15A1	chr9	101777699	5218	1399

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000374994_ENST00000375001_TGFBR1_chr9_101910066_COL15A1_chr9_101777699_length(amino acids)=1399
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS
KTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN
GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL
RPNIPNRWQSCEGPSSEDSLTTAAAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSP
PPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRG
PPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEPGPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKG
QAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGSTQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIK
VLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFPGPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGA
PGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPGVIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPEL
ITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLAYLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGE
TVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPPAILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYL
RDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLST
YRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNWDSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYC

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:101910066/chr9:101777699)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TGFBR1 P36897	COL15A1 P39059
FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269\|PubMed:15761148, ECO:0000269\|PubMed:16754747, ECO:0000269\|PubMed:18758450, ECO:0000269\|PubMed:7774578, ECO:0000269\|PubMed:8752209, ECO:0000269\|PubMed:8980228, ECO:0000269\|PubMed:9346908}.	FUNCTION: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269\|PubMed:10049780}.; FUNCTION: Restin potently inhibits angiogenesis. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

385462466

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Hgene

TGFBR1

101910066

COL15A1

101777699

ENST00000374994

175_204

427

Domain

Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585

Hgene

TGFBR1

101910066

COL15A1

101777699

ENST00000374994

175_204

504

Domain

Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585

Hgene

TGFBR1

101910066

COL15A1

101777699

ENST00000374994

175_204

508

Domain

Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>281_TGFBR1_COL15A1	ENST00000374994	ENST00000375001	TGFBR1	chr9	101910066	COL15A1	chr9	101777699	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS KTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL RPNIPNRWQSCEGPSSEDSLTTAAAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSP PPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRG PPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEPGPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKG QAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGSTQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIK VLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFPGPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGA PGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPGVIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPEL ITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLAYLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGE TVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPPAILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYL RDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLST YRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNWDSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYC	1399
3D view using mol* of 281_TGFBR1_COL15A1

PDB file >>>HKFP_407_TGFBR1_COL15A1	ENST00000374994	ENST00000375001	TGFBR1	chr9	101910066	COL15A1	chr9	101777699	MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS KTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL RPNIPNRWQSCEGPSSEDSLTTAAAATEVSLSTFEDEEASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSP PPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRG PPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEPGPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKG QAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGSTQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIK VLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFPGPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGA PGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPGVIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPEL ITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLAYLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGE TVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPPAILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYL RDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSNPHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLST YRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNWDSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYC	1399_TGFBR1_COL15A1

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

TGFBR1_COL15A1 does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

281_TGFBR1_COL15A1.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

281_TGFBR1_COL15A1_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Larotrectinib	-9.53744	-9.53744	-52.8184
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Larotrectinib	-9.106630000000001	-9.106630000000001	-49.2397
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Midostaurin	-7.63198	-7.63198	-53.3456
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Nilotinib	-7.441260000000001	-7.58086	-58.3156
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Nilotinib	-7.441260000000001	-7.58086	-58.3156
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Midostaurin	-7.32896	-7.32896	-54.2051
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Midostaurin	-7.042839999999999	-7.042839999999999	-31.949
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Tofacitinib	-7.003760000000001	-7.0152600000000005	-40.5833
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Tofacitinib	-7.003760000000001	-7.0152600000000005	-40.5833
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Midostaurin	-6.96794	-6.96794	-44.6084
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Capmatinib	-6.9587699999999995	-6.96437	-40.0046
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Afatinib	-6.9405600000000005	-7.12286	-50.3236
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Afatinib	-6.9405600000000005	-7.12286	-50.3236
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Afatinib	-6.93916	-7.12286	-50.3236
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Baricitinib	-6.82574	-6.82574	-38.3927
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Fedratinib	-6.8166899999999995	-6.86809	-55.3548
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Fedratinib	-6.8166899999999995	-6.86809	-55.3548
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Asciminib	-6.78763	-7.15073	-50.3929
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Nilotinib	-6.71426	-7.639060000000001	-56.6773
281_TGFBR1_COL15A1-DOCK_HTVS_1-001	Nilotinib	-6.71426	-7.639060000000001	-56.6773

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Kinase-Substrate Information of TGFBR1_COL15A1

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
TGFBR1	P36897	human	TP63	Q9H3D4-2	S68	TFDALsPsPAIPSNT
TGFBR1	P36897	human	SMAD2	Q15796	S467	sVRCssMs_______
TGFBR1	P36897	human	ENG	P17813	S646	StNHSIGsTQstPCS
TGFBR1	P36897	human	TP63	Q9H3D4-2	S66	SSTFDALsPsPAIPS
TGFBR1	P36897	human	OTUB1	Q96FW1	S18	QEPLGsDsEGVNCLA
TGFBR1	P36897	human	TGFBR3	Q03167	S831	SPPASENsSAAHSIG
TGFBR1	P36897	human	SMAD2	Q15796	S465	sPsVRCssMs_____
TGFBR1	P36897	human	EEF1A1	P68104	S300	EMHHEALsEALPGDN	GTP_EFTU_D2
TGFBR1	P36897	human	ENG	P17813	S649	HSIGsTQstPCStSS
TGFBR1	P36897	human	SMAD2	Q15796	S464	GsPsVRCssMs____

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
TGFBR1	ID	Description	0.00e+00
TGFBR1	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	9.37e-04
TGFBR1	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	9.37e-04
TGFBR1	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	9.37e-04
TGFBR1	GO:0030509	BMP signaling pathway	9.37e-04
TGFBR1	GO:0001837	epithelial to mesenchymal transition	9.37e-04
TGFBR1	GO:0071772	response to BMP	9.37e-04
TGFBR1	GO:0071773	cellular response to BMP stimulus	9.37e-04
TGFBR1	GO:0062009	secondary palate development	1.36e-03
TGFBR1	GO:0007179	transforming growth factor beta receptor signaling pathway	1.52e-03
TGFBR1	GO:0061384	heart trabecula morphogenesis	1.61e-03
TGFBR1	GO:0060317	cardiac epithelial to mesenchymal transition	1.61e-03
TGFBR1	GO:0048762	mesenchymal cell differentiation	1.61e-03
TGFBR1	GO:0003007	heart morphogenesis	1.61e-03
TGFBR1	GO:0071560	cellular response to transforming growth factor beta stimulus	1.65e-03
TGFBR1	GO:0003203	endocardial cushion morphogenesis	1.65e-03
TGFBR1	GO:0071559	response to transforming growth factor beta	1.65e-03
TGFBR1	GO:0030513	positive regulation of BMP signaling pathway	1.65e-03
TGFBR1	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1.65e-03
TGFBR1	GO:0055010	ventricular cardiac muscle tissue morphogenesis	1.80e-03
TGFBR1	GO:0061383	trabecula morphogenesis	1.80e-03
TGFBR1	GO:0048546	digestive tract morphogenesis	1.80e-03
TGFBR1	GO:0060485	mesenchyme development	1.80e-03
TGFBR1	GO:0003197	endocardial cushion development	1.92e-03
TGFBR1	GO:0090287	regulation of cellular response to growth factor stimulus	2.11e-03
TGFBR1	GO:0072132	mesenchyme morphogenesis	2.11e-03
TGFBR1	GO:0003229	ventricular cardiac muscle tissue development	2.11e-03
TGFBR1	GO:0010718	positive regulation of epithelial to mesenchymal transition	2.11e-03
TGFBR1	GO:0055008	cardiac muscle tissue morphogenesis	2.18e-03
TGFBR1	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2.64e-03
TGFBR1	GO:0003208	cardiac ventricle morphogenesis	2.64e-03
TGFBR1	GO:0060411	cardiac septum morphogenesis	2.64e-03
TGFBR1	GO:1904888	cranial skeletal system development	2.64e-03
TGFBR1	GO:0003002	regionalization	2.64e-03
TGFBR1	GO:0060415	muscle tissue morphogenesis	2.64e-03
TGFBR1	GO:0048732	gland development	2.78e-03
TGFBR1	GO:0003151	outflow tract morphogenesis	2.91e-03
TGFBR1	GO:0048644	muscle organ morphogenesis	2.91e-03
TGFBR1	GO:0001570	vasculogenesis	2.98e-03
TGFBR1	GO:0007389	pattern specification process	3.06e-03
TGFBR1	GO:0060021	roof of mouth development	3.40e-03
TGFBR1	GO:0003279	cardiac septum development	4.67e-03
TGFBR1	GO:0010717	regulation of epithelial to mesenchymal transition	4.81e-03
TGFBR1	GO:0030510	regulation of BMP signaling pathway	5.58e-03
TGFBR1	GO:0002065	columnar/cuboidal epithelial cell differentiation	5.64e-03
TGFBR1	GO:0003206	cardiac chamber morphogenesis	5.74e-03
TGFBR1	GO:0003231	cardiac ventricle development	5.74e-03
TGFBR1	GO:0007368	determination of left/right symmetry	6.13e-03
TGFBR1	GO:0048565	digestive tract development	6.13e-03
TGFBR1	GO:0007498	mesoderm development	6.18e-03

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Related Drugs to TGFBR1_COL15A1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning TGFBR1-COL15A1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to TGFBR1_COL15A1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date