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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:TLK2_IRAK3

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: TLK2_IRAK3
	KinaseFusionDB ID: KFG6582
	FusionGDB2.0 ID: KFG6582
		Hgene	Tgene
	Gene symbol	TLK2	IRAK3
	Gene ID	11011	11213
	Gene name	tousled like kinase 2	interleukin 1 receptor associated kinase 3
	Synonyms	HsHPK\|MRD57\|PKU-ALPHA	ASRT5\|IRAKM
	Cytomap	17q23.2	12q14.3
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase tousled-like 2	interleukin-1 receptor-associated kinase 3IL-1 receptor-associated kinase Minactive IL-1 receptor-associated kinase 3
	Modification date	20240403	20240305
	UniProtAcc	Q86UE8	Q9Y616
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000326270, ENST00000343388, ENST00000346027, ENST00000542523, ENST00000582809, ENST00000577616,	ENST00000457197, ENST00000545837, ENST00000261233,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: TLK2 [Title/Abstract] AND IRAK3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TLK2(60679541)-IRAK3(66620503), # samples:2

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TLK2	GO:0006468	protein phosphorylation	12660173
Hgene	TLK2	GO:0006974	DNA damage response	12660173
Hgene	TLK2	GO:0018105	peptidyl-serine phosphorylation	20016786
Hgene	TLK2	GO:0035556	intracellular signal transduction	12660173
Hgene	TLK2	GO:0071480	cellular response to gamma radiation	12660173
Hgene	TLK2	GO:1902275	regulation of chromatin organization	12660173
Tgene	IRAK3	GO:0006468	protein phosphorylation	10383454

Kinase Fusion gene breakpoints across TLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across IRAK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-FD-A6TG-01A	TLK2	chr17	60679541	IRAK3	chr12	66620503
ChimerDB4	TCGA-FD-A6TG	TLK2	chr17	60679541	IRAK3	chr12	66620502

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000582809	ENST00000261233	TLK2	chr17	60679541	IRAK3	chr12	66620503	9704	960
ENST00000582809	ENST00000261233	TLK2	chr17	60679541	IRAK3	chr12	66620502	9704	960

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000582809_ENST00000261233_TLK2_chr17_60679541_IRAK3_chr12_66620503_length(amino acids)=960
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI
RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD
VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST
QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS

--------------------------------------------------------------

>ENST00000582809_ENST00000261233_TLK2_chr17_60679541_IRAK3_chr12_66620502_length(amino acids)=960
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI
RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD
VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST
QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:60679541/chr12:66620503)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TLK2 Q86UE8	IRAK3 Q9Y616
FUNCTION: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:9427565, PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269\|PubMed:10523312, ECO:0000269\|PubMed:11470414, ECO:0000269\|PubMed:12660173, ECO:0000269\|PubMed:12955071, ECO:0000269\|PubMed:20016786, ECO:0000269\|PubMed:22354037, ECO:0000269\|PubMed:29955062, ECO:0000269\|PubMed:33323470, ECO:0000269\|PubMed:35136069, ECO:0000269\|PubMed:9427565}.	FUNCTION: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250\|UniProtKB:Q8K4B2, ECO:0000269\|PubMed:10383454, ECO:0000269\|PubMed:29686383}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Tgene

TLK2

60679541

IRAK3

66620502

ENST00000582809

165_452

156

536

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

TLK2

60679541

IRAK3

66620503

ENST00000582809

165_452

156

536

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>507_TLK2_IRAK3	ENST00000582809	ENST00000261233	TLK2	chr17	60679541	IRAK3	chr12	66620502	MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS	960
3D view using mol* of 507_TLK2_IRAK3

PDB file >>>TKFP_859_TLK2_IRAK3	ENST00000582809	ENST00000261233	TLK2	chr17	60679541	IRAK3	chr12	66620503	MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS	960_TLK2_IRAK3
PDB file >>>TKFP_860_TLK2_IRAK3	ENST00000582809	ENST00000261233	TLK2	chr17	60679541	IRAK3	chr12	66620502	MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS	960_TLK2_IRAK3

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

TLK2_IRAK3 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/507_TLK2_IRAK3.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

507_TLK2_IRAK3.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

507_TLK2_IRAK3_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
507_TLK2_IRAK3-DOCK_HTVS_1-001	Sorafenib	-7.23045	-7.24255	-47.309
507_TLK2_IRAK3-DOCK_HTVS_1-001	Sorafenib	-7.23045	-7.24255	-47.309
507_TLK2_IRAK3-DOCK_HTVS_1-001	Encorafenib	-5.62016	-6.00866	-55.6337
507_TLK2_IRAK3-DOCK_HTVS_1-001	Larotrectinib	-5.60156	-5.60156	-32.4343
507_TLK2_IRAK3-DOCK_HTVS_1-001	Upadacitinib	-5.53854	-5.539540000000001	-37.7668
507_TLK2_IRAK3-DOCK_HTVS_1-001	Crizotinib	-5.53517	-5.87137	-40.6407
507_TLK2_IRAK3-DOCK_HTVS_1-001	Crizotinib	-5.53517	-5.87137	-40.6407
507_TLK2_IRAK3-DOCK_HTVS_1-001	Tivozanib	-5.3983099999999995	-5.3983099999999995	-41.9318
507_TLK2_IRAK3-DOCK_HTVS_1-001	Ruxolitinib	-5.36798	-5.36798	-35.7484
507_TLK2_IRAK3-DOCK_HTVS_1-001	Nilotinib	-5.303780000000001	-6.22858	-50.2534
507_TLK2_IRAK3-DOCK_HTVS_1-001	Nilotinib	-5.303780000000001	-6.22858	-50.2534
507_TLK2_IRAK3-DOCK_HTVS_1-001	Tepotinib	-5.225230000000001	-5.22633	-48.68
507_TLK2_IRAK3-DOCK_HTVS_1-001	Lapatinib	-5.2217199999999995	-5.3105199999999995	-47.0999
507_TLK2_IRAK3-DOCK_HTVS_1-001	Upadacitinib	-5.21673	-5.21773	-32.4223
507_TLK2_IRAK3-DOCK_HTVS_1-001	Midostaurin	-5.21253	-5.21253	-46.1976
507_TLK2_IRAK3-DOCK_HTVS_1-001	Tofacitinib	-5.1996	-5.2111	-35.9928
507_TLK2_IRAK3-DOCK_HTVS_1-001	Tofacitinib	-5.1996	-5.2111	-35.9928
507_TLK2_IRAK3-DOCK_HTVS_1-001	Nintedanib	-5.19356	-5.67356	-48.7572
507_TLK2_IRAK3-DOCK_HTVS_1-001	Nintedanib	-5.19356	-5.67356	-48.7572
507_TLK2_IRAK3-DOCK_HTVS_1-001	Nintedanib	-5.19356	-5.67356	-48.7572

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Kinase-Substrate Information of TLK2_IRAK3

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
TLK2	Q86UE8	human	ASF1B	Q9NVP2	S198	PGLLPENsMDCI___
TLK2	Q86UE8	human	ASF1A	Q9Y294	S192	GWSTSENsLNVMLES

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
TLK2	ID	Description	0.00e+00
TLK2	GO:0006334	nucleosome assembly	4.25e-04
TLK2	GO:0034728	nucleosome organization	4.25e-04
TLK2	GO:0065004	protein-DNA complex assembly	8.59e-04
TLK2	GO:0140861	DNA repair-dependent chromatin remodeling	6.29e-03
TLK2	GO:0001835	blastocyst hatching	6.29e-03
TLK2	GO:0035188	hatching	6.29e-03
TLK2	GO:0071684	organism emergence from protective structure	6.29e-03
TLK2	GO:0031297	replication fork processing	1.04e-02
TLK2	GO:0045005	DNA-templated DNA replication maintenance of fidelity	1.05e-02
TLK2	GO:0001824	blastocyst development	1.96e-02
TLK2	GO:0006261	DNA-templated DNA replication	2.47e-02
TLK2	GO:0001649	osteoblast differentiation	3.60e-02
TLK2	GO:0006260	DNA replication	3.60e-02
TLK2	GO:0001701	in utero embryonic development	4.65e-02
TLK2	GO:0042692	muscle cell differentiation	4.65e-02
TLK2	GO:0001503	ossification	4.65e-02

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Related Drugs to TLK2_IRAK3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning TLK2-IRAK3 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to TLK2_IRAK3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date