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Kinase Fusion Gene:TMSB4X_CAMK1D |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: TMSB4X_CAMK1D | KinaseFusionDB ID: KFG6638 | FusionGDB2.0 ID: KFG6638 | Hgene | Tgene | Gene symbol | TMSB4X | CAMK1D | Gene ID | 7114 | 57118 | |
Gene name | thymosin beta 4 X-linked | calcium/calmodulin dependent protein kinase ID | ||||||||||
Synonyms | FX|PTMB4|TB4X|TMSB4 | CKLiK|CaM-K1|CaMKID | ||||||||||
Cytomap | Xp22.2 | 10p13 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | thymosin beta-4prothymosin beta-4t beta-4thymosin, beta 4, X chromosome | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | ||||||||||
Modification date | 20240407 | 20240305 | ||||||||||
UniProtAcc | P62328 | Q8IU85 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000380635, ENST00000380636, ENST00000451311, ENST00000380633, | ENST00000378845, ENST00000378847, ENST00000487696, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TMSB4X [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TMSB4X(12995342)-CAMK1D(12569979), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TMSB4X | GO:0042989 | sequestering of actin monomers | 1447300|1999398 |
Hgene | TMSB4X | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 21106936 |
Hgene | TMSB4X | GO:1905273 | positive regulation of proton-transporting ATP synthase activity, rotational mechanism | 21106936 |
Hgene | TMSB4X | GO:2001028 | positive regulation of endothelial cell chemotaxis | 21106936 |
Hgene | TMSB4X | GO:2001171 | positive regulation of ATP biosynthetic process | 21106936 |
Tgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
Kinase Fusion gene breakpoints across TMSB4X (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across CAMK1D (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | BF245645 | TMSB4X | chrX | 12995342 | CAMK1D | chr10 | 12569979 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:12995342/:12569979) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TMSB4X | CAMK1D |
FUNCTION: Plays an important role in the organization of the cytoskeleton (PubMed:1999398, PubMed:10848969). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:1999398, PubMed:10848969). {ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398}.; FUNCTION: [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). {ECO:0000250|UniProtKB:P62326, ECO:0000269|PubMed:7694679}. | FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of TMSB4X_CAMK1D |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
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Related Drugs to TMSB4X_CAMK1D |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning TMSB4X-CAMK1D and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to TMSB4X_CAMK1D |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |