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Kinase Fusion Gene:TNIK_EIF5A2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: TNIK_EIF5A2 | KinaseFusionDB ID: KFG6647 | FusionGDB2.0 ID: KFG6647 | Hgene | Tgene | Gene symbol | TNIK | EIF5A2 | Gene ID | 23043 | 56648 | |
| Gene name | TRAF2 and NCK interacting kinase | eukaryotic translation initiation factor 5A2 | ||||||||||
| Synonyms | MRT54 | EIF-5A2|eIF5AII | ||||||||||
| Cytomap | 3q26.2-q26.31 | 3q26.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | TRAF2 and NCK-interacting protein kinase | eukaryotic translation initiation factor 5A-2eIF-5A-2eukaryotic initiation factor 5A | ||||||||||
| Modification date | 20240407 | 20240416 | ||||||||||
| UniProtAcc | Q9UKE5 | Q9GZV4 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000284483, ENST00000341852, ENST00000357327, ENST00000369326, ENST00000436636, ENST00000460047, ENST00000464785, ENST00000465393, ENST00000470834, ENST00000475336, ENST00000488470, ENST00000538048, | ENST00000295822, ENST00000460117, ENST00000474096, ENST00000487522, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TNIK [Title/Abstract] AND EIF5A2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TNIK(170785460)-EIF5A2(170612662), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TNIK | GO:0006468 | protein phosphorylation | 10521462|15342639|22797597 |
| Hgene | TNIK | GO:0030036 | actin cytoskeleton organization | 15342639 |
| Hgene | TNIK | GO:0035556 | intracellular signal transduction | 10521462 |
| Hgene | TNIK | GO:0046330 | positive regulation of JNK cascade | 15342639 |
| Hgene | TNIK | GO:0046777 | protein autophosphorylation | 10521462|15342639 |
| Hgene | TNIK | GO:0048814 | regulation of dendrite morphogenesis | 20159449 |
| Kinase Fusion gene breakpoints across TNIK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across EIF5A2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | EC495694 | TNIK | chr3 | 170785460 | EIF5A2 | chr3 | 170612662 |
| CCLE | MKN1 | TNIK | chr3 | 171177796 | EIF5A2 | chr3 | 170612212 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:170785460/chr3:170612662) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TNIK | EIF5A2 |
| FUNCTION: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388}. | FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of TNIK_EIF5A2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| TNIK | Q9UKE5 | human | SMAD1 | Q15797 | T322 | sNVNRNStIENTRRH | MH2 |
| TNIK | Q9UKE5 | human | TCF7L2 | Q9NQB0 | S177 | QALkDARsPsPAHIV | CTNNB1_binding |
| TNIK | Q9UKE5 | human | HTT | P42858 | S13 | kLMkAFEsLksFQQQ | |
| TNIK | Q9UKE5 | human | HTT | P42858 | T3 | _____MAtLEkLMkA |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| TNIK | ID | Description | 0.00e+00 |
| TNIK | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 2.23e-02 |
| TNIK | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 2.78e-02 |
| TNIK | GO:0097191 | extrinsic apoptotic signaling pathway | 2.78e-02 |
| TNIK | GO:2001234 | negative regulation of apoptotic signaling pathway | 2.78e-02 |
| TNIK | GO:0033002 | muscle cell proliferation | 2.78e-02 |
| TNIK | GO:0045165 | cell fate commitment | 3.10e-02 |
| TNIK | GO:2001233 | regulation of apoptotic signaling pathway | 4.35e-02 |
| TNIK | GO:0097050 | type B pancreatic cell apoptotic process | 4.35e-02 |
| TNIK | GO:0098598 | learned vocalization behavior or vocal learning | 4.35e-02 |
| TNIK | GO:0099004 | calmodulin dependent kinase signaling pathway | 4.35e-02 |
| TNIK | GO:0031223 | auditory behavior | 4.35e-02 |
| TNIK | GO:0007638 | mechanosensory behavior | 4.35e-02 |
| TNIK | GO:0042762 | regulation of sulfur metabolic process | 4.35e-02 |
| TNIK | GO:1903599 | positive regulation of autophagy of mitochondrion | 4.35e-02 |
| TNIK | GO:2000479 | regulation of cAMP-dependent protein kinase activity | 4.35e-02 |
| TNIK | GO:0001710 | mesodermal cell fate commitment | 4.35e-02 |
| TNIK | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 4.35e-02 |
| TNIK | GO:0045721 | negative regulation of gluconeogenesis | 4.38e-02 |
| TNIK | GO:0031053 | primary miRNA processing | 4.38e-02 |
| TNIK | GO:0010560 | positive regulation of glycoprotein biosynthetic process | 4.38e-02 |
| TNIK | GO:1903020 | positive regulation of glycoprotein metabolic process | 4.38e-02 |
| TNIK | GO:0045724 | positive regulation of cilium assembly | 4.38e-02 |
| TNIK | GO:1903672 | positive regulation of sprouting angiogenesis | 4.38e-02 |
| TNIK | GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 4.38e-02 |
| TNIK | GO:0010996 | response to auditory stimulus | 4.38e-02 |
| TNIK | GO:0060795 | cell fate commitment involved in formation of primary germ layer | 4.38e-02 |
| TNIK | GO:0061036 | positive regulation of cartilage development | 4.38e-02 |
| TNIK | GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 4.38e-02 |
| TNIK | GO:0048333 | mesodermal cell differentiation | 4.38e-02 |
| TNIK | GO:0000132 | establishment of mitotic spindle orientation | 4.38e-02 |
| TNIK | GO:0003161 | cardiac conduction system development | 4.38e-02 |
| TNIK | GO:0032350 | regulation of hormone metabolic process | 4.38e-02 |
| TNIK | GO:0040001 | establishment of mitotic spindle localization | 4.38e-02 |
| TNIK | GO:1903146 | regulation of autophagy of mitochondrion | 4.38e-02 |
| TNIK | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 4.38e-02 |
| TNIK | GO:0051294 | establishment of spindle orientation | 4.38e-02 |
| TNIK | GO:0047496 | vesicle transport along microtubule | 4.38e-02 |
| TNIK | GO:0035196 | miRNA processing | 4.38e-02 |
| TNIK | GO:0043666 | regulation of phosphoprotein phosphatase activity | 4.38e-02 |
| TNIK | GO:0031648 | protein destabilization | 4.38e-02 |
| TNIK | GO:2001259 | positive regulation of cation channel activity | 4.38e-02 |
| TNIK | GO:0006890 | retrograde vesicle-mediated transpor | 8.24e-03 |
| TNIK | GO:0006111 | regulation of gluconeogenesis | 4.38e-02 |
| TNIK | GO:0010559 | regulation of glycoprotein biosynthetic process | 4.38e-02 |
| TNIK | GO:0045912 | negative regulation of carbohydrate metabolic process | 4.38e-02 |
| TNIK | GO:0051293 | establishment of spindle localization | 4.38e-02 |
| TNIK | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 4.38e-02 |
| TNIK | GO:0060038 | cardiac muscle cell proliferation | 4.38e-02 |
| TNIK | GO:0010921 | regulation of phosphatase activity | 4.38e-02 |
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Related Drugs to TNIK_EIF5A2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning TNIK-EIF5A2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to TNIK_EIF5A2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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