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Kinase Fusion Gene:TNIP1_CAMK2A |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: TNIP1_CAMK2A | KinaseFusionDB ID: KFG6657 | FusionGDB2.0 ID: KFG6657 | Hgene | Tgene | Gene symbol | TNIP1 | CAMK2A | Gene ID | 10318 | 815 | |
Gene name | TNFAIP3 interacting protein 1 | calcium/calmodulin dependent protein kinase II alpha | ||||||||||
Synonyms | ABIN-1|NAF1|VAN|nip40-1 | CAMKA|CaMKIINalpha|CaMKIIalpha|MRD53|MRT63 | ||||||||||
Cytomap | 5q33.1 | 5q32 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | TNFAIP3-interacting protein 1A20-binding inhibitor of NF-kappa-B activation 1HIV-1 Nef-interacting proteinNef-associated factor 1 SNPvirion-associated nuclear shuttling protein | calcium/calmodulin-dependent protein kinase type II subunit alphaCaM kinase II alpha subunitCaM-kinase II alpha chainCaMK-II alpha subunitcaM kinase II subunit alphacaMK-II subunit alphacalcium/calmodulin-dependent protein kinase (CaM kinase) II alp | ||||||||||
Modification date | 20240403 | 20240407 | ||||||||||
UniProtAcc | Q15025 | Q9UQM7 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000315050, ENST00000389378, ENST00000518977, ENST00000520931, ENST00000521591, ENST00000522226, ENST00000523200, ENST00000523338, ENST00000524280, ENST00000521423, | ENST00000348628, ENST00000351010, ENST00000398376, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TNIP1 [Title/Abstract] AND CAMK2A [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TNIP1(150439879)-CAMK2A(149669286), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TNIP1 | GO:0009101 | glycoprotein biosynthetic process | 9923610 |
Hgene | TNIP1 | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction | 16684768 |
Hgene | TNIP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12220502 |
Hgene | TNIP1 | GO:1903003 | positive regulation of protein deubiquitination | 16684768 |
Tgene | CAMK2A | GO:0006468 | protein phosphorylation | 17052756 |
Tgene | CAMK2A | GO:0035458 | cellular response to interferon-beta | 35568036 |
Tgene | CAMK2A | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
Tgene | CAMK2A | GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT | 11972023|35568036 |
Tgene | CAMK2A | GO:0071346 | cellular response to type II interferon | 11972023 |
Kinase Fusion gene breakpoints across TNIP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across CAMK2A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-BP-4965-01A | TNIP1 | chr5 | 150439879 | CAMK2A | chr5 | 149669286 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:150439879/:149669286) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TNIP1 | CAMK2A |
FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. | FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of TNIP1_CAMK2A |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
CAMK2A | Q9UQM7 | human | AKAP5 | P24588 | S92 | LVtRRKRsESsKQQK | WSK |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | T455 | LTIRGVDtVsRssLE | |
CAMK2A | Q9UQM7 | human | HRH1 | P35367 | T142 | YLKYRtKtRASATIL | 7tm_1 |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S484 | KRRKRMssGtEECGE | |
CAMK2A | Q9UQM7 | human | CREB3L3 | Q68CJ9 | S395 | ADTTREEsPGSPGAD | |
CAMK2A | Q9UQM7 | human | ETS2 | P15036 | S310 | LDVQRVPsFEsFEDD | Ets1_N_flank |
CAMK2A | Q9UQM7 | human | ITPKA | P23677 | T311 | EHAQRAVtKPRYMQW | IPK |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S457 | IRGVDtVsRssLEMs | |
CAMK2A | Q9UQM7 | human | NCOR2 | Q9Y618 | S2426 | AsGDRPPsVSSVHsE | |
CAMK2A | Q9UQM7 | human | KCNJ11 | Q14654 | T180 | QAHRRAEtLIFSKHA | |
CAMK2A | Q9UQM7 | human | NOX5 | Q96PH1-4 | S498 | RSVtMRKsQRSsKGS | FAD_binding_8 |
CAMK2A | Q9UQM7 | human | SCN8A | Q9UQD0 | T642 | RSVKRNstVDCNGVV | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | ITGB1 | P05556 | T788 | PIyksAVttVVNPky | Integrin_b_cyt |
CAMK2A | Q9UQM7 | human | TH | P07101-4 | S35 | AIMVRGQsPRFIGRR | TOH_N |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S12 | LLPRGTssFRRFtRE | |
CAMK2A | Q9UQM7 | human | ETS2 | P15036 | S313 | QRVPsFEsFEDDCsQ | Ets1_N_flank |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S61 | PQLDLQAsKKLPDLY | |
CAMK2A | Q9UQM7 | human | TCAP | O15273 | S157 | GALRRsLsRSMsQEA | Telethonin |
CAMK2A | Q9UQM7 | human | SLN | O00631 | T5 | ___MGINtRELFLNF | Sarcolipin |
CAMK2A | Q9UQM7 | human | CAMK2A | Q9UQM7 | T286 | sCMHRQEtVDCLKKF | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S464 | sRssLEMsPLAPVNs | |
CAMK2A | Q9UQM7 | human | CHAT | P28329-3 | T456 | VDNIRSAtPEALAFV | Carn_acyltransf |
CAMK2A | Q9UQM7 | human | CAMK2A | Q9UQM7 | T305 | kLkGAILttMLAtRN | |
CAMK2A | Q9UQM7 | human | ETS1 | P14921 | S285 | QRVPsyDsFDsEDyP | Ets1_N_flank |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S571 | PWPLRRtsAQGQPsP | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | SPR | P35270 | S213 | QQLARETsVDPDMRK | adh_short |
CAMK2A | Q9UQM7 | human | SCN8A | Q9UQD0 | S541 | NRIGRKFsIMNQsLL | |
CAMK2A | Q9UQM7 | human | CREB3L3 | Q68CJ9 | S360 | FAPVRVFsRTLHNDA | |
CAMK2A | Q9UQM7 | human | SLC1A3 | P43003 | T26 | QQGVRKRtLLAKkkV | |
CAMK2A | Q9UQM7 | human | PTTG1 | O95997 | S31 | LkLGsGPsIkALDGR | Securin |
CAMK2A | Q9UQM7 | human | SMAD2 | Q15796 | S260 | TLsPVNHsLDLQPVT | |
CAMK2A | Q9UQM7 | human | TH | P07101-4 | S19 | KGFRRAVsELDAKQA | TOH_N |
CAMK2A | Q9UQM7 | human | CDKN1B | P46527 | S10 | NVRVSNGsPsLErMD | |
CAMK2A | Q9UQM7 | human | SRF | P11831 | S103 | RGLKRsLsEMEIGMV | |
CAMK2A | Q9UQM7 | human | CYLD | Q9NQC7 | S362 | FyTLNGSsVDSQPQs | CYLD_phos_site |
CAMK2A | Q9UQM7 | human | AKAP5 | P24588 | T87 | AsLKRLVtRRKRsES | WSK |
CAMK2A | Q9UQM7 | human | RYR2 | Q92736 | S2814 | IsQTSQVsVDAAHGY | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S528 | KPRssrGsIFtFRRR | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | HDAC5 | Q9UQL6 | S498 | RPLSRtQsSPLPQsP | |
CAMK2A | Q9UQM7 | human | VIM | P08670 | S83 | GVRLLQDsVdFsLAd | Filament_head |
CAMK2A | Q9UQM7 | human | ITGB1BP1 | O14713 | T38 | GGLsRsstVAsLDTD | ICAP-1_inte_bdg |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S497 | GEDRLPKsDsEDGPR | |
CAMK2A | Q9UQM7 | human | NOX5 | Q96PH1-4 | S475 | WTNRLYEsFKASDPL | FAD_binding_8 |
CAMK2A | Q9UQM7 | human | SLC6A4 | P31645 | S13 | LNSQKQLsACEDGED | |
CAMK2A | Q9UQM7 | human | TH | P07101 | S71 | RFIGRRQsLIEDARK | TOH_N |
CAMK2A | Q9UQM7 | human | SMAD2 | Q15796 | S110 | SFSEQTRsLDGRLQV | MH1 |
CAMK2A | Q9UQM7 | human | NR1I2 | O75469 | T290 | LCQLRFNtVFNAETG | Hormone_recep |
CAMK2A | Q9UQM7 | human | FLNA | P21333 | S2523 | VTGPRLVsNHsLHET | |
CAMK2A | Q9UQM7 | human | BECN1 | Q14457 | S96 | MstEsANsFTLIGEA | |
CAMK2A | Q9UQM7 | human | PPP1R14A | Q96A00 | S130 | GLRQPsPsHDGsLsP | PP1_inhibitor |
CAMK2A | Q9UQM7 | human | KCNQ2 | O43526-4 | S438 | QTVRRsPsADQSLED | KCNQ_channel |
CAMK2A | Q9UQM7 | human | ETS1 | P14921 | S282 | NsLQRVPsyDsFDsE | Ets1_N_flank |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1925 | QRsLKHAsFLFRQQA | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S510 | PRAMNHLsLTrGLsR | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | GFPT1 | Q06210 | S261 | CNLsRVDsttCLFPV | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S11 | FLLPRGTssFRRFtR | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S577 | tsAQGQPsPGTSAPG | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | CTNNB1 | P35222 | S552 | QDtQRRtsMGGtQQQ | |
CAMK2A | Q9UQM7 | human | DLGAP1 | O14490-2 | S44 | CRRMRSGsYIKAMGD | |
CAMK2A | Q9UQM7 | human | CREB3L3 | Q68CJ9 | T429 | TLVLRNAtEGLGQVA | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1934 | LFRQQAGsGLsEEDA | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S539 | FRRRDLGsEADFADD | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | ITGB1 | P05556 | T789 | IyksAVttVVNPkyE | Integrin_b_cyt |
CAMK2A | Q9UQM7 | human | ALOX5 | P09917 | S272 | CsLERQLsLEQEVQQ | Lipoxygenase |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S516 | LsLTrGLsRTsMKPR | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | ID1 | P41134 | S36 | GEVVRCLsEQSVAIS | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S460 | VDtVsRssLEMsPLA | |
CAMK2A | Q9UQM7 | human | HRH1 | P35367 | S398 | WKRLRsHsRQyVSGL | 7tm_1 |
CAMK2A | Q9UQM7 | human | ETS1 | P14921 | S257 | DsFEsIEsyDsCDRL | Ets1_N_flank |
CAMK2A | Q9UQM7 | human | CLCN3 | P51790 | S109 | ERHRRINsKKKESAW | |
CAMK2A | Q9UQM7 | human | CTNNB1 | P35222 | T332 | VNIMRTytyEkLLWT | |
CAMK2A | Q9UQM7 | human | SCN8A | Q9UQD0 | S561 | PFLSRHNsKSSIFSF | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | IL6ST | P40189 | S782 | QVFSRsEsTQPLLDS | |
CAMK2A | Q9UQM7 | human | HSF1 | Q00613 | S230 | PkYSRQFsLEHVHGS | |
CAMK2A | Q9UQM7 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
CAMK2A | Q9UQM7 | human | CAMK2A | Q9UQM7-2 | T286 | SCMHRQEtVDCLKKF | |
CAMK2A | Q9UQM7 | human | SMAD2 | Q15796 | S240 | SDQQLNQsMDTGsPA | |
CAMK2A | Q9UQM7 | human | SCN8A | Q9UQD0 | S641 | RRSVKRNstVDCNGV | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S483 | sKRRKRMssGtEECG | |
CAMK2A | Q9UQM7 | human | KCND1 | Q9NSA2 | S555 | TASVSRGsMQELDML | |
CAMK2A | Q9UQM7 | human | FBXO43 | Q4G163 | T234 | FSQQKTStIDDSKDD | |
CAMK2A | Q9UQM7 | human | CAMK2A | Q9UQM7 | T306 | LkGAILttMLAtRNF | |
CAMK2A | Q9UQM7 | human | RRAD | P55042 | S273 | AGTRRREsLGKKAKR | |
CAMK2A | Q9UQM7 | human | TH | P07101-4 | S44 | RFIGRRQsLIEDARK | TOH_N |
CAMK2A | Q9UQM7 | human | RCHY1 | Q96PM5 | T154 | ICLEDIHtsRVVAHV | zf-RING_2 |
CAMK2A | Q9UQM7 | human | STMN1 | P16949 | S16 | kELEKrAsGQAFELI | Stathmin |
CAMK2A | Q9UQM7 | human | PTTG1 | O95997 | S89 | KQKQPsFsAKKMTEK | Securin |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | T17 | TssFRRFtREsLAAI | |
CAMK2A | Q9UQM7 | human | TH | P07101 | S19 | KGFRRAVsELDAKQA | TOH_N |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1920 | RRHLLQRsLKHAsFL | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1885 | KFMAANPsKISYEPI | |
CAMK2A | Q9UQM7 | human | GRIN2A | Q12879 | S1459 | RVYKKMPsIESDV__ | NMDAR2_C |
CAMK2A | Q9UQM7 | human | CYLD | Q9NQC7 | S418 | TTENRFHsLPFsLtK | CYLD_phos_site |
CAMK2A | Q9UQM7 | human | NCOR2 | Q9Y618 | S2453 | VWEDRPssAGstPFP | |
CAMK2A | Q9UQM7 | human | OPRM1 | P35372 | S268 | LKsVRMLsGsKEKDR | 7tm_1 |
CAMK2A | Q9UQM7 | human | NOX5 | Q96PH1-4 | S659 | ANKEKKDsITGLQTR | NAD_binding_6 |
CAMK2A | Q9UQM7 | human | KIF3A | Q9Y496 | S687 | KTGRRKRsAkPEtVI | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S667 | QRALsAVsVLtsALE | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | DAGLA | Q9Y4D2 | S782 | APLATMEsLSDTESL | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S20 | FRRFtREsLAAIEKR | |
CAMK2A | Q9UQM7 | human | CARD11 | Q9BXL7 | S116 | KEPTRRFstIVVEEG | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1937 | QQAGsGLsEEDAPER | |
CAMK2A | Q9UQM7 | human | SLC1A3 | P43003 | T37 | KkkVQNItkEDVKSY | |
CAMK2A | Q9UQM7 | human | PLCB3 | Q01970 | S537 | PSLEPQKsLGDEGLN | |
CAMK2A | Q9UQM7 | human | PPP2R2B | Q00005-2 | S22 | PNTILsssCHTEADI | |
CAMK2A | Q9UQM7 | human | RCHY1 | Q96PM5 | S155 | CLEDIHtsRVVAHVL | zf-RING_2 |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1865 | TKRVLGEsGEMDALK | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S2007 | DLADFPPsPDRDRES | |
CAMK2A | Q9UQM7 | human | CYLD | Q9NQC7 | S772 | LFKkIFPsLELNITD | UCH |
CAMK2A | Q9UQM7 | human | CD44 | P16070 | S706 | LNGEAsksQEMVHLV | |
CAMK2A | Q9UQM7 | human | NOX5 | Q96PH1-4 | S502 | MRKsQRSsKGSEILL | FAD_binding_8 |
CAMK2A | Q9UQM7 | human | ESPL1 | Q14674 | S1501 | TDNWRKMsFEILRGs | |
CAMK2A | Q9UQM7 | human | CACNA1H | O95180 | S1198 | tPLRRAEsLDPRPLR | |
CAMK2A | Q9UQM7 | human | TH | P07101-3 | S40 | RFIGRRQsLIEDARK | TOH_N |
CAMK2A | Q9UQM7 | human | DLG4 | P78352 | S73 | ITLERGNsGLGFsIA | PDZ |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1503 | NAMKKLGsKKPQKPI | |
CAMK2A | Q9UQM7 | human | BECN1 | Q14457 | S93 | ARMMstEsANsFTLI | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S471 | sPLAPVNsHERRsKR | |
CAMK2A | Q9UQM7 | human | PTTG1 | O95997 | T66 | AtRkALGtVNRATEK | Securin |
CAMK2A | Q9UQM7 | human | HRH1 | P35367 | S396 | FTWKRLRsHsRQyVS | 7tm_1 |
CAMK2A | Q9UQM7 | human | ETS2 | P15036 | S246 | FPkSRLSsVsVTYCS | Ets1_N_flank |
CAMK2A | Q9UQM7 | human | BECN1 | Q14457 | S90 | IPPARMMstEsANsF | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1998 | RGSDYSHsEDLADFP | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S1003 | AAQGQLPsCIATPYS | Na_trans_assoc |
CAMK2A | Q9UQM7 | human | CTNNB1 | P35222 | T472 | ICALRHLtsRHQEAE | Arm |
CAMK2A | Q9UQM7 | human | GRIN2B | Q13224 | S1303 | NKLRRQHsyDtFVDL | NMDAR2_C |
CAMK2A | Q9UQM7 | human | GRIA1 | P42261 | S567 | FSPYEWHsEEFEEGR | Lig_chan |
CAMK2A | Q9UQM7 | human | GLO1 | Q04760 | T107 | ELTHNWGtEDDETQS | Glyoxalase |
CAMK2A | Q9UQM7 | human | RYR2 | Q92736 | S2808 | YNRTRRIsQTSQVsV | |
CAMK2A | Q9UQM7 | human | SNCA | P37840 | S129 | NEAyEMPsEEGyQDy | Synuclein |
CAMK2A | Q9UQM7 | human | MAPT | P10636-8 | S262 | NVKskIGstENLkHQ | Tubulin-binding |
CAMK2A | Q9UQM7 | human | MAPT | P10636-8 | S416 | sNVsstGsIDMVDsP | |
CAMK2A | Q9UQM7 | human | HRH1 | P35367 | T140 | LRYLKYRtKtRASAT | 7tm_1 |
CAMK2A | Q9UQM7 | human | TH | P07101-3 | S19 | KGFRRAVsELDAKQA | TOH_N |
CAMK2A | Q9UQM7 | human | DAGLA | Q9Y4D2 | S808 | RSIRGsPsLHAVLER | |
CAMK2A | Q9UQM7 | human | SPTBN4 | Q9H254 | S2254 | RRPERQEsVDQSEEA | |
CAMK2A | Q9UQM7 | human | PPP2R2B | Q00005-2 | S20 | RPPNTILsssCHTEA | |
CAMK2A | Q9UQM7 | human | NOX5 | Q96PH1-4 | T494 | KRLsRSVtMRKsQRS | FAD_binding_8 |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | T570 | VPWPLRRtsAQGQPs | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | KCNJ11 | Q14654 | T224 | MQVVRKTtSPEGEVV | IRK_C |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S664 | GARQRALsAVsVLts | Na_trans_cytopl |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S42 | GSTTLQEsREGLPEE | |
CAMK2A | Q9UQM7 | human | SCN5A | Q14524 | S499 | DRLPKsDsEDGPRAM | |
CAMK2A | Q9UQM7 | human | PTTG1 | O95997 | S87 | PLKQKQPsFsAKKMT | Securin |
CAMK2A | Q9UQM7 | human | PLN | P26678 | T17 | SAIRRAstIEMPQQA | Phospholamban |
CAMK2A | Q9UQM7 | human | TCAP | O15273 | S161 | RsLsRSMsQEAQRG_ | Telethonin |
CAMK2A | Q9UQM7 | human | PPP2R2B | Q00005-2 | S21 | PPNTILsssCHTEAD | |
CAMK2A | Q9UQM7 | human | ETS1 | P14921 | S251 | GkLGGQDsFEsIEsy | Ets1_N_flank |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
CAMK2A | ID | Description | 0.00e+00 |
CAMK2A | GO:0006816 | calcium ion transport | 3.58e-08 |
CAMK2A | GO:0034765 | regulation of monoatomic ion transmembrane transport | 3.58e-08 |
CAMK2A | GO:0050804 | modulation of chemical synaptic transmission | 5.08e-08 |
CAMK2A | GO:0099177 | regulation of trans-synaptic signaling | 5.08e-08 |
CAMK2A | GO:0097553 | calcium ion transmembrane import into cytosol | 5.08e-08 |
CAMK2A | GO:0048167 | regulation of synaptic plasticity | 6.48e-08 |
CAMK2A | GO:0070588 | calcium ion transmembrane transport | 6.48e-08 |
CAMK2A | GO:0042391 | regulation of membrane potential | 7.35e-08 |
CAMK2A | GO:0009410 | response to xenobiotic stimulus | 6.47e-07 |
CAMK2A | GO:0010038 | response to metal ion | 7.60e-07 |
CAMK2A | GO:1902074 | response to salt | 8.59e-07 |
CAMK2A | GO:0071248 | cellular response to metal ion | 5.61e-06 |
CAMK2A | GO:0007611 | learning or memory | 6.01e-06 |
CAMK2A | GO:0071241 | cellular response to inorganic substance | 1.54e-05 |
CAMK2A | GO:0010959 | regulation of metal ion transport | 1.70e-05 |
CAMK2A | GO:1904062 | regulation of monoatomic cation transmembrane transport | 1.70e-05 |
CAMK2A | GO:0032355 | response to estradiol | 1.70e-05 |
CAMK2A | GO:0050890 | cognition | 1.70e-05 |
CAMK2A | GO:0007613 | memory | 2.81e-05 |
CAMK2A | GO:1902075 | cellular response to salt | 5.00e-05 |
CAMK2A | GO:0043279 | response to alkaloid | 9.45e-05 |
CAMK2A | GO:0048168 | regulation of neuronal synaptic plasticity | 1.57e-04 |
CAMK2A | GO:0060047 | heart contraction | 1.96e-04 |
CAMK2A | GO:0050806 | positive regulation of synaptic transmission | 2.32e-04 |
CAMK2A | GO:0003015 | heart process | 2.58e-04 |
CAMK2A | GO:1903522 | regulation of blood circulation | 2.71e-04 |
CAMK2A | GO:0003012 | muscle system process | 2.87e-04 |
CAMK2A | GO:0050808 | synapse organization | 4.97e-04 |
CAMK2A | GO:0006836 | neurotransmitter transport | 6.01e-04 |
CAMK2A | GO:0008016 | regulation of heart contraction | 6.01e-04 |
CAMK2A | GO:0019722 | calcium-mediated signaling | 6.01e-04 |
CAMK2A | GO:0071312 | cellular response to alkaloid | 6.01e-04 |
CAMK2A | GO:0001666 | response to hypoxia | 6.01e-04 |
CAMK2A | GO:0098739 | import across plasma membrane | 6.01e-04 |
CAMK2A | GO:0043270 | positive regulation of monoatomic ion transport | 6.21e-04 |
CAMK2A | GO:0051090 | regulation of DNA-binding transcription factor activity | 6.90e-04 |
CAMK2A | GO:0035865 | cellular response to potassium ion | 7.21e-04 |
CAMK2A | GO:0001508 | action potential | 7.21e-04 |
CAMK2A | GO:0036293 | response to decreased oxygen levels | 7.79e-04 |
CAMK2A | GO:0007612 | learning | 7.99e-04 |
CAMK2A | GO:0042136 | neurotransmitter biosynthetic process | 8.41e-04 |
CAMK2A | GO:0030902 | hindbrain development | 9.86e-04 |
CAMK2A | GO:0001504 | neurotransmitter uptake | 9.96e-04 |
CAMK2A | GO:0022898 | regulation of transmembrane transporter activity | 1.01e-03 |
CAMK2A | GO:0006813 | potassium ion transport | 1.04e-03 |
CAMK2A | GO:0050769 | positive regulation of neurogenesis | 1.05e-03 |
CAMK2A | GO:0061337 | cardiac conduction | 1.10e-03 |
CAMK2A | GO:0048738 | cardiac muscle tissue development | 1.10e-03 |
CAMK2A | GO:0090257 | regulation of muscle system process | 1.10e-03 |
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Related Drugs to TNIP1_CAMK2A |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning TNIP1-CAMK2A and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to TNIP1_CAMK2A |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |