Ensembl transtripts involved in fusion gene | ENST ids | ENST00000316664, ENST00000333602, ENST00000381916, ENST00000392400, ENST00000428187, ENST00000468819,
| ENST00000395290, ENST00000531165, ENST00000310513, ENST00000358597, ENST00000361904, ENST00000395292, ENST00000532048, ENST00000539455,
|
Hgene | Tgene |
TNK2
Q07912 | CELF1
Q92879 |
FUNCTION: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}. | FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}. |
Kinase | GOID | GO term | P.adjust |
TNK2 | ID | Description | 0.00e+00 |
TNK2 | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | 3.61e-03 |
TNK2 | GO:0060767 | epithelial cell proliferation involved in prostate gland development | 3.61e-03 |
TNK2 | GO:1901655 | cellular response to ketone | 3.61e-03 |
TNK2 | GO:0050678 | regulation of epithelial cell proliferation | 5.15e-03 |
TNK2 | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 6.55e-03 |
TNK2 | GO:0050673 | epithelial cell proliferation | 6.55e-03 |
TNK2 | GO:0050680 | negative regulation of epithelial cell proliferation | 6.60e-03 |
TNK2 | GO:0072331 | signal transduction by p53 class mediator | 6.60e-03 |
TNK2 | GO:0071383 | cellular response to steroid hormone stimulus | 8.82e-03 |
TNK2 | GO:1901654 | response to ketone | 8.82e-03 |
TNK2 | GO:0071241 | cellular response to inorganic substance | 9.77e-03 |
TNK2 | GO:0097191 | extrinsic apoptotic signaling pathway | 9.77e-03 |
TNK2 | GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | 1.33e-02 |
TNK2 | GO:0030521 | androgen receptor signaling pathway | 1.36e-02 |
TNK2 | GO:0030850 | prostate gland development | 1.36e-02 |
TNK2 | GO:0048009 | insulin-like growth factor receptor signaling pathway | 1.38e-02 |
TNK2 | GO:0046686 | response to cadmium ion | 1.53e-02 |
TNK2 | GO:0060135 | maternal process involved in female pregnancy | 1.53e-02 |
TNK2 | GO:0048638 | regulation of developmental growth | 1.53e-02 |
TNK2 | GO:0048545 | response to steroid hormone | 1.53e-02 |
TNK2 | GO:0061180 | mammary gland epithelium development | 1.53e-02 |
TNK2 | GO:0001655 | urogenital system development | 1.53e-02 |
TNK2 | GO:0038034 | signal transduction in absence of ligand | 1.53e-02 |
TNK2 | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand | 1.53e-02 |
TNK2 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 1.89e-02 |
TNK2 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 2.11e-02 |
TNK2 | GO:1904029 | regulation of cyclin-dependent protein kinase activity | 2.12e-02 |
TNK2 | GO:2001233 | regulation of apoptotic signaling pathway | 2.12e-02 |
TNK2 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 2.63e-02 |
TNK2 | GO:0048732 | gland development | 2.63e-02 |
TNK2 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 2.63e-02 |
TNK2 | GO:1903076 | regulation of protein localization to plasma membrane | 2.97e-02 |
TNK2 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 3.67e-02 |
TNK2 | GO:0010595 | positive regulation of endothelial cell migration | 4.03e-02 |
TNK2 | GO:0030879 | mammary gland development | 4.10e-02 |
TNK2 | GO:1904375 | regulation of protein localization to cell periphery | 4.17e-02 |
TNK2 | GO:0043401 | steroid hormone mediated signaling pathway | 4.17e-02 |
TNK2 | GO:0001890 | placenta development | 4.85e-02 |
TNK2 | GO:0043535 | regulation of blood vessel endothelial cell migration | 4.85e-02 |
TNK2 | GO:0036294 | cellular response to decreased oxygen levels | 5.04e-02 |
TNK2 | GO:0007009 | plasma membrane organization | 5.16e-02 |
TNK2 | GO:0048660 | regulation of smooth muscle cell proliferation | 5.16e-02 |
TNK2 | GO:0071453 | cellular response to oxygen levels | 5.16e-02 |
TNK2 | GO:0048659 | smooth muscle cell proliferation | 5.16e-02 |
TNK2 | GO:0010634 | positive regulation of epithelial cell migration | 5.16e-02 |
TNK2 | GO:0035265 | organ growth | 5.16e-02 |
TNK2 | GO:0006469 | negative regulation of protein kinase activity | 5.16e-02 |
TNK2 | GO:0001936 | regulation of endothelial cell proliferation | 5.16e-02 |
TNK2 | GO:0007219 | Notch signaling pathway | 5.16e-02 |