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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:TPT1_PRKD2

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: TPT1_PRKD2
KinaseFusionDB ID: KFG6713
FusionGDB2.0 ID: KFG6713
HgeneTgene
Gene symbol

TPT1

PRKD2

Gene ID

7178

25865

Gene nametumor protein, translationally-controlled 1protein kinase D2
SynonymsHRF|TCTP|p02|p23HSPC187|PKD2|nPKC-D2
Cytomap

13q14.13

19q13.32

Type of geneprotein-codingprotein-coding
Descriptiontranslationally-controlled tumor proteinfortilinhistamine-releasing factorserine/threonine-protein kinase D2
Modification date2024041120240411
UniProtAcc

P13693

Q9BZL6

Ensembl transtripts involved in fusion geneENST idsENST00000530705, ENST00000309246, 
ENST00000379055, ENST00000379056, 
ENST00000379060, ENST00000529421, 
ENST00000291281, ENST00000433867, 
ENST00000593492, ENST00000595515, 
ENST00000600194, ENST00000601806, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: TPT1 [Title/Abstract] AND PRKD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TPT1(45911312)-PRKD2(47206722), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKD2

GO:0006468

protein phosphorylation

22228765

TgenePRKD2

GO:0045944

positive regulation of transcription by RNA polymerase II

17077180

TgenePRKD2

GO:0046777

protein autophosphorylation

17077180

TgenePRKD2

GO:0050852

T cell receptor signaling pathway

17077180


check buttonKinase Fusion gene breakpoints across TPT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across PRKD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0CD579216TPT1chr13

45911312

PRKD2chr19

47206722



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:45911312/:47206722)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TPT1

P13693

PRKD2

Q9BZL6

FUNCTION: Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344). {ECO:0000269|PubMed:12167714, ECO:0000269|PubMed:15162379, ECO:0000269|PubMed:15958728, ECO:0000269|PubMed:18325344}.FUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of TPT1_PRKD2


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKD2Q9BZL6humanIFNAR1P17181S535SSQTsQDsGNysNED
PRKD2Q9BZL6humanPAK4O96013S99MsVTRsNsLRRDsPP
PRKD2Q9BZL6humanPI4KBQ9UBF8-2S294SNLKRtAsNPKVENE
PRKD2Q9BZL6humanCTTNQ14247S298EKLAkHEsQQDyskGHS1_rep
PRKD2Q9BZL6humanSETQ01105-2S171KDLTKRSsQTQNKAsNAP
PRKD2Q9BZL6humanARFIP1P53367-2S100LELVRKWsLNTYKCTArfaptin
PRKD2Q9BZL6humanITGB4P16144-2T1736EFVSRTLttSGTLST
PRKD2Q9BZL6humanMFFQ9GZY8S172GQLVRNDsLWHRsDsMiff
PRKD2Q9BZL6humanCIB1Q99828S78ERICRVFsTSPAKDS
PRKD2Q9BZL6humanVASPP50552S239GAKLRKVsKQEEASG
PRKD2Q9BZL6humanHDAC7Q8WUI4S181NPLLRKEsAPPsLRR
PRKD2Q9BZL6humanSSH1Q8WYL5S978sPLKRSHsLAKLGSL
PRKD2Q9BZL6humanHDAC5Q9UQL6S498RPLSRtQsSPLPQsP
PRKD2Q9BZL6humanPKD2Q13563S801SSLPRPMsSRSFPRs
PRKD2Q9BZL6humanMARK2Q7KZI7S400HkVQRsVsANPKQRR
PRKD2Q9BZL6humanPRKD2Q9BZL6S876QGLAERIsVL_____
PRKD2Q9BZL6humanRIN1Q13671S292QLLRREssVGyRVPA
PRKD2Q9BZL6humanSSH1Q8WYL5S937SNLtRssssDsIHsV
PRKD2Q9BZL6humanVASPP50552S157EHIERRVsNAGGPPA
PRKD2Q9BZL6humanVASPP50552S322TtLPRMkssssVttS


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKD2IDDescription0.00e+00
PRKD2GO:0043535regulation of blood vessel endothelial cell migration4.20e-03
PRKD2GO:0043534blood vessel endothelial cell migration4.20e-03
PRKD2GO:1902903regulation of supramolecular fiber organization4.20e-03
PRKD2GO:0043536positive regulation of blood vessel endothelial cell migration5.49e-03
PRKD2GO:0010594regulation of endothelial cell migration5.49e-03
PRKD2GO:0090049regulation of cell migration involved in sprouting angiogenesis5.49e-03
PRKD2GO:0001667ameboidal-type cell migration5.82e-03
PRKD2GO:0002042cell migration involved in sprouting angiogenesis6.55e-03
PRKD2GO:0110053regulation of actin filament organization6.55e-03
PRKD2GO:0043542endothelial cell migration6.55e-03
PRKD2GO:1905477positive regulation of protein localization to membrane6.55e-03
PRKD2GO:0010632regulation of epithelial cell migration6.81e-03
PRKD2GO:0032956regulation of actin cytoskeleton organization9.96e-03
PRKD2GO:0010595positive regulation of endothelial cell migration9.96e-03
PRKD2GO:0030833regulation of actin filament polymerization1.06e-02
PRKD2GO:0090314positive regulation of protein targeting to membrane1.08e-02
PRKD2GO:0010631epithelial cell migration1.08e-02
PRKD2GO:0090132epithelium migration1.08e-02
PRKD2GO:0032970regulation of actin filament-based process1.08e-02
PRKD2GO:0090130tissue migration1.08e-02
PRKD2GO:0008064regulation of actin polymerization or depolymerization1.09e-02
PRKD2GO:0030832regulation of actin filament length1.10e-02
PRKD2GO:0051090regulation of DNA-binding transcription factor activity1.16e-02
PRKD2GO:0090313regulation of protein targeting to membrane1.16e-02
PRKD2GO:0030041actin filament polymerization1.16e-02
PRKD2GO:0090050positive regulation of cell migration involved in sprouting angiogenesis1.18e-02
PRKD2GO:0010634positive regulation of epithelial cell migration1.26e-02
PRKD2GO:1905475regulation of protein localization to membrane1.32e-02
PRKD2GO:0002040sprouting angiogenesis1.46e-02
PRKD2GO:0007015actin filament organization1.50e-02
PRKD2GO:0008154actin polymerization or depolymerization1.50e-02
PRKD2GO:0032271regulation of protein polymerization1.63e-02
PRKD2GO:0022411cellular component disassembly1.80e-02
PRKD2GO:0030838positive regulation of actin filament polymerization2.00e-02
PRKD2GO:0007160cell-matrix adhesion2.36e-02
PRKD2GO:0051289protein homotetramerization2.36e-02
PRKD2GO:0051091positive regulation of DNA-binding transcription factor activity2.36e-02
PRKD2GO:0032623interleukin-2 production2.55e-02
PRKD2GO:0032663regulation of interleukin-2 production2.55e-02
PRKD2GO:0045860positive regulation of protein kinase activity3.31e-02
PRKD2GO:0051258protein polymerization3.36e-02
PRKD2GO:1903533regulation of protein targeting3.71e-02
PRKD2GO:0033627cell adhesion mediated by integrin4.48e-02
PRKD2GO:0051262protein tetramerization4.57e-02
PRKD2GO:0032273positive regulation of protein polymerization4.57e-02
PRKD2GO:0060562epithelial tube morphogenesis4.57e-02
PRKD2GO:0032386regulation of intracellular transport4.57e-02
PRKD2GO:0033674positive regulation of kinase activity4.57e-02
PRKD2GO:0007044cell-substrate junction assembly4.57e-02

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Related Drugs to TPT1_PRKD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning TPT1-PRKD2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to TPT1_PRKD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate