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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:TRIM24_FGFR1

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: TRIM24_FGFR1
	KinaseFusionDB ID: KFG6748
	FusionGDB2.0 ID: KFG6748
		Hgene	Tgene
	Gene symbol	TRIM24	FGFR1
	Gene ID	8805	2260
	Gene name	tripartite motif containing 24	fibroblast growth factor receptor 1
	Synonyms	PTC6\|RNF82\|TF1A\|TIF1\|TIF1A\|TIF1ALPHA\|hTIF1	BFGFR\|CD331\|CEK\|ECCL\|FGFBR\|FGFR-1\|FLG\|FLT-2\|FLT2\|HBGFR\|HH2\|HRTFDS\|KAL2\|N-SAM\|OGD\|bFGF-R-1
	Cytomap	7q33-q34	8p11.23
	Type of gene	protein-coding	protein-coding
	Description	transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1	fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
	Modification date	20240411	20240416
	UniProtAcc	O15164	Q9NVK5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000343526, ENST00000415680, ENST00000497516,	ENST00000496629, ENST00000326324, ENST00000335922, ENST00000356207, ENST00000397091, ENST00000397103, ENST00000397108, ENST00000397113, ENST00000425967, ENST00000447712, ENST00000532791, ENST00000341462,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: TRIM24 [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRIM24	GO:0016567	protein ubiquitination	19556538
Hgene	TRIM24	GO:0071391	cellular response to estrogen stimulus	21164480
Tgene	FGFR1	GO:0008284	positive regulation of cell population proliferation	8663044
Tgene	FGFR1	GO:0008543	fibroblast growth factor receptor signaling pathway	8663044\|21885851
Tgene	FGFR1	GO:0010863	positive regulation of phospholipase C activity	18480409
Tgene	FGFR1	GO:0018108	peptidyl-tyrosine phosphorylation	8622701\|18480409
Tgene	FGFR1	GO:0043406	positive regulation of MAP kinase activity	8622701\|18480409
Tgene	FGFR1	GO:0044344	cellular response to fibroblast growth factor stimulus	21885851
Tgene	FGFR1	GO:0046777	protein autophosphorylation	8622701
Tgene	FGFR1	GO:2001028	positive regulation of endothelial cell chemotaxis	21885851

Kinase Fusion gene breakpoints across TRIM24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across FGFR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerKB3	.	TRIM24	chr7	138255748	FGFR1	chr8	38277253

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000343526	ENST00000341462	TRIM24	chr7	138255748	FGFR1	chr8	38277253	5968	1128

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000343526_ENST00000341462_TRIM24_chr7_138255748_FGFR1_chr8_38277253_length(amino acids)=1128
MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR
LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI
IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE
QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE
INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD
PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ
GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS
SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK
PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ
LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW
SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLD

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:/chr8:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TRIM24 O15164	FGFR1 Q9NVK5
FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269\|PubMed:16322096, ECO:0000269\|PubMed:19556538, ECO:0000269\|PubMed:21164480, ECO:0000269\|PubMed:24820418, ECO:0000269\|PubMed:32324863, ECO:0000269\|PubMed:33724611}.	FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	6	17	478_767	269	732	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	6	17	478_767	271	734	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	7	18	478_767	358	821	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	7	18	478_767	360	821	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	7	18	478_767	360	823	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	8	19	478_767	352	813	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	8	19	478_767	358	821	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	TRIM24	138255748	FGFR1	38277253	ENST00000343526	8	19	478_767	391	854	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>530_TRIM24_FGFR1	ENST00000343526	ENST00000341462	TRIM24	chr7	138255748	FGFR1	chr8	38277253	MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLD	1128
3D view using mol* of 530_TRIM24_FGFR1

PDB file >>>TKFP_906_TRIM24_FGFR1	ENST00000343526	ENST00000341462	TRIM24	chr7	138255748	FGFR1	chr8	38277253	MALPRVHRAASEEQPQEEEEVVGGGGRRPRSRFPGGGKGRTMEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAAR LNLLDTCAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHI IDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKE QLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVE INKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCD PSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRMQ GPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPS SPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV HKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDK PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLD	1128_TRIM24_FGFR1

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

TRIM24_FGFR1 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/530_TRIM24_FGFR1.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

530_TRIM24_FGFR1.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

530_TRIM24_FGFR1_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Netarsudil	-6.8463899999999995	-6.857489999999999	-34.742
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Netarsudil	-6.8463899999999995	-6.857489999999999	-34.742
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Ponatinib	-5.79332	-5.9999199999999995	-44.0285
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Ponatinib	-5.79332	-5.9999199999999995	-44.0285
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Ponatinib	-5.79332	-5.9999199999999995	-44.0285
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Neratinib	-5.7506900000000005	-5.93659	-36.7428
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Lapatinib	-5.61906	-5.70786	-58.2924
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Larotrectinib	-5.578069999999999	-5.578069999999999	-37.6923
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Neratinib	-5.47708	-6.38298	-40.4821
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Palbociclib	-5.4035400000000005	-5.8730400000000005	-50.5879
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Palbociclib	-5.4035400000000005	-5.8730400000000005	-50.5879
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Palbociclib	-5.4035400000000005	-5.8730400000000005	-50.5879
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Regorafenib	-5.29881	-5.29881	-44.4439
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Asciminib	-5.17053	-5.5336300000000005	-37.5178
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Asciminib	-5.1123199999999995	-5.47542	-44.5599
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Entrectinib	-5.07453	-6.50393	-44.2774
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Fostamatinib	-5.06117	-6.41507	-46.7342
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Fostamatinib	-5.06117	-6.41507	-46.7342
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Acalabrutinib	-5.0601	-5.0742	-41.5788
530_TRIM24_FGFR1-DOCK_HTVS_1-001	Acalabrutinib	-5.0601	-5.0742	-41.5788

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Kinase-Substrate Information of TRIM24_FGFR1

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
FGFR1	P11362	human	IDH1	O75874	Y42	VELDLHsyDLGIENR	Iso_dh
FGFR1	P11362	human	PDP1	Q9P0J1	Y94	SILkANEySFkVPEF
FGFR1	P11362	human	FGFR1	P11362	Y653	RDIHHIDyykKTTNG	PK_Tyr_Ser-Thr
FGFR1	P11362	human	FGFR1	P11362	Y583	RRPPGLEyCyNPsHN	PK_Tyr_Ser-Thr
FGFR1	P11362	human	AMOTL2	Q9Y2J4	Y107	kGEELPTyEEAKAHS
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y680	KLHCIVTyCEyCQEE
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y683	CIVTyCEyCQEEKTL
FGFR1	P11362	human	FGFR1	P11362	Y585	PPGLEyCyNPsHNPE	PK_Tyr_Ser-Thr
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y557	QCIGPNGyMEPYCSt	zf-FCS
FGFR1	P11362	human	PDK1	Q15118	Y136	AEDAkAIyDFTDTVI	BCDHK_Adom3
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y502	CQSCVSEykQVGSHP	zf-FCS
FGFR1	P11362	human	STAT3	P40763	Y705	DPGsAAPyLktKFIC
FGFR1	P11362	human	LDHA	P00338	Y83	kIVSGkDyNVTANsk	Ldh_1_N
FGFR1	P11362	human	PDK1	Q15118	Y244	RRLCDLyyINSPELE
FGFR1	P11362	human	FGFR1	P11362	Y730	SNCTNELyMMMRDCW	PK_Tyr_Ser-Thr
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y729	LRCVTCNyCSQLCKk	zf-FCS
FGFR1	P11362	human	FGFR1	P11362	Y654	DIHHIDyykKTTNGR	PK_Tyr_Ser-Thr
FGFR1	P11362	human	ITGB4	P16144	Y1564	LQGYSVEyQLLNGGE	fn3
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y595	KRNsLPQyQATMPDG
FGFR1	P11362	human	FGFR1	P11362	Y154	NRMPVAPyWTSPEKM
FGFR1	P11362	human	FGFR1	P11362	Y766	ALTSNQEyLDLSMPL
FGFR1	P11362	human	FGFR1	P11362	Y463	MLAGVSEyELPEDPR
FGFR1	P11362	human	PDP1	Q9P0J1	Y381	DQLNDNEyTkFIPPN	PP2C
FGFR1	P11362	human	PLCG1	P19174	Y783	EGRNPGFyVEANPMP
FGFR1	P11362	human	LDHA	P00338	Y10	tLkDQLIyNLLkEEQ
FGFR1	P11362	human	PDHA1	P08559	Y301	MsDPGVsyRtREEIQ	E1_dh
FGFR1	P11362	human	PDK1	Q15118	Y243	ARRLCDLyyINSPEL
FGFR1	P11362	human	ACAT1	P24752	Y407	HALKQGEyGLASICN	Thiolase_C
FGFR1	P11362	human	ZMYM2	Q9UBW7	Y605	TMPDGkLyNFCNsSC

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
FGFR1	ID	Description	0.00e+00
FGFR1	GO:0006085	acetyl-CoA biosynthetic process	8.15e-05
FGFR1	GO:1905564	positive regulation of vascular endothelial cell proliferation	1.18e-04
FGFR1	GO:0006090	pyruvate metabolic process	1.18e-04
FGFR1	GO:0006084	acetyl-CoA metabolic process	1.35e-04
FGFR1	GO:0035384	thioester biosynthetic process	2.67e-04
FGFR1	GO:0071616	acyl-CoA biosynthetic process	2.67e-04
FGFR1	GO:0101023	vascular endothelial cell proliferation	2.73e-04
FGFR1	GO:1905562	regulation of vascular endothelial cell proliferation	2.73e-04
FGFR1	GO:0033866	nucleoside bisphosphate biosynthetic process	2.76e-04
FGFR1	GO:0034030	ribonucleoside bisphosphate biosynthetic process	2.76e-04
FGFR1	GO:0034033	purine nucleoside bisphosphate biosynthetic process	2.76e-04
FGFR1	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	8.66e-04
FGFR1	GO:0006637	acyl-CoA metabolic process	9.91e-04
FGFR1	GO:0035383	thioester metabolic process	9.91e-04
FGFR1	GO:0001938	positive regulation of endothelial cell proliferation	1.43e-03
FGFR1	GO:0033865	nucleoside bisphosphate metabolic process	1.70e-03
FGFR1	GO:0033875	ribonucleoside bisphosphate metabolic process	1.70e-03
FGFR1	GO:0034032	purine nucleoside bisphosphate metabolic process	1.70e-03
FGFR1	GO:0046434	organophosphate catabolic process	2.55e-03
FGFR1	GO:0048015	phosphatidylinositol-mediated signaling	3.05e-03
FGFR1	GO:0044272	sulfur compound biosynthetic process	3.08e-03
FGFR1	GO:0006163	purine nucleotide metabolic process	3.52e-03
FGFR1	GO:0001936	regulation of endothelial cell proliferation	3.91e-03
FGFR1	GO:0072521	purine-containing compound metabolic process	3.91e-03
FGFR1	GO:0006099	tricarboxylic acid cycle	3.91e-03
FGFR1	GO:0001667	ameboidal-type cell migration	3.91e-03
FGFR1	GO:0001935	endothelial cell proliferation	4.69e-03
FGFR1	GO:0009152	purine ribonucleotide biosynthetic process	5.28e-03
FGFR1	GO:0050679	positive regulation of epithelial cell proliferation	5.46e-03
FGFR1	GO:0044242	cellular lipid catabolic process	5.64e-03
FGFR1	GO:0009260	ribonucleotide biosynthetic process	5.82e-03
FGFR1	GO:0046390	ribose phosphate biosynthetic process	6.17e-03
FGFR1	GO:0006164	purine nucleotide biosynthetic process	7.83e-03
FGFR1	GO:0009395	phospholipid catabolic process	7.83e-03
FGFR1	GO:0072522	purine-containing compound biosynthetic process	8.19e-03
FGFR1	GO:0009165	nucleotide biosynthetic process	1.06e-02
FGFR1	GO:1901293	nucleoside phosphate biosynthetic process	1.06e-02
FGFR1	GO:0006790	sulfur compound metabolic process	1.24e-02
FGFR1	GO:0043536	positive regulation of blood vessel endothelial cell migration	1.35e-02
FGFR1	GO:0016042	lipid catabolic process	1.37e-02
FGFR1	GO:0009150	purine ribonucleotide metabolic process	1.71e-02
FGFR1	GO:0006096	glycolytic process	1.71e-02
FGFR1	GO:0009259	ribonucleotide metabolic process	1.92e-02
FGFR1	GO:0019693	ribose phosphate metabolic process	1.99e-02
FGFR1	GO:0050678	regulation of epithelial cell proliferation	2.15e-02
FGFR1	GO:0010595	positive regulation of endothelial cell migration	3.30e-02
FGFR1	GO:0050673	epithelial cell proliferation	3.30e-02
FGFR1	GO:0043535	regulation of blood vessel endothelial cell migration	4.35e-02
FGFR1	GO:0016052	carbohydrate catabolic process	4.80e-02

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Related Drugs to TRIM24_FGFR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning TRIM24-FGFR1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to TRIM24_FGFR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
TRIM24	FGFR1	Breast Invasive Ductal Carcinoma	MyCancerGenome
TRIM24	FGFR1	Colon Adenocarcinoma	MyCancerGenome
TRIM24	FGFR1	Dysembryoplastic Neuroepithelial Tumor	MyCancerGenome
TRIM24	FGFR1	High Grade Ovarian Serous Adenocarcinoma	MyCancerGenome
TRIM24	FGFR1	Invasive Breast Carcinoma	MyCancerGenome

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TRIM24	C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene	FGFR1	C1563720	Kallmann Syndrome 2 (disorder)	18	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C1845146	Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate	6	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	FGFR1	C0011570	Mental Depression	5	PSYGENET
Tgene	FGFR1	C0011581	Depressive disorder	5	CTD_human;PSYGENET
Tgene	FGFR1	C0220658	Pfeiffer Syndrome	5	GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C0432283	Osteoglophonic dwarfism	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	FGFR1	C0041696	Unipolar Depression	4	CTD_human;PSYGENET
Tgene	FGFR1	C0406612	Encephalocraniocutaneous lipomatosis	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	FGFR1	C0005586	Bipolar Disorder	3	PSYGENET
Tgene	FGFR1	C0795998	JACKSON-WEISS SYNDROME	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C1269683	Major Depressive Disorder	3	PSYGENET
Tgene	FGFR1	C0006142	Malignant neoplasm of breast	2	CGI;CTD_human
Tgene	FGFR1	C0007131	Non-Small Cell Lung Carcinoma	2	CTD_human
Tgene	FGFR1	C0007137	Squamous cell carcinoma	2	CTD_human
Tgene	FGFR1	C0027022	Myeloproliferative disease	2	CTD_human
Tgene	FGFR1	C0162809	Kallmann Syndrome	2	CTD_human;ORPHANET
Tgene	FGFR1	C0432122	Interfrontal craniofaciosynostosis	2	GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C0678222	Breast Carcinoma	2	CGI;CTD_human
Tgene	FGFR1	C1257931	Mammary Neoplasms, Human	2	CTD_human
Tgene	FGFR1	C1458155	Mammary Neoplasms	2	CTD_human
Tgene	FGFR1	C4704874	Mammary Carcinoma, Human	2	CTD_human

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date