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Kinase Fusion Gene:TRIM8_PRKX |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: TRIM8_PRKX | KinaseFusionDB ID: KFG6787 | FusionGDB2.0 ID: KFG6787 | Hgene | Tgene | Gene symbol | TRIM8 | PRKX | Gene ID | 81603 | 5613 | |
| Gene name | tripartite motif containing 8 | protein kinase cAMP-dependent X-linked catalytic subunit | ||||||||||
| Synonyms | FSGSNEDS|GERP|RNF27 | PKX1 | ||||||||||
| Cytomap | 10q24.32 | Xp22.33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | E3 ubiquitin-protein ligase TRIM8RING-type E3 ubiquitin transferase TRIM8glioblastoma-expressed RING finger proteinprobable E3 ubiquitin-protein ligase TRIM8ring finger protein 27tripartite motif protein TRIM8 | cAMP-dependent protein kinase catalytic subunit PRKXprotein kinase PKX1protein kinase Xprotein kinase X-linkedserine/threonine-protein kinase PRKX | ||||||||||
| Modification date | 20240305 | 20240411 | ||||||||||
| UniProtAcc | Q9BZR9 | P51817 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000302424, ENST00000487927, | ENST00000262848, ENST00000425240, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TRIM8 [Title/Abstract] AND PRKX [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRIM8 | GO:0007249 | canonical NF-kappaB signal transduction | 27995356 |
| Hgene | TRIM8 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 23077300 |
| Hgene | TRIM8 | GO:0044790 | suppression of viral release by host | 18248090 |
| Hgene | TRIM8 | GO:0045087 | innate immune response | 18248090 |
| Hgene | TRIM8 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 23077300 |
| Hgene | TRIM8 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
| Hgene | TRIM8 | GO:0070534 | protein K63-linked ubiquitination | 27995356 |
| Tgene | PRKX | GO:0018105 | peptidyl-serine phosphorylation | 16491121 |
| Tgene | PRKX | GO:0030099 | myeloid cell differentiation | 9860982 |
| Tgene | PRKX | GO:0030155 | regulation of cell adhesion | 17980165 |
| Tgene | PRKX | GO:0030334 | regulation of cell migration | 17980165 |
| Tgene | PRKX | GO:0046777 | protein autophosphorylation | 10026146|16491121 |
| Tgene | PRKX | GO:0060562 | epithelial tube morphogenesis | 17980165 |
| Tgene | PRKX | GO:0060993 | kidney morphogenesis | 17980165 |
| Tgene | PRKX | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development | 17980165 |
| Kinase Fusion gene breakpoints across TRIM8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PRKX (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | SW1463 | TRIM8 | chr10 | 104404364 | PRKX | chrX | 3525338 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRIM8 | PRKX |
| FUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response (PubMed:27981609, PubMed:28747347). Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791, PubMed:27981609, PubMed:34871740). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148). Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction (PubMed:28747347). {ECO:0000269|PubMed:12163497, ECO:0000269|PubMed:20516148, ECO:0000269|PubMed:22084099, ECO:0000269|PubMed:23152791, ECO:0000269|PubMed:28747347, ECO:0000269|PubMed:34871740}. | FUNCTION: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of TRIM8_PRKX |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PRKX | P51817 | human | SMAD6 | O43541 | S435 | RKVPPGYsIKVFDFE | MH2 |
| PRKX | P51817 | human | PKD1 | P98161 | S4166 | EPLPSRSsRGsKVSP |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PRKX | ID | Description | 0.00e+00 |
| PRKX | GO:0034405 | response to fluid shear stress | 6.30e-04 |
| PRKX | GO:0072163 | mesonephric epithelium development | 1.48e-03 |
| PRKX | GO:0072164 | mesonephric tubule development | 1.48e-03 |
| PRKX | GO:0001823 | mesonephros development | 1.48e-03 |
| PRKX | GO:0072073 | kidney epithelium development | 2.51e-03 |
| PRKX | GO:0001822 | kidney development | 8.40e-03 |
| PRKX | GO:0072001 | renal system development | 8.40e-03 |
| PRKX | GO:0031589 | cell-substrate adhesion | 8.87e-03 |
| PRKX | GO:0072014 | proximal tubule development | 1.44e-02 |
| PRKX | GO:0072205 | metanephric collecting duct development | 1.44e-02 |
| PRKX | GO:0072173 | metanephric tubule morphogenesis | 1.44e-02 |
| PRKX | GO:0003183 | mitral valve morphogenesis | 1.44e-02 |
| PRKX | GO:0009950 | dorsal/ventral axis specification | 1.44e-02 |
| PRKX | GO:0072017 | distal tubule development | 1.44e-02 |
| PRKX | GO:0072070 | loop of Henle development | 1.44e-02 |
| PRKX | GO:0003174 | mitral valve development | 1.44e-02 |
| PRKX | GO:0034616 | response to laminar fluid shear stress | 1.44e-02 |
| PRKX | GO:0042994 | cytoplasmic sequestering of transcription factor | 1.44e-02 |
| PRKX | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 1.44e-02 |
| PRKX | GO:0051290 | protein heterotetramerization | 1.44e-02 |
| PRKX | GO:0072044 | collecting duct development | 1.44e-02 |
| PRKX | GO:0072176 | nephric duct development | 1.44e-02 |
| PRKX | GO:0032926 | negative regulation of activin receptor signaling pathway | 1.47e-02 |
| PRKX | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity | 1.47e-02 |
| PRKX | GO:0001502 | cartilage condensation | 1.47e-02 |
| PRKX | GO:0003184 | pulmonary valve morphogenesis | 1.47e-02 |
| PRKX | GO:0051220 | cytoplasmic sequestering of protein | 1.47e-02 |
| PRKX | GO:0072234 | metanephric nephron tubule development | 1.47e-02 |
| PRKX | GO:0003177 | pulmonary valve development | 1.47e-02 |
| PRKX | GO:0036303 | lymph vessel morphogenesis | 1.47e-02 |
| PRKX | GO:0060392 | negative regulation of SMAD protein signal transduction | 1.47e-02 |
| PRKX | GO:0098743 | cell aggregation | 1.47e-02 |
| PRKX | GO:0003148 | outflow tract septum morphogenesis | 1.47e-02 |
| PRKX | GO:0072273 | metanephric nephron morphogenesis | 1.47e-02 |
| PRKX | GO:0072170 | metanephric tubule development | 1.47e-02 |
| PRKX | GO:0072243 | metanephric nephron epithelium development | 1.47e-02 |
| PRKX | GO:0003181 | atrioventricular valve morphogenesis | 1.49e-02 |
| PRKX | GO:0032925 | regulation of activin receptor signaling pathway | 1.49e-02 |
| PRKX | GO:0051291 | protein heterooligomerization | 1.49e-02 |
| PRKX | GO:0003171 | atrioventricular valve development | 1.49e-02 |
| PRKX | GO:0072207 | metanephric epithelium development | 1.49e-02 |
| PRKX | GO:0001945 | lymph vessel development | 1.49e-02 |
| PRKX | GO:0003338 | metanephros morphogenesis | 1.49e-02 |
| PRKX | GO:0060674 | placenta blood vessel development | 1.49e-02 |
| PRKX | GO:0090162 | establishment of epithelial cell polarity | 1.60e-02 |
| PRKX | GO:0003180 | aortic valve morphogenesis | 1.75e-02 |
| PRKX | GO:0030279 | negative regulation of ossification | 1.78e-02 |
| PRKX | GO:0072210 | metanephric nephron development | 1.78e-02 |
| PRKX | GO:0000578 | embryonic axis specification | 1.78e-02 |
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Related Drugs to TRIM8_PRKX |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning TRIM8-PRKX and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to TRIM8_PRKX |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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