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Kinase Fusion Gene:TRPM7_TMEM104 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: TRPM7_TMEM104 | KinaseFusionDB ID: KFG6838 | FusionGDB2.0 ID: KFG6838 | Hgene | Tgene | Gene symbol | TRPM7 | TMEM104 | Gene ID | 54822 | 54868 | |
Gene name | transient receptor potential cation channel subfamily M member 7 | transmembrane protein 104 | ||||||||||
Synonyms | ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK | SLC38A12 | ||||||||||
Cytomap | 15q21.2 | 17q25.1 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | transient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase | transmembrane protein 104 | ||||||||||
Modification date | 20240411 | 20240403 | ||||||||||
UniProtAcc | Q96QT4 | Q8NE00 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000313478, ENST00000560955, ENST00000561443, | ENST00000335464, ENST00000417024, ENST00000582330, ENST00000582773, ENST00000584171, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TRPM7 [Title/Abstract] AND TMEM104 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TRPM7(50949978)-TMEM104(72832066), # samples:3 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Kinase Fusion gene breakpoints across TRPM7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across TMEM104 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-C8-A1HI-01A | TRPM7 | chr15 | 50949978 | TMEM104 | chr17 | 72826201 |
ChimerDB4 | TCGA-C8-A1HI-01A | TRPM7 | chr15 | 50949978 | TMEM104 | chr17 | 72832066 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50949978/:72832066) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TRPM7 | TMEM104 |
FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741). Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of TRPM7_TMEM104 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
TRPM7 | Q96QT4 | human | MYH9 | P35579 | S1808 | VKskykAsItALEAk | Myosin_tail_1 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1482 | VssLAGFtDCHRTsI | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1258 | AQkAsEAsKVHNEIt | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1287 | DDGPVRPsVWKKHGV | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1537 | EMPsEEGtLNGLtsP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1404 | PPTKFFVstPsQPsC | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1387 | KNQKLGssSTsIPHL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1405 | PTKFFVstPsQPsCK | |
TRPM7 | Q96QT4 | human | PLCG2 | P16885 | T1045 | LQPESMRtEkyDPMP | |
TRPM7 | Q96QT4 | human | ANXA1 | P04083 | S5 | ___MAMVsEFLKQAW | |
TRPM7 | Q96QT4 | human | PLCG2 | P16885 | S1164 | AVKSGFRsVPLKNGY | C2 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1390 | KLGssSTsIPHLssP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1435 | KATEGDNtEFGAFVG | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1265 | sKVHNEItRELsIsK | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1542 | EGtLNGLtsPFKPAM | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1463 | sNKIKILsNNNTsEN | |
TRPM7 | Q96QT4 | human | EEF2K | O00418 | S78 | ssGsPANsFHFkEAW | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1685 | QRAAQKLtFAFNQMK | Alpha_kinase |
TRPM7 | Q96QT4 | human | TMOD1 | P28289 | S2 | ______MsyRRELEK | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1851 | LNLQPGNsTKESEST | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1358 | SSGALFPsAVsPPEL | |
TRPM7 | Q96QT4 | human | TMOD1 | P28289 | T54 | GLRQKDQtTKAPTGP | Tropomodulin |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1695 | FNQMKPKsIPYSPRF | Alpha_kinase |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1468 | ILsNNNTsENtLkRV | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1543 | GtLNGLtsPFKPAMD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1660 | EVVNTWSsIYKEDTV | Alpha_kinase |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1193 | DDKFHsGsEERIRVT | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1477 | NtLkRVssLAGFtDC | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1860 | KESESTNsVRLML__ | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1471 | NNNTsENtLkRVssL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1569 | NLMRLsQsIPFTPVP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1583 | PPRGEPVtVYRLEES | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1830 | DLKRNDYtPDkIIFP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1615 | CAKIEFLsKEEMGGG | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1446 | AFVGHRDsMDLQRFK | |
TRPM7 | Q96QT4 | human | MYH9 | P35579 | S1803 | EMEGtVKskykAsIt | Myosin_tail_1 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1456 | LQRFKEtsNKIKILs | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1255 | TLTAQkAsEAsKVHN | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1455 | DLQRFKEtsNKIKIL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1779 | GENLTDPsVIKAEEK | Alpha_kinase |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1163 | DGPkLFLtEEDQkKL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1476 | ENtLkRVssLAGFtD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1598 | SPNILNNsMSSWSQL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1567 | RNNLMRLsQsIPFTP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1191 | EKDDKFHsGsEERIR | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1551 | PFKPAMDtNYYYSAV | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1493 | RTsIPVHsKQAEKIs | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1533 | PsNREMPsEEGtLNG | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1505 | KIsRRPstEDtHEVD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1271 | ItRELsIsKHLAQNL | |
TRPM7 | Q96QT4 | human | MYH9 | P35579 | T1800 | kLQEMEGtVKskykA | Myosin_tail_1 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1508 | RRPstEDtHEVDsKA | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1407 | KFFVstPsQPsCKsH | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1513 | EDtHEVDsKAALIPD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1527 | DWLQDRPsNREMPsE |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
TRPM7 | ID | Description | 0.00e+00 |
TRPM7 | GO:0031032 | actomyosin structure organization | 7.27e-03 |
TRPM7 | GO:0006909 | phagocytosis | 7.27e-03 |
TRPM7 | GO:0022604 | regulation of cell morphogenesis | 7.27e-03 |
TRPM7 | GO:0032743 | positive regulation of interleukin-2 production | 7.27e-03 |
TRPM7 | GO:0006911 | phagocytosi | 9.84e-05 |
TRPM7 | GO:0010631 | epithelial cell migration | 8.26e-03 |
TRPM7 | GO:0090132 | epithelium migration | 8.26e-03 |
TRPM7 | GO:0090130 | tissue migration | 8.26e-03 |
TRPM7 | GO:0032623 | interleukin-2 production | 8.26e-03 |
TRPM7 | GO:0032663 | regulation of interleukin-2 production | 8.26e-03 |
TRPM7 | GO:0010324 | membrane invagination | 8.26e-03 |
TRPM7 | GO:1902808 | positive regulation of cell cycle G1/S phase transition | 8.26e-03 |
TRPM7 | GO:0042060 | wound healing | 9.39e-03 |
TRPM7 | GO:1903131 | mononuclear cell differentiation | 1.20e-02 |
TRPM7 | GO:0071277 | cellular response to calcium ion | 1.20e-02 |
TRPM7 | GO:0001667 | ameboidal-type cell migration | 1.24e-02 |
TRPM7 | GO:1901989 | positive regulation of cell cycle phase transition | 2.00e-02 |
TRPM7 | GO:0030168 | platelet activation | 2.36e-02 |
TRPM7 | GO:0008360 | regulation of cell shape | 2.48e-02 |
TRPM7 | GO:0051592 | response to calcium ion | 2.50e-02 |
TRPM7 | GO:0045807 | positive regulation of endocytosis | 2.76e-02 |
TRPM7 | GO:0010634 | positive regulation of epithelial cell migration | 3.40e-02 |
TRPM7 | GO:0043534 | blood vessel endothelial cell migration | 3.45e-02 |
TRPM7 | GO:1902075 | cellular response to salt | 3.88e-02 |
TRPM7 | GO:0071248 | cellular response to metal ion | 3.88e-02 |
TRPM7 | GO:1902806 | regulation of cell cycle G1/S phase transition | 4.07e-02 |
TRPM7 | GO:0002285 | lymphocyte activation involved in immune response | 4.08e-02 |
TRPM7 | GO:0007596 | blood coagulation | 4.18e-02 |
TRPM7 | GO:0050817 | coagulation | 4.18e-02 |
TRPM7 | GO:0071241 | cellular response to inorganic substance | 4.18e-02 |
TRPM7 | GO:0007599 | hemostasis | 4.18e-02 |
TRPM7 | GO:0002274 | myeloid leukocyte activation | 4.33e-02 |
TRPM7 | GO:0032984 | protein-containing complex disassembly | 4.33e-02 |
TRPM7 | GO:0090068 | positive regulation of cell cycle process | 4.33e-02 |
TRPM7 | GO:0002699 | positive regulation of immune effector process | 4.33e-02 |
TRPM7 | GO:0044843 | cell cycle G1/S phase transition | 4.33e-02 |
TRPM7 | GO:0032429 | regulation of phospholipase A2 activity | 4.33e-02 |
TRPM7 | GO:0033034 | positive regulation of myeloid cell apoptotic process | 4.33e-02 |
TRPM7 | GO:0043542 | endothelial cell migration | 4.33e-02 |
TRPM7 | GO:0030100 | regulation of endocytosis | 4.33e-02 |
TRPM7 | GO:0007343 | egg activation | 4.33e-02 |
TRPM7 | GO:0031340 | positive regulation of vesicle fusion | 4.33e-02 |
TRPM7 | GO:0045625 | regulation of T-helper 1 cell differentiation | 4.33e-02 |
TRPM7 | GO:0010632 | regulation of epithelial cell migration | 4.33e-02 |
TRPM7 | GO:0002366 | leukocyte activation involved in immune response | 4.33e-02 |
TRPM7 | GO:0002263 | cell activation involved in immune response | 4.33e-02 |
TRPM7 | GO:0051146 | striated muscle cell differentiation | 4.33e-02 |
TRPM7 | GO:0002732 | positive regulation of dendritic cell cytokine production | 4.33e-02 |
TRPM7 | GO:0032957 | inositol trisphosphate metabolic process | 4.33e-02 |
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Related Drugs to TRPM7_TMEM104 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning TRPM7-TMEM104 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to TRPM7_TMEM104 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |