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Kinase Fusion Gene:TTK_BCKDHB |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: TTK_BCKDHB | KinaseFusionDB ID: KFG6894 | FusionGDB2.0 ID: KFG6894 | Hgene | Tgene | Gene symbol | TTK | BCKDHB | Gene ID | 7272 | 594 | |
Gene name | TTK protein kinase | branched chain keto acid dehydrogenase E1 subunit beta | ||||||||||
Synonyms | CT96|ESK|MPH1|MPS1|MPS1L1|PYT | BCKDE1B|BCKDH E1-beta|E1B|MSUD1B|OVD1B | ||||||||||
Cytomap | 6q14.1 | 6q14.1 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | dual specificity protein kinase TTKcancer/testis antigen 96monopolar spindle 1 kinasemonopolar spindle 1-like 1phosphotyrosine picked threonine kinasephosphotyrosine picked threonine-protein kinase | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrialE1b-beta subunit of the branched-chain complexbranched chain alpha-ketoacid dehydrogenase E1-beta subunitbranched chain keto acid dehydrogenase E1 betabranched chain keto acid dehydrogenase E1, | ||||||||||
Modification date | 20240305 | 20240411 | ||||||||||
UniProtAcc | P33981 | P21953 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000515751, ENST00000230510, ENST00000369798, ENST00000509894, | ENST00000545529, ENST00000320393, ENST00000356489, ENST00000369760, ENST00000486968, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: TTK [Title/Abstract] AND BCKDHB [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BCKDHB(80912929)-TTK(80751836), # samples:3 TTK(80724303)-BCKDHB(80910651), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BCKDHB | GO:0009083 | branched-chain amino acid catabolic process | 3593587 |
Kinase Fusion gene breakpoints across TTK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across BCKDHB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-UF-A71A-01A | TTK | chr6 | 80724303 | BCKDHB | chr6 | 80910651 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:80912929/:80751836) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TTK | BCKDHB |
FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:29162720}. | FUNCTION: Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. {ECO:0000269|PubMed:10745006, ECO:0000269|PubMed:9582350}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of TTK_BCKDHB |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
TTK | P33981 | human | USP16 | Q9Y5T5 | S415 | VEDEDQDsEEEKDND | UCH |
TTK | P33981 | human | HSP90AA1 | P07900 | T115 | GtIAksGtkAFMEAL | HATPase_c |
TTK | P33981 | human | TTK | P33981 | S742 | QQIINQIsKLHAIID | Pkinase |
TTK | P33981 | human | BLM | P54132 | S1296 | TsPAEDssPGISLSs | |
TTK | P33981 | human | TTK | P33981 | T46 | NKISADttDNsGTVN | |
TTK | P33981 | human | USP16 | Q9Y5T5 | T554 | EVLtssPtRNLNGAY | UCH |
TTK | P33981 | human | ABL1 | P00519 | T735 | DTEWRSVtLPRDLQS | |
TTK | P33981 | human | TTK | P33981 | T288 | sPDCDVktDDsVVPC | |
TTK | P33981 | human | TTK | P33981 | T33 | kFkNEDLtDELsLNK | |
TTK | P33981 | human | HSPA9 | P38646 | T62 | VVGIDLGtTNsCVAV | HSP70 |
TTK | P33981 | human | TTK | P33981 | S321 | SkPsGNDsCELRNLk | |
TTK | P33981 | human | TTK | P33981 | T12 | DLsGRELtIDsIMNk | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | S22 | RsLNNFIsQRVEGGs | |
TTK | P33981 | human | ARHGEF17 | Q96PE2 | T1007 | APsLEDVtKQYMLNL | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | S610 | ELKKQVEsAELkNQR | MAD |
TTK | P33981 | human | TTK | P33981 | T371 | LLAkLEEtkEyQEPE | |
TTK | P33981 | human | TTK | P33981 | T849 | HNSsSsktFEkkRGK | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | S62 | AEQIRSksHLIQVER | MAD |
TTK | P33981 | human | ARHGEF17 | Q96PE2 | T944 | DEGsQDQtGsLsRAR | |
TTK | P33981 | human | TTK | P33981 | T795 | HPYVQIQtHPVNQMA | |
TTK | P33981 | human | MAP4 | P27816 | S928 | SRLAtNtsAPDLkNV | Tubulin-binding |
TTK | P33981 | human | CDCA8 | Q53HL2 | T230 | DskEIFLtVPVGGGE | Borealin |
TTK | P33981 | human | BUB1B | O60566 | S670 | TLsIkkLsPIIEDsR | |
TTK | P33981 | human | TTK | P33981 | T686 | VkDSQVGtVNYMPPE | Pkinase |
TTK | P33981 | human | TTK | P33981 | S821 | GQLVGLNsPNsILkA | |
TTK | P33981 | human | TTK | P33981 | T676 | NQMQPDttsVVkDSQ | Pkinase |
TTK | P33981 | human | NCAPH2 | Q6IBW4 | S492 | FVQEtELsQRIRDWE | CNDH2_C |
TTK | P33981 | human | ARHGEF17 | Q96PE2 | T751 | AATSEEPtGFSVDSN | |
TTK | P33981 | human | USP16 | Q9Y5T5 | S552 | DLEVLtssPtRNLNG | UCH |
TTK | P33981 | human | BLM | P54132 | S1290 | QKYSEWTsPAEDssP | |
TTK | P33981 | human | TTK | P33981 | S847 | ESHNSsSsktFEkkR | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | T8 | MEDLGENtMVLstLR | |
TTK | P33981 | human | TTK | P33981 | S7 | _MEsEDLsGRELtID | |
TTK | P33981 | human | CDCA8 | Q53HL2 | T94 | AtADLDItEINkLtA | |
TTK | P33981 | human | TTK | P33981 | S362 | TLKNktEssLLAkLE | |
TTK | P33981 | human | TTK | P33981 | T45 | LNKISADttDNsGTV | |
TTK | P33981 | human | BUB1B | O60566 | S1043 | WkVGkLtsPGALLFQ | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | S598 | AAASLPsskEVAELK | MAD |
TTK | P33981 | human | BLM | P54132 | S144 | KKLEFSssPDSLSTI | BLM_N |
TTK | P33981 | human | TTK | P33981 | S49 | SADttDNsGTVNQIM | |
TTK | P33981 | human | TTK | P33981 | T805 | VNQMAkGttEEMkyV | |
TTK | P33981 | human | BUB1B | O60566 | S435 | REAELLtsAEkRAEM | |
TTK | P33981 | human | CDCA8 | Q53HL2 | T169 | KRssRANtVtPAVGR | Borealin |
TTK | P33981 | human | TTK | P33981 | S80 | EkNSVPLsDALLNkL | |
TTK | P33981 | human | MAP4 | P27816 | T927 | LSRLAtNtsAPDLkN | Tubulin-binding |
TTK | P33981 | human | CDCA8 | Q53HL2 | T88 | QALEEAAtADLDItE | |
TTK | P33981 | human | TTK | P33981 | S824 | VGLNsPNsILkAAkT | |
TTK | P33981 | human | TTK | P33981 | T564 | LEEADNQtLDSYRNE | Pkinase |
TTK | P33981 | human | HSPA9 | P38646 | S65 | IDLGtTNsCVAVMEG | HSP70 |
TTK | P33981 | human | BUB1B | O60566 | S543 | LsEkKNksPPADPPR | |
TTK | P33981 | human | TTK | P33981 | S37 | EDLtDELsLNKISAD | |
TTK | P33981 | human | SLC4A4 | Q9Y6R1 | S12 | AVLDRGAsFLKHVCD | |
TTK | P33981 | human | TTK | P33981 | T806 | NQMAkGttEEMkyVL | |
TTK | P33981 | human | CHEK2 | O96017 | T68 | SsLEtVstQELYsIP | |
TTK | P33981 | human | CDCA8 | Q53HL2 | S238 | VPVGGGEsLRLLAsD | Borealin |
TTK | P33981 | human | TTK | P33981 | T675 | ANQMQPDttsVVkDS | Pkinase |
TTK | P33981 | human | TTK | P33981 | S363 | LKNktEssLLAkLEE | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | T716 | LELFSRQtVA_____ | MAD |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | T323 | SWERLDQtMGLSIRT | MAD |
TTK | P33981 | human | TTK | P33981 | S845 | GGESHNSsSsktFEk | |
TTK | P33981 | human | TTK | P33981 | T360 | sITLKNktEssLLAk | |
TTK | P33981 | human | TTK | P33981 | S582 | LNkLQQHsDkIIRLY | Pkinase |
TTK | P33981 | human | TTK | P33981 | S436 | VFSVskQsPPIsTSk | |
TTK | P33981 | human | TTK | P33981 | Y811 | GttEEMkyVLGQLVG | |
TTK | P33981 | human | RMI2 | Q96E14 | S112 | MGVVQACsPEPCLQA | RMI2 |
TTK | P33981 | human | TTK | P33981 | S15 | GRELtIDsIMNkVRD | |
TTK | P33981 | human | MAD1L1 | Q9Y6D9 | T624 | RLkEVFQtkIQEFRK | MAD |
TTK | P33981 | human | TTK | P33981 | S677 | QMQPDttsVVkDSQV | Pkinase |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
TTK | ID | Description | 0.00e+00 |
TTK | GO:0000819 | sister chromatid segregation | 1.28e-07 |
TTK | GO:0045930 | negative regulation of mitotic cell cycle | 1.28e-07 |
TTK | GO:0051983 | regulation of chromosome segregation | 1.28e-07 |
TTK | GO:0140014 | mitotic nuclear division | 1.28e-07 |
TTK | GO:0007093 | mitotic cell cycle checkpoint signaling | 1.28e-07 |
TTK | GO:0051306 | mitotic sister chromatid separation | 1.31e-07 |
TTK | GO:0098813 | nuclear chromosome segregation | 2.15e-07 |
TTK | GO:1905818 | regulation of chromosome separation | 2.44e-07 |
TTK | GO:0000070 | mitotic sister chromatid segregation | 3.09e-07 |
TTK | GO:0051304 | chromosome separation | 3.09e-07 |
TTK | GO:0000075 | cell cycle checkpoint signaling | 3.58e-07 |
TTK | GO:1901991 | negative regulation of mitotic cell cycle phase transition | 3.72e-07 |
TTK | GO:0045786 | negative regulation of cell cycle | 7.28e-07 |
TTK | GO:0033045 | regulation of sister chromatid segregation | 7.85e-07 |
TTK | GO:0007059 | chromosome segregation | 8.37e-07 |
TTK | GO:0000280 | nuclear division | 1.03e-06 |
TTK | GO:0033044 | regulation of chromosome organization | 1.05e-06 |
TTK | GO:0048285 | organelle fission | 1.51e-06 |
TTK | GO:0007094 | mitotic spindle assembly checkpoint signaling | 1.51e-06 |
TTK | GO:0071173 | spindle assembly checkpoint signaling | 1.51e-06 |
TTK | GO:0071174 | mitotic spindle checkpoint signaling | 1.51e-06 |
TTK | GO:1901988 | negative regulation of cell cycle phase transition | 1.51e-06 |
TTK | GO:0031577 | spindle checkpoint signaling | 1.51e-06 |
TTK | GO:0033046 | negative regulation of sister chromatid segregation | 1.51e-06 |
TTK | GO:0033048 | negative regulation of mitotic sister chromatid segregation | 1.51e-06 |
TTK | GO:0045841 | negative regulation of mitotic metaphase/anaphase transition | 1.51e-06 |
TTK | GO:2000816 | negative regulation of mitotic sister chromatid separation | 1.51e-06 |
TTK | GO:0051985 | negative regulation of chromosome segregation | 1.61e-06 |
TTK | GO:1902100 | negative regulation of metaphase/anaphase transition of cell cycle | 1.61e-06 |
TTK | GO:1905819 | negative regulation of chromosome separation | 1.61e-06 |
TTK | GO:0033047 | regulation of mitotic sister chromatid segregation | 2.13e-06 |
TTK | GO:0045839 | negative regulation of mitotic nuclear division | 2.40e-06 |
TTK | GO:0010948 | negative regulation of cell cycle process | 2.51e-06 |
TTK | GO:0010965 | regulation of mitotic sister chromatid separation | 2.79e-06 |
TTK | GO:0051784 | negative regulation of nuclear division | 3.54e-06 |
TTK | GO:1901990 | regulation of mitotic cell cycle phase transition | 4.24e-06 |
TTK | GO:0030071 | regulation of mitotic metaphase/anaphase transition | 1.42e-05 |
TTK | GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 1.56e-05 |
TTK | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 1.56e-05 |
TTK | GO:2001251 | negative regulation of chromosome organization | 1.56e-05 |
TTK | GO:1901987 | regulation of cell cycle phase transition | 1.62e-05 |
TTK | GO:0044784 | metaphase/anaphase transition of cell cycle | 1.69e-05 |
TTK | GO:0044772 | mitotic cell cycle phase transition | 1.84e-05 |
TTK | GO:0007088 | regulation of mitotic nuclear division | 3.54e-05 |
TTK | GO:0007052 | mitotic spindle organization | 5.09e-05 |
TTK | GO:0051783 | regulation of nuclear division | 7.91e-05 |
TTK | GO:0010639 | negative regulation of organelle organization | 1.16e-04 |
TTK | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 1.17e-04 |
TTK | GO:0045910 | negative regulation of DNA recombination | 1.32e-04 |
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Related Drugs to TTK_BCKDHB |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning TTK-BCKDHB and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to TTK_BCKDHB |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |