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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:TTK_TMEM63B

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: TTK_TMEM63B
KinaseFusionDB ID: KFG6895
FusionGDB2.0 ID: KFG6895
HgeneTgene
Gene symbol

TTK

TMEM63B

Gene ID

7272

55362

Gene nameTTK protein kinasetransmembrane protein 63B
SynonymsCT96|ESK|MPH1|MPS1|MPS1L1|PYTC6orf110
Cytomap

6q14.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase TTKcancer/testis antigen 96monopolar spindle 1 kinasemonopolar spindle 1-like 1phosphotyrosine picked threonine kinasephosphotyrosine picked threonine-protein kinaseCSC1-like protein 2
Modification date2024030520240403
UniProtAcc

P33981

Q5T3F8

Ensembl transtripts involved in fusion geneENST idsENST00000230510, ENST00000369798, 
ENST00000509894, ENST00000515751, 
ENST00000527188, ENST00000259746, 
ENST00000323267, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: TTK [Title/Abstract] AND TMEM63B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TTK(80721265)-TMEM63B(44119583), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonKinase Fusion gene breakpoints across TTK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across TMEM63B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-DX-A23Y-01ATTKchr6

80721265

TMEM63Bchr6

44119583

ChimerDB4TCGA-DX-A23YTTKchr6

80721265

TMEM63Bchr6

44119582



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:80721265/chr6:44119583)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTK

P33981

TMEM63B

Q5T3F8

FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:29162720}.FUNCTION: Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). {ECO:0000250|UniProtKB:Q3TWI9}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of TTK_TMEM63B


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
TTKP33981humanUSP16Q9Y5T5S415VEDEDQDsEEEKDNDUCH
TTKP33981humanHSP90AA1P07900T115GtIAksGtkAFMEALHATPase_c
TTKP33981humanTTKP33981S742QQIINQIsKLHAIIDPkinase
TTKP33981humanBLMP54132S1296TsPAEDssPGISLSs
TTKP33981humanTTKP33981T46NKISADttDNsGTVN
TTKP33981humanUSP16Q9Y5T5T554EVLtssPtRNLNGAYUCH
TTKP33981humanABL1P00519T735DTEWRSVtLPRDLQS
TTKP33981humanTTKP33981T288sPDCDVktDDsVVPC
TTKP33981humanTTKP33981T33kFkNEDLtDELsLNK
TTKP33981humanHSPA9P38646T62VVGIDLGtTNsCVAVHSP70
TTKP33981humanTTKP33981S321SkPsGNDsCELRNLk
TTKP33981humanTTKP33981T12DLsGRELtIDsIMNk
TTKP33981humanMAD1L1Q9Y6D9S22RsLNNFIsQRVEGGs
TTKP33981humanARHGEF17Q96PE2T1007APsLEDVtKQYMLNL
TTKP33981humanMAD1L1Q9Y6D9S610ELKKQVEsAELkNQRMAD
TTKP33981humanTTKP33981T371LLAkLEEtkEyQEPE
TTKP33981humanTTKP33981T849HNSsSsktFEkkRGK
TTKP33981humanMAD1L1Q9Y6D9S62AEQIRSksHLIQVERMAD
TTKP33981humanARHGEF17Q96PE2T944DEGsQDQtGsLsRAR
TTKP33981humanTTKP33981T795HPYVQIQtHPVNQMA
TTKP33981humanMAP4P27816S928SRLAtNtsAPDLkNVTubulin-binding
TTKP33981humanCDCA8Q53HL2T230DskEIFLtVPVGGGEBorealin
TTKP33981humanBUB1BO60566S670TLsIkkLsPIIEDsR
TTKP33981humanTTKP33981T686VkDSQVGtVNYMPPEPkinase
TTKP33981humanTTKP33981S821GQLVGLNsPNsILkA
TTKP33981humanTTKP33981T676NQMQPDttsVVkDSQPkinase
TTKP33981humanNCAPH2Q6IBW4S492FVQEtELsQRIRDWECNDH2_C
TTKP33981humanARHGEF17Q96PE2T751AATSEEPtGFSVDSN
TTKP33981humanUSP16Q9Y5T5S552DLEVLtssPtRNLNGUCH
TTKP33981humanBLMP54132S1290QKYSEWTsPAEDssP
TTKP33981humanTTKP33981S847ESHNSsSsktFEkkR
TTKP33981humanMAD1L1Q9Y6D9T8MEDLGENtMVLstLR
TTKP33981humanTTKP33981S7_MEsEDLsGRELtID
TTKP33981humanCDCA8Q53HL2T94AtADLDItEINkLtA
TTKP33981humanTTKP33981S362TLKNktEssLLAkLE
TTKP33981humanTTKP33981T45LNKISADttDNsGTV
TTKP33981humanBUB1BO60566S1043WkVGkLtsPGALLFQ
TTKP33981humanMAD1L1Q9Y6D9S598AAASLPsskEVAELKMAD
TTKP33981humanBLMP54132S144KKLEFSssPDSLSTIBLM_N
TTKP33981humanTTKP33981S49SADttDNsGTVNQIM
TTKP33981humanTTKP33981T805VNQMAkGttEEMkyV
TTKP33981humanBUB1BO60566S435REAELLtsAEkRAEM
TTKP33981humanCDCA8Q53HL2T169KRssRANtVtPAVGRBorealin
TTKP33981humanTTKP33981S80EkNSVPLsDALLNkL
TTKP33981humanMAP4P27816T927LSRLAtNtsAPDLkNTubulin-binding
TTKP33981humanCDCA8Q53HL2T88QALEEAAtADLDItE
TTKP33981humanTTKP33981S824VGLNsPNsILkAAkT
TTKP33981humanTTKP33981T564LEEADNQtLDSYRNEPkinase
TTKP33981humanHSPA9P38646S65IDLGtTNsCVAVMEGHSP70
TTKP33981humanBUB1BO60566S543LsEkKNksPPADPPR
TTKP33981humanTTKP33981S37EDLtDELsLNKISAD
TTKP33981humanSLC4A4Q9Y6R1S12AVLDRGAsFLKHVCD
TTKP33981humanTTKP33981T806NQMAkGttEEMkyVL
TTKP33981humanCHEK2O96017T68SsLEtVstQELYsIP
TTKP33981humanCDCA8Q53HL2S238VPVGGGEsLRLLAsDBorealin
TTKP33981humanTTKP33981T675ANQMQPDttsVVkDSPkinase
TTKP33981humanTTKP33981S363LKNktEssLLAkLEE
TTKP33981humanMAD1L1Q9Y6D9T716LELFSRQtVA_____MAD
TTKP33981humanMAD1L1Q9Y6D9T323SWERLDQtMGLSIRTMAD
TTKP33981humanTTKP33981S845GGESHNSsSsktFEk
TTKP33981humanTTKP33981T360sITLKNktEssLLAk
TTKP33981humanTTKP33981S582LNkLQQHsDkIIRLYPkinase
TTKP33981humanTTKP33981S436VFSVskQsPPIsTSk
TTKP33981humanTTKP33981Y811GttEEMkyVLGQLVG
TTKP33981humanRMI2Q96E14S112MGVVQACsPEPCLQARMI2
TTKP33981humanTTKP33981S15GRELtIDsIMNkVRD
TTKP33981humanMAD1L1Q9Y6D9T624RLkEVFQtkIQEFRKMAD
TTKP33981humanTTKP33981S677QMQPDttsVVkDSQVPkinase


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
TTKIDDescription0.00e+00
TTKGO:0000819sister chromatid segregation1.28e-07
TTKGO:0045930negative regulation of mitotic cell cycle1.28e-07
TTKGO:0051983regulation of chromosome segregation1.28e-07
TTKGO:0140014mitotic nuclear division1.28e-07
TTKGO:0007093mitotic cell cycle checkpoint signaling1.28e-07
TTKGO:0051306mitotic sister chromatid separation1.31e-07
TTKGO:0098813nuclear chromosome segregation2.15e-07
TTKGO:1905818regulation of chromosome separation2.44e-07
TTKGO:0000070mitotic sister chromatid segregation3.09e-07
TTKGO:0051304chromosome separation3.09e-07
TTKGO:0000075cell cycle checkpoint signaling3.58e-07
TTKGO:1901991negative regulation of mitotic cell cycle phase transition3.72e-07
TTKGO:0045786negative regulation of cell cycle7.28e-07
TTKGO:0033045regulation of sister chromatid segregation7.85e-07
TTKGO:0007059chromosome segregation8.37e-07
TTKGO:0000280nuclear division1.03e-06
TTKGO:0033044regulation of chromosome organization1.05e-06
TTKGO:0048285organelle fission1.51e-06
TTKGO:0007094mitotic spindle assembly checkpoint signaling1.51e-06
TTKGO:0071173spindle assembly checkpoint signaling1.51e-06
TTKGO:0071174mitotic spindle checkpoint signaling1.51e-06
TTKGO:1901988negative regulation of cell cycle phase transition1.51e-06
TTKGO:0031577spindle checkpoint signaling1.51e-06
TTKGO:0033046negative regulation of sister chromatid segregation1.51e-06
TTKGO:0033048negative regulation of mitotic sister chromatid segregation1.51e-06
TTKGO:0045841negative regulation of mitotic metaphase/anaphase transition1.51e-06
TTKGO:2000816negative regulation of mitotic sister chromatid separation1.51e-06
TTKGO:0051985negative regulation of chromosome segregation1.61e-06
TTKGO:1902100negative regulation of metaphase/anaphase transition of cell cycle1.61e-06
TTKGO:1905819negative regulation of chromosome separation1.61e-06
TTKGO:0033047regulation of mitotic sister chromatid segregation2.13e-06
TTKGO:0045839negative regulation of mitotic nuclear division2.40e-06
TTKGO:0010948negative regulation of cell cycle process2.51e-06
TTKGO:0010965regulation of mitotic sister chromatid separation2.79e-06
TTKGO:0051784negative regulation of nuclear division3.54e-06
TTKGO:1901990regulation of mitotic cell cycle phase transition4.24e-06
TTKGO:0030071regulation of mitotic metaphase/anaphase transition1.42e-05
TTKGO:1902099regulation of metaphase/anaphase transition of cell cycle1.56e-05
TTKGO:0007091metaphase/anaphase transition of mitotic cell cycle1.56e-05
TTKGO:2001251negative regulation of chromosome organization1.56e-05
TTKGO:1901987regulation of cell cycle phase transition1.62e-05
TTKGO:0044784metaphase/anaphase transition of cell cycle1.69e-05
TTKGO:0044772mitotic cell cycle phase transition1.84e-05
TTKGO:0007088regulation of mitotic nuclear division3.54e-05
TTKGO:0007052mitotic spindle organization5.09e-05
TTKGO:0051783regulation of nuclear division7.91e-05
TTKGO:0010639negative regulation of organelle organization1.16e-04
TTKGO:1902850microtubule cytoskeleton organization involved in mitosis1.17e-04
TTKGO:0045910negative regulation of DNA recombination1.32e-04

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Related Drugs to TTK_TMEM63B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning TTK-TMEM63B and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to TTK_TMEM63B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate