Description | tyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2 | protein SETHLA-DR-associated protein IISET nuclear oncogeneSET translocation (myeloid leukemia-associated)Template-Activating Factor-I, chromatin remodelling factorchromatin remodelling factorinhibitor of granzyme A-activated DNaseinhibitor-2 of pr |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000344730, ENST00000367623, ENST00000392043, ENST00000408940, ENST00000502732, ENST00000504405, ENST00000507173, ENST00000511413, ENST00000512653, | ENST00000322030, ENST00000372688, ENST00000372692, ENST00000409104, ENST00000477806,
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Hgene | Tgene |
ABL2
P42684 | SET
Q7Z333 |
FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. | FUNCTION: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
Kinase | GOID | GO term | P.adjust |
ABL2 | ID | Description | 0.00e+00 |
ABL2 | GO:0010863 | positive regulation of phospholipase C activity | 1.90e-03 |
ABL2 | GO:1900274 | regulation of phospholipase C activity | 1.90e-03 |
ABL2 | GO:0010518 | positive regulation of phospholipase activity | 2.54e-03 |
ABL2 | GO:0010517 | regulation of phospholipase activity | 2.82e-03 |
ABL2 | GO:0060193 | positive regulation of lipase activity | 2.82e-03 |
ABL2 | GO:0000302 | response to reactive oxygen species | 2.92e-03 |
ABL2 | GO:1903829 | positive regulation of protein localization | 3.11e-03 |
ABL2 | GO:0043086 | negative regulation of catalytic activity | 3.11e-03 |
ABL2 | GO:0072593 | reactive oxygen species metabolic process | 3.11e-03 |
ABL2 | GO:0060191 | regulation of lipase activity | 3.11e-03 |
ABL2 | GO:0009650 | UV protection | 3.67e-03 |
ABL2 | GO:0090280 | positive regulation of calcium ion import | 5.18e-03 |
ABL2 | GO:0042542 | response to hydrogen peroxide | 5.18e-03 |
ABL2 | GO:1905477 | positive regulation of protein localization to membrane | 5.24e-03 |
ABL2 | GO:0032956 | regulation of actin cytoskeleton organization | 6.73e-03 |
ABL2 | GO:0071675 | regulation of mononuclear cell migration | 6.73e-03 |
ABL2 | GO:0007265 | Ras protein signal transduction | 6.73e-03 |
ABL2 | GO:0010288 | response to lead ion | 6.73e-03 |
ABL2 | GO:0035024 | negative regulation of Rho protein signal transduction | 6.73e-03 |
ABL2 | GO:1902473 | regulation of protein localization to synapse | 7.03e-03 |
ABL2 | GO:0061041 | regulation of wound healing | 7.26e-03 |
ABL2 | GO:1904375 | regulation of protein localization to cell periphery | 7.56e-03 |
ABL2 | GO:0032970 | regulation of actin filament-based process | 7.89e-03 |
ABL2 | GO:0033598 | mammary gland epithelial cell proliferation | 7.89e-03 |
ABL2 | GO:0090218 | positive regulation of lipid kinase activity | 7.89e-03 |
ABL2 | GO:0050900 | leukocyte migration | 8.69e-03 |
ABL2 | GO:0006979 | response to oxidative stress | 8.70e-03 |
ABL2 | GO:0030010 | establishment of cell polarity | 8.72e-03 |
ABL2 | GO:0007159 | leukocyte cell-cell adhesion | 9.38e-03 |
ABL2 | GO:0042744 | hydrogen peroxide catabolic process | 9.38e-03 |
ABL2 | GO:0042060 | wound healing | 9.38e-03 |
ABL2 | GO:0009314 | response to radiation | 9.40e-03 |
ABL2 | GO:0090279 | regulation of calcium ion import | 9.40e-03 |
ABL2 | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 9.40e-03 |
ABL2 | GO:1903034 | regulation of response to wounding | 9.45e-03 |
ABL2 | GO:1905475 | regulation of protein localization to membrane | 1.05e-02 |
ABL2 | GO:0046578 | regulation of Ras protein signal transduction | 1.05e-02 |
ABL2 | GO:0006935 | chemotaxis | 1.11e-02 |
ABL2 | GO:0042330 | taxis | 1.11e-02 |
ABL2 | GO:0043550 | regulation of lipid kinase activity | 1.12e-02 |
ABL2 | GO:0055001 | muscle cell development | 1.15e-02 |
ABL2 | GO:0007264 | small GTPase mediated signal transduction | 1.22e-02 |
ABL2 | GO:0050777 | negative regulation of immune response | 1.26e-02 |
ABL2 | GO:0071674 | mononuclear cell migration | 1.27e-02 |
ABL2 | GO:1990090 | cellular response to nerve growth factor stimulus | 1.34e-02 |
ABL2 | GO:0051346 | negative regulation of hydrolase activity | 1.34e-02 |
ABL2 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 1.34e-02 |
ABL2 | GO:0046580 | negative regulation of Ras protein signal transduction | 1.34e-02 |
ABL2 | GO:0070509 | calcium ion import | 1.34e-02 |