UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:UBXN7_MAP3K7

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: UBXN7_MAP3K7
	KinaseFusionDB ID: KFG6972
	FusionGDB2.0 ID: KFG6972
		Hgene	Tgene
	Gene symbol	UBXN7	MAP3K7
	Gene ID	26043	6885
	Gene name	UBX domain protein 7	mitogen-activated protein kinase kinase kinase 7
	Synonyms	UBXD7	CSCF\|FMD2\|MEKK7\|TAK1\|TGF1a
	Cytomap	3q29	6q15
	Type of gene	protein-coding	protein-coding
	Description	UBX domain-containing protein 7UBX domain containing 7	mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1
	Modification date	20240403	20240408
	UniProtAcc	O94888	O43318
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000296328, ENST00000428095, ENST00000535858,	ENST00000369325, ENST00000369327, ENST00000369329, ENST00000369332, ENST00000369320, ENST00000479630,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: UBXN7 [Title/Abstract] AND MAP3K7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP3K7(91223298)-UBXN7(196144366), # samples:3 UBXN7(196144366)-MAP3K7(91223298), # samples:1

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MAP3K7	GO:0000165	MAPK cascade	8663074\|11865055
Tgene	MAP3K7	GO:0006954	inflammatory response	34017102
Tgene	MAP3K7	GO:0007249	canonical NF-kappaB signal transduction	10882101\|19675569\|34871740\|35952808
Tgene	MAP3K7	GO:0007252	I-kappaB phosphorylation	11460167
Tgene	MAP3K7	GO:0007254	JNK cascade	9079627
Tgene	MAP3K7	GO:0034142	toll-like receptor 4 signaling pathway	25371197
Tgene	MAP3K7	GO:0038066	p38MAPK cascade	11460167
Tgene	MAP3K7	GO:0038172	interleukin-33-mediated signaling pathway	20532808
Tgene	MAP3K7	GO:0038173	interleukin-17A-mediated signaling pathway	31376257
Tgene	MAP3K7	GO:0042742	defense response to bacterium	11460167
Tgene	MAP3K7	GO:0043123	positive regulation of canonical NF-kappaB signal transduction	11460167
Tgene	MAP3K7	GO:0043507	positive regulation of JUN kinase activity	11460167
Tgene	MAP3K7	GO:0051403	stress-activated MAPK cascade	9079627

Kinase Fusion gene breakpoints across UBXN7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across MAP3K7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChiTaRS5.0	BI492160	UBXN7	chr3	196144366	MAP3K7	chr6	91223298

Top

Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms

Top

Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:91223298/:196144366)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
UBXN7 O94888	MAP3K7 O43318
FUNCTION: Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates. {ECO:0000269\|PubMed:22537386}.	FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:9079627, PubMed:16893890). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:8663074, PubMed:11460167). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:8663074, PubMed:11460167, PubMed:12589052). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:8663074, PubMed:12589052). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). {ECO:0000250\|UniProtKB:Q62073, ECO:0000269\|PubMed:10094049, ECO:0000269\|PubMed:11460167, ECO:0000269\|PubMed:12589052, ECO:0000269\|PubMed:16845370, ECO:0000269\|PubMed:16893890, ECO:0000269\|PubMed:21512573, ECO:0000269\|PubMed:8663074, ECO:0000269\|PubMed:9079627}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Top

Kinase-Substrate Information of UBXN7_MAP3K7

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
MAP3K7	O43318	human	TUBA1B	P68363	T334	DVNAAIAtIktkrsI	Tubulin_C
MAP3K7	O43318	human	PTPN3	P26045	S359	PAMRRsLsVEHLETK
MAP3K7	O43318	human	EIF4B	P23588	S230	kyRDRyDsDRyRDGy
MAP3K7	O43318	human	HNRNPA2B1	P22626	T176	IVLQkyHtINGHNAE	RRM_1
MAP3K7	O43318	human	FLNA	P21333	T1286	sVDARALtQtGGPHV	Filamin
MAP3K7	O43318	human	RBMX	P38159	T216	PRDDGystkDsyssR	RBM1CTR
MAP3K7	O43318	human	MAP3K7	O43318	T184	GtACDIQtHMtNNKG	PK_Tyr_Ser-Thr
MAP3K7	O43318	human	TAB1	Q15750	S452	STNTHTQssSSssDG
MAP3K7	O43318	human	MAP3K7	O43318	S192	HMtNNKGsAAWMAPE	PK_Tyr_Ser-Thr
MAP3K7	O43318	human	PKP2	Q99959	S82	GNLHRtssVPEyVyN
MAP3K7	O43318	human	TAB1	Q15750	S456	HTQssSSssDGGLFR
MAP3K7	O43318	human	HIPK2	Q9H2X6	Y361	SkAVCstyLQsRYyR	Pkinase
MAP3K7	O43318	human	HSP90B1	P14625	S674	yQtGkDIstNyyAsQ	HSP90
MAP3K7	O43318	human	HSP90B1	P14625	T669	MkAQAyQtGkDIstN	HSP90
MAP3K7	O43318	human	HSP90B1	P14625	T675	QtGkDIstNyyAsQk	HSP90
MAP3K7	O43318	human	RAB1A	P62820	T75	AGQERFRtItSSyyR	Ras
MAP3K7	O43318	human	RAB8A	P61006	T72	AGQERFRtITTAyyR	Ras
MAP3K7	O43318	human	CDC25C	P30307	S216	sGLyRsPsMPENLNR	M-inducer_phosp
MAP3K7	O43318	human	POLD2	P49005	T33	RVPVATytNSSQPFR
MAP3K7	O43318	human	HDAC7	Q8WUI4	S155	FPLRKtVsEPNLkLR
MAP3K7	O43318	human	HDAC4	P56524	S246	FPLRkTAsEPNLKLR
MAP3K7	O43318	human	TUBB	P07437	T166	yPDrIMNtFsVVPsP	Tubulin
MAP3K7	O43318	human	KSR1	Q8IVT5	S406	TRLRRtEsVPsDINN
MAP3K7	O43318	human	TAB1	Q15750	S457	TQssSSssDGGLFRS
MAP3K7	O43318	human	TNFAIP8L2	Q6P589	S3	_____MEsFSSKSLA
MAP3K7	O43318	human	MAP3K7	O43318	T187	CDIQtHMtNNKGsAA	PK_Tyr_Ser-Thr
MAP3K7	O43318	human	TAB1	Q15750	S453	TNTHTQssSSssDGG
MAP3K7	O43318	human	GAPVD1	Q14C86	T1013	LGPDRFstLtDDPsP
MAP3K7	O43318	human	PRKAA2	P54646	T172	sDGEFLRtsCGsPNy	Pkinase
MAP3K7	O43318	human	GAPVD1	Q14C86	S1012	DLGPDRFstLtDDPs
MAP3K7	O43318	human	E2F1	Q01094	S337	IVsPPPSsPPSSLTT
MAP3K7	O43318	human	IKBKB	O14920	S177	AkELDQGsLCtsFVG	Pkinase
MAP3K7	O43318	human	ATAT1	Q5SQI0	S237	GDIkPYSsSDREFLK
MAP3K7	O43318	human	HDAC5	Q9UQL6	S259	FPLRkTAsEPNLKVR
MAP3K7	O43318	human	IKBKB	O14920	S181	DQGsLCtsFVGTLQy	Pkinase
MAP3K7	O43318	human	MAP3K7	O43318	T178	LKICDFGtACDIQtH	PK_Tyr_Ser-Thr
MAP3K7	O43318	human	EEF1A1	P68104	T261	ykIGGIGtVPVGrVE	GTP_EFTU_D2
MAP3K7	O43318	human	LDHA	P00338	T3	_____MAtLkDQLIy

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
MAP3K7	ID	Description	0.00e+00
MAP3K7	GO:0006476	protein deacetylation	1.13e-03
MAP3K7	GO:0035601	protein deacylation	1.13e-03
MAP3K7	GO:0098732	macromolecule deacylation	1.13e-03
MAP3K7	GO:0018205	peptidyl-lysine modification	4.06e-03
MAP3K7	GO:0070555	response to interleukin-1	1.06e-02
MAP3K7	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	1.86e-02
MAP3K7	GO:0018394	peptidyl-lysine acetylation	1.86e-02
MAP3K7	GO:0009895	negative regulation of catabolic process	1.86e-02
MAP3K7	GO:0002756	MyD88-independent toll-like receptor signaling pathway	2.20e-02
MAP3K7	GO:0010832	negative regulation of myotube differentiation	2.20e-02
MAP3K7	GO:0045216	cell-cell junction organization	2.20e-02
MAP3K7	GO:0051090	regulation of DNA-binding transcription factor activity	2.20e-02
MAP3K7	GO:0006096	glycolytic process	2.20e-02
MAP3K7	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	2.20e-02
MAP3K7	GO:1903312	negative regulation of mRNA metabolic process	2.20e-02
MAP3K7	GO:0034446	substrate adhesion-dependent cell spreading	2.20e-02
MAP3K7	GO:0051091	positive regulation of DNA-binding transcription factor activity	2.20e-02
MAP3K7	GO:0048025	negative regulation of mRNA splicin	4.82e-04
MAP3K7	GO:0002223	stimulatory C-type lectin receptor signaling pathway	2.20e-02
MAP3K7	GO:0090042	tubulin deacetylation	2.20e-02
MAP3K7	GO:1990840	response to lectin	2.20e-02
MAP3K7	GO:1990858	cellular response to lectin	2.20e-02
MAP3K7	GO:0051098	regulation of binding	2.20e-02
MAP3K7	GO:0034138	toll-like receptor 3 signaling pathway	2.20e-02
MAP3K7	GO:0050686	negative regulation of mRNA processing	2.20e-02
MAP3K7	GO:0071347	cellular response to interleukin-1	2.20e-02
MAP3K7	GO:0038095	Fc-epsilon receptor signaling pathway	2.27e-02
MAP3K7	GO:0006090	pyruvate metabolic process	2.45e-02
MAP3K7	GO:0033119	negative regulation of RNA splicing	2.48e-02
MAP3K7	GO:0071900	regulation of protein serine/threonine kinase activity	2.58e-02
MAP3K7	GO:0072659	protein localization to plasma membrane	2.67e-02
MAP3K7	GO:0070498	interleukin-1-mediated signaling pathway	3.17e-02
MAP3K7	GO:0043276	anoikis	3.37e-02
MAP3K7	GO:0086019	cell-cell signaling involved in cardiac conduction	3.37e-02
MAP3K7	GO:0043393	regulation of protein binding	3.38e-02
MAP3K7	GO:0001508	action potential	3.44e-02
MAP3K7	GO:0002753	cytosolic pattern recognition receptor signaling pathway	3.44e-02
MAP3K7	GO:0043543	protein acylation	3.44e-02
MAP3K7	GO:0007043	cell-cell junction assembly	4.06e-02
MAP3K7	GO:0051154	negative regulation of striated muscle cell differentiation	4.10e-02
MAP3K7	GO:1990778	protein localization to cell periphery	4.10e-02
MAP3K7	GO:0010506	regulation of autophagy	4.10e-02
MAP3K7	GO:0016052	carbohydrate catabolic process	4.10e-02
MAP3K7	GO:0006509	membrane protein ectodomain proteolysis	4.38e-02
MAP3K7	GO:0140894	endolysosomal toll-like receptor signaling pathway	4.49e-02
MAP3K7	GO:0010830	regulation of myotube differentiation	4.68e-02
MAP3K7	GO:0043666	regulation of phosphoprotein phosphatase activity	4.68e-02
MAP3K7	GO:0006110	regulation of glycolytic process	5.60e-02
MAP3K7	GO:0086002	cardiac muscle cell action potential involved in contraction	5.70e-02

Top

Related Drugs to UBXN7_MAP3K7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning UBXN7-MAP3K7 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

Top

Related Diseases to UBXN7_MAP3K7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Top

Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date