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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ULK1_NOC4L

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: ULK1_NOC4L
KinaseFusionDB ID: KFG6989
FusionGDB2.0 ID: KFG6989
HgeneTgene
Gene symbol

ULK1

NOC4L

Gene ID

8408

79050

Gene nameunc-51 like autophagy activating kinase 1nucleolar complex associated 4 homolog
SynonymsATG1|ATG1A|UNC51|Unc51.1|hATG1NET49|NOC4|UTP19
Cytomap

12q24.33

12q24.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homolognucleolar complex protein 4 homologNOC4 protein homologNOC4-like proteinnucleolar complex-associated protein 4-like protein
Modification date2024040720240305
UniProtAcc

O75385

Q9BVI4

Ensembl transtripts involved in fusion geneENST idsENST00000321867, ENST00000540647, 
ENST00000538784, ENST00000535343, 
ENST00000330579, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: ULK1 [Title/Abstract] AND NOC4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ULK1(132401607)-NOC4L(132635526), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneULK1

GO:0000045

autophagosome assembly

19225151|28890335

HgeneULK1

GO:0006914

autophagy

18936157|25891078

HgeneULK1

GO:0008285

negative regulation of cell population proliferation

21795849

HgeneULK1

GO:0010508

positive regulation of autophagy

25126726|29487085|35670107

HgeneULK1

GO:0016241

regulation of macroautophagy

20921139

HgeneULK1

GO:0018105

peptidyl-serine phosphorylation

25126726|27103069

HgeneULK1

GO:0018107

peptidyl-threonine phosphorylation

27103069

HgeneULK1

GO:0031333

negative regulation of protein-containing complex assembly

25126726

HgeneULK1

GO:0046777

protein autophosphorylation

18936157

HgeneULK1

GO:1903059

regulation of protein lipidation

19225151


check buttonKinase Fusion gene breakpoints across ULK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across NOC4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-BC-A10U-01AULK1chr12

132401607

NOC4Lchr12

132635526



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000321867ENST00000330579ULK1chr12132401607NOC4Lchr1213263552632231002

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000321867_ENST00000330579_ULK1_chr12_132401607_NOC4L_chr12_132635526_length(amino acids)=1002
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIGGALSLLALNGLFILIHKHNLEYP
DFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELD
ADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGR

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:132401607/chr12:132635526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ULK1

O75385

NOC4L

Q9BVI4

FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:31123703, PubMed:29487085). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
727
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
HgeneULK1132401607NOC4L132635526ENST00000321867212816_27811051DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>298_ULK1_NOC4LENST00000321867ENST00000330579ULK1chr12132401607NOC4Lchr12132635526
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIGGALSLLALNGLFILIHKHNLEYP
DFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELD
ADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGR
1002
3D view using mol* of 298_ULK1_NOC4L
PDB file >>>HKFP_435_ULK1_NOC4LENST00000321867ENST00000330579ULK1chr12132401607NOC4Lchr12132635526
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIGGALSLLALNGLFILIHKHNLEYP
DFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELD
ADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGR
1002_ULK1_NOC4L


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ULK1_NOC4L does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
298_ULK1_NOC4L.png
all structure sitemap plddt 298_ULK1_NOC4L.png
298_ULK1_NOC4L.png
all structure sitemap plddt2 298_ULK1_NOC4L.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

298_ULK1_NOC4L_ramachandran.png
all structure ULK1-NOC4L

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
all structure ULK1-NOC4L
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
298_ULK1_NOC4L-DOCK_HTVS_1-001Sorafenib-6.85849-6.870589999999999-46.9871
298_ULK1_NOC4L-DOCK_HTVS_1-001Sorafenib-6.85849-6.870589999999999-46.9871
298_ULK1_NOC4L-DOCK_HTVS_1-001Regorafenib-6.715669999999999-6.715669999999999-46.6774
298_ULK1_NOC4L-DOCK_HTVS_1-001Netarsudil-6.67315-6.68425-52.6775
298_ULK1_NOC4L-DOCK_HTVS_1-001Netarsudil-6.67315-6.68425-52.6775
298_ULK1_NOC4L-DOCK_HTVS_1-001Netarsudil-6.25082-6.26192-50.6674
298_ULK1_NOC4L-DOCK_HTVS_1-001Netarsudil-6.25082-6.26192-50.6674
298_ULK1_NOC4L-DOCK_HTVS_1-001Acalabrutinib-5.80595-5.82005-47.3507
298_ULK1_NOC4L-DOCK_HTVS_1-001Acalabrutinib-5.80595-5.82005-47.3507
298_ULK1_NOC4L-DOCK_HTVS_1-001Pralsetinib-5.708080000000001-5.799580000000001-49.1268
298_ULK1_NOC4L-DOCK_HTVS_1-001Encorafenib-5.68456-6.07306-54.4653
298_ULK1_NOC4L-DOCK_HTVS_1-001Palbociclib-5.63255-6.03945-45.5088
298_ULK1_NOC4L-DOCK_HTVS_1-001Palbociclib-5.63255-6.03945-45.5088
298_ULK1_NOC4L-DOCK_HTVS_1-001Ripretinib-5.617999999999999-5.625-46.1294
298_ULK1_NOC4L-DOCK_HTVS_1-001Ripretinib-5.617999999999999-5.625-46.1294
298_ULK1_NOC4L-DOCK_HTVS_1-001Palbociclib-5.59316-6.0000599999999995-45.0931
298_ULK1_NOC4L-DOCK_HTVS_1-001Mobocertinib-5.52531-5.53301-50.5531
298_ULK1_NOC4L-DOCK_HTVS_1-001Nilotinib-5.46626-5.60586-45.5429
298_ULK1_NOC4L-DOCK_HTVS_1-001Nilotinib-5.46626-5.60586-45.5429
298_ULK1_NOC4L-DOCK_HTVS_1-001Ponatinib-5.46138-5.66798-46.5059

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Kinase-Substrate Information of ULK1_NOC4L


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
ULK1O75385humanCDC37Q16543S339HMQRCIDsGLWVPNsCDC37_C
ULK1O75385humanATG9AQ7Z3C6S761QsIPRsAsYPCAAPR
ULK1O75385humanFBP1P09467S88LVMNMLKsSFATCVLFBPase
ULK1O75385humanRIPK1Q13546T337ssRsNsAtEQPGSLH
ULK1O75385humanNR3C2P08235S843NEEKMHQsAMYELCQHormone_recep
ULK1O75385humanRIPK1Q13546S296YLsQLEEsVEEDVks
ULK1O75385humanSMCR8Q8TEV9S400PSQDRPPsSsLEECP
ULK1O75385humanSTING1Q86WV6S366QEPELLIsGMEkPLP
ULK1O75385humanBNIP3LO60238S35PPAGLNssWVELPMNBNIP3
ULK1O75385humanATG13O75143S355DTETVSNssEGRAsP
ULK1O75385humanYAP1P46937S227VQQNMMNsASGPLPD
ULK1O75385humanATG16L1Q676U5S278PAGGLLDsITNIFGR
ULK1O75385humanSQSTM1Q13501S349sskEVDPstGELQsL
ULK1O75385humanATG9AQ7Z3C6S14EyQRLEAsysDsPPG
ULK1O75385humanRIPK1Q13546S335VPssRsNsAtEQPGS
ULK1O75385humanPFKMP08237S762yEIDLDTsDHAHLEH
ULK1O75385humanBECN1Q14457S30QPLkLDTsFkILDRV
ULK1O75385humanRPTORQ8N122S792DKMRRAssYSsLNSL
ULK1O75385humanRPTORQ8N122S877HIHQAGGsPPAssts
ULK1O75385humanBECN1Q14457S337LVPyGNHsYLESLTDAPG6
ULK1O75385humanENO1P06733S282QLADLyksFIkDyPVEnolase_C
ULK1O75385humanBECN1Q14457S96MstEsANsFTLIGEA
ULK1O75385humanRB1CC1Q8TDY2S986ELQsLEQsHLkELED
ULK1O75385humanRB1CC1Q8TDY2S943EMENIMHsQNCEIKE
ULK1O75385humanSMCR8Q8TEV9S562IRFQASIsPPELGET
ULK1O75385humanSDCBPO00560S60LsQyMGLsLNEEEIRPeptidase_M50
ULK1O75385humanATG4BQ9Y4P1S316SIAELDPsIAVGFFCPeptidase_C54
ULK1O75385humanSESN2P58004S254NNsGGFEsARDVEALPA26
ULK1O75385humanULK1O75385S317SHLASPPsLGEMQQL
ULK1O75385humanRIPK1Q13546S291kFRPFYLsQLEEsVE
ULK1O75385humanSDCBPO00560S6__MsLyPsLEDLkVD
ULK1O75385humanHK1P19367S124NIVHGSGsQLFDHVAHexokinase_1
ULK1O75385humanRIPK1Q13546S345EQPGSLHssQGLGMG
ULK1O75385humanBNIP3Q12983S17QEESLQGsWVELHFsBNIP3
ULK1O75385humanSESN2P58004S73GLEALMSsGRVDNLAPA26
ULK1O75385humanAMBRA1Q9C0C7S635ssSRLELsSSAsPQE
ULK1O75385humanSMCR8Q8TEV9S492SKsDsQAsLtVPLsP
ULK1O75385humanDENND3A2RUS2S490ELAPRNSsLRLtDTA
ULK1O75385humanFLCNQ8NFG4S406CVRIIPYsSQYEEAYFolliculin_C
ULK1O75385humanAMBRA1Q9C0C7S465SQASVYTsATEGRGF
ULK1O75385humanRPTORQ8N122S855QRVLDtssLtQsAPA
ULK1O75385humanRPTORQ8N122S859DtssLtQsAPAsPtN
ULK1O75385humanSQSTM1Q13501S403ESLSQMLsMGFsDEGUBA_5
ULK1O75385humanSEC23AQ15436S207LQEMLGLskVPLTQASec23_trunk
ULK1O75385humanATG13O75143S389INQVTLTsLDIPFAM
ULK1O75385humanFBP1P09467S63HLyGIAGsTNVTGDQFBPase
ULK1O75385humanSMCR8Q8TEV9T666ASRDISktsLDNYSD
ULK1O75385humanPFKMP08237S74EATWESVsMMLQLGGPFK
ULK1O75385humanRIPK1Q13546S357GMGPVEEsWFAPSLE
ULK1O75385humanPRKNO60260S108sLTRVDLsssVLPGD
ULK1O75385humanATG101Q9BSB4S203ITDALGTsVTTTMRR
ULK1O75385humanRIPK1Q13546S389ANyHLyGsRMDRQTK
ULK1O75385humanSEC23BQ15437S186SCEGISksYVFRGTkSec23_trunk
ULK1O75385humanENO1P06733S115ANAILGVsLAVCkAGEnolase_N
ULK1O75385humanRPTORQ8N122S863LtQsAPAsPtNkGVH
ULK1O75385humanFLCNQ8NFG4S537EDTQkLLsILGAsEEFolliculin_C
ULK1O75385humanFUNDC1Q8IVP5S17DyEsDDDsyEVLDLT
ULK1O75385humanFLCNQ8NFG4S542LLsILGAsEEDNVKLFolliculin_C
ULK1O75385humanHK1P19367S364TRLGVEPsDDDCVSVHexokinase_2
ULK1O75385humanRIPK1Q13546S320AVVkRMQsLQLdCVA
ULK1O75385humanRB1CC1Q8TDY2S1323EMQNVRTsLIAEQQT
ULK1O75385humanRIPK1Q13546S333VAVPssRsNsAtEQP
ULK1O75385humanRIPK1Q13546S346QPGSLHssQGLGMGP
ULK1O75385humanMAD1L1Q9Y6D9S546RTKVLHMsLNPTsVAMAD
ULK1O75385humanBECN1Q14457S15NNSTMQVsFVCQRCS
ULK1O75385humanSEC16AO15027S846LAQPINFsVSLSNSH
ULK1O75385humanATG14Q6ZNE5S29LARDLVDsVDDAEGL
ULK1O75385humanSEC23AQ15436T405FKMGFGGtLEIKTSRSec23_BS
ULK1O75385humanATG101Q9BSB4S11RSEVLEVsVEGRQVEATG101
ULK1O75385humanPIK3C3Q8NEB9S249ESsPILTsFELVKVP
ULK1O75385humanDENND3A2RUS2S472THRRMVVsMPNLQDI
ULK1O75385humanRIPK1Q13546S262YCPREIIsLMKLCWEPK_Tyr_Ser-Thr
ULK1O75385humanBECN1Q14457S279ATFHIWHsGQFGTINAPG6
ULK1O75385humanFLIIQ13045S64KLEHLSVsHNNLTTLLRR_8


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
ULK1IDDescription0.00e+00
ULK1GO:0016236macroautophagy2.30e-21
ULK1GO:0061912selective autophagy4.62e-21
ULK1GO:0000422autophagy of mitochondrion4.62e-21
ULK1GO:0061726mitochondrion disassembly4.62e-21
ULK1GO:1903008organelle disassembly1.34e-20
ULK1GO:0010508positive regulation of autophagy1.70e-20
ULK1GO:0010506regulation of autophagy7.32e-20
ULK1GO:0000045autophagosome assembly2.46e-18
ULK1GO:1905037autophagosome organization4.91e-18
ULK1GO:0022411cellular component disassembly2.18e-17
ULK1GO:0007033vacuole organization4.47e-16
ULK1GO:0031331positive regulation of cellular catabolic process5.89e-16
ULK1GO:0000423mitophagy4.68e-13
ULK1GO:0098780response to mitochondrial depolarisation5.46e-13
ULK1GO:0016241regulation of macroautophagy2.58e-11
ULK1GO:0016239positive regulation of macroautophagy9.94e-11
ULK1GO:0016237lysosomal microautophagy1.92e-09
ULK1GO:0034497protein localization to phagophore assembly site6.13e-09
ULK1GO:1903059regulation of protein lipidation2.60e-07
ULK1GO:0042594response to starvation4.33e-07
ULK1GO:0006605protein targeting6.95e-07
ULK1GO:0071496cellular response to external stimulus7.92e-07
ULK1GO:0006096glycolytic process9.50e-07
ULK1GO:0006497protein lipidation1.01e-06
ULK1GO:0031669cellular response to nutrient levels1.01e-06
ULK1GO:0031667response to nutrient levels1.01e-06
ULK1GO:0016052carbohydrate catabolic process1.07e-06
ULK1GO:0050746regulation of lipoprotein metabolic process1.26e-06
ULK1GO:0042158lipoprotein biosynthetic process1.27e-06
ULK1GO:0009267cellular response to starvation1.84e-06
ULK1GO:0044804nucleophagy1.85e-06
ULK1GO:0031668cellular response to extracellular stimulus1.95e-06
ULK1GO:0006090pyruvate metabolic process3.61e-06
ULK1GO:0062197cellular response to chemical stress4.65e-06
ULK1GO:0042157lipoprotein metabolic process7.58e-06
ULK1GO:0010639negative regulation of organelle organization1.24e-05
ULK1GO:0010821regulation of mitochondrion organization1.45e-05
ULK1GO:0007034vacuolar transport2.57e-05
ULK1GO:0030242autophagy of peroxisome2.57e-05
ULK1GO:0034727piecemeal microautophagy of the nucleus2.57e-05
ULK1GO:0001558regulation of cell growth3.09e-05
ULK1GO:1903146regulation of autophagy of mitochondrion3.13e-05
ULK1GO:0006002fructose 6-phosphate metabolic process3.28e-05
ULK1GO:0006006glucose metabolic process4.92e-05
ULK1GO:0072594establishment of protein localization to organelle5.77e-05
ULK1GO:0006623protein targeting to vacuole6.02e-05
ULK1GO:0042149cellular response to glucose starvation6.96e-05
ULK1GO:1903599positive regulation of autophagy of mitochondrion8.06e-05
ULK1GO:0016049cell growth9.57e-05

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Related Drugs to ULK1_NOC4L


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning ULK1-NOC4L and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to ULK1_NOC4L


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate