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Kinase Fusion Gene:ULK2_MBD3 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ULK2_MBD3 | KinaseFusionDB ID: KFG7000 | FusionGDB2.0 ID: KFG7000 | Hgene | Tgene | Gene symbol | ULK2 | MBD3 | Gene ID | 9706 | 64180 | |
| Gene name | unc-51 like autophagy activating kinase 2 | |||||||||||
| Synonyms | ATG1B|Unc51.2 | |||||||||||
| Cytomap | 17p11.2 | |||||||||||
| Type of gene | protein-coding | |||||||||||
| Description | serine/threonine-protein kinase ULK2 | |||||||||||
| Modification date | 20240403 | |||||||||||
| UniProtAcc | Q8IYT8 | O95983 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000361658, ENST00000395544, ENST00000580130, | ENST00000156825, ENST00000434436, ENST00000585967, ENST00000590550, ENST00000592012, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ULK2 [Title/Abstract] AND MBD3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ULK2(19746434)-MBD3(1585213), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ULK2 | GO:0006914 | autophagy | 18936157 |
| Hgene | ULK2 | GO:0046777 | protein autophosphorylation | 18936157 |
| Kinase Fusion gene breakpoints across ULK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MBD3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-AN-A0XT-01A | ULK2 | chr17 | 19746434 | MBD3 | chr19 | 1585213 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19746434/:1585213) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ULK2 | MBD3 |
| FUNCTION: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. | FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12124384, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:18644863, ECO:0000269|PubMed:23361464, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:9774669}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ULK2_MBD3 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| ULK2 | Q8IYT8 | human | STING1 | Q86WV6 | S366 | QEPELLIsGMEkPLP | |
| ULK2 | Q8IYT8 | human | BECN1 | Q14457 | S30 | QPLkLDTsFkILDRV | |
| ULK2 | Q8IYT8 | human | RPTOR | Q8N122 | S792 | DKMRRAssYSsLNSL | |
| ULK2 | Q8IYT8 | human | DENND3 | A2RUS2 | S490 | ELAPRNSsLRLtDTA | |
| ULK2 | Q8IYT8 | human | RPTOR | Q8N122 | S855 | QRVLDtssLtQsAPA | |
| ULK2 | Q8IYT8 | human | RPTOR | Q8N122 | S859 | DtssLtQsAPAsPtN | |
| ULK2 | Q8IYT8 | human | SEC16A | O15027 | S846 | LAQPINFsVSLSNSH | |
| ULK2 | Q8IYT8 | human | PIK3C3 | Q8NEB9 | S249 | ESsPILTsFELVKVP | |
| ULK2 | Q8IYT8 | human | DENND3 | A2RUS2 | S472 | THRRMVVsMPNLQDI |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| ULK2 | ID | Description | 0.00e+00 |
| ULK2 | GO:0010506 | regulation of autophagy | 4.49e-04 |
| ULK2 | GO:0061912 | selective autophagy | 4.49e-04 |
| ULK2 | GO:0000045 | autophagosome assembly | 4.51e-04 |
| ULK2 | GO:1905037 | autophagosome organization | 4.51e-04 |
| ULK2 | GO:0007041 | lysosomal transport | 4.91e-04 |
| ULK2 | GO:0016241 | regulation of macroautophagy | 6.84e-04 |
| ULK2 | GO:0007034 | vacuolar transport | 7.04e-04 |
| ULK2 | GO:0009267 | cellular response to starvation | 7.32e-04 |
| ULK2 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process | 7.68e-04 |
| ULK2 | GO:0042594 | response to starvation | 1.06e-03 |
| ULK2 | GO:0007033 | vacuole organization | 1.16e-03 |
| ULK2 | GO:0006622 | protein targeting to lysosome | 1.24e-03 |
| ULK2 | GO:0031669 | cellular response to nutrient levels | 1.24e-03 |
| ULK2 | GO:0031668 | cellular response to extracellular stimulus | 1.61e-03 |
| ULK2 | GO:0045022 | early endosome to late endosome transport | 1.88e-03 |
| ULK2 | GO:0006623 | protein targeting to vacuole | 1.93e-03 |
| ULK2 | GO:0098927 | vesicle-mediated transport between endosomal compartments | 1.93e-03 |
| ULK2 | GO:0042149 | cellular response to glucose starvation | 1.93e-03 |
| ULK2 | GO:0016236 | macroautophagy | 1.93e-03 |
| ULK2 | GO:0071496 | cellular response to external stimulus | 2.09e-03 |
| ULK2 | GO:0097352 | autophagosome maturation | 2.39e-03 |
| ULK2 | GO:0061462 | protein localization to lysosome | 2.39e-03 |
| ULK2 | GO:0072666 | establishment of protein localization to vacuole | 2.55e-03 |
| ULK2 | GO:0031331 | positive regulation of cellular catabolic process | 2.55e-03 |
| ULK2 | GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 2.55e-03 |
| ULK2 | GO:0016239 | positive regulation of macroautophagy | 3.17e-03 |
| ULK2 | GO:0072665 | protein localization to vacuole | 4.06e-03 |
| ULK2 | GO:0010507 | negative regulation of autophagy | 4.06e-03 |
| ULK2 | GO:0031667 | response to nutrient levels | 4.06e-03 |
| ULK2 | GO:0022411 | cellular component disassembly | 4.06e-03 |
| ULK2 | GO:0032465 | regulation of cytokinesis | 4.09e-03 |
| ULK2 | GO:0006661 | phosphatidylinositol biosynthetic process | 7.84e-03 |
| ULK2 | GO:1903008 | organelle disassembly | 9.43e-03 |
| ULK2 | GO:0010508 | positive regulation of autophagy | 9.65e-03 |
| ULK2 | GO:0046488 | phosphatidylinositol metabolic process | 1.00e-02 |
| ULK2 | GO:0016482 | cytosolic transport | 1.34e-02 |
| ULK2 | GO:0051302 | regulation of cell division | 1.35e-02 |
| ULK2 | GO:0000910 | cytokinesis | 1.35e-02 |
| ULK2 | GO:0031330 | negative regulation of cellular catabolic process | 1.60e-02 |
| ULK2 | GO:0046474 | glycerophospholipid biosynthetic process | 1.60e-02 |
| ULK2 | GO:0032984 | protein-containing complex disassembly | 2.11e-02 |
| ULK2 | GO:0045017 | glycerolipid biosynthetic process | 2.15e-02 |
| ULK2 | GO:0008654 | phospholipid biosynthetic process | 2.16e-02 |
| ULK2 | GO:0090068 | positive regulation of cell cycle process | 2.25e-02 |
| ULK2 | GO:0030242 | autophagy of peroxisome | 2.46e-02 |
| ULK2 | GO:0044829 | positive regulation by host of viral genome replication | 2.46e-02 |
| ULK2 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | 2.51e-02 |
| ULK2 | GO:0071895 | odontoblast differentiation | 2.51e-02 |
| ULK2 | GO:0001666 | response to hypoxia | 2.51e-02 |
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Related Drugs to ULK2_MBD3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ULK2-MBD3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ULK2_MBD3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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