| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:WDFY3_MAPK10 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: WDFY3_MAPK10 | KinaseFusionDB ID: KFG7113 | FusionGDB2.0 ID: KFG7113 | Hgene | Tgene | Gene symbol | WDFY3 | MAPK10 | Gene ID | 23001 | 5602 | |
| Gene name | WD repeat and FYVE domain containing 3 | mitogen-activated protein kinase 10 | ||||||||||
| Synonyms | ALFY|BCHS|MCPH18|ZFYVE25 | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | ||||||||||
| Cytomap | 4q21.23 | 4q21.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | WD repeat and FYVE domain-containing protein 3autophagy-linked FYVE protein | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | Q8IZQ1 | P53779 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000295888, ENST00000322366, ENST00000512267, | ENST00000359221, ENST00000361569, ENST00000395157, ENST00000395160, ENST00000395161, ENST00000395166, ENST00000395169, ENST00000449047, ENST00000513839, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: WDFY3 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | WDFY3(85818064)-MAPK10(87222013), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across WDFY3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MAPK10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-EA-A3HS-01A | WDFY3 | chr4 | 85818064 | MAPK10 | chr4 | 87222013 |
| CCLE | LN382 | WDFY3 | chr4 | 85818064 | MAPK10 | chr4 | 86952584 |
| CCLE | LN382 | WDFY3 | chr4 | 85853423 | MAPK10 | chr4 | 86952584 |
| CCLE | LN382 | WDFY3 | chr4 | 85800559 | MAPK10 | chr4 | 86952584 |
| CCLE | LN382 | WDFY3 | chr4 | 85887362 | MAPK10 | chr4 | 86952584 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:85818064/:87222013) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WDFY3 | MAPK10 |
| FUNCTION: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27008544}. | FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of WDFY3_MAPK10 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAPK10 | P53779 | human | APP | P05067-4 | T668 | VEVDAAVtPEERHLs | APP_amyloid |
| MAPK10 | P53779 | human | ATN1 | P54259 | S739 | EEyETPEsPVPPARs | Atrophin-1 |
| MAPK10 | P53779 | human | BID | P55957 | T59 | EGyDELQtDGNRsSH | BID |
| MAPK10 | P53779 | human | MYC | P01106 | T73 | kkFELLPtPPLsPsR | Myc_N |
| MAPK10 | P53779 | human | OSBP2 | Q969R2 | S762 | ECSKVMHssPssPsS | Oxysterol_BP |
| MAPK10 | P53779 | human | CDKN1A | P38936 | S98 | GGRRPGTsPALLQGT | |
| MAPK10 | P53779 | human | OSBP2 | Q969R2 | S766 | VMHssPssPsSDGKQ | Oxysterol_BP |
| MAPK10 | P53779 | human | MYC | P01106 | S86 | sRRsGLCsPSyVAVt | Myc_N |
| MAPK10 | P53779 | human | CDKN1A | P38936 | S130 | sGEQAEGsPGGPGDs | |
| MAPK10 | P53779 | human | OSBP2 | Q969R2 | S768 | HssPssPsSDGKQKT | Oxysterol_BP |
| MAPK10 | P53779 | human | MYC | P01106 | S77 | LLPtPPLsPsRRsGL | Myc_N |
| MAPK10 | P53779 | human | NFATC1 | O95644 | S172 | YRDPsCLsPASSLSS | |
| MAPK10 | P53779 | human | OSBP2 | Q969R2 | S763 | CSKVMHssPssPsSD | Oxysterol_BP |
| MAPK10 | P53779 | human | APLP2 | Q06481 | T736 | VEVDPMLtPEERHLN | APP_amyloid |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAPK10 | ID | Description | 0.00e+00 |
| MAPK10 | GO:2000278 | regulation of DNA biosynthetic process | 7.35e-03 |
| MAPK10 | GO:0044772 | mitotic cell cycle phase transition | 7.35e-03 |
| MAPK10 | GO:0044346 | fibroblast apoptotic process | 8.62e-03 |
| MAPK10 | GO:0071897 | DNA biosynthetic process | 8.62e-03 |
| MAPK10 | GO:0000082 | G1/S transition of mitotic cell cycle | 1.37e-02 |
| MAPK10 | GO:0051402 | neuron apoptotic process | 1.37e-02 |
| MAPK10 | GO:0044843 | cell cycle G1/S phase transition | 1.37e-02 |
| MAPK10 | GO:0010332 | response to gamma radiation | 1.37e-02 |
| MAPK10 | GO:0048146 | positive regulation of fibroblast proliferation | 1.37e-02 |
| MAPK10 | GO:0009416 | response to light stimulus | 1.37e-02 |
| MAPK10 | GO:0097193 | intrinsic apoptotic signaling pathway | 1.37e-02 |
| MAPK10 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 1.55e-02 |
| MAPK10 | GO:1901990 | regulation of mitotic cell cycle phase transition | 1.55e-02 |
| MAPK10 | GO:2000573 | positive regulation of DNA biosynthetic process | 1.55e-02 |
| MAPK10 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 2.05e-02 |
| MAPK10 | GO:0009314 | response to radiation | 2.05e-02 |
| MAPK10 | GO:0048145 | regulation of fibroblast proliferation | 2.05e-02 |
| MAPK10 | GO:0034644 | cellular response to UV | 2.05e-02 |
| MAPK10 | GO:1901987 | regulation of cell cycle phase transition | 2.26e-02 |
| MAPK10 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 2.26e-02 |
| MAPK10 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 2.26e-02 |
| MAPK10 | GO:0050673 | epithelial cell proliferation | 2.26e-02 |
| MAPK10 | GO:0048144 | fibroblast proliferation | 2.27e-02 |
| MAPK10 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 2.34e-02 |
| MAPK10 | GO:1902749 | regulation of cell cycle G2/M phase transition | 2.45e-02 |
| MAPK10 | GO:0071482 | cellular response to light stimulus | 2.65e-02 |
| MAPK10 | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 2.80e-02 |
| MAPK10 | GO:0010212 | response to ionizing radiation | 3.05e-02 |
| MAPK10 | GO:0000086 | G2/M transition of mitotic cell cycle | 3.05e-02 |
| MAPK10 | GO:0043393 | regulation of protein binding | 3.05e-02 |
| MAPK10 | GO:2001235 | positive regulation of apoptotic signaling pathway | 3.06e-02 |
| MAPK10 | GO:0035264 | multicellular organism growth | 3.06e-02 |
| MAPK10 | GO:0009411 | response to UV | 3.14e-02 |
| MAPK10 | GO:0044839 | cell cycle G2/M phase transition | 3.14e-02 |
| MAPK10 | GO:0010950 | positive regulation of endopeptidase activity | 3.14e-02 |
| MAPK10 | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 3.33e-02 |
| MAPK10 | GO:0010952 | positive regulation of peptidase activity | 3.52e-02 |
| MAPK10 | GO:0072331 | signal transduction by p53 class mediator | 3.63e-02 |
| MAPK10 | GO:0071478 | cellular response to radiation | 3.69e-02 |
| MAPK10 | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 3.69e-02 |
| MAPK10 | GO:0032872 | regulation of stress-activated MAPK cascade | 3.69e-02 |
| MAPK10 | GO:0042770 | signal transduction in response to DNA damage | 3.69e-02 |
| MAPK10 | GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 3.69e-02 |
| MAPK10 | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 3.69e-02 |
| MAPK10 | GO:0048469 | cell maturation | 3.71e-02 |
| MAPK10 | GO:2000116 | regulation of cysteine-type endopeptidase activity | 3.71e-02 |
| MAPK10 | GO:1902806 | regulation of cell cycle G1/S phase transition | 4.16e-02 |
| MAPK10 | GO:0051403 | stress-activated MAPK cascade | 4.52e-02 |
| MAPK10 | GO:0002573 | myeloid leukocyte differentiation | 4.52e-02 |
Top |
Related Drugs to WDFY3_MAPK10 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning WDFY3-MAPK10 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to WDFY3_MAPK10 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |