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Kinase Fusion Gene:WEE1_HDLBP |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: WEE1_HDLBP | KinaseFusionDB ID: KFG7124 | FusionGDB2.0 ID: KFG7124 | Hgene | Tgene | Gene symbol | WEE1 | HDLBP | Gene ID | 7465 | 3069 | |
| Gene name | WEE1 G2 checkpoint kinase | high density lipoprotein binding protein | ||||||||||
| Synonyms | WEE1A|WEE1hu | HBP|PRO2900|VGL | ||||||||||
| Cytomap | 11p15.4 | 2q37.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | wee1-like protein kinaseWEE1 homologWEE1+ homologprotein kinasewee1A kinase | vigilinHDL-binding protein | ||||||||||
| Modification date | 20240407 | 20240411 | ||||||||||
| UniProtAcc | P30291 | Q00341 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000299613, ENST00000450114, | ENST00000476807, ENST00000310931, ENST00000391975, ENST00000391976, ENST00000427183, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: WEE1 [Title/Abstract] AND HDLBP [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | WEE1(9598810)-HDLBP(242186557), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | WEE1 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 7743995|8348613|8428596 |
| Kinase Fusion gene breakpoints across WEE1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across HDLBP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-BR-8295 | WEE1 | chr11 | 9598810 | HDLBP | chr2 | 242186557 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:9598810/:242186557) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| WEE1 | HDLBP |
| FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. | FUNCTION: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of WEE1_HDLBP |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| WEE1 | P30291 | human | HSP90AA1 | P07900 | Y38 | SLIINtFySNkEIFL | |
| WEE1 | P30291 | human | CDK2 | P24941 | Y15 | EkIGEGtyGVVykAR | Pkinase |
| WEE1 | P30291 | human | CDK1 | P06493 | Y15 | EkIGEGtyGVVykGR | Pkinase |
| WEE1 | P30291 | human | ERG | P11308 | Y183 | FQRLtPSyNADILLS | SAM_PNT |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| WEE1 | ID | Description | 0.00e+00 |
| WEE1 | GO:0018105 | peptidyl-serine phosphorylation | 1.79e-03 |
| WEE1 | GO:0051054 | positive regulation of DNA metabolic process | 1.79e-03 |
| WEE1 | GO:0018209 | peptidyl-serine modification | 1.79e-03 |
| WEE1 | GO:0045740 | positive regulation of DNA replication | 1.79e-03 |
| WEE1 | GO:0042307 | positive regulation of protein import into nucleus | 1.79e-03 |
| WEE1 | GO:0042306 | regulation of protein import into nucleus | 3.09e-03 |
| WEE1 | GO:0046824 | positive regulation of nucleocytoplasmic transport | 3.09e-03 |
| WEE1 | GO:0044773 | mitotic DNA damage checkpoint signaling | 4.75e-03 |
| WEE1 | GO:0044774 | mitotic DNA integrity checkpoint signaling | 4.75e-03 |
| WEE1 | GO:1900182 | positive regulation of protein localization to nucleus | 4.88e-03 |
| WEE1 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 5.16e-03 |
| WEE1 | GO:0046822 | regulation of nucleocytoplasmic transport | 5.16e-03 |
| WEE1 | GO:2001252 | positive regulation of chromosome organization | 5.16e-03 |
| WEE1 | GO:1902749 | regulation of cell cycle G2/M phase transition | 5.43e-03 |
| WEE1 | GO:0006275 | regulation of DNA replication | 5.50e-03 |
| WEE1 | GO:0000077 | DNA damage checkpoint signaling | 5.50e-03 |
| WEE1 | GO:0031570 | DNA integrity checkpoint signaling | 5.50e-03 |
| WEE1 | GO:0007098 | centrosome cycle | 5.50e-03 |
| WEE1 | GO:0000086 | G2/M transition of mitotic cell cycle | 5.50e-03 |
| WEE1 | GO:0007093 | mitotic cell cycle checkpoint signaling | 5.50e-03 |
| WEE1 | GO:1900180 | regulation of protein localization to nucleus | 5.50e-03 |
| WEE1 | GO:0031023 | microtubule organizing center organization | 5.85e-03 |
| WEE1 | GO:0044839 | cell cycle G2/M phase transition | 5.85e-03 |
| WEE1 | GO:0090316 | positive regulation of intracellular protein transport | 5.85e-03 |
| WEE1 | GO:0006606 | protein import into nucleus | 5.85e-03 |
| WEE1 | GO:0051170 | import into nucleus | 5.98e-03 |
| WEE1 | GO:0042770 | signal transduction in response to DNA damage | 7.43e-03 |
| WEE1 | GO:0000075 | cell cycle checkpoint signaling | 7.43e-03 |
| WEE1 | GO:1901991 | negative regulation of mitotic cell cycle phase transition | 7.47e-03 |
| WEE1 | GO:0032388 | positive regulation of intracellular transport | 7.59e-03 |
| WEE1 | GO:0033157 | regulation of intracellular protein transport | 9.28e-03 |
| WEE1 | GO:0033044 | regulation of chromosome organization | 1.05e-02 |
| WEE1 | GO:0045930 | negative regulation of mitotic cell cycle | 1.05e-02 |
| WEE1 | GO:0000082 | G1/S transition of mitotic cell cycle | 1.05e-02 |
| WEE1 | GO:1901988 | negative regulation of cell cycle phase transition | 1.18e-02 |
| WEE1 | GO:0006260 | DNA replication | 1.18e-02 |
| WEE1 | GO:0044843 | cell cycle G1/S phase transition | 1.18e-02 |
| WEE1 | GO:0051222 | positive regulation of protein transport | 1.38e-02 |
| WEE1 | GO:0034504 | protein localization to nucleus | 1.38e-02 |
| WEE1 | GO:0010948 | negative regulation of cell cycle process | 1.42e-02 |
| WEE1 | GO:1904951 | positive regulation of establishment of protein localization | 1.42e-02 |
| WEE1 | GO:0006913 | nucleocytoplasmic transport | 1.42e-02 |
| WEE1 | GO:0051169 | nuclear transport | 1.42e-02 |
| WEE1 | GO:0032386 | regulation of intracellular transport | 1.44e-02 |
| WEE1 | GO:1901990 | regulation of mitotic cell cycle phase transition | 1.56e-02 |
| WEE1 | GO:0055015 | ventricular cardiac muscle cell development | 1.57e-02 |
| WEE1 | GO:0042176 | regulation of protein catabolic process | 1.57e-02 |
| WEE1 | GO:0045793 | positive regulation of cell size | 1.64e-02 |
| WEE1 | GO:0045786 | negative regulation of cell cycle | 1.64e-02 |
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Related Drugs to WEE1_HDLBP |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning WEE1-HDLBP and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to WEE1_HDLBP |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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