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Kinase Fusion Gene:YES1_KDELR2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: YES1_KDELR2 | KinaseFusionDB ID: KFG7198 | FusionGDB2.0 ID: KFG7198 | Hgene | Tgene | Gene symbol | YES1 | KDELR2 | Gene ID | 7525 | 11014 | |
| Gene name | YES proto-oncogene 1, Src family tyrosine kinase | KDEL endoplasmic reticulum protein retention receptor 2 | ||||||||||
| Synonyms | HsT441|P61-YES|Yes|c-yes | ELP-1|ELP1|ERD2.2|OI21 | ||||||||||
| Cytomap | 18p11.32 | 7p22.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | tyrosine-protein kinase YesYES1 proto-oncogene, Src family tyrosine kinaseYamaguchi sarcoma oncogenecellular yes-1 proteinproto-oncogene c-Yesproto-oncogene tyrosine-protein kinase YESv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | ER lumen protein-retaining receptor 2(Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2ERD-2-like proteinERD2-like protein 1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2KDEL receptor 2 | ||||||||||
| Modification date | 20240411 | 20240305 | ||||||||||
| UniProtAcc | P07947 | P33947 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000314574, ENST00000577611, ENST00000577961, ENST00000584307, | ENST00000258739, ENST00000463747, ENST00000490996, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: YES1 [Title/Abstract] AND KDELR2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | YES1(722376)-KDELR2(6501879), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KDELR2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 1325562|18086916 |
| Kinase Fusion gene breakpoints across YES1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across KDELR2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BE927703 | YES1 | chr18 | 722376 | KDELR2 | chr7 | 6501879 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:722376/:6501879) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YES1 | KDELR2 |
| FUNCTION: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. | FUNCTION: Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (PubMed:1325562, PubMed:18086916, PubMed:33053334). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). {ECO:0000250|UniProtKB:Q5ZKX9, ECO:0000269|PubMed:1325562, ECO:0000269|PubMed:18086916, ECO:0000269|PubMed:33053334}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of YES1_KDELR2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| YES1 | P07947 | human | YAP1 | P46937 | Y407 | sGLsMsSySVPRtPD | |
| YES1 | P07947 | human | CDC37 | Q16543 | Y4 | ____MVDysVWDHIE | CDC37_N |
| YES1 | P07947 | human | NFE2L2 | Q16236 | Y576 | RDEDGkPysPSEYSL | |
| YES1 | P07947 | human | PTK2 | Q05397 | Y925 | DRsNDkVyENVtGLV | Focal_AT |
| YES1 | P07947 | human | ANXA2 | P07355 | Y24 | HstPPsAyGsVkAyt | |
| YES1 | P07947 | human | NPHS1 | O60500 | Y1193 | SGAWGPLyDEVQMGP | |
| YES1 | P07947 | human | YAP1 | P46937 | Y391 | PFLNsGtyHSRDEst | |
| YES1 | P07947 | human | ERBB2 | P04626 | Y877 | LDIDEtEyHADGGkV | PK_Tyr_Ser-Thr |
| YES1 | P07947 | human | WWTR1 | Q9GZV5 | Y305 | PFLNGGPyHsREQst | |
| YES1 | P07947 | human | PTK2 | Q05397 | Y861 | PIGNQHIyQPVGKPD | |
| YES1 | P07947 | human | WBP2 | Q969T9 | Y231 | AEAAASAyyNPGNPH | |
| YES1 | P07947 | human | CDKN1B | P46527 | Y89 | GsLPEFyyRPPRPPK | |
| YES1 | P07947 | human | DPYSL2 | Q16555 | Y479 | kPFPDFVyKRIKARS | |
| YES1 | P07947 | human | WBP2 | Q969T9 | Y192 | MMDGAMGyVQPPPPP | |
| YES1 | P07947 | human | ETS1 | P14921 | Y283 | sLQRVPsyDsFDsED | Ets1_N_flank |
| YES1 | P07947 | human | ALOX5 | P09917 | Y54 | ERGAVDSyDVTVDEE | PLAT |
| YES1 | P07947 | human | CDKN1B | P46527 | Y88 | kGsLPEFyyRPPRPP | |
| YES1 | P07947 | human | ALOX5 | P09917 | Y446 | RAMKDLtyAsLCFPE | Lipoxygenase |
| YES1 | P07947 | human | CDKN1B | P46527 | Y74 | HkPLEGkyEWQEVEk | CDI |
| YES1 | P07947 | human | CDC37 | Q16543 | Y298 | GLDPVEVyEsLPEEL | CDC37_C |
| YES1 | P07947 | human | CDK4 | P11802 | Y17 | AEIGVGAyGTVYkAR | Pkinase |
| YES1 | P07947 | human | ALOX5 | P09917 | Y43 | HLLDKPFyNDFERGA | PLAT |
| YES1 | P07947 | human | SOCS1 | O15524 | Y80 | LLDACGFyWGPLSVH | SH2 |
| YES1 | P07947 | human | GLO1 | Q04760 | Y136 | GIAVPDVysACkRFE | Glyoxalase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| YES1 | ID | Description | 0.00e+00 |
| YES1 | GO:0042060 | wound healing | 8.33e-04 |
| YES1 | GO:0061041 | regulation of wound healing | 2.06e-03 |
| YES1 | GO:0035850 | epithelial cell differentiation involved in kidney development | 2.71e-03 |
| YES1 | GO:1903034 | regulation of response to wounding | 2.80e-03 |
| YES1 | GO:0061005 | cell differentiation involved in kidney development | 2.80e-03 |
| YES1 | GO:0050678 | regulation of epithelial cell proliferation | 2.80e-03 |
| YES1 | GO:1904036 | negative regulation of epithelial cell apoptotic process | 2.96e-03 |
| YES1 | GO:0050673 | epithelial cell proliferation | 3.43e-03 |
| YES1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 3.43e-03 |
| YES1 | GO:0050847 | progesterone receptor signaling pathway | 3.43e-03 |
| YES1 | GO:0022407 | regulation of cell-cell adhesion | 3.43e-03 |
| YES1 | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway | 3.43e-03 |
| YES1 | GO:0072182 | regulation of nephron tubule epithelial cell differentiation | 3.43e-03 |
| YES1 | GO:0045444 | fat cell differentiation | 3.43e-03 |
| YES1 | GO:0072160 | nephron tubule epithelial cell differentiation | 4.17e-03 |
| YES1 | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development | 5.16e-03 |
| YES1 | GO:1904035 | regulation of epithelial cell apoptotic process | 6.68e-03 |
| YES1 | GO:0072009 | nephron epithelium development | 7.54e-03 |
| YES1 | GO:0072234 | metanephric nephron tubule development | 8.20e-03 |
| YES1 | GO:0072202 | cell differentiation involved in metanephros development | 8.20e-03 |
| YES1 | GO:0045765 | regulation of angiogenesis | 8.20e-03 |
| YES1 | GO:1901342 | regulation of vasculature development | 8.20e-03 |
| YES1 | GO:0072170 | metanephric tubule development | 8.20e-03 |
| YES1 | GO:0072243 | metanephric nephron epithelium development | 8.20e-03 |
| YES1 | GO:1900407 | regulation of cellular response to oxidative stress | 8.20e-03 |
| YES1 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell | 8.20e-03 |
| YES1 | GO:2000737 | negative regulation of stem cell differentiation | 8.20e-03 |
| YES1 | GO:1904019 | epithelial cell apoptotic process | 8.20e-03 |
| YES1 | GO:0045598 | regulation of fat cell differentiation | 8.20e-03 |
| YES1 | GO:1903037 | regulation of leukocyte cell-cell adhesion | 8.20e-03 |
| YES1 | GO:0045667 | regulation of osteoblast differentiation | 8.20e-03 |
| YES1 | GO:0072073 | kidney epithelium development | 8.20e-03 |
| YES1 | GO:0072207 | metanephric epithelium development | 8.40e-03 |
| YES1 | GO:0072006 | nephron development | 8.66e-03 |
| YES1 | GO:0007159 | leukocyte cell-cell adhesion | 1.01e-02 |
| YES1 | GO:0030856 | regulation of epithelial cell differentiation | 1.01e-02 |
| YES1 | GO:0030099 | myeloid cell differentiation | 1.01e-02 |
| YES1 | GO:0043434 | response to peptide hormone | 1.01e-02 |
| YES1 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 1.01e-02 |
| YES1 | GO:1902882 | regulation of response to oxidative stress | 1.01e-02 |
| YES1 | GO:0010634 | positive regulation of epithelial cell migration | 1.02e-02 |
| YES1 | GO:0001503 | ossification | 1.07e-02 |
| YES1 | GO:0032570 | response to progesterone | 1.23e-02 |
| YES1 | GO:1904994 | regulation of leukocyte adhesion to vascular endothelial cell | 1.27e-02 |
| YES1 | GO:0045785 | positive regulation of cell adhesion | 1.37e-02 |
| YES1 | GO:0035329 | hippo signaling | 1.39e-02 |
| YES1 | GO:0022408 | negative regulation of cell-cell adhesion | 1.39e-02 |
| YES1 | GO:1901654 | response to ketone | 1.42e-02 |
| YES1 | GO:0045581 | negative regulation of T cell differentiation | 1.76e-02 |
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Related Drugs to YES1_KDELR2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning YES1-KDELR2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to YES1_KDELR2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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