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Kinase Fusion Gene:YWHAB_STK4 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: YWHAB_STK4 | KinaseFusionDB ID: KFG7211 | FusionGDB2.0 ID: KFG7211 | Hgene | Tgene | Gene symbol | YWHAB | STK4 | Gene ID | 7529 | 6789 | |
Gene name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta | serine/threonine kinase 4 | ||||||||||
Synonyms | GW128|HEL-S-1|HS1|KCIP-1|YWHAA | KRS2|MST1|YSK3 | ||||||||||
Cytomap | 20q13.12 | 20q13.12 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | 14-3-3 protein beta/alpha14-3-3 alphaepididymis secretory protein Li 1protein 1054protein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptidetyrosine 3-monooxygenase/tryptophan 5-mono | serine/threonine-protein kinase 4STE20-like kinase MST1hippo homologkinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | ||||||||||
Modification date | 20240411 | 20240416 | ||||||||||
UniProtAcc | P31946 | Q8N2I9 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000479421, ENST00000353703, ENST00000372839, | ENST00000372801, ENST00000372806, ENST00000396731, ENST00000499879, ENST00000487587, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: YWHAB [Title/Abstract] AND STK4 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK4(43653771)-YWHAB(43530171), # samples:1 YWHAB(43514527)-STK4(43615773), # samples:2 YWHAB(43514527)-STK4(43703659), # samples:2 YWHAB(43514527)-STK4(43703658), # samples:2 YWHAB(43516383)-STK4(43703658), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YWHAB | GO:0035308 | negative regulation of protein dephosphorylation | 17255105 |
Hgene | YWHAB | GO:0043085 | positive regulation of catalytic activity | 17255105 |
Hgene | YWHAB | GO:0051220 | cytoplasmic sequestering of protein | 10869435 |
Tgene | STK4 | GO:0000902 | cell morphogenesis | 11805089 |
Tgene | STK4 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
Tgene | STK4 | GO:0006468 | protein phosphorylation | 11805089 |
Tgene | STK4 | GO:0006468 | protein phosphorylation | 8566796 |
Tgene | STK4 | GO:0006606 | protein import into nucleus | 16751106 |
Tgene | STK4 | GO:0006915 | apoptotic process | 21212262 |
Tgene | STK4 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
Tgene | STK4 | GO:0032092 | positive regulation of protein binding | 22292086 |
Tgene | STK4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
Tgene | STK4 | GO:0035329 | hippo signaling | 20412773 |
Tgene | STK4 | GO:0035556 | intracellular signal transduction | 8566796 |
Tgene | STK4 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
Tgene | STK4 | GO:0046777 | protein autophosphorylation | 11805089 |
Tgene | STK4 | GO:0050821 | protein stabilization | 19962960 |
Kinase Fusion gene breakpoints across YWHAB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across STK4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-A8-A09A-01A | YWHAB | chr20 | 43514527 | STK4 | chr20 | 43615773 |
ChimerDB4 | TCGA-A8-A09A | YWHAB | chr20 | 43514527 | STK4 | chr20 | 43615772 |
ChimerDB4 | TCGA-VR-A8ET-01A | YWHAB | chr20 | 43514527 | STK4 | chr20 | 43703659 |
ChimerDB4 | TCGA-VR-A8ET | YWHAB | chr20 | 43514527 | STK4 | chr20 | 43703658 |
ChimerDB4 | TCGA-VR-A8ET | YWHAB | chr20 | 43516383 | STK4 | chr20 | 43703658 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43653771/:43530171) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
YWHAB | STK4 |
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}. | FUNCTION: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. {ECO:0000269|PubMed:13679039}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of YWHAB_STK4 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
STK4 | Q13043 | human | TNNI3 | P19429 | T129 | ITEIADLtQkIFDLR | Troponin |
STK4 | Q13043 | human | PRDX1 | Q06830 | T183 | GWkPGsDtIkPDVQk | 1-cysPrx_C |
STK4 | Q13043 | human | NR3C1 | P04150 | S682 | VPkDGLksQELFDEI | Hormone_recep |
STK4 | Q13043 | human | GJA1 | P17302 | S255 | HAtsGALsPAkDCGs | |
STK4 | Q13043 | human | STK4 | Q13043 | T183 | DtMAkRNtVIGTPFW | Pkinase |
STK4 | Q13043 | human | FOXO1 | Q12778 | S212 | SSAGWkNsIRHNLsL | Forkhead |
STK4 | Q13043 | human | ABL1 | P00519 | T735 | DTEWRSVtLPRDLQS | |
STK4 | Q13043 | human | FOXO1 | Q12778 | S218 | NsIRHNLsLHSkFIR | Forkhead |
STK4 | Q13043 | human | NR3C1 | P04150 | T562 | StWRIMTtLNMLGGR | Hormone_recep |
STK4 | Q13043 | human | MOB1A | Q9H8S9 | T35 | LLkHAEAtLGsGNLR | Mob1_phocein |
STK4 | Q13043 | human | PRKAA1 | Q13131 | T183 | sDGEFLRtsCGsPNy | Pkinase |
STK4 | Q13043 | human | H2BC3 | P33778 | S14 | APAPkkGskkAItkA | Histone |
STK4 | Q13043 | human | STK38 | Q15208 | T444 | DWVFINytyKRFEGL | Pkinase_C |
STK4 | Q13043 | human | TNNI3 | P19429 | T143 | RGKFKRPtLRrVrIs | Troponin |
STK4 | Q13043 | human | STK4 | Q13043 | T353 | TMTDGANtMIEHDDt | |
STK4 | Q13043 | human | FOXO3 | O43524 | S243 | INPDGGksGkAPRRR | Forkhead |
STK4 | Q13043 | human | FOXO3 | O43524 | S209 | SSAGWkNsIRHNLsL | Forkhead |
STK4 | Q13043 | human | NR3C1 | P04150 | T668 | EEYLCMKtLLLLSSV | Hormone_recep |
STK4 | Q13043 | human | LATS1 | O95835 | T1079 | EHAFyEFtFRRFFDD | |
STK4 | Q13043 | human | UNC5B | Q8IZJ1 | T428 | FHPVNFKtARPSNPQ | |
STK4 | Q13043 | human | BECN1 | Q14457 | T108 | GEASDGGtMENLSRR | BH3 |
STK4 | Q13043 | human | PRDX1 | Q06830 | T90 | CHLAWVNtPkkQGGL | AhpC-TSA |
STK4 | Q13043 | human | FOXO3 | O43524 | S231 | QNEGTGKssWWIINP | Forkhead |
STK4 | Q13043 | human | IRF3 | Q14653 | T75 | RDkPDLPtWkRNFRs | IRF |
STK4 | Q13043 | human | FOXO1 | Q12778 | S235 | NEGTGKssWWMLNPE | Forkhead |
STK4 | Q13043 | human | NR3C1 | P04150 | S746 | TFLDKTMsIEFPEML | |
STK4 | Q13043 | human | AURKB | Q96GD4 | T232 | APsLRRktMCGtLDy | Pkinase |
STK4 | Q13043 | human | FOXO1 | Q12778 | S234 | QNEGTGKssWWMLNP | Forkhead |
STK4 | Q13043 | human | FOXO3 | O43524 | S232 | NEGTGKssWWIINPD | Forkhead |
STK4 | Q13043 | human | TNNI3 | P19429 | T31 | sNyRAyAtEPHAKKK | Troponin-I_N |
STK4 | Q13043 | human | MAP1LC3B | Q9GZQ8 | T50 | QLPVLDktkFLVPDH | ATG8 |
STK4 | Q13043 | human | NR4A1 | P22736 | T366 | AsPANLLtSLVRAHL | |
STK4 | Q13043 | human | FOXO3 | O43524 | S215 | NsIRHNLsLHSRFMR | Forkhead |
STK4 | Q13043 | human | MOB1B | Q7L9L4 | T35 | LLkHAEAtLGsGNLR | Mob1_phocein |
STK4 | Q13043 | human | ITGA2 | P17301 | S1180 | IDETtELss______ | |
STK4 | Q13043 | human | STK4 | Q13043 | T367 | tLPSQLGtMVINAED | |
STK4 | Q13043 | human | SIK3 | Q9Y2K2 | T221 | TPGQLLKtWCGSPPY | Pkinase |
STK4 | Q13043 | human | PRDX1 | Q06830 | T18 | PAPNFkAtAVMPDGQ | AhpC-TSA |
STK4 | Q13043 | human | H2AX | P16104 | S139 | GkkAtQAsQEy____ | |
STK4 | Q13043 | human | TNNI3 | P19429 | T51 | sRKLQLKtLLLQIAK | Troponin |
STK4 | Q13043 | human | MOB1B | Q7L9L4 | T12 | FGsRssktFKPkkNI | |
STK4 | Q13043 | human | IRF3 | Q14653 | T253 | PDPGMSLtDRGVMsY | IRF-3 |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
STK4 | ID | Description | 0.00e+00 |
STK4 | GO:0035329 | hippo signaling | 2.20e-04 |
STK4 | GO:0090257 | regulation of muscle system process | 2.20e-04 |
STK4 | GO:0034599 | cellular response to oxidative stress | 2.20e-04 |
STK4 | GO:0003012 | muscle system process | 2.62e-04 |
STK4 | GO:0062197 | cellular response to chemical stress | 4.69e-04 |
STK4 | GO:0009267 | cellular response to starvation | 4.89e-04 |
STK4 | GO:0071496 | cellular response to external stimulus | 5.56e-04 |
STK4 | GO:0042594 | response to starvation | 9.62e-04 |
STK4 | GO:0006979 | response to oxidative stress | 9.95e-04 |
STK4 | GO:0031669 | cellular response to nutrient levels | 1.53e-03 |
STK4 | GO:0031668 | cellular response to extracellular stimulus | 2.39e-03 |
STK4 | GO:0031667 | response to nutrient levels | 2.51e-03 |
STK4 | GO:0042149 | cellular response to glucose starvation | 2.97e-03 |
STK4 | GO:0010508 | positive regulation of autophagy | 2.97e-03 |
STK4 | GO:0034614 | cellular response to reactive oxygen species | 3.08e-03 |
STK4 | GO:0043525 | positive regulation of neuron apoptotic process | 3.62e-03 |
STK4 | GO:0099024 | plasma membrane invagination | 3.79e-03 |
STK4 | GO:0010506 | regulation of autophagy | 4.46e-03 |
STK4 | GO:1903943 | regulation of hepatocyte apoptotic process | 4.53e-03 |
STK4 | GO:0010324 | membrane invagination | 4.53e-03 |
STK4 | GO:0070301 | cellular response to hydrogen peroxide | 4.73e-03 |
STK4 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | 4.86e-03 |
STK4 | GO:0046777 | protein autophosphorylation | 5.13e-03 |
STK4 | GO:0006995 | cellular response to nitrogen starvation | 5.13e-03 |
STK4 | GO:0043562 | cellular response to nitrogen levels | 5.13e-03 |
STK4 | GO:0000302 | response to reactive oxygen species | 5.40e-03 |
STK4 | GO:0090235 | regulation of metaphase plate congression | 5.47e-03 |
STK4 | GO:0045786 | negative regulation of cell cycle | 5.47e-03 |
STK4 | GO:0060537 | muscle tissue development | 7.06e-03 |
STK4 | GO:0043523 | regulation of neuron apoptotic process | 7.54e-03 |
STK4 | GO:0043502 | regulation of muscle adaptation | 8.31e-03 |
STK4 | GO:0016055 | Wnt signaling pathway | 8.31e-03 |
STK4 | GO:0198738 | cell-cell signaling by wnt | 8.31e-03 |
STK4 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 9.33e-03 |
STK4 | GO:0006390 | mitochondrial transcription | 9.33e-03 |
STK4 | GO:0042542 | response to hydrogen peroxide | 9.33e-03 |
STK4 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore | 1.04e-02 |
STK4 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | 1.04e-02 |
STK4 | GO:0097284 | hepatocyte apoptotic process | 1.04e-02 |
STK4 | GO:0051402 | neuron apoptotic process | 1.13e-02 |
STK4 | GO:1904035 | regulation of epithelial cell apoptotic process | 1.14e-02 |
STK4 | GO:0061744 | motor behavior | 1.16e-02 |
STK4 | GO:0043500 | muscle adaptation | 1.23e-02 |
STK4 | GO:0018105 | peptidyl-serine phosphorylation | 1.28e-02 |
STK4 | GO:0006929 | substrate-dependent cell migration | 1.39e-02 |
STK4 | GO:0018209 | peptidyl-serine modification | 1.44e-02 |
STK4 | GO:0051984 | positive regulation of chromosome segregation | 1.44e-02 |
STK4 | GO:0030879 | mammary gland development | 1.57e-02 |
STK4 | GO:0033135 | regulation of peptidyl-serine phosphorylation | 1.71e-02 |
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Related Drugs to YWHAB_STK4 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning YWHAB-STK4 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to YWHAB_STK4 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |