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Kinase Fusion Gene:CALM1_MINK1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CALM1_MINK1 | KinaseFusionDB ID: KFG835 | FusionGDB2.0 ID: KFG835 | Hgene | Tgene | Gene symbol | CALM1 | MINK1 | Gene ID | 801 | 50488 | |
| Gene name | calmodulin 1 | misshapen like kinase 1 | ||||||||||
| Synonyms | CALML2|CAM2|CAM3|CAMB|CAMC|CAMI|CAMIII|CPVT4|DD132|LQT14|PHKD|PHKD1|caM | B55|MAP4K6|MEKKK 6|MINK|YSK2|ZC3 | ||||||||||
| Cytomap | 14q32.11 | 17p13.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | calmodulin-1Calmodulin-2Calmodulin-3calmodulin 1 (phosphorylase kinase, delta)phosphorylase kinase subunit deltaphosphorylase kinase subunit delta 1phosphorylase kinase, delta subunitprepro-calmodulin 1 | misshapen-like kinase 1GCK family kinase MINKMAPK/ERK kinase kinase kinase 6MEK kinase kinase 6misshapen/NIK-related kinasemitogen-activated protein kinase kinase kinase kinase 6 | ||||||||||
| Modification date | 20240411 | 20240411 | ||||||||||
| UniProtAcc | P0DP23 | Q8N4C8 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000555132, ENST00000356978, ENST00000447653, ENST00000544280, ENST00000553542, | ENST00000347992, ENST00000355280, ENST00000453408, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CALM1 [Title/Abstract] AND MINK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CALM1(90863532)-MINK1(4791027), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CALM1 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 20226167 |
| Hgene | CALM1 | GO:0016240 | autophagosome membrane docking | 28890335 |
| Hgene | CALM1 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 8631777 |
| Hgene | CALM1 | GO:0035307 | positive regulation of protein dephosphorylation | 8631777 |
| Hgene | CALM1 | GO:0035458 | cellular response to interferon-beta | 35568036 |
| Hgene | CALM1 | GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT | 11972023|35568036 |
| Hgene | CALM1 | GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 8631777 |
| Hgene | CALM1 | GO:0051592 | response to calcium ion | 7607248 |
| Hgene | CALM1 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 22067155 |
| Hgene | CALM1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 26164367 |
| Hgene | CALM1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 20226167 |
| Hgene | CALM1 | GO:0071346 | cellular response to type II interferon | 11972023 |
| Hgene | CALM1 | GO:0140056 | organelle localization by membrane tethering | 28890335 |
| Hgene | CALM1 | GO:1990456 | mitochondrion-endoplasmic reticulum membrane tethering | 28890335 |
| Tgene | MINK1 | GO:0046777 | protein autophosphorylation | 15469942 |
| Kinase Fusion gene breakpoints across CALM1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MINK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BF898266 | CALM1 | chr14 | 90863532 | MINK1 | chr17 | 4791027 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:90863532/:4791027) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CALM1 | MINK1 |
| FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:23893133, PubMed:26969752, PubMed:27165696, PubMed:28890335, PubMed:31454269, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:23893133, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:31454269, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. {ECO:0000269|PubMed:31330532}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631}. | FUNCTION: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CALM1_MINK1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MINK1 | Q8N4C8 | human | SMAD1 | Q15797 | T322 | sNVNRNStIENTRRH | MH2 |
| MINK1 | Q8N4C8 | human | NR3C1 | P04150 | T562 | StWRIMTtLNMLGGR | Hormone_recep |
| MINK1 | Q8N4C8 | human | NR3C1 | P04150 | T635 | IINEQRMtLPCMYDQ | Hormone_recep |
| MINK1 | Q8N4C8 | human | NR3C1 | P04150 | T524 | NKtIVPAtLPQLTPT | |
| MINK1 | Q8N4C8 | human | LATS1 | O95835 | T1079 | EHAFyEFtFRRFFDD |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MINK1 | ID | Description | 0.00e+00 |
| MINK1 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 3.98e-04 |
| MINK1 | GO:0071559 | response to transforming growth factor beta | 3.98e-04 |
| MINK1 | GO:1902895 | positive regulation of miRNA transcription | 1.28e-03 |
| MINK1 | GO:2000630 | positive regulation of miRNA metabolic process | 1.28e-03 |
| MINK1 | GO:0061180 | mammary gland epithelium development | 1.28e-03 |
| MINK1 | GO:1902893 | regulation of miRNA transcription | 1.28e-03 |
| MINK1 | GO:0061614 | miRNA transcription | 1.28e-03 |
| MINK1 | GO:2000628 | regulation of miRNA metabolic process | 1.65e-03 |
| MINK1 | GO:0140747 | regulation of ncRNA transcription | 1.68e-03 |
| MINK1 | GO:0010586 | miRNA metabolic process | 1.97e-03 |
| MINK1 | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 2.42e-03 |
| MINK1 | GO:0030879 | mammary gland development | 2.43e-03 |
| MINK1 | GO:0098781 | ncRNA transcription | 2.43e-03 |
| MINK1 | GO:0043401 | steroid hormone mediated signaling pathway | 2.43e-03 |
| MINK1 | GO:0035265 | organ growth | 3.74e-03 |
| MINK1 | GO:0009755 | hormone-mediated signaling pathway | 4.17e-03 |
| MINK1 | GO:0071383 | cellular response to steroid hormone stimulus | 4.55e-03 |
| MINK1 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 5.21e-03 |
| MINK1 | GO:0045165 | cell fate commitment | 7.69e-03 |
| MINK1 | GO:0048545 | response to steroid hormone | 9.72e-03 |
| MINK1 | GO:0030522 | intracellular receptor signaling pathway | 1.06e-02 |
| MINK1 | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 1.36e-02 |
| MINK1 | GO:0007059 | chromosome segregation | 1.39e-02 |
| MINK1 | GO:0042711 | maternal behavior | 1.39e-02 |
| MINK1 | GO:0048732 | gland development | 1.39e-02 |
| MINK1 | GO:0031943 | regulation of glucocorticoid metabolic process | 1.39e-02 |
| MINK1 | GO:0060746 | parental behavior | 1.39e-02 |
| MINK1 | GO:0014004 | microglia differentiation | 1.46e-02 |
| MINK1 | GO:0042921 | glucocorticoid receptor signaling pathway | 1.53e-02 |
| MINK1 | GO:0031958 | corticosteroid receptor signaling pathway | 1.59e-02 |
| MINK1 | GO:0090030 | regulation of steroid hormone biosynthetic process | 1.65e-02 |
| MINK1 | GO:0006704 | glucocorticoid biosynthetic process | 1.66e-02 |
| MINK1 | GO:0001710 | mesodermal cell fate commitment | 1.66e-02 |
| MINK1 | GO:0060644 | mammary gland epithelial cell differentiation | 1.66e-02 |
| MINK1 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 1.66e-02 |
| MINK1 | GO:0031053 | primary miRNA processing | 1.90e-02 |
| MINK1 | GO:0051220 | cytoplasmic sequestering of protein | 1.95e-02 |
| MINK1 | GO:0061744 | motor behavior | 1.95e-02 |
| MINK1 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 1.95e-02 |
| MINK1 | GO:0046885 | regulation of hormone biosynthetic process | 1.95e-02 |
| MINK1 | GO:0071549 | cellular response to dexamethasone stimulus | 1.95e-02 |
| MINK1 | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | 1.95e-02 |
| MINK1 | GO:0008211 | glucocorticoid metabolic process | 1.98e-02 |
| MINK1 | GO:0030325 | adrenal gland development | 2.12e-02 |
| MINK1 | GO:1903672 | positive regulation of sprouting angiogenesis | 2.12e-02 |
| MINK1 | GO:0060603 | mammary gland duct morphogenesis | 2.15e-02 |
| MINK1 | GO:0060795 | cell fate commitment involved in formation of primary germ layer | 2.28e-02 |
| MINK1 | GO:0061036 | positive regulation of cartilage development | 2.28e-02 |
| MINK1 | GO:0051647 | nucleus localization | 2.30e-02 |
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Related Drugs to CALM1_MINK1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CALM1-MINK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CALM1_MINK1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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